Diabetes mellitus gestacional : comparación de la validez de los criterios diagnósticos de las pruebas ADA y OMS con base al estándar de referencia NDDG

Tesis (Doctorado en Medicina) UANL

La Ca??ada Real Segoviana a su paso por Madrid

Se trata de un conjunto de estudios de diversa ??ndole sobre la Ca??ada Real Segoviana a su paso por la provincia de Madrid desde varios puntos de vista: tur??stico y relacionados con el medio ambiente natural y humano..

La Ca??ada Leonesa

Gu??a que pretende animar al conocimiento de las ca??adas. Propone un itinerario que parte de la Sierra de Guadarrama y llega hasta Talavera de la Reina. Hace una introducci??n hist??rica y describe brevemente el medio natural..

Los juegos en La Il??ada y en La Eneida

Se hace un estudio comparativo y una descripci??n de las competiciones atl??ticas que aparecen en las obras de Homero y Virgilio, la Il??ada y la Eneida, respectivamente. En la Eneida, Virgilio adopta muchos elementos hom??ricos, sin embargo, los adopta a rasgos y aspectos propios de su ??poca.

La Ca??ada Real de la Plata a su paso por la provincia de Zamora : tratamiento multidisciplinar de los temas transversales

Contiene : 1- Gu??a did??ctica, 2- Actividades (cuaderno de ruta), 3- Proyecto de trabajo y 4- Disquete. El ejemplar con n??mero de Registro x no tiene disquete ni diapositivas. No consta centro realizador. Premio Nacional a la Innovaci??n Educativa, 1997

Memoria hist??rica versus historia ense??ada

El art??culo forma parte de un monogr??fico dedicado a memoria hist??rica y educaci??n.

Batxillerat d'Arts Esc??niques, M??sica i Dansa a l'institut XXV Olimp??ada

Resumen basado en el de la publicaci??n

Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis

The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P< 0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P< 0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. © 2013 Elsevier B.V.

Polimorfismos dos genes ADA e CNTNAP2 em indivíduos com Transtornos do Espectro do Autismo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ópera e literatura em cena: uma análise da obra juvenil aída, adaptada por han mi-ho e ilustrada por Lucia Sforza

This text’s objective is to present an analysis of Aída, adapted by Han Mi-Ho (2012) and illustrated by Lucia Sforza, from the classic eponymous opera by Giuseppe Verdi. This book is part of the collection Classical music on the scene, published by FTD, which aims to introduce stories of important librettos regarded as classics in the music field to young audiences. More specifically, we intend to verify in this text, with Bakhtinian principles, how the dialogue between Verdi’s work and HanMi-Ho’s is actualized. To achieve these objectives, we will present a reflection of what provides the pleasure in reading. In this text we built the hypothesis that Han-Mi-Ho’s strategy to rescue a classic opera and adapt it in the form of an illustrated narrative for the young reader provides the contact with an attractive and playful text that leads to critical reflection and expands his knowledge through the rescue of the cultural memory. The appropriation of a classic cultural production adapted to the narrative language and targeted to a young audience can act as an appraisal factor in the identity of the reader. Through it, he is able to raise his self-esteem, because he perceives that he is considered as a production receiver, while at the same time he is recognized as the heir of a traditional cultural heritage.

Sēfer ʿAṣîrat ham-maggēfā : doś zainin (segules u-refues) den (oilem) for tzu šṭelin wi man zol (nizehar) zain (be-es ha-ḥadaš)... ḥatîmat gedôlê rôfe'îm miq-q"q Berlin

Digitalisat der Ausg. Frankfurṭ-de-Odr, 1770/71

Leila Ada : Leben und Ende einer israelitischen Jungfrau

[Osborn W. Trenery Heighway]

B cells in ADA deficiency

Deficiency of the enzyme adenosine deaminase (ADA) results in severe lymphopenia in humans. Mice with an inactivating mutation in the ADA gene also exhibit profound lymphopenia, as well as pulmonary insufficiency and ribcage abnormalities. In fact, the mouse model has a phenotype that is remarkably similar to that of the human disease, making the mice valuable tools for unraveling the mechanism of lymphocyte destruction in absence of this housekeeping gene. T cell deficiency in ADA deficiency has been extensively studied by others, revealing a block in early thymocyte development. In contrast, our studies revealed that early B cell development in the bone marrow is normal. ADA-deficient mice, however, exhibit profound defects in germinal center formation, preventing antigen-dependent B cell maturation in the spleen. ADA-deficient spleen B cells display significant defects in proliferation and activation signaling, and produce more IgM than their normal counterparts, suggesting that extrafollicular plasmablasts are overrepresented. B cells from ADA-deficient mouse spleens undergo apoptosis more readily than those from normal mouse spleens. Levels of ADA's substrates, adenosine and 2′-deoxyadenosine, are elevated in both bone marrow and spleen in ADA-deficient mice. S ′-adenosyihomoeysteine hydrolase (SAH hydrolase) activity is significantly inhibited in both locales, as well. dATP levels, though, are only elevated in spleen, where B cell development is impaired, and not in bone marrow, where B cell ontogeny is normal. This finding points to dATP as the causative agent of lymphocyte death in ADA deficiency. ADA deficiency results in inhibition of the enzyme ribonucleotide reductase, thereby depleting nucleoside pools needed for DNA repair. Another mouse model that lacks a functional gene encoding a protein involved in DNA repair and/or cell cycle checkpoint regulation, p53-binding protein 1, exhibits blocks in T and B cell development that are similar to those seen in ADA-deficient mice. Unraveling the mechanisms of lymphocyte destruction in ADA deficiency may further understanding of lymphocyte biology, facilitate better chemotherapeutic treatment for lymphoproliferative diseases, and improve gene and enzyme therapy regimens attempted for ADA deficiency. ^