A toxicokinetic model for thiamethoxam in rats: implications for higher-tier risk assessment

Risk assessment for mammals is currently based on external exposure measurements, but effects of toxicants are better correlated with the systemically available dose than with the external administered dose. So for risk assessment of pesticides, toxicokinetics should be interpreted in the context of potential exposure in the field taking account of the timescale of exposure and individual patterns of feeding. Internal concentration is the net result of absorption, distribution, metabolism and excretion (ADME). We present a case study for thiamethoxam to show how data from ADME study on rats can be used to parameterize a body burden model which predicts body residue levels after exposures to LD50 dose either as a bolus or eaten at different feeding rates. Kinetic parameters were determined in male and female rats after an intravenous and oral administration of 14C labelled by fitting one-compartment models to measured pesticide concentrations in blood for each individual separately. The concentration of thiamethoxam in blood over time correlated closely with concentrations in other tissues and so was considered representative of pesticide concentration in the whole body. Body burden model simulations showed that maximum body weight-normalized doses of thiamethoxam were lower if the same external dose was ingested normally than if it was force fed in a single bolus dose. This indicates lower risk to rats through dietary exposure than would be estimated from the bolus LD50. The importance of key questions that should be answered before using the body burden approach in risk assessment, data requirements and assumptions made in this study are discussed in detail.

Consensus Statement: Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies

Chromosomal microarray (CMA) is increasingly utilized for genetic testing of individuals with unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), or multiple congenital anomalies (MCA). Performing CMA and G-banded karyotyping on every patient substantially increases the total cost of genetic testing. The International Standard Cytogenomic Array (ISCA) Consortium held two international workshops and conducted a literature review of 33 studies, including 21,698 patients tested by CMA. We provide an evidence-based summary of clinical cytogenetic testing comparing CMA to G-banded karyotyping with respect to technical advantages and limitations, diagnostic yield for various types of chromosomal aberrations, and issues that affect test interpretation. CMA offers a much higher diagnostic yield (15%-20%) for genetic testing of individuals with unexplained DD/ID, ASD, or MCA than a G-banded karyotype (similar to 3%, excluding Down syndrome and other recognizable chromosomal syndromes), primarily because of its higher sensitivity for submicroscopic deletions and duplications. Truly balanced rearrangements and low-level mosaicism are generally not detectable by arrays, but these are relatively infrequent causes of abnormal phenotypes in this population (<1%). Available evidence strongly supports the use of CMA in place of G-banded karyotyping as the first-tier cytogenetic diagnostic test for patients with DD/ID, ASD, or MCA. G-banded karyotype analysis should be reserved for patients with obvious chromosomal syndromes (e.g., Down syndrome), a family history of chromosomal rearrangement, or a history of multiple miscarriages.

Studie av subsynkron interaktion (SSTI) mellan ett HVDC system med spänningsstyva strömriktare och en närliggande generator

Syftet med examensarbetet är att studera den subsynkrona interaktionen (subsynchronous torsional interaktion, SSTI) mellan ett HVDC system med spänningsstyva strömriktare och en närliggande generator. Studien utförs med hjälp av datorsimuleringar och fokuserar på att studera dämpkaraktäristiken för SSTI. Studien ska visa hur faktorer såsom den överförda effektens storlek och riktning, vald driftmod och kraftsystemets kortslutningseffekt påverkar dämpkaraktäristiken. Rapporten beskriver subsynkron oscillation (SSO) och tillvägagångssättet vid en SSTI undersökning. En kort introduktion till HVDC Light ges. Studien visar att HVDC Light ökar dämpningen för det frekvensområde som är intressant. Resultaten presenteras som diagram med beräknad dämpkaraktäristik.

Vad händer med dialogen? : En studie av dialogisk interaktion mellan pedagog och barn i förskolan

The overall purpose of this study is to gain knowledge about dialogues in the setting of the preschool. The more in-depth purpose is to highlight what happens in dialogues between a teacher and a child when more children join the situation of interaction in which the dialogue is taking place. A further purpose is to attempt to understand what it is that influences change in the dialogue and what significance the actions of the teacher can have for this change. The study is based on several questions that concern interaction in preschools, who it is that initiates an increase in the number of participants in those situations that involve dialogue, and what happens with the dialogue when more children join and what causes the change in the dialogue. The study is based on video observations from a preschool; approximately 10 teachers and 50 children between the ages of one and six took part in the study. The situations that were observed and documented in video format were everyday activities (both indoor and outdoor) that were led at a nominal level by teachers. In total, 40 films were recorded. Film length was between one and 60 minutes. In 32 of the films, there was interaction between a teacher and several children, and 18 of these included dialogues between a teacher and several children. Dialogue is here given a specific significance and refers to the interaction that can be described in terms of presence, listening, reciprocity, and extending. This definition of dialogue derives from a combination of Martin Buber’s philosophy of dialogue and aspects of interaction that earlier research found to be significant for children’s learning. In two of the 18 films that showed dialogue, no other children became part of the situation of interaction; the remaining 16 films were transcribed; and both verbal and non-verbal events were made apparent in the transcriptions. Analyses of the recorded material and of the transcriptions were conducted using analytical terms borrowed from conversation analysis as well as the central term for this study dialogue.  The results demonstrate a complex practice and also demonstrate that dialogues in the sense given in this study take place between children and teachers. Situations of interaction also occur where dialogues take place in which a number of children join. It can be the child joining the situation of interaction who takes the initiative to an increased number of participants; however, it can also be the teacher or the child in the dialogue. The initial address can take place during a moment of transition in the interaction or at the same time as another participant is talking. The dialogue often changes when more children join the situation where the dialogue is taking place. The dialogue can end completely or be interrupted and resume. The results further demonstrate that the dialogue can continue without seemingly being affected by the fact that more children join. This happens when the child joining and the teacher in the dialogue interact in a non-verbal manner at the same time as the teacher is talking with the child in the dialogue. The dialogue can also be continued with more participants. Who takes the initiative, how the initial address occurs, and which content is given focus by the different participants are all factors that seem to affect what happens to the dialogue. How the teacher acts when more children join also appears to be significant in terms of what happens with the dialogue when more children join. In those situations where the teacher begins talking with a number of children about different subjects, the interaction ceases to be dialogic. When the teacher asks the joining child to wait, the dialogue is both interrupted and resumed, and on those occasions when the dialogue continues with more participants, the teacher listens to the joining child and the participants take turns speaking.

Den oemotståndliga svetsen mellan ljud och bild : En kvalitativ studie om interaktion i TV- och datorspel

Denna undersökning syftar till att studera förhållandet mellan ljud, bild och spelare i en TV- och datorspelssituation. Med hjälp av fokusgruppdiskussioner berörs frågor på det audiovisuella området, där deltagarna är aktiva spelare som har tillryggalagt ett mycket stort antal speltimmar som de bygger sina kunskaper på. Här framkommer att ljud och musik fyller viktiga funktioner för spelarens möjlighet att interagera och leva sig in i spelet och att varje spel har en unik ljud- eller musikmiljö som spelarna tycks förhålla sig till på olika sätt beroende på varför man spelar och om man spelar ensam eller tillsammans med andra, det vill säga singelplayer eller multiplayer. Informanternas kunskaper utgör styrkan i denna undersökning men det vore önskvärt att utöka studien med fler fokusgruppdiskussioner samt djupintervjuer med utvalda informanter för att fördjupa materialet. Som förslag på vidare forskning vore det intressant att studera användandet av virtuella headsets där en stereoskopisk 3D bild skapas som spårar huvudets rörelser, för att undersöka om detta kan ha en inverkan på hur vi uppfattar ljudet i ett spel.

Samtal och interaktion vid matematisk problemlösning : En intervjustudie om hur lärare organiserar sin undervisning med matematiska problem

Syftet med denna studie var att undersöka hur lärare organiserar sin undervisning med matematiska problem. Undersökningen har gjorts med hjälp av fem observationer av undervisningstillfällen samt intervjuer med fem undervisande lärare i matematik. Resultatet från undersökningen visar att kommunikation utgör en stor del av undervisningen med matematiska problem. Lärarna skapar tillfällen till samtal och interaktion i sin undervisning genom hela problemlösningsprocessen trots att deras definition av matematiska problem skiljer sig. Gemensamt för lärarnas undervisning är att den, likt forskning, organiseras i olika faser vilket är ett begrepp som beskrivs ytterligare i bakgrunden av den här studien. Trots denna gemensamma fasindelning visar resultatet att undervisningen organiseras olika inom dessa faser, även i de fall där flera lärare har deltagit i samma typ av fortbildning inom problemlösning. Resultatet visar även att sociomatiska normer är något som påverkar lärarnas organisering av arbetet med matematiska problem samt att undervisning med matematiska problem förekommer i olika stor utsträckning.

The German two-tier board and the German corporate governance code

This paper deals with some interesting recent corporate governance developments in Germany. The focus is in particular on the German Corporate Governance Code, its parts, layout and how it deals with the various organs of German public corporations. The German Code is quite unique since it applies a Code of Good Practice to a two-tier board system, thus making it necessary to deal with the role and functions and the relationship between the management and the supervisory board. This paper concludes that several changes to the German law relating to public corporations since the middle of the 1990s and the introduction of the German Code will ensure that the two-tier board system will remain the favoured board structure for public corporations in Germany. It is, however, submitted that employee participation at supervisory board level will provide particular political challenges for Germany in the near future.

Citation patterns within the leading top-tier finance journals implications for journal rankings and other issues

This paper examines all citations and self-citations to a list of 95 finance journals appearing in the Journal of Finance, Journal of Financial Economics and Review of Financial Studies from 1995 through 2005. Additionally, the publication profile of 100 prolific authors in top-tier finance journals is tabulated for these 95 journals. Citations to non-finance journals in economics and accounting are also tabulated for comparison with their finance counterpart along with working papers. Six ranking schemes are constructed with each scheme identifying the top fifty finance journals. Citations to finance journals are highly concentrated within ten journals and similarly for self-citations. Authors of papers appearing in top-tier finance journals pay scant attention to the bulk of research published in other finance journals. Furthermore, these authors cite other economic journals with greater frequency than their counterpart in finance. Of the top fifty finance journals identified in this paper, only 21 are listed in Social Sciences Citation Index (SSCI), and this compares to approximately 500 listed economic journals. Some glaring omissions from SSCI are identified, but most notably the Journal of Applied Corporate Finance, Journal of Financial Research, Journal of Empirical Finance and Journal of Fixed Income. An analysis of 2006 citations patterns is also presented. The top-tier mantra assigned to finance journals has a void with the decision by the Journal of Business to cease publication with the November 2006 issue. This paper identifies five finance journals anyone of which could potentially fill the void.

Email categorization using (2+1)-tier classification algorithms

In this paper we have proposed a spam filtering technique using (2+1)-tier classification approach. The main focus of this paper is to reduce the false positive (FP) rate which is considered as an important research issue in spam filtering. In our approach, firstly the email message will classify using first two tier classifiers and the outputs will appear to the analyzer. The analyzer will check the labeling of the output emails and send to the corresponding mailboxes based on labeling, for the case of identical prediction. If there are any misclassifications occurred by first two tier classifiers then tier-3 classifier will invoked by the analyzer and the tier-3 will take final decision. This technique reduced the analyzing complexity of our previous work. It has also been shown that the proposed technique gives better performance in terms of reducing false positive as well as better accuracy.

Multi-tier phishing email classification with an impact of classifier rescheduling

Protecting user's mailbox from infiltration of phishing email is a significant research issue now a day. Many researches are going on filtering phishing using classification based algorithms and achieve substantial performance. It has been studied and investigated with different classification algorithms and observed that the outputs of the classifiers vary from one another with same corpora. This paper presents the impact of classifier rescheduling of multi-tier classification of phishing email to observe the best scheduling in the classification process. In our method, the features of phishing email will be extracted and classified in a sequential fashion by using the multi-tier classification and the outputs will be sent to the decision fusion process. Empirical evidence proofs that the impact of rescheduling of classifiers among the tiers gives diverse outcomes in terms of accuracy as well as number of false positive instances.

Performance evaluation of multi-tier ensemble classifiers for phishing websites

This article is devoted to large multi-tier ensemble classifiers generated as ensembles of ensembles and applied to phishing websites. Our new ensemble construction is a special case of the general and productive multi-tier approach well known in information security. Many efficient multi-tier classifiers have been considered in the literature. Our new contribution is in generating new large systems as ensembles of ensembles by linking a top-tier ensemble to another middletier ensemble instead of a base classifier so that the top~ tier ensemble can generate the whole system. This automatic generation capability includes many large ensemble classifiers in two tiers simultaneously and automatically combines them into one hierarchical unified system so that one ensemble is an integral part of another one. This new construction makes it easy to set up and run such large systems. The present article concentrates on the investigation of performance of these new multi~tier ensembles for the example of detection of phishing websites. We carried out systematic experiments evaluating several essential ensemble techniques as well as more recent approaches and studying their performance as parts of multi~level ensembles with three tiers. The results presented here demonstrate that new three-tier ensemble classifiers performed better than the base classifiers and standard ensembles included in the system. This example of application to the classification of phishing websites shows that the new method of combining diverse ensemble techniques into a unified hierarchical three-tier ensemble can be applied to increase the performance of classifiers in situations where data can be processed on a large computer.

Empirical investigation of multi-tier ensembles for the detection of cardiac autonomic neuropathy using subsets of the Ewing Features

This article is devoted to an empirical investigation of per- formance of several new large multi-tier ensembles for the detection of cardiac autonomic neuropathy (CAN) in diabetes patients using subsets of the Ewing features. We used new data collected by the diabetes screening research initiative (DiScRi) project, which is more than ten times larger than the data set originally used by Ewing in the investigation of CAN. The results show that new multi-tier ensembles achieved better performance compared with the outcomes published in the literature previously. The best accuracy 97.74% of the detection of CAN has been achieved by the novel multi-tier combination of AdaBoost and Bagging, where AdaBoost is used at the top tier and Bagging is used at the middle tier, for the set consisting of the following four Ewing features: the deep breathing heart rate change, the Valsalva manoeuvre heart rate change, the hand grip blood pressure change and the lying to standing blood pressure change.

A multi-tier ensemble construction of classifiers for phishing email detection and filtering

This paper is devoted to multi-tier ensemble classifiers for the detection and filtering of phishing emails. We introduce a new construction of ensemble classifiers, based on the well known and productive multi-tier approach. Our experiments evaluate their performance for the detection and filtering of phishing emails. The multi-tier constructions are well known and have been used to design effective classifiers for email classification and other applications previously. We investigate new multi-tier ensemble classifiers, where diverse ensemble methods are combined in a unified system by incorporating different ensembles at a lower tier as an integral part of another ensemble at the top tier. Our novel contribution is to investigate the possibility and effectiveness of combining diverse ensemble methods into one large multi-tier ensemble for the example of detection and filtering of phishing emails. Our study handled a few essential ensemble methods and more recent approaches incorporated into a combined multi-tier ensemble classifier. The results show that new large multi-tier ensemble classifiers achieved better performance compared with the outcomes of the base classifiers and ensemble classifiers incorporated in the multi-tier system. This demonstrates that the new method of combining diverse ensembles into one unified multi-tier ensemble can be applied to increase the performance of classifiers if diverse ensembles are incorporated in the system.