Prognostic Value Of Dna And Mrna E6/e7 Of Human Papillomavirus In The Evolution Of Cervical Intraepithelial Neoplasia Grade 2.


Autoria(s): Discacciati, Michelle G; da Silva, Ismael Dcg; Villa, Luisa L; Reis, Leandro; Hayashi, Priscila; Costa, Maria C; Rabelo-Santos, Silvia H; Zeferino, Luiz C
Contribuinte(s)

UNIVERSIDADE DE ESTADUAL DE CAMPINAS

Data(s)

2014

27/11/2015

27/11/2015

Resumo

This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL). This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months. Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up were 69.4% for women with alpha-9 HPV versus 91.7% for other HPV species or HPV-negative status (P < 0.05). For women with HPV 16, the CIN 2 regression rate at the 12-month follow-up was 61.4% versus 89.5% for other HPV types or HPV-negative status (P < 0.05). The CIN 2 regression rate was 68.3% for women who tested positive for HPV E6/E7 mRNA versus 82.0% for the negative results, but this difference was not statistically significant. The expectant management for women with biopsy-confirmed CIN 2 and previous cytological tests showing LSIL exhibited a very high rate of spontaneous regression. HPV 16 is associated with a higher CIN 2 progression rate than other HPV infections. HPV E6/E7 mRNA is not a prognostic marker of the CIN 2 clinical outcome, although this analysis cannot be considered conclusive. Given the small sample size, this study could be considered a pilot for future larger studies on the role of predictive markers of CIN 2 evolution.

9

15-22

Identificador

Biomarker Insights. v. 9, p. 15-22, 2014.

1177-2719

10.4137/BMI.S14296

http://www.ncbi.nlm.nih.gov/pubmed/24812482

http://repositorio.unicamp.br/jspui/handle/REPOSIP/201388

24812482

Idioma(s)

eng

Relação

Biomarker Insights

Biomark Insights

Direitos

aberto

Fonte

PubMed

Palavras-Chave #E6 Protein #Cervical Intraepithelial Neoplasia #Disease Progression #Human Papillomavirus-16 #Neoplasm Regression #Papillomavirus E7 Proteins #Spontaneous #Viral Oncogene Proteins
Tipo

Artigo de periódico