Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism


Autoria(s): Antolín Llovera, Meritxell; Leivar Rico, Pablo; Arró i Plans, Montserrat; Ferrer i Prats, Albert; Boronat i Margosa, Albert; Campos Martínez, Narciso
Contribuinte(s)

Universitat de Barcelona

Data(s)

12/03/2014

Resumo

The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.

Identificador

http://hdl.handle.net/2445/51383

Idioma(s)

eng

Publicador

Landes Bioscience

Direitos

(c) Landes Bioscience , 2011

info:eu-repo/semantics/openAccess

Palavras-Chave #Genètica vegetal #Proteïnes vegetals #Metabolisme de les plantes #Biosíntesi #Isoprenoides #Plant genetics #Plant proteins #Plant metabolism #Biosynthesis #Isopentenoids
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/acceptedVersion