La Comďie Franȧise. Premir̈e sřie.

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Sadatake zakki. Miscellaneous antiquarian writings of Sadatake Ise.

Mode of access: Internet.

Indentation size effect and strain rate sensitivity of nanocrystalline Mg-Al alloys

Deformation Behaviour of microcrystalline (mc) and nanocrystalline (nc) Mg-5%Al alloys produced by hot extrusion of ball-milled powders were investigated using instrumented indentation tests. The hardness values of the mc and nc metals exhibited indentation size effect (ISE), with nc alloys showing weaker ISE. The highly localized dislocation activities resulted in a small activation volume, hence enhanced strain rate sensitivity. Relative higher strain rate sensitivity and the negative Hall-Petch Relationship suggested the increasingly important role of grain boundary mediated mechanisms when the grain size decreased to nanometer region.

Association study of calcitonin gene-related polypeptide-alpha (CALCA) gene polymorphism with migraine

Migraine is a neurological disorder that is associated with increased levels of calcitonin gene-related peptide (CGRP) in plasma. CGRP, being one of the mediators of neurogenic inflammation and a phenomenon implicated in the pathogenesis of migraine headache, is thus suggested to have an important role in migraine pathophysiology. Polymorphisms of the CALCA gene have been linked to Parkinson's disease, ovarian cancer and essential hypertension, suggesting a functional role for these polymorphisms. Given the strong evidence linking CGRP and migraine, it is hypothesised that polymorphisms in the CALCA gene may play a role in migraine pathogenesis. Seemingly non functional intronic polymorphisms are capable of disrupting normal RNA processing or introducing a splice site in the transcript. A 16 bp deletion in the first intron of the CALCA gene has been reported to be a good match for the binding site for a transcription factor expressed strongly in neural crest derived cells, AP-2. This deletion also eliminates an intron splicing enhancer (ISE) that may potentially cause exon skipping. This study investigated the role of the 16 bp intronic deletion in the CALCA gene in migraineurs and matched control individuals. Six hundred individuals were genotyped for the deletion by polymerase chain reaction followed by fragment analysis on the 3130 Genetic Analyser. The results of this study showed no significant association between the intronic 16 bp deletion in the CALCA gene and migraine in the tested Australian Caucasian population. However, given the evidence linking CGRP and migraine, further investigation of variants with this gene may be warranted.

The Spartan-3E Tutorial 1 : Introduction to FPGA Programming, Version 2.0

This tutorial is designed to help new users become familiar with using the Spartan-3E board. The tutorial steps through: writing a small program in VHDL which carries out simple combinational logic; connecting the program inputs and outputs to the switches, buttons and LEDs on the Spartan-3E board; downloading the program to the Spartan-3E board using version 14.7 of the Xilinx ISE; and simulating the program using the iSim Simulator.

Indentation size effect and shear transformation zone size in a bulk metallic glass in two different structural states

The existence of an indentation size effect (ISE) in the onset of yield in a Zr-based bulk metallic glass (BMG) is investigated by employing spherical-tip nanoindentation experiments. Statistically significant data on the load at which the first pop-in in the displacement occurs were obtained for three different tip radii and in two different structural states (as-cast and structurally relaxed) of the BMG. Hertzian contact mechanics were employed to convert the pop-in loads to the maximum shear stress underneath the indenter. Results establish the existence of an ISE in the BMG of both structural states, with shear yield stress increasing with decreasing tip radius. Structural relaxation was found to increase the yield stress and decrease the variability in the data, indicating ``structural homogenization'' with annealing. Statistical analysis of the data was employed to estimate the shear transformation zone (STZ) size. Results of this analysis indicate an STZ size of similar to 25 atoms, which increases to similar to 34 atoms upon annealing. These observations are discussed in terms of internal structure changes that occur during structural relaxation and their interaction with the stressed volumes in spherical indentation of a metallic glass. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

An automatic imaging spectroscopic ellipsometer for characterization of nano-film pattern on solid substrate

In order to characterize the physical and spatial properties of nano-film pattern on solid substrates, an automatic imaging spectroscopic ellipsometer (ISE) based on a polarizer - compensator - specimen - analyzer configuration in the visible region is presented. It can provide the spectroscopic ellipsometric parameters psi (x, y, lambda) and Delta (x, y, lambda) of a large area specimen with a lateral resolution in the order of some microns. A SiO2 stepped layers pattern is used to demonstrate the function of the ISE which shows potential application in thin film devices' such as high-throughput bio-chips.

Kontrol esparruan ikasketa eta garapenerako oinarrizko ingurune praktiko, ireki eta askea

Embedded system design (VHDL description) based on Xilinx's Spartan3E Development Kit to perform real-time PID control and monitoring of DC motors.

Validación de métodos analíticos para la determinación de Amonio, Nitrato y Carbono Orgánico en aguas de estuario.

[es]El principal objetivo de este trabajo es la validación de métodos analíticos nuevos como son la determinación de amonio, nitrato y carbono orgánico total en muestras de aguas de estuario ya que no se han encontrado estudios para este tipo de muestras. A partir de este objetivo principal, se pretende, por un lado, comprobar la influencia de la diferente salinidad de las muestras en el desarrollo de métodos potenciométricos mediante ISE para la medida de nitrato y amonio y del equipo de TOC-VCSN para la determinación de carbono orgánico. Además, con la ayuda de cálculos estadísticos, determinar la incertidumbre asociada a la determinación de la concentración de amonio, nitrato y carbono orgánico en las muestras. Y, por último, analizar la posible variación de las muestras a lo largo del tiempo para comprobar su estabilidad.

A field effect transistor using highly nitrogen-doped CVD diamond for power device applications

A new idea of power device, which contains highly nitrogen-doped CVD diamond and Schottky contact, is proposed to actualise a power device with diamond. Two-dimensional simulation is conducted using ISE TCAD device simulator. While comparably high current is obtained in a transient simulation as expected, this current does not contribute to the drain-source current because of the symmetry of the device. Using an asymmetric structure or bias conditions, the device has high potential as an electric device for extremely high power, high frequency and high temperature. © 2003 Elsevier Science B.V. All rights reserved.

一篇探索真核细胞核起源的力作——读李靖炎先生的长篇近作“The primitive nucleus model and the origin of the cell nucleus”

《胞内共生与细胞研究》( 《Endocytobiosis and Cell Research》)是由国际胞内共生学会(International Society of Endocytobiology, ISE)主办的期刊, 它主要发表有关内共生物(endosy mbioses)和真核细胞的起源、发展、分化、进化和系统发育的研究论文. 在胞内共生和真核细胞的起源进化研究领域享有声誉. 去年该杂志发表了我国学者李靖炎先生的长篇论著“The primitive nucleus model and the origin of the cell nucleus(原始细胞核的模型与细胞核的起源)”(见1999, 13(1-3):1-86). 国外一家 SCI 收录的专业性刊物为中国学者发表一篇长达86页的 Review, 实不多见, 是我国学者在此领域的殊荣。

Finite Element studies on indentation size effect using a higher order strain gradient theory

In this work, a Finite Element implementation of a higher order strain gradient theory (due to Fleck and Hutchinson, 2001) has been used within the framework of large deformation elasto-viscoplasticity to study the indentation of metals with indenters of various geometries. Of particular interest is the indentation size effect (ISE) commonly observed in experiments where the hardness of a range of materials is found to be significantly higher at small depths of indentation but reduce to a lower, constant value at larger depths. That the ISE can be explained by strain gradient plasticity is well known but this work aims to qualitatively compare a gamut of experimental observations on this effect with predictions from a higher order strain gradient theory. Results indicate that many of the experimental observations are qualitatively borne out by our simulations. However, areas exist where conflicting experimental results make assessment of numerical predictions difficult. © 2012 Elsevier Ltd. All rights reserved.

稀土离子选择电极在非线性响应区域的响应特性及其数学模型

离子选择电极（简称ISE）是一种传感器。它能将体系中的组分活度（或浓度）的改变情况以电信号方式输出。ISE的这种特点使其成为分析和监测体系组成变化的一种有效手段。理论上ISE既能够测试体系中待测离子的活度（或浓度），则一切与活度（或浓度）有直接联系或间接联系的体小性质就能通过实验测定而获得定量数据或作定性的了解。事实上这是比较困难的。这种困难主要来自两个方面。一方面是并不具备所有各种离子的专属电极；同时，对某种离子敏感的电极也还会对其它共存离子有不同程度的响应，也就是说，ISE的选择性是相对的，是随体系中主要离子和其它共存离子之间的组成比例改变而改变的。因此ISE在大多数具有复杂组成的实际体系中的应用受到限制。另一方面是并未引起人们普遍关注的一个方面，即ISE的常规分析范围是处在能斯特电位响应区域，而众多的实际体系不但具有复杂的组分，而且组分浓度比较高，ISE在这类体系中虽然存在一定的电位响应，但表现出的可能是亚能斯特响应或非能斯特反应，由此而产生的问题是测量精度降低，难以达到定量分析目的。由此可见，为了适应实际体系的要求，可以从上述两个方面入手来扩大ISE在各类体系中的应用范围，即努力开发和研制新型材料的ISE，并且积极开展ISE在非能斯特（或非线性）电位响应区域的响应特性的研究。众所周知，稀土资源是我国一个丰富而又宝贵的资源。近年来稀土资源的开发利用已成为重要的科研课题，稀土离子选择电极（简称RE－ISE）也应运而生，目前工作有无机材料膜电极和功能高分子膜电极。我们对这两类RE－ISE在具有较复杂组成且组分浓度较高的稀土体系中研究了它们的响应特性，以探索将RE－ISE应用于这类体系的可能性，从而寻找一种适合于这类体系的直接、快速测定方法，这对于有关体系的溶液化学的研究（如萃取化学、络合物化学等），无论是从应用上，还是从理论上都是很有意义的。此外从扩大ISE的范围出发，从充分发挥ISE的功能出发，开展非线性区域电极响应特性的研究不仅对RE－ISE而且对其它类型的ISE也都具有实际意义。本论文分三部分：文献综述，包括ISE在溶液体系中测定活度系数以及平衡常数的研究工作和计算机在ISE方法中的应用研究工作；RE－ISE在非线性响应区域响应特性的研究及其响应特性的数学模拟，分CeO_2膜RE－ISE和功能高分子膜RE－ISE两篇报告；最后是RE－ISE在非线性响应区域的数学模型研究。