Marcas de influência do echúwabo no português de Moçambique: a questão dos verbos nas redes sociais

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Phenotypic expression of homozygous hemoglobin S in relation to β-globin haplotypes, glutathione S-transferase polymorphisms and detoxification enzymes

Sickle cell anemia (SCA) shows a pathophysiology that involves multiple changes in sickle cell erythrocytes, vaso-occlusive episodes, hemolysis, activation of inflammatory mediators, endothelial cell dysfunction, and oxidative stress. These events complicate treatment and culminate in the development of manifestations such as anemia, pain crises and multiorgan dysfunction. The aim of this study was to evaluate, in SCA patients, oxidative stress and antioxidant capacity markers, correlating them to treatment with hydroxyurea (HU), β-globin haplotypes and glutathione S-transferase polymorphisms (GSTT1, GSTM1 and GSTP1), in comparison to a control group (CG). The study groups were composed of 48 individuals without hemoglobinopathies (CG), SCA patients treated with HU [AF (+HU), N = 13] and untreated SCA patients [AF (-HU), N = 15], after informed consent. The groups were analyzed using cytological, electrophoretic, chromatographic and molecular methods and information from medical records. The GSTM1 and GSTT1 polymorphisms were determined by multiplex PCR, while the GSTP1 polymorphism by PCR-RFLP. Biochemical parameters were measured using spectrophotometric methods [TBARS, TEAC and catalase (CAT) and GST activities] and a chromatographic method [glutathione (GSH)]. The fetal Hb (Hb F) levels observed in the SCA (+HU) group (10.9%) confirmed the already well-described pharmacological effect of HU, but the SCA (-HU) group also had high Hb F levels (6.1%), which may have been influenced by genetic factors not targeted in this study. We found a higher frequency of the Bantu haplotype (48.2%), followed by the Benin (32.1%) and also Cameroon haplotypes, rare in our population, and 19.7% of atypical haplotypes. The presence of Bantu haplotype was related to higher lipid peroxidation levels in patients, but also, it conferred a differential response to HU treatment, raising Hb F levels in 52.6% (P = 0.03). The protective effect of Hb F was confirmed, because the increase in their levels resulted in a 41.3% decrease in lipid peroxidation levels (r = -0.74, P = 0.0156). The genotypic frequency of the GST polymorphisms observed was similar to that of other studies in the Brazilian population, and its association with biochemical markers revealed a significant difference only for the GSTP1 polymorphism, where patients with genotype V/V showed higher GSH and TEAC levels (P = 0.04 and P = 0.03, respectively) compared to patients with genotype I/I. The TBARS levels were about five to eight times higher in the SCA (+HU) and SCA (-HU) groups, respectively, compared to controls, and HU produced a 35.2% decrease in lipid peroxidation levels in the SCA (+HU) group (P < 0.0001). Moreover, the SCA (+HU) group showed higher TEAC levels when compared to CG (P = 0.002). We did not find any significant difference in GST activity between the groups studied (P = 0.76), but CAT activity was about 17 and 30% lower in SCA (+HU) and SCA (-HU) groups, respectively (P < 0.00001). Plasma GSH levels were ~2 times higher in SCA patients than in the control group (P = 0.0005) and showed a positive correlation with TBARS levels, confirming its antioxidant function. HU treatment contributed to higher CAT activity and TEAC levels and lower lipid peroxidation, and its pharmacological effect showed a “haplotype-dependent” response. These findings may contribute to elucidating the potential of HU in ameliorating oxidative stress in SCA subjects.

A norma-padrão Europeia e a mudança linguística na Escola Moçambicana

In Mozambique, the portuguese language is considered the official language, second language, national language and competes with more than twenty Bantu languages spoken by the majority of population. The standard norm lose away their floor to the Mozambican Portuguese which carries own characteristics pertaining to the sociolinguistic context of the country. Schools attempt their best, but they cannot teach the European standard due the multilingual and Portuguese contact with African languages, a fact that is reflected in the media and in the literature through their oral and written forms. These difficulties result in high rates of failures due to problems encountered in using the European standard by teachers and writers who prepare the school books. This research suggests the standardization of the Mozambican variant as well as the preparation of dictionaries and grammars illustrating the sociolinguistic reality of Mozambique in order to improve the quality of education. It also emphasizes the need for a self-esteem spirit on Mozambicans in general as a conduit to eliminate the soaring bias that Mozambicans can not speak portuguese language

Khoisan hunter-gatherers have been the largest population throughout most of modern-human demographic history

The Khoisan people from Southern Africa maintained ancient lifestyles as hunter-gatherers or pastoralists up to modern times, though little else is known about their early history. Here we infer early demographic histories of modern humans using whole-genome sequences of five Khoisan individuals and one Bantu speaker. Comparison with a 420 K SNP data set from worldwide individuals demonstrates that two of the Khoisan genomes from the Ju/'hoansi population contain exclusive Khoisan ancestry. Coalescent analysis shows that the Khoisan and their ancestors have been the largest populations since their split with the non-Khoisan population similar to 100-150 kyr ago. In contrast, the ancestors of the non-Khoisan groups, including Bantu-speakers and non-Africans, experienced population declines after the split and lost more than half of their genetic diversity. Paleoclimate records indicate that the precipitation in southern Africa increased similar to 80-100 kyr ago while west-central Africa became drier. We hypothesize that these climate differences might be related to the divergent-ancient histories among human populations.

Comparing genetic and linguistic diversity in African populations with a focus on the Khoisan of southern Africa

The interaction between disciplines in the study of human population history is of primary importance, profiting from the biological and cultural characteristics of humankind. In fact, data from genetics, linguistics, archaeology and cultural anthropology can be combined to allow for a broader research perspective. This multidisciplinary approach is here applied to the study of the prehistory of sub-Saharan African populations: in this continent, where Homo sapiens originally started his evolution and diversification, the understanding of the patterns of human variation has a crucial relevance. For this dissertation, molecular data is interpreted and complemented with a major contribution from linguistics: linguistic data are compared to the genetic data and the research questions are contextualized within a linguistic perspective. In the four articles proposed, we analyze Y chromosome SNPs and STRs profiles and full mtDNA genomes on a representative number of samples to investigate key questions of African human variability. Some of these questions address i) the amount of genetic variation on a continental scale and the effects of the widespread migration of Bantu speakers, ii) the extent of ancient population structure, which has been lost in present day populations, iii) the colonization of the southern edge of the continent together with the degree of population contact/replacement, and iv) the prehistory of the diverse Khoisan ethnolinguistic groups, who were traditionally understudied despite representing one of the most ancient divergences of modern human phylogeny. Our results uncover a deep level of genetic structure within the continent and a multilayered pattern of contact between populations. These case studies represent a valuable contribution to the debate on our prehistory and open up further research threads.

Woher kommen die Infixe im Isu (Kameruner Grasland)?

Die westliche Ring-Sprache Isu (Süd-Bantoid) des Kameruner Graslands setzt ein palatales Infix zum Ausdruck einer Reihe verwandter verbaler Funktionen – imperfektiver Aspekt, Pluraktional, Kausativ – ein. Damit hebt sie sich deutlich vom engeren Bantu- und weiteren Benue-Kongo-Habitus ab, der sich dadurch auszeichnet, Kategorien dieser Art entweder durch verbale Suffixe oder durch Periphrase mithilfe von Hilfsverben zu kodieren. Morphologische Distributionsanalyse, interne Rekonstruktion und externer Vergleich innerhalb der Ring-Gruppe ermöglichen es, die historischen Ursprünge dieses palatalen Infixes einzukreisen und es als Abbauprodukt einer Hochvokal-Reduplikation (ursprünglich in Progressivfunktion) zu identifizieren, wie sie (a) in anderen Niger-Kongo-Sprachen nicht unüblich ist, und (b) wie sie sogar als kognate Vorläuferkonstruktion in der Süd-Ring-Sprache Babungo nachgewiesen werden kann. Funktional-diachron gesehen, wurde im Isu ein vormaliger Progressiv in zunehmendem Maße als Imperfektiv grammatikalisiert und ist damit in die Domäne der älteren Imperfektiv-Strategie -ə (< *-a) eingedrungen. Auf diese Art fügen sich das Isu und seine nächsten Verwandten trotz dieser eigentümlichen Infix-Phänomene sauber in das Gesamtbild westafrikanischer Sprachen ein.

Comments on the review by Kathrin Tiewa

The review of the book Matrix nominal Phrases in Kiswahili Bantu (2009), Rüdiger Köppe Verlag, in Afrikanistik online is lucid and welcome. We appreciate it very much. There are, however, a few inexactitudes that need to be corrected.

Mandombe

Mandombe, one of the most recent modern African scripts, was originally designed to write the Bantu languages of the Congos, and eventually all languages on the continent. Its symbols are made of simple and composite geometrical forms which predate the script. It is apparently the only African script which has gained some social success without any political support.

The sociolinguistic situation of ǂHoan, a moribund 'Khoisan' language of Botswana

In 2010, we conducted a sociolinguistic survey on the moribund 'Khoisan' language ǂHoan (Ju-ǂHoan), spoken in Botswana at the fringe of the Kalahari Desert. The survey aimed at investigating language use, degrees of multilingualism and language attitude among the ǂHoan speakers. Data collection was done on the basis of a questionnaire. We found that the positive language attitude of individuals towards ǂHoan often conflicts with the community's attitude towards this language, resulting in a split of actual language use between the family and more formal situations. All ǂHoan speakers are at least bilingual speaking the local lingua franca Kgalagadi (Bantu) besides ǂHoan. Most of them are in fact even trilingual, speaking Gǀui (Khoe-Kwadi) in addition to ǂHoan and Kgalagadi. Most of our results stand in line with an earlier sociolinguistic survey on ǂHoan by Batibo (2005a) which was carried out in 2003. In comparing Batibo's results to ours, changes in the sociolinguistic situation of ǂHoan as well as differences between the different villages will be pointed out.

Didática da escrita em contextos multilingues : o caso de Moçambique - desafios linguísticos, metodológicos e contextuais

Tese de doutoramento, Linguística (Linguística Aplicada), Universidade de Lisboa, Faculdade de Letras, 2016

Les sociétés bantoues du Congo belge et les problèmes de la politique indigène; étude de la politique coloniale adoptée au Congo belge et de ses problèmes dans l'ordre sociologique, politique et économique.

Mode of access: Internet.

History of South Africa, from 1795-1872,

Vols 1-2, 4th ed., carefully rev. and enl.; v. 3, 3d ed., carefully rev. and enl.

Molecular markers and human history: A tale of two haplogroup systems

To chronicle demographic movement across African Asian corridors, a variety of molecular (sequence analysis, restriction mapping and denaturing high performance liquid chromatography etc.) and statistical (correspondence analysis, AMOVA, calculation of diversity indices and phylogenetic inference, etc.) techniques were employed to assess the phylogeographic patterns of mtDNA control region and Y chromosomal variation among 14 sub-Saharan, North African and Middle Eastern populations. The patterns of genetic diversity revealed evidence of multiple migrations across several African Asian passageways as well within the African continent itself. The two-part analysis uncovered several interesting results which include the following: (1) a north (Egypt and Middle East Asia) to south (sub-Saharan Africa) partitioning of both mtDNA and Y chromosomal haplogroup diversity, (2) a genetic diversity gradient in sub-Saharan Africa from east to west, (3) evidence in favor of the Levantine Corridor over the Horn of Africa as the major genetic conduit since the Last Glacial Maximum, (4) a substantially higher mtDNA versus Y chromosomal sub-Saharan component in the Middle East collections, (5) a higher representation of East versus West African mtDNA haplotypes in the Arabian Peninsula populations versus no such bias in the Levant groups and lastly, (6) genetic remnants of the Bantu demographic expansion in sub-Saharan Africa. ^