202 resultados para Elorriaga, Joseba


Relevância:

10.00% 10.00%

Publicador:

Resumo:

We demonstrate the influence of the relative humidity (RH) on the wavelength of fiber Bragg grating sensors (FBGS), performing tests with five FBGS at different humidity and temperature conditions. These tests were performed in a climate chamber whose RH changes according to a scheduled profile from 30% to 90%, in steps of 10%. These profiles were repeated for a wide range of temperatures from to , in steps of . Two different types of instrumentation methods have been tested, spot welding and epoxy bonding, in two different materials, steel and carbon fiber reinforced polymer (CFRP). We discuss the results for each type of sensor and instrumentation method by analyzing the linearity of the Bragg wavelength with RH and temperature.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are molecularly classified according to the abnormal prion protein (PrPSc) conformations along with polymorphism of codon 129 of the PRNP gene. Recently, a novel human disease, termed "protease-sensitive prionopathy", has been described. This disease shows a distinct clinical and neuropathological phenotype and it is associated to an abnormal prion protein more sensitive to protease digestion. Case presentation: We report the case of a 75-year-old-man who developed a clinical course and presented pathologic lesions compatible with sporadic Creutzfeldt-Jakob disease, and biochemical findings reminiscent of "protease-sensitive prionopathy". Neuropathological examinations revealed spongiform change mainly affecting the cerebral cortex, putamen/globus pallidus and thalamus, accompanied by mild astrocytosis and microgliosis, with slight involvement of the cerebellum. Confluent vacuoles were absent. Diffuse synaptic PrP deposits in these regions were largely removed following proteinase treatment. PrP deposition, as revealed with 3F4 and 1E4 antibodies, was markedly sensitive to pre-treatment with proteinase K. Molecular analysis of PrPSc showed an abnormal prion protein more sensitive to proteinase K digestion, with a five-band pattern of 28, 24, 21, 19, and 16 kDa, and three aglycosylated isoforms of 19, 16 and 6 kDa. This PrPSc was estimated to be 80% susceptible to digestion while the pathogenic prion protein associated with classical forms of sporadic Creutzfeldt-Jakob disease were only 2% (type VV2) and 23% (type MM1) susceptible. No mutations in the PRNP gene were found and genotype for codon 129 was heterozygous methionine/valine. Conclusions: A novel form of human disease with abnormal prion protein sensitive to protease and MV at codon 129 was described. Although clinical signs were compatible with sporadic Creutzfeldt-Jakob disease, the molecular subtype with the abnormal prion protein isoforms showing enhanced protease sensitivity was reminiscent of the "protease-sensitive prionopathy". It remains to be established whether the differences found between the latter and this case are due to the polymorphism at codon 129. Different degrees of proteinase K susceptibility were easily determined with the chemical polymer detection system which could help to detect proteinase-susceptible pathologic prion protein in diseases other than the classical ones.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Although many optical fibre applications are based on their capacity to transmit optical signals with low losses, it can also be desirable for the optical fibre to be strongly affected by a certain physical parameter in the environment. In this way, it can be used as a sensor for this parameter. There are many strong arguments for the use of POFs as sensors. In addition to being easy to handle and low cost, they demonstrate advantages common to all multimode optical fibres. These specifically include flexibility, small size, good electromagnetic compatibility behaviour, and in general, the possibility of measuring any phenomenon without physically interacting with it. In this paper, a sensor based on POF is designed and analysed with the aim of measuring the volume and turbidity of a low viscosity fluid, in this case water, as it passes through a pipe. A comparative study with a commercial sensor is provided to validate the proven flow measurement. Likewise, turbidity is measured using different colour dyes. Finally, this paper will present the most significant results and conclusions from all the tests which are carried out.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Máster de Farmacología “Desarrollo, Evaluación y Uso Racional de Medicamentos” - E-mail de la autora: amets88@hotmail.com

Relevância:

10.00% 10.00%

Publicador:

Resumo:

456 p.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

[ES]La tesis tiene como objetivo profundizar en el conocimiento de la relación que existe entre el indeterminismo y el fallo del principio de conservación de la energía en la mecánica newtoniana bajo procesos que consisten en una sucesión infinita de colisiones perfectamente elásticas, llamados supertareas newtonianas. Se propone una supertarea, que nombramos STMNC, que muestra no ser conservativa pero que, bajo los mecanismos hasta ahora conocidos, no es manifiestamente indeterminista. Se demuestra, con un planteamiento general que llamamos G¿1, que tal proceso es de hecho indeterminista antes de que la supertarea llegue a ejecutarse; no obstante, se señalan las dificultades para que el proceso sea indeterminista una vez que la supertarea concluye, es decir, una vez que la energía se pierde. Con esto, y tras el análisis de las fuentes del indeterminismo y la pérdida de la energía, se sugiere que el único aspecto en común entre ambas anomalías, cuando emergen bajo estos procesos, es la infinidad de colisiones que involucran. Para obtener estos resultados se sigue la siguiente estrategia. En la primera parte, se analizan los argumentos en torno a las paradojas de Zenón, unos a favor y otros en contra de las ideas de espacio y tiempo que permiten la ejecución de las supertareas. En la segunda parte, se analizan los argumentos que amenazan a los procesos que tratamos de ser inconsistentes y de no ser newtonianos. En conjunto, con estas dos partes garantizamos que las supertareas newtonianas son procesos legítimos, brindando así sentido a nuestro resultado principal. En la tercera parte, se analizan las diversas fuentes del indeterminismo en la mecánica newtoniana bajo supertareas y la relación que dichas fuentes guardan con el indeterminismo.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Beñat Oihartzabali Gorazarre: Festschrift for Bernard Oyharçabal / Ricardo Etxepare, Ricardo Gómez, Joseba Andoni Lakarra (arg./eds)

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Las traineras son un tipo de embarcación a remo que se utilizan para competir en regatas. Con el fin de entender la física que impulsa estas embarcaciones, se ha llevado a cabo este proyecto que finaliza con un simulador de trainera. La primera parte del proyecto, la que tiene que ver con este documento, abarca la simulación del remo en sí y el cálculo de las fuerzas o físicas que lo rodeen. Dentro de este documento, comenzaremos con la fuerza ejercida por el remero y lo que conlleva en la rotación local del remo. Para esta rotación hay diferentes variables que se han estudiado y que pueden alterar la velocidad del remo y la fuerza que ejercen al conjunto de la trainera. La razón por la cual se mueve el remo depende de valores introducidos manualmente los cuales se pueden cambiar obteniendo diferentes resultados. Para una visualización rápida e intuitiva de los cálculos se ha utilizado la representación en 3D de la trainera y todos sus componentes. Con este simulador se pueden apreciar detalles en movimiento y en posición de cualquier componente de la trainera.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Lan honetan Laudio Ikastolaren azterketa pedagogikoa egin dut eta Laud io Ikastolaren funtzionamendua hobeto ulertzeko baliagarria izan zait. Azterketa honetarako hainbat gauzetan arreta jarri behar izan dut eta informazio asko jaso. Esan daiteke b ehaketa lana puntu gar rantzitsu bat izan dela lan hau burutzeko. Behaketa lan h onekin irakaslearen jokabidean arreta handia ipini dut eta horrek , egiten dituen gauza onak eta baita txarrak ere detektatzeko baliagarria izan zait.