996 resultados para Pilgrims (New Plymouth Colony)


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Mode of access: Internet.

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Mode of access: Internet.

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The solutions to Traveling Salesman Problem can be widely applied in many real-world problems. Ant colony optimization algorithms can provide an approximate solution to a Traveling Salesman Problem. However, most ant colony optimization algorithms suffer premature convergence and low convergence rate. With these observations in mind, a novel ant colony system is proposed, which employs the unique feature of critical tubes reserved in the Physaurm-inspired mathematical model. A series of experiments are conducted, which are consolidated by two realworld Traveling Salesman Problems. The experimental results show that the proposed new ant colony system outperforms classical ant colony system, genetic algorithm, and particle swarm optimization algorithm in efficiency and robustness.

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Background Despite a revived interest in fat grafting procedures, clinicians still fail to demonstrate clearly the in vivo behavior of fat grafts as a dynamic tissue substitute. However, the basic principles in cellular biology teach us that cells can survive and develop, provided that a structural matrix exists that directs their behavior. The purpose of this in vitro study was to analyze that behavior of crude fat grafts, cultured on a three-dimensional laminin-rich matrix. Methods Nonprocessed, human fat biopsy specimens (approximately 1 mm) were inoculated on Matrigel-coated wells to which culture medium was added. The control group consisted of fat biopsy specimens embedded in medium alone. The cellular proliferation pattern was followed over 6 weeks. Additional cultures of primary generated cellular spheroids were performed and eventually subjected to adipogenic differentiation media. Results A progressive outgrowth of fibroblast-like cells from the core fat biopsy specimen was observed in both groups. Within the Matrigel group, an interconnecting three-dimensional network of spindle-shaped cells was established. This new cell colony reproduced spheroids that functioned again as solitary sources of cellular proliferation. Addition of differentiation media resulted in lipid droplet deposition in the majority of generated cells, indicating the initial steps of adipogenic differentiation. Conclusions The authors noticed that crude, nonprocessed fat biopsy specimens do have considerable potential for future tissue engineering-based applications, provided that the basic principles of developmental, cellular biology are respected. Spontaneous in vitro expansion of the stromal cells present in fat grafts within autologous and injectable matrices could create "off-the-shelf" therapies for reconstructive procedures.

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This paper examines some of the practices and assessments of community development today. It begins with two tales, one recounting the apparent unfulfilled policy promises for community development, the other recounting a situation where there is no community development policy agenda and no community development rhetoric, but where real grass roots community development is apparent. These two tales lead us to consideration of the nature of community development and the issue regarding the match between the discourses of community development with the practices. The paper moves to a discussion of reasons to celebrate community development in 2005. This discussion is followed by consideration of current contextual factors constraining the practices of community development. In the context of the arguments for optimism it is also important to recognise and reflect on the orthodoxies of community development. Six orthodoxies are discussed. The paper concludes with three practical suggestions for community development activities that could begin immediately.

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Introductory: Thomas Davidson and his philosophy, by the editor.--The task of the twentieth century.--The educational problems set by the nineteenth century to the twentieth.--The history of the experiment.--The underlying spirit as shown by the letters written by Mr. Davidson to his class.--The vitality of the ideal as shown by the life of the movement after the death of its founder, by the editor.