944 resultados para Charlevoix Summer Home Association (Charlevoix, Mich.)
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This collection is a valuable source on home economics history in South Carolina during the twentieth century. While there is information on the SCHEA from its beginning in 1914 to 1980, the actual records do not start until 1920. An outline of what the South Carolina Home Economics Association was doing from 1914 to 1920, is provided in the “historical file” (see Box 1, folders 1 to 4). The inclusive dates for a particular series may vary and, for most series, the records are incomplete. The collection contains all the records normally created by an organization, including constitutions, correspondence, minutes, reports, handbooks, etc. A wide variety of research topics could be developed from the records, including the SCHEA’s impact on the legislative process in South Carolina (e.g. the passage of the bill for the enrichment of cornmeal and grits in 1943), its cooperation and relationship with relief agencies in the state and its role in improving child health during the 1930s.
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Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset neurological disease resulting from mutations in the SACS gene encoding sacsin, a 4,579-aa protein of unknown function. Originally identified as a founder disease in Québec, ARSACS is now recognized worldwide. Prominent features include pyramidal spasticity and cerebellar ataxia, but the underlying pathology and pathophysiological mechanisms are unknown. We have generated an animal model for ARSACS, sacsin knockout mice, that display age-dependent neurodegeneration of cerebellar Purkinje cells. To explore the pathophysiological basis for this observation, we examined the cell biological properties of sacsin. We show that sacsin localizes to mitochondria in non-neuronal cells and primary neurons and that it interacts with dynamin-related protein 1, which participates in mitochondrial fission. Fibroblasts from ARSACS patients show a hyperfused mitochondrial network, consistent with defects in mitochondrial fission. Sacsin knockdown leads to an overly interconnected and functionally impaired mitochondrial network, and mitochondria accumulate in the soma and proximal dendrites of sacsin knockdown neurons. Disruption of mitochondrial transport into dendrites has been shown to lead to abnormal dendritic morphology, and we observe striking alterations in the organization of dendritic fields in the cerebellum of knockout mice that precedes Purkinje cell death. Our data identifies mitochondrial dysfunction/mislocalization as the likely cellular basis for ARSACS and indicates a role for sacsin in regulation of mitochondrial dynamics.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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v. 1. General report.--v. 2. New York State College of Agriculture.--v. 3. College of Arts and Sciences.--v. 4. School of Education.--v. 5. College of Engineering.--v. 6. Graduate School.--v. 7. New York State College of Home Economics.--v. 8. School of Hotel Administration.--v. 9. New York State School of Industrial and Labor Relations.--v. 10. College of Architecture, Graduate School of Business and Public Administration, Division of Extramural Courses, Law School, Medical College, School of Nursing, Graduate School of Nutrition, Summer Session, New York State Veterinary College.
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Instrumental. Apple blossom march / Pemberton pierce -- The arrow dance / Arthur M. Cohen -- Beatrice, caprice / William R. Stobbe -- Belle of Cuba quickstep / Arthur M. Cohen -- Birds in the night / Arthur S. Sullivan -- Birdie waltz / Lena R. Lecroy -- Carnations Idyl / Heinrich Lichner -- El cielo / Arthur M. Cohen -- Five o'clock in the morning / Claribel -- Good night / A. Loeschorn -- Janet's choice / Claribel -- Just a little sunshine waltz / F. A. Lorrilliere -- Little maid of Arcadee / Arthur Sullivan -- Looking back / Arthur S. Sullivan -- Maggie's secret / Claribel -- Marie waltz / G. F. H. Laurence -- Nemesis gallop / Arthur M. Cohen -- Rays of sunshine march / Adam Geibel -- Rose et Marguerites / E. Waldteufel -- Rosebud waltz / Pemberton Pierce -- Silver chimes / Claribel -- Silver brook schottische / Arthur M. Cohen -- Slumber song / S. Heller -- Starlight polka / Pemberton Pierce -- Strangers yet / Claribel -- Sweetheart's waltz / G.F.H. Laurence -- Take back the heart ; Won't you tell me why, robin? ; You and I / Claribel.