Prognostic Value Of Dna And Mrna E6/e7 Of Human Papillomavirus In The Evolution Of Cervical Intraepithelial Neoplasia Grade 2.
Contribuinte(s) |
UNIVERSIDADE DE ESTADUAL DE CAMPINAS |
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Data(s) |
2014
27/11/2015
27/11/2015
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Resumo |
This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL). This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months. Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up were 69.4% for women with alpha-9 HPV versus 91.7% for other HPV species or HPV-negative status (P < 0.05). For women with HPV 16, the CIN 2 regression rate at the 12-month follow-up was 61.4% versus 89.5% for other HPV types or HPV-negative status (P < 0.05). The CIN 2 regression rate was 68.3% for women who tested positive for HPV E6/E7 mRNA versus 82.0% for the negative results, but this difference was not statistically significant. The expectant management for women with biopsy-confirmed CIN 2 and previous cytological tests showing LSIL exhibited a very high rate of spontaneous regression. HPV 16 is associated with a higher CIN 2 progression rate than other HPV infections. HPV E6/E7 mRNA is not a prognostic marker of the CIN 2 clinical outcome, although this analysis cannot be considered conclusive. Given the small sample size, this study could be considered a pilot for future larger studies on the role of predictive markers of CIN 2 evolution. 9 15-22 |
Identificador |
Biomarker Insights. v. 9, p. 15-22, 2014. 1177-2719 10.4137/BMI.S14296 http://www.ncbi.nlm.nih.gov/pubmed/24812482 http://repositorio.unicamp.br/jspui/handle/REPOSIP/201388 24812482 |
Idioma(s) |
eng |
Relação |
Biomarker Insights Biomark Insights |
Direitos |
aberto |
Fonte |
PubMed |
Palavras-Chave | #E6 Protein #Cervical Intraepithelial Neoplasia #Disease Progression #Human Papillomavirus-16 #Neoplasm Regression #Papillomavirus E7 Proteins #Spontaneous #Viral Oncogene Proteins |
Tipo |
Artigo de periódico |