Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell

We have discovered that intracellular redox state appears to be a necessary and sufficient modulator of the balance between self-renewal and differentiation in dividing oligodendrocyte-type-2 astrocyte progenitor cells. The intracellular redox state of freshly isolated progenitors allows prospective isolation of cells with different self-renewal characteristics. Redox state is itself modulated by cell-extrinsic signaling molecules that alter the balance between self-renewal and differentiation: growth factors that promote self-renewal cause progenitors to become more reduced, while signaling molecules that promote differentiation cause progenitors to become more oxidized. Moreover, pharmacological antagonists of the redox effects of these cell-extrinsic signaling molecules antagonize their effects on self-renewal and differentiation, indicating that cell-extrinsic signaling molecules that modulate this balance converge on redox modulation as a critical component of their effector mechanism.

Characteristics of the deep ocean carbon system during the past 150,000 years: ΣCO2 distributions, deep water flow patterns, and abrupt climate change

Studies of carbon isotopes and cadmium in bottom-dwelling foraminifera from ocean sediment cores have advanced our knowledge of ocean chemical distributions during the late Pleistocene. Last Glacial Maximum data are consistent with a persistent high-ΣCO2 state for eastern Pacific deep water. Both tracers indicate that the mid-depth North and tropical Atlantic Ocean almost always has lower ΣCO2 levels than those in the Pacific. Upper waters of the Last Glacial Maximum Atlantic are more ΣCO2-depleted and deep waters are ΣCO2-enriched compared with the waters of the present. In the northern Indian Ocean, δ13C and Cd data are consistent with upper water ΣCO2 depletion relative to the present. There is no evident proximate source of this ΣCO2-depleted water, so I suggest that ΣCO2-depleted North Atlantic intermediate/deep water turns northward around the southern tip of Africa and moves toward the equator as a western boundary current. At long periods (>15,000 years), Milankovitch cycle variability is evident in paleochemical time series. But rapid millennial-scale variability can be seen in cores from high accumulation rate series. Atlantic deep water chemical properties are seen to change in as little as a few hundred years or less. An extraordinary new 52.7-m-long core from the Bermuda Rise contains a faithful record of climate variability with century-scale resolution. Sediment composition can be linked in detail with the isotope stage 3 interstadials recorded in Greenland ice cores. This new record shows at least 12 major climate fluctuations within marine isotope stage 5 (about 70,000–130,000 years before the present).

Quiescent state and outburst evolution of SGR 0501+4516

We report on the quiescent state of the soft gamma repeater SGR 0501+4516 observed by XMM–Newton on 2009 August 30. The source exhibits an absorbed flux ∼75 times lower than that measured at the peak of the 2008 outburst, and a rather soft spectrum, with the same value of the blackbody temperature observed with ROSAT back in 1992. This new observation is put into the context of all existing X-ray data since its discovery in 2008 August, allowing us to complete the study of the timing and spectral evolution of the source from outburst until its quiescent state. The set of deep XMM–Newton observations performed during the few years time-scale of its outburst allows us to monitor the spectral characteristics of this magnetar as a function of its rotational period, and their evolution along these years. After the first ∼10 d, the initially hot and bright surface spot progressively cooled down during the decay. We discuss the behaviour of this magnetar in the context of its simulated secular evolution, inferring a plausible dipolar field at birth of 3 × 1014 G, and a current (magnetothermal) age of ∼10 kyr.

Europe as International Actor: Maximizing Nation-State Sovereignty. CES Germany & Europe Working Papers, No. 06.3, 1996

The continually increasing literature on foreign- and security-policy dimensions of the European Union (EU) has provided no remedy for the widespread helplessness in gaining a purchase on Europe as an international actor. The basic hindrance to understanding this policy comes from an all-too-literal interpretation of the acronym involved: the CFSP is understood as a total or partial replacement of the nation-states' foreign and security policy. This article aims to point the way to a new understanding of the CFSP in which this policy is not based on the integration of nation­ state foreign and security policy. I suggest that the proper way to grasp the phenomenon of the CFSP is to describe it as an international regime whose goal is to administer links between economic integration and foreign- and security­ policy cooperation in the sense of maximizing the sovereignty of member states. This requires, on the one hand, the prevention of "spillovers" from the economic area that could interfere with the foreign- and security-policy indepen­ dence of member states. On the other hand, it demands applying the EU's economic potential to reinforce the foreign- and security-policy range of member states. Due to the logic of this policy, CFSP priorities and fields of ac­ tion differ profoundly from those of a national foreign and security policy. Expectations on the evolution of the CFSP must be aware of these basic characteristics of this policy.

Consolidation characteristics of outer Bengal Fan deposits (Table 1)

The state of consolidation of outer Bengal Fan deposits is closely related to their depositional history. Early Pleistocene sediments are underconsolidated, i.e., fabric strength is lower than under equilibrium with the present overburden stress, at depths greater than 60-80 mbsf. This may be due to rapid accumulation (>15-20 cm/k.y.) and overlying low-permeability (<10**-7 cm/s) deposits. The underlying Pliocene sediments are overconsolidated, i.e., fabric strength is higher than in equilibrium with the present overburden stress; at Sites 717 and 719 the sediments are slightly overconsolidated, whereas at Site 718 the overconsolidation is significant. Overconsolidation is explained by erosion that occurred during the early Pleistocene for which a stratigraphic gap was recorded in the drilled cores. The eroded section is estimated to be in the range of 10-40 m at Sites 717 and 719, respectively, and 130-150 m at Site 718. Below 250-300 mbsf the most sediments are normally consolidated. The amount of erosion seems to be related to block rotation and uplift due to intraplate deformation.

School bus acceleration characteristics.

Arkansas State Highway and Transportation Department, Little Rock

Trends in selected water-quality characteristics, Powder River and tributaries, Montana and Wyoming, water years 1968-88 and 1975-88 /

Mode of access: Internet.

Evaluation of state motorcycle helmet laws using the National Electronic Injury Surveillance System. Final report.

Mode of access: Internet.

Solid state data acquisition and processing system (SSDAPS). Volume III: description, installation, calibration, and operating procedures. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Alcohol and highway safety 1978: a review of the state of knowledge (summary volume).

Mode of access: Internet.

Performance characteristics of 1977 GM 305 CID engine. Final report.

National Highway Traffic Safety Administration, Office of Research and Development, Washington, D.C.

Evaluation of New York State's Mandatory Occupant Restraint Law: volume V - fatalities and injuries among motor vehicle occupants covered by the law.

National Highway Traffic Safety Administration, Washington, D.C.

Annotated bibliography of research on operational characteristics and geometric implications of longer and wider trucks. Interim report.

Texas State Department of Highways and Public Transportation, Transportation Planning Division, Austin

Correlation of design and control characteristics with accidents at rural multi-lane highway intersections in Indiana. Interim report.

Federal Highway Administration, Washington, D.C.

Solid state data acquisition and processing system (SSDAPS). Volume I: system summary and volume II: description, operation, and verification test report. Final report.

National Highway Traffic Safety Administration, Washington, D.C.