988 resultados para Garat, Pierre-Jean, 1762-1823 biografías


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T. 1: Histoire naturelle des animaux (Contiene : Introduction a l'histoire naturelle par. M. Daubenton; Les animaux quadrupedes et les cetaces ; Ornitologie, par M. Mauduyt ; Discours genaraux sur la nature des oiseaux [y la primera parte del Dictionnaire d'Ornithologie] (viii, lxxxxii, 691 p., [1] en bl.) -- T. 2: Oiseaux (Contiene : Dictionnaire d'ornithologie; Les animaux quadrupedes, ovipares, et les serpents par M. Daubenton ([4], 712 p.) -- T. 3: Les poissons ([4], lx, 435 p., [1] en bl.) -- T. 4-8: Insectes / par M. Olivier ([4], ccclxxiij, [3] en bl., 331, [1] en bl. ; [4], 793, [1] en bl. ; [4], 704 ; [4], 827, [1] en bl. ; [4], 722 p.; contiene tambien "Discours préliminaire et plan du dictionnaire des insectes / par M. Mauduyt" (cclxxxviii p.)) -- T. 9-10: Entomologie, ou histoire naturelle des crustaces, des arachnides et des insectes / par M. Latreille ... et m. Godart ; [Le Peletier de Saint-Fargeau, Serville et Guerin] ([4], 828 ; [6], 832, [2] p.)

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Mode of access: Internet.

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Mode of access: Internet.

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Mode of access: Internet.

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Mode of access: Internet.

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http://www.archive.org/details/westernmissionsa00smetrich

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Tese de doutoramento, Biologia (Biologia Marinha e Aquacultura), Universidade de Lisboa, Faculdade de Ciências, 2015

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HER2 gene amplification is observed in about 15% of breast cancers. The subgroup of HER2-positive breast cancers appears to be heterogeneous and presents complex patterns of gene amplification at the locus on chromosome 17q12-21. The molecular variations within the chromosome 17q amplicon and their clinical implications remain largely unknown. Besides the well-known TOP2A gene encoding Topoisomerase IIA, other genes might also be amplified and could play functional roles in breast cancer development and progression. This review will focus on the current knowledge concerning the HER2 amplicon heterogeneity, its clinical and biological impact and the pitfalls associated with the evaluation of gene amplifications at this locus, with particular attention to TOP2A and the link between TOP2A and anthracycline benefit. In addition it will discuss the clinical and biological implications of the amplification of ten other genes at this locus (MED1, STARD3, GRB7, THRA, RARA, IGFPB4, CCR7, KRT20, KRT19 and GAST) in breast cancer.

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