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Kirjallisuusarvostelu

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Kirjallisuusarvostelu

Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes

BACKGROUND Foxi3 is a member of the large forkhead box family of transcriptional regulators, which have a wide range of biological activities including manifold developmental processes. Heterozygous mutation in Foxi3 was identified in several hairless dog breeds characterized by sparse fur coat and missing teeth. A related phenotype called hypohidrotic ectodermal dysplasia (HED) is caused by mutations in the ectodysplasin (Eda) pathway genes. RESULTS Expression of Foxi3 was strictly confined to the epithelium in developing ectodermal appendages in mouse embryos, but no expression was detected in the epidermis. Foxi3 was expressed in teeth and hair follicles throughout embryogenesis, but in mammary glands only during the earliest stages of development. Foxi3 expression was decreased and increased in Eda loss- and gain-of-function embryos, respectively, and was highly induced by Eda protein in embryonic skin explants. Also activin A treatment up-regulated Foxi3 mRNA levels in vitro. CONCLUSIONS Eda and activin A were identified as upstream regulators of Foxi3. Foxi3 is a likely transcriptional target of Eda in ectodermal appendage placodes suggesting that HED phenotype may in part be produced by compromised Foxi3 activity. In addition to hair and teeth, Foxi3 may have a role in nail, eye, and mammary, sweat, and salivary gland development.

Temporal and spatial distribution of anurans in the Pampa Region (Santa Maria, RS).

The present study aimed to determine the richness, occurrence constancy, reproductive modes. standard of abundance distribution, season of vocalization and to test correlation among climatic variables and activity of vocalization of anurans in a region of the Pampa Biome, Santa Maria, Rio Grande do Sul State. During the period of Novernber/2001 to October/2002 monthly collections were carried out utilizing the `survey at breeding site` method and examination of specimens kept in the Colecao Herpetologica do Setor de Zoologia da Universidade Federal de Santa Maria (ZUFSM). Tire Occurrence of 25 species of anurans was recorded. The anurofauna recorded represents 30% of the species known to Occur in Rio Grande do Sul, and comprises species generally associated with grasslands in this state and neighboring countries. Four reproductive modes were recorded: mode 1 (14 species: 58.3%) mode 11 and 30 (9 species` 37.5%) and mode 24 (1 species; 4.2%). The low diversification of reproductive modes is likely related to the homogeneity of the grassland habitat. Most species were constant or accessory in the Study area and the species abundance distribution patterns fit in the Broken Stick and Log-normal models. characterized by homogeneity of species abundance distribution. Most species showed great plasticity in habitat. but few were plastic in vocalization sites use. There was a weak positive correlation between species richness and precipitation. There was also a weak positive correlation between the abundance of species calling activity and maximum average temperatures. These correlations indicated that, in the study area. the abundance of calling males is more affected by the temperature, and species richness is more affected by precipitation, despite the fact that significantly higher species richness occurs during the hottest period of the year. These results showed that the climatological variables examined were not enough to explain the seasonal occurrence of species, thus the influence of other environmental variables merit to be tested in future studies.

Viol??ncia contra a mulher: Lei Maria da Penha

Trata da Lei 11.340/2006, Lei Maria da Penha, que aborda a viol??ncia contra a mulher, viol??ncia dom??stica e viol??ncia familiar

G??nero, ra??a e espa??os de poder: o caso de Maria Ant??nia e Geraldo

O caso relata uma situa????o de promo????o em ??rg??o p??blico na qual dois funcion??rios ??? uma mulher negra e um homem branco - se mostram como candidatos ao cargo. S??o apresentados os perfis e habilidades profissionais dos dois servidores e, ao final, a decis??o tomada pelo Secret??rio, chefe de ambos. O estudo suscita discuss??es sobre pr??ticas discriminat??rias nos espa??os de poder das institui????es p??blicas e o papel do dirigente para combater ou difundir tais pr??ticas. Pode ser aplicado em cursos sobre lideran??a, gest??o de pessoas e ??tica e servi??o p??blico

Caso Maria Rita

O caso retrata conflito entre interesse coletivo e interesses individuais ao narrar o problema de uma moradora de baixa renda cuja casa, assim como as de outros moradores, dever?? ser removida para alargamento da avenida em que est?? localizada. A prefeitura prop??e uma indeniza????o aos moradores, mas confere prazo curto e op????es limitadas para o acordo. A moradora Maria Rita defronta-se com as consequ??ncias desfavor??veis da remo????o e sente-se pressionada a fechar um acordo. O caso vem sendo usado para ilustrar processo e t??cnicas de negocia????o, mas tamb??m pode ser aplicado em cursos sobre ??tica

Programa de melhoria do atendimento aos usu??rios do ambulat??rio Maria da Gl??ria

Este projeto refere-se ?? implementa????o de um conjunto de a????es destinadas ?? melhoria do atendimento e do ambiente f??sico do ambulat??rio Maria da Gl??ria, no Hospital Escola da Faculdade de Medicina do Tri??ngulo Mineiro, onde s??o atendidos diariamente mais de 1000 usu??rios. Neste mesmo ambiente convivem, aproximadamente, 600 pessoas entre professores, m??dicos, servidores e alunos. Foram realizados treinamentos espec??ficos para a humaniza????o do atendimento ao p??blico, e efetuadas mudan??as no padr??o de cor do Hospital, visando a cria????o de um ambiente mais agrad??vel. Pesquisa realizada junto aos usu??rios constata que o ??ndice de reclama????es do p??blico caiu em torno de 89%