The HER2 amplicon in breast cancer: Topoisomerase IIA and beyond


Autoria(s): Jacot, William; Fiche, Maryse; Zaman, Khalil; Wolfer, Anita; Lamy, Pierre-Jean
Data(s)

01/08/2013

Resumo

HER2 gene amplification is observed in about 15% of breast cancers. The subgroup of HER2-positive breast cancers appears to be heterogeneous and presents complex patterns of gene amplification at the locus on chromosome 17q12-21. The molecular variations within the chromosome 17q amplicon and their clinical implications remain largely unknown. Besides the well-known TOP2A gene encoding Topoisomerase IIA, other genes might also be amplified and could play functional roles in breast cancer development and progression. This review will focus on the current knowledge concerning the HER2 amplicon heterogeneity, its clinical and biological impact and the pitfalls associated with the evaluation of gene amplifications at this locus, with particular attention to TOP2A and the link between TOP2A and anthracycline benefit. In addition it will discuss the clinical and biological implications of the amplification of ten other genes at this locus (MED1, STARD3, GRB7, THRA, RARA, IGFPB4, CCR7, KRT20, KRT19 and GAST) in breast cancer.

Identificador

https://serval.unil.ch/notice/serval:BIB_CAEDD592301F

info:pmid:23628726

pmid:23628726

doi:10.1016/j.bbcan.2013.04.004

isiid:000320475800011

Idioma(s)

eng

Fonte

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer18361146-157

Palavras-Chave #Breast cancer; HER2; Amplicon; Genetics; Cancer Research; Oncology
Tipo

info:eu-repo/semantics/review

article