Methodus legendi cognoscendique historiam tam sacram quam profanam. Accessit oratio de historiae dignitate... item panegyricus scriptus in honorem festivitatis qua... Henricus Julius,... in episcopatus Mindensis possessionem indulcebatur, auctore Reinero Reineccio Steinhemio. Ad calcem addita est Commentiuncula ["sic"] de Widechindo Magno, rege Saxon., dynasta Angrivariorum, etc. Editio 2a. [Reinero Reineccio historico in inclyta Acad. Julia amico colendo. S. P. D. David Chytraeus. In methodum historicam Reineri Reineccii Carmen Simonis Mencii. Historiae et Reineri Reineccii genio, Arnoldus Freitagius. Historiae encomium per Andream Alciatum. De Westphalorum Saxonia et Widechindo Magno, etc., Petrus Lotichius secundus. De eodem Widechindo Magno Michael Bojemus.]

Comprend : Historiae encomium... ad Galeacium vice-comitem scriptum ; Clarissimo... viro Reinero Reineccio... principis Brunovicensis etc. historico, in inclyta acad. Julia, amico colendo s. p. d. David Chytraeus ; Historiae et cl. viri Reineri Reineccii genio Arnoldus Freitagius ; De Westphalorum Saxonia et Widechindo Magno etc. Petrus Lotichius Secundus ; In Methodum historicam... Reineri Reineccii Carmen ; De... Widechindo Magno Michael Bojemus

2a. Memoria del directorio

Informes correspondientes al segundo año (1 de abril de 1910 a 31 de marzo de 1911).

Aproximaciones al estudio de la interacción individuo-paisaje a modo de evocacion comunicativa intrapersonal (2a. parte)

El análisis de la interacción individuo-paisaje presenta numerosas perspectivas de estudio vinculadas a la generación e interpretación de simbolismos e imaginarios. La capacidad significante y/o de evocación comunicativa del paisaje encuentra, en la comunicación intrapersonal, una argumentación relevante en el proceso de construcción de un aparato teórico que permita estudiar el proceso de apropiación y vivencia del paisaje en términos de manifestación comunicativa. El despliegue de un aparato teórico que permita interpretar el mensaje del paisaje así como descodificar su discurso intangible, representa el objetivo principal de la investigación que se presenta a continuación.

Manual de CATMARC, 2a edició: una primera lectura

Comentari crític a la segona edició del Manual del CATMARC. Es comenta la nova estructura adoptada i els criteris que sembla que s'han seguit. Si a la primera edició (1987) el format estava recolzat en l'Instltut Cátala de Bibliografía, la segona no presenta cap institució que l'avali. Al format originari s'afegeixen, sense aparent justificado, nous camps, alguns adaptáis d'USMARC. Camps d'ús local del SICAB que trenquen el caràcter de norma acceptadaque tenia CATMARC. El format d'autoritats modifica el d'USMARC, en el qual es basa. Un apéndix llista els canvis introduïts a la nova edició del format, tot indicant lurs fonts.

Front propagation in the A+B->2A reaction under subdiffusion

We consider an irreversible autocatalytic conversion reaction A+B->2A under subdiffusion described by continuous-time random walks. The reactants transformations take place independently of their motion and are described by constant rates. The analog of this reaction in the case of normal diffusion is described by the Fisher-Kolmogorov-Petrovskii-Piskunov equation leading to the existence of a nonzero minimal front propagation velocity, which is really attained by the front in its stable motion. We show that for subdiffusion, this minimal propagation velocity is zero, which suggests propagation failure.

LB11058, a new cephalosporin with high penicillin-binding protein 2a affinity and activity in experimental endocarditis due to homogeneously methicillin-resistant Staphylococcus aureus.

LB11058 is a new synthetic cephalosporin with good affinity for staphylococcal penicillin-binding protein 2a (PBP2a). LB11058 was tested in vitro and in rats with experimental aortic endocarditis against three methicillin-resistant Staphylococcus aureus (MRSA) strains, one penicillinase-negative strain (strain COL), and two penicillinase-producing strains (COL-Bla+ and P8-Hom). The MICs of LB11058 for the organisms were 1 mg/liter. The MICs of vancomycin and ceftriaxone were 1 and >/=64 mg/liter, respectively. In population analysis profiles, none of the MRSA strains grew at >/=2 mg of LB11058/liter. Rats with endocarditis were treated for 5 days. LB11058 was highly bound to serum proteins in rats (>/=98%). However, binding was saturable above a threshold of 250 mg/liter. Therefore, continuous concentrations of 250 mg/liter in serum were infused to ensure a free fraction (>/=5 mg/liter) above the drug's MIC for the entire infusion period. Control treatments included simulation of human serum kinetics produced by intravenous vancomycin (1 g twice daily, free drug concentration above MIC, >/=90% of infusion period) or ceftriaxone (2 g/24 h, free drug concentrations above the MIC, 0% of infusion period). LB11058 successfully treated 10 of 10 (100%) and 13 of 14 (93%) of rats infected with COL-Bla+ and P8-Hom, respectively. This was comparable to vancomycin (sterilization of 8 of 12 [66%] and 6 of 8 [75%] rats, respectively). Ceftriaxone was inactive. Low concentrations of LB11058 (5 and 10 mg/liter, continuously infused) in serum were ineffective, as predicted by the pharmacodynamic parameters. At appropriate doses, LB11058 was highly effective both in vitro and in vivo. This finding supports the development of this beta-lactam with high PBP2a affinity for the treatment of MRSA infections.

Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism

The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.