Arturo Ardao: la época puesta en pensamiento

Respecto de la intensa y extensa obra de Arturo Ardao, se sustenta la tesis que la misma constituye una filosofía en el sentido hegeliano de seria época puesta en pensamiento. No obstante el producirse desde América y no desde Europa, el afincarse en la inteligencia frente a la razón aunque no contra ella, el sustentar la perspectiva de apertura a lo posible como discernimiento crítico del cerramiento de lo necesario, la filosofía de Ardao (que se nutre de la historia de la filosofía especialmente en América y su historia de la filosofía o historia de las ideas filosóficas en América, ejercida siempre como reflexión filosófica) se configura como la época puesta en pensamiento con un grado de novedad que, además de situarla más allá de los límites de la ortodoxia hegeliana, implica una fecunda contribución al discernimiento crítico como aporte a una perspectiva universalista de emancipación humana desde nuestra América.

Linhart, Badiou y Rancière, a propósito de las fábricas y la política

Este artículo analiza las reflexiones de intelectuales franceses sobre la relación entre la política y las fábricas. Robert Linhart, Alain Badiou, y Jacques Rancière fueron discípulos de Louis Althusser con quien rompieron a propósito del Mayo francés de 1968 y de la emergencia del maoísmo. Revisamos sus trayectos intelectuales y políticos desde aquella coyuntura, cómo evalúan las proletarizaciones estudiantiles en relación a las organizaciones sindicales, los métodos de lucha y la formación de los grupos de la nueva izquierda setentista. Analizamos cómo aquella reflexión sobre la unidad obrero estudiantil se va transformando respecto de la crisis del movimiento comunista, de los estados socialistas y cómo se desarrollan los argumentos referidos a la teoría y la historia de los trabajadores. Por último presentamos las argumentaciones contemporáneas de Badiou y Rancière referidas a la crisis del pensamiento político contemporáneo, al papel adjudicado a los trabajadores en ella y a la reformulación de la emancipación humana.

Linhart, Badiou y Rancière, a propósito de las fábricas y la política

Este artículo analiza las reflexiones de intelectuales franceses sobre la relación entre la política y las fábricas. Robert Linhart, Alain Badiou, y Jacques Rancière fueron discípulos de Louis Althusser con quien rompieron a propósito del Mayo francés de 1968 y de la emergencia del maoísmo. Revisamos sus trayectos intelectuales y políticos desde aquella coyuntura, cómo evalúan las proletarizaciones estudiantiles en relación a las organizaciones sindicales, los métodos de lucha y la formación de los grupos de la nueva izquierda setentista. Analizamos cómo aquella reflexión sobre la unidad obrero estudiantil se va transformando respecto de la crisis del movimiento comunista, de los estados socialistas y cómo se desarrollan los argumentos referidos a la teoría y la historia de los trabajadores. Por último presentamos las argumentaciones contemporáneas de Badiou y Rancière referidas a la crisis del pensamiento político contemporáneo, al papel adjudicado a los trabajadores en ella y a la reformulación de la emancipación humana.

Linhart, Badiou y Rancière, a propósito de las fábricas y la política

Este artículo analiza las reflexiones de intelectuales franceses sobre la relación entre la política y las fábricas. Robert Linhart, Alain Badiou, y Jacques Rancière fueron discípulos de Louis Althusser con quien rompieron a propósito del Mayo francés de 1968 y de la emergencia del maoísmo. Revisamos sus trayectos intelectuales y políticos desde aquella coyuntura, cómo evalúan las proletarizaciones estudiantiles en relación a las organizaciones sindicales, los métodos de lucha y la formación de los grupos de la nueva izquierda setentista. Analizamos cómo aquella reflexión sobre la unidad obrero estudiantil se va transformando respecto de la crisis del movimiento comunista, de los estados socialistas y cómo se desarrollan los argumentos referidos a la teoría y la historia de los trabajadores. Por último presentamos las argumentaciones contemporáneas de Badiou y Rancière referidas a la crisis del pensamiento político contemporáneo, al papel adjudicado a los trabajadores en ella y a la reformulación de la emancipación humana.

La emancipación no es inefable

El pensamiento social crítico tiene una nueva demanda. Le urge revisarse en sus conceptos fundamentales, dialogar con las experiencias de los movimientos sociales y hacer valer el recurso del método: el hacer conceptual radical del pensamiento y la acción social por una emancipación humana. Desde la experiencia de trabajo del Grupo América Latina, Filosofía Social y Axiología (GALFISA) se exponen algunos elementos alcanzados y construidos en conjunto y que compartimos para seguir narrando juntos la emancipación. Abstract The critical social thought has a new demand. Is urgent to review its fundamental concepts, dialogue with the experiences of the social movements and give value to the resource of the method: Of making radical conceptual of the thought and the social action for a human emancipation. From the experience of the Latin America, Social Philosophy and Axiology working group (GALFISA) some elements that where reached and built together are exposed, elements that we shared in the continuing task of narrating together the emancipation.

Folk schools: Um estudo de caso

O presente trabalho tem como âmbito de estudo o campo da educação não formal. Trata-se de uma investigação qualitativa descritiva, com o objectivo geral de descrever todos os aspectos da actividade de uma folk school, um espaço de educação não formal, situada no sul da Dinamarca, sob as perspectivas de professores e alunos. Participaram neste estudo três entidades que fazem parte deste modelo de educação não formal, tendo sido realizadas entrevistas ao Director, a três professores e a sete alunos. Para a recolha de dados foi utilizado um guião de entrevista semi-estruturada. Os dados recolhidos pelas entrevistas foram organizados em categorias e foi realizada a análise de conteúdo. Como resultado deste estudo temos a descrição do funcionamento da escola analisada, bem como testemunhos da forma como este tipo de educação desenvolve o espírito de comunidade e cidadania, potenciando, também, o desenvolvimento pessoal e profissional. /ABSTRACT: This work develops in the study field of non-formal education. It is a descriptive, qualitative research, with the overall aim of describing all aspects of the activity of a folk school, located in southern Denmark, an institution of non­formal education, seen through the perspectives of both teachers and students. Three entities that are involved in this type of non-formal education have participated in present study, so the director, three teachers and seven students were interviewed. ln order to collect data we applied semi-structured interviews. The data thus obtained in the interviews was organized into categories and, afterwards, their content was analyzed. From this study results the description of the activity done in the school studied, as well as the testimony of how this kind of education develops a spirit of community and citizenship, also enhancing the personal and professional development and improvement.

Social inclusion of vulnerable groups through participatory and emancipatory approaches. Implementing active citizenship and socially innovative actions in the framework of civil & human rights model of disability

The research hypothesis of the thesis is that “an open participation in the co-creation of the services and environments, makes life easier for vulnerable groups”; assuming that the participatory and emancipatory approaches are processes of possible actions and changes aimed at facilitating people’s lives. The adoption of these approaches is put forward as the common denominator of social innovative practices that supporting inclusive processes allow a shift from a medical model to a civil and human rights approach to disability. The theoretical basis of this assumption finds support in many principles of Inclusive Education and the main focus of the hypothesis of research is on participation and emancipation as approaches aimed at facing emerging and existing problems related to inclusion. The framework of reference for the research is represented by the perspectives adopted by several international documents concerning policies and interventions to promote and support the leadership and participation of vulnerable groups. In the first part an in-depth analysis of the main academic publications on the central themes of the thesis has been carried out. After investigating the framework of reference, the analysis focuses on the main tools of participatory and emancipatory approaches, which are able to connect with the concepts of active citizenship and social innovation. In the second part two case studies concerning participatory and emancipatory approaches in the areas of concern are presented and analyzed as example of the improvement of inclusion, through the involvement and participation of persons with disability. The research has been developed using a holistic and interdisciplinary approach, aimed at providing a knowledge-base that fosters a shift from a situation of passivity and care towards a new scenario based on the person’s commitment in the elaboration of his/her own project of life.

Human Rights, Local Plights: The Implications of Rights Discourses in the Struggle over Arab-Palestinian Bedouin Land in Israel

A widely diffused, engaged approach understands human rights as an opportunity to enhance moral progress. Less visible has a critical realm of research that reveals the often ambiguous social life of human rights discourses. This article draws on a specific case study from the intricate issue of how activism for Arab-Palestinian Bedouin citizens in Southern Israel engages with the global human rights discourse. It follows the implications of mobilization, focusing on events related to a campaign against house demolitions in informal,unrecognised settlements. The case shows how human rights discourses tend to silence the agency of political subjects, victimizing and patronizing those who seek emancipation. The ethnographic insights emphasize the role of a range of carnivalesque and spontaneous acts ofresistance, which subvert the patronizing implications of the human rights language.

Prognostic Value Of Dna And Mrna E6/e7 Of Human Papillomavirus In The Evolution Of Cervical Intraepithelial Neoplasia Grade 2.

This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL). This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months. Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up were 69.4% for women with alpha-9 HPV versus 91.7% for other HPV species or HPV-negative status (P < 0.05). For women with HPV 16, the CIN 2 regression rate at the 12-month follow-up was 61.4% versus 89.5% for other HPV types or HPV-negative status (P < 0.05). The CIN 2 regression rate was 68.3% for women who tested positive for HPV E6/E7 mRNA versus 82.0% for the negative results, but this difference was not statistically significant. The expectant management for women with biopsy-confirmed CIN 2 and previous cytological tests showing LSIL exhibited a very high rate of spontaneous regression. HPV 16 is associated with a higher CIN 2 progression rate than other HPV infections. HPV E6/E7 mRNA is not a prognostic marker of the CIN 2 clinical outcome, although this analysis cannot be considered conclusive. Given the small sample size, this study could be considered a pilot for future larger studies on the role of predictive markers of CIN 2 evolution.

Integrated Proteomics Identified Up-regulated Focal Adhesion-mediated Proteins In Human Squamous Cell Carcinoma In An Orthotopic Murine Model.

Understanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral squamous cell carcinoma (OSCC), mass spectrometry-based proteomics and biological network analysis. Our results indicated the up-regulation of proteins involved in actin cytoskeleton organization and cell-cell junction assembly events and their expression was validated in human OSCC tissues. In addition, the functional relevance of talin-1 in OSCC adhesion, migration and invasion was demonstrated. Taken together, this study identified specific processes deregulated in oral cancer and provided novel refined OSCC-targeting molecules.

Hypertrophic Adenoid Is A Major Infection Site Of Human Bocavirus 1.

Human bocavirus 1 (HBoV1) is associated with respiratory infections worldwide, mainly in children. Similar to other parvoviruses, it is believed that HBoV1 can persist for long periods of time in humans, probably through maintaining concatemers of the virus single-stranded DNA genome in the nuclei of infected cells. Recently, HBoV-1 was detected in high rates in adenoid and palatine tonsils samples from patients with chronic adenotonsillar diseases, but nothing is known about the virus replication levels in those tissues. A 3-year prospective hospital-based study was conducted to detect and quantify HBoV1 DNA and mRNAs in samples of the adenoids (AD), palatine tonsils (PT), nasopharyngeal secretions (NPS), and peripheral blood (PB) from patients undergoing tonsillectomy for tonsillar hypertrophy or recurrent tonsillitis. HBoV1 was detected in 25.3% of the AD samples, while the rates of detection in the PT, NPS, and PB samples were 7.2%, 10.5%, and 1.7%, respectively. The viral loads were higher in AD samples, and 27.3% of the patients with HBoV had mRNA detectable in this tissue. High viral loads and detectable mRNA in the AD were associated with HBoV1 detection in the other sample sites. The adenoids are an important site of HBoV1 replication and persistence in children with tonsillar hypertrophy. The adenoids contain high HBoV1 loads and are frequently positive for HBoV mRNA, and this is associated with the detection of HBoV1 in secretions.

The Effect Of Celastrol, A Triterpene With Antitumorigenic Activity, On Conformational And Functional Aspects Of The Human 90kda Heat Shock Protein Hsp90α, A Chaperone Implicated In The Stabilization Of The Tumor Phenotype.

Hsp90 is a molecular chaperone essential for cell viability in eukaryotes that is associated with the maturation of proteins involved in important cell functions and implicated in the stabilization of the tumor phenotype of various cancers, making this chaperone a notably interesting therapeutic target. Celastrol is a plant-derived pentacyclic triterpenoid compound with potent antioxidant, anti-inflammatory and anticancer activities; however, celastrol's action mode is still elusive. In this work, we investigated the effect of celastrol on the conformational and functional aspects of Hsp90α. Interestingly, celastrol appeared to target Hsp90α directly as the compound induced the oligomerization of the chaperone via the C-terminal domain as demonstrated by experiments using a deletion mutant. The nature of the oligomers was investigated by biophysical tools demonstrating that a two-fold excess of celastrol induced the formation of a decameric Hsp90α bound throughout the C-terminal domain. When bound, celastrol destabilized the C-terminal domain. Surprisingly, standard chaperone functional investigations demonstrated that neither the in vitro chaperone activity of protecting against aggregation nor the ability to bind a TPR co-chaperone, which binds to the C-terminus of Hsp90α, were affected by celastrol. Celastrol interferes with specific biological functions of Hsp90α. Our results suggest a model in which celastrol binds directly to the C-terminal domain of Hsp90α causing oligomerization. However, the ability to protect against protein aggregation (supported by our results) and to bind to TPR co-chaperones are not affected by celastrol. Therefore celastrol may act primarily by inducing specific oligomerization that affects some, but not all, of the functions of Hsp90α. To the best of our knowledge, this study is the first work to use multiple probes to investigate the effect that celastrol has on the stability and oligomerization of Hsp90α and on the binding of this chaperone to Tom70. This work provides a novel mechanism by which celastrol binds Hsp90α.

Lawsonia Inermis-mediated Synthesis Of Silver Nanoparticles: Activity Against Human Pathogenic Fungi And Bacteria With Special Reference To Formulation Of An Antimicrobial Nanogel.

Lawsonia inermis mediated synthesis of silver nanoparticles (Ag-NPs) and its efficacy against Candida albicans, Microsporum canis, Propioniabacterium acne and Trichophyton mentagrophytes is reported. A two-step mechanism has been proposed for bioreduction and formation of an intermediate complex leading to the synthesis of capped nanoparticles was developed. In addition, antimicrobial gel for M. canis and T. mentagrophytes was also formulated. Ag-NPs were synthesized by challenging the leaft extract of L. inermis with 1 mM AgNO₃. The Ag-NPs were characterized by Ultraviolet-Visible (UV-Vis) spectrophotometer and Fourier transform infrared spectroscopy (FTIR). Transmission electron microscopy (TEM), nanoparticle tracking and analysis sytem (NTA) and zeta potential was measured to detect the size of Ag-NPs. The antimicrobial activity of Ag-NPs was evaluated by disc diffusion method against the test organisms. Thus these Ag-NPs may prove as a better candidate drug due to their biogenic nature. Moreover, Ag-NPs may be an answer to the drug-resistant microorganisms.

Overlapped Sequence Types (sts) And Serogroups Of Avian Pathogenic (apec) And Human Extra-intestinal Pathogenic (expec) Escherichia Coli Isolated In Brazil.

Avian pathogenic Escherichia coli (APEC) strains belong to a category that is associated with colibacillosis, a serious illness in the poultry industry worldwide. Additionally, some APEC groups have recently been described as potential zoonotic agents. In this work, we compared APEC strains with extraintestinal pathogenic E. coli (ExPEC) strains isolated from clinical cases of humans with extra-intestinal diseases such as urinary tract infections (UTI) and bacteremia. PCR results showed that genes usually found in the ColV plasmid (tsh, iucA, iss, and hlyF) were associated with APEC strains while fyuA, irp-2, fepC sitDchrom, fimH, crl, csgA, afa, iha, sat, hlyA, hra, cnf1, kpsMTII, clpVSakai and malX were associated with human ExPEC. Both categories shared nine serogroups (O2, O6, O7, O8, O11, O19, O25, O73 and O153) and seven sequence types (ST10, ST88, ST93, ST117, ST131, ST155, ST359, ST648 and ST1011). Interestingly, ST95, which is associated with the zoonotic potential of APEC and is spread in avian E. coli of North America and Europe, was not detected among 76 APEC strains. When the strains were clustered based on the presence of virulence genes, most ExPEC strains (71.7%) were contained in one cluster while most APEC strains (63.2%) segregated to another. In general, the strains showed distinct genetic and fingerprint patterns, but avian and human strains of ST359, or ST23 clonal complex (CC), presented more than 70% of similarity by PFGE. The results demonstrate that some zoonotic-related STs (ST117, ST131, ST10CC, ST23CC) are present in Brazil. Also, the presence of moderate fingerprint similarities between ST359 E. coli of avian and human origin indicates that strains of this ST are candidates for having zoonotic potential.

Impact Of Pharmacist Interventions On Drug-related Problems And Laboratory Markers In Outpatients With Human Immunodeficiency Virus Infection.

Substantial complexity has been introduced into treatment regimens for patients with human immunodeficiency virus (HIV) infection. Many drug-related problems (DRPs) are detected in these patients, such as low adherence, therapeutic inefficacy, and safety issues. We evaluated the impact of pharmacist interventions on CD4+ T-lymphocyte count, HIV viral load, and DRPs in patients with HIV infection. In this 18-month prospective controlled study, 90 outpatients were selected by convenience sampling from the Hospital Dia-University of Campinas Teaching Hospital (Brazil). Forty-five patients comprised the pharmacist intervention group and 45 the control group; all patients had HIV infection with or without acquired immunodeficiency syndrome. Pharmaceutical appointments were conducted based on the Pharmacotherapy Workup method, although DRPs and pharmacist intervention classifications were modified for applicability to institutional service limitations and research requirements. Pharmacist interventions were performed immediately after detection of DRPs. The main outcome measures were DRPs, CD4+ T-lymphocyte count, and HIV viral load. After pharmacist intervention, DRPs decreased from 5.2 (95% confidence interval [CI] =4.1-6.2) to 4.2 (95% CI =3.3-5.1) per patient (P=0.043). A total of 122 pharmacist interventions were proposed, with an average of 2.7 interventions per patient. All the pharmacist interventions were accepted by physicians, and among patients, the interventions were well accepted during the appointments, but compliance with the interventions was not measured. A statistically significant increase in CD4+ T-lymphocyte count in the intervention group was found (260.7 cells/mm(3) [95% CI =175.8-345.6] to 312.0 cells/mm(3) [95% CI =23.5-40.6], P=0.015), which was not observed in the control group. There was no statistical difference between the groups regarding HIV viral load. This study suggests that pharmacist interventions in patients with HIV infection can cause an increase in CD4+ T-lymphocyte counts and a decrease in DRPs, demonstrating the importance of an optimal pharmaceutical care plan.