Prolongación de la vida de los seres humanos: longevidad y calidad de vida

Incluye Bibliografía

Caracterização de agravos causados por cães e gatos a seres humanos no município de jaboticabal, são paulo, durante o período de 2000 A 2009

The lack of proper control of dogs and cats population and irresponsible pet ownership are factors that favor animal attack and pose serious public health concern. The aim of the present study was to characterize the injuries caused by dogs and cats to humans in the municipality of Jaboticabal, between the years 2000 and 2009, with a view to demonstrate the importance of aggression control in reducing both the risk for rabies transmission and the number of post exposure prophylaxis administration. A retrospective and descriptive study was conducted. 3,972 out of 4,149 records of patients who sought the public health service after being attacked by an animal were analyzed. Dogs were the species that most caused injuries. In the moment of the attack, the doǵs clinical status was declared as healthy in 81.8% of records; and in 81.1% of cases this status were maintained throughout the entire observation period of the aggressor. Most of injuries were characterized by bites in hands or feet, with multiple and superficial wounds. The number of injuries was high, therefore it is crucial to implement strategies to reduce injuries caused by animal attack through health promotion, educational activities and strengthening of integration of public health and veterinary services so that the decision to institute post-exposure prophylaxis is taken with criteria and safety.

Desenvolvimento de uma base de dados para fatores de transcrição de seres humanos e suas redes de interação: Human Transcriptional Regulation Interaction Database (HTRIDB 2.0)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Trabalho com redução à condição análoga à de escravos e ofensa à dignidade da pessoa humana: tráfico de mulheres para fins de exploração sexual comercial, no Brasil (2002-2008)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Eles e Elas: comparação intersexual na categorização social e formação das primeiras impressões em seres humanos

O objetivo da presente pesquisa foi compreender, sob uma perspectiva evolucionista, os mecanismos, preferências e as diferenças sexuais subjacentes a uma análise as primeiras impressões em seres humanos. Investigamos: (1) ocorrências de diferenças sexuais na categorização social e na formação das primeiras impressões; (2) a influência do sexo e da cor de pele e (3) ocorrência de preconceitos (com relação ao sexo e/ou a cor de pele do sujeito estímulo) e suas influências na formação das primeiras impressões. Para isso, tratamos de expor uma amostra de 43 indivíduos ( 17 a 34 anos) à oito vídeos (4 perfis: homens negros e brancos, mulheres brancas e negras) com duração de 20’’ cada. Durante o procedimento experimental foi requerido que o participante respondesse a um questionário (escala likert; 0-6). Nesse, o participante avaliava a atratividade física, a competência, sucesso na carreira, agressividade, confiabilidade, atribuía uma nota para a cor da pele, e qualidade geral. Foi feito um teste GLM com medidas repetidas e post hoc teste t student pareado, a fim fazer uma análise mais detalhada das diferenças encontradas nas avaliações. Nossos resultados apontam que a característica que afeta mais a avaliação tanto de homens como das mulheres é a atratividade física, o que foi possível concluir que as outras características em análise é menos dependente da primeira impressão e construída ao longo do convívio. As mulheres tendem a fazer uma avaliação mais minuciosa, o que corrobora outros estudos sobre diferenças sexuais. Devido ao pequeno N, não possível analisarmos a influência da cor da pele do sujeito estímulo na avaliação, evidenciando a necessidade de ampliação futura desse projeto. A análise post hoc nos mostrou um ligeiro preconceito contra as mulheres negras, o que também corrobora... (Resumo completo, clicar acesso eletrônico abaixo)

Reflexões sobre a possibilidade de uma tutela penal internacional dos direitos humanos sobre as pesquisas científicas com seres humanos

Marchetto Patrícia BorbaNa sociedade contemporânea, além da esfera pública de poder, possuímos uma esfera privada de poder, na qual se encontra grandes empresas multinacionais. Esses novos “detentores do Poder” são particulares, grupos ou pessoas, que se tornaram de certa forma desproporcionais socialmente em relação ao restante da sociedade. Neste patamar se encontram as grandes indústrias farmacêuticas, as quais além de possuírem uma função de suma importância para a sociedade mundial concentram grande poder econômico, social e até mesmo político. Desta forma, observa-se a existência de uma responsabilidade social das indústrias farmacêuticas vinculada com a necessidade de respeitar certas diretrizes incluídas na temática da bioética, já que trabalham com a ciência estritamente relacionada com a saúde e a vida da pessoa humana, e dos Direitos Humanos em geral. No entanto, tais indústrias por vezes acabam praticando ações que desrespeitam tais preceitos, como a realização de pesquisas científicas com seres humanos sem respeito as normas que tutelam a matéria e gerando verdadeira lesão aos Direitos Humanos, causando um verdadeiro terror científico. Esta relação tirana de poder que as grandes indústrias farmacêuticas impõe perante a sociedade deve ser tutelada pelo Direito Penal, sobretudo, para além dos limites dos Estados em que ocorrem as condutas, buscando uma tutela penal internacional. Desta forma, o presente trabalho pretende demonstrar a importância da existência de uma tutela internacional, com a possível utilização do Tribunal Penal Internacional e o enquadramento de tais condutas como crimes contra a Humanidade.

As trevas da razão esclarecida e as pesquisas em seres humanos em Tuskegee e na Guatemala: um caso de bioética

This work is aimed at examining the paradox of modernity, from the opposition between Enlightenment ideals and historical events that followed, especially during the twentieth century, as well as to study the impact of mismatch on Bioethics, adopting as a reference epistemological critical theory of the Frankfurt School. Bioethics presents itself as a shaky science, devoid of references, and primarily impacted by the emptying of ethics. The reason desubjectivation established by and exacerbated by modern enlightenment, was able to erect dark scary for humanity and promote barbaric practices in the name of a science that promises order and progress. This paradox and the fallacy of reason enlightened by scientific advances are wide open, always accompanied by ethical and moral returns scary. Some examples are the surveys conducted in Tuskegee and Guatemala, and treated in this study, which show how far modern rationality and all its consequences

Efeito de soluções fluoretadas contendo xilitol e sorbitol no número de estreptococos do grupo mutans na saliva de seres humanos

The objective of this study was to assess the effect of 0.05% sodium fluoride solutions containing 2.5% or 12.5% xylitol on the number of Streptococcus mutans in the human mouth. Fifty boys between 8 and 16 years of age participated in this double-blind crossover study. Of the original 50 boys, 33 finished the study. Participants were randomly divided into four groups. The following solutions were employed: placebo solution; 0.05% sodium fluoride solution; 0.05% sodium fluoride + 2.5% xylitol + 2% sorbitol; 0.05% sodium fluoride + 12.5% xylitol + 2% sorbitol. Each solution was used for a 28-day period (20 mL/day, twice a day), with a 10-day washout period between solutions. There were no significant differences (P = 0.32) between the two xylitol-containing solutions (2.5% vs. 12.5%) concerning the number of Streptococcus mutans. However, there was a significant difference between these two xylitol-containing solutions and the sodium fluoride and placebo solutions (P < 0.001). Our results suggest that the 0.05% sodium fluoride solutions containing either 2.5% or 12.5% xylitol caused a significant reduction in the number of Streptococcus mutans.

El mito del quebrantahuesos depredador de seres humanos

Se ha creído durante mucho tiempo que el quebrantahuesos acomete a los hombres con la intención de matarlos y devorarlos. Esta historia fabulosa, originada en tierras suizas durante el siglo XVIII, contrasta con la mirada inofensiva, o al menos de indiferencia, con la que se le ha caracterizado en la cultura mediterránea. No obstante, la fuerza del mito del Gypaetus barbatus, como un ave dañina y perjudicial para el hombre, derivó en su desprotección como especie hasta prácticamente nuestros días. En este artículo damos a conocer, a rebufo de la mala fama del quebrantón como depredador humano, un antiguo documento en el que se narran los estragos en seres humanos y en ganado atribuidos a un supuesto quebrantahuesos y la muerte, de esta peligrosa bestia, acaecida en el año 1797 en la localidad alicantina de Benimantell.

Variabilidade genética de Leishmania spp. circulantes entre seres humanos e cães e infecção de flebotomíneos em áreas endêmicas para as leishmanioses no Rio Grande do Norte

Leishmania infantum is the main etiologic agent of visceral leishmaniasis in the New World. The pattern of distribution of leishmaniasis has changed substantially and has presented an emerging profile within the periphery of the Large Urban Centers. Leishmania infection can compromise skin, mucosa and viscera. Only 10% of the individuals infected develop the disease and 90% of human infection is asymptomatic. The main factors involved in the development of the disease are the host immune response, the vector’s species and the parasite’s genetic content. The sequencing of Leishmania isolated seeks to increase the understanding of the symptoms of individuals. The aim of this study was to evaluate the genetic diversity of circulating Leishmania strains among humans, and symptomatic and asymptomatic, and dogs from endemic areas of Rio Grande do Norte State and analyze sandflies from endemic areas for cutaneous and visceral disease. The genetic variability was evaluated by the use of markers hsp70 , ITS1 and a whole genome sequencing was also carried out. The amplified hsp70 and ITS1 of samples were analyzed and assembled using a Phred / Phrap package. The dendograms were constructed using the same methodology, but adding 500 bootstraps, followed by inferences on the relationships between Leishmania variants. The sequences of the 20 Brazilian isolates were mapped to the reference genome L. infantum JPCM5, using the Bowtie2 program and the identification of 36 contigs. The information of the valid SNPs were used in the PCA. SNPs were visualized by Geneious 7.1 and IGV. The genome annotations were transferred to their respective chromosomes and displayed on Geneious. The matching sequences of all chromosomes were aligned using Mauve. The phylogenetic trees were calculated according to maximum likelihood and JTT models. Sandflies were analyzed by PCR for the identification of Leishmania infection, a blood meal source and GAPDH sand fly. As a result, hsp70 and ITS1 were not capable of identifying genetic variability among human isolates from symptomatic and asymptomatic, and dogs. The complete sequencing of the 20 Brazilian isolates revealed a strong similarity between the circulating Leishmania strains in Rio Grande do Norte. The isolates collected in the city of Natal from humans and canines remained grouped in all analyzes, suggesting that there is genotypic and geographic proximity among the isolates. The isolated samples in the 1990s had a higher genotypic diversity when compared to freshly isolated samples. All isolates presented 36 chromosomes with variable ploidy among them, no correlation was found between the number of amastina genes copies, gp63, A2 and SSG with such clinic forms. In general, we did not find correlation between symptomatic and asymptomatic clinical forms and the gene content of the Brazilian isolates of Leishmania. 34,28% of the sandflies collected in the upper west region were L. longipalpis and the main sources of blood meal were humans, dogs and chickens.

Variabilidade genética de Leishmania spp. circulantes entre seres humanos e cães e infecção de flebotomíneos em áreas endêmicas para as leishmanioses no Rio Grande do Norte

Leishmania infantum is the main etiologic agent of visceral leishmaniasis in the New World. The pattern of distribution of leishmaniasis has changed substantially and has presented an emerging profile within the periphery of the Large Urban Centers. Leishmania infection can compromise skin, mucosa and viscera. Only 10% of the individuals infected develop the disease and 90% of human infection is asymptomatic. The main factors involved in the development of the disease are the host immune response, the vector’s species and the parasite’s genetic content. The sequencing of Leishmania isolated seeks to increase the understanding of the symptoms of individuals. The aim of this study was to evaluate the genetic diversity of circulating Leishmania strains among humans, and symptomatic and asymptomatic, and dogs from endemic areas of Rio Grande do Norte State and analyze sandflies from endemic areas for cutaneous and visceral disease. The genetic variability was evaluated by the use of markers hsp70 , ITS1 and a whole genome sequencing was also carried out. The amplified hsp70 and ITS1 of samples were analyzed and assembled using a Phred / Phrap package. The dendograms were constructed using the same methodology, but adding 500 bootstraps, followed by inferences on the relationships between Leishmania variants. The sequences of the 20 Brazilian isolates were mapped to the reference genome L. infantum JPCM5, using the Bowtie2 program and the identification of 36 contigs. The information of the valid SNPs were used in the PCA. SNPs were visualized by Geneious 7.1 and IGV. The genome annotations were transferred to their respective chromosomes and displayed on Geneious. The matching sequences of all chromosomes were aligned using Mauve. The phylogenetic trees were calculated according to maximum likelihood and JTT models. Sandflies were analyzed by PCR for the identification of Leishmania infection, a blood meal source and GAPDH sand fly. As a result, hsp70 and ITS1 were not capable of identifying genetic variability among human isolates from symptomatic and asymptomatic, and dogs. The complete sequencing of the 20 Brazilian isolates revealed a strong similarity between the circulating Leishmania strains in Rio Grande do Norte. The isolates collected in the city of Natal from humans and canines remained grouped in all analyzes, suggesting that there is genotypic and geographic proximity among the isolates. The isolated samples in the 1990s had a higher genotypic diversity when compared to freshly isolated samples. All isolates presented 36 chromosomes with variable ploidy among them, no correlation was found between the number of amastina genes copies, gp63, A2 and SSG with such clinic forms. In general, we did not find correlation between symptomatic and asymptomatic clinical forms and the gene content of the Brazilian isolates of Leishmania. 34,28% of the sandflies collected in the upper west region were L. longipalpis and the main sources of blood meal were humans, dogs and chickens.