The recent development and performance of ethical investments

In this chapter, we assess the recent development and performance of ethical investments around the world. Ethical investments include both socially responsible investments (following Environmental, Social and Governance criteria) and faith-based investments (following religious principles). After presenting the development of each type of funds in a historical context, we analyse their ethical screening process, highlighting similarities and differences across funds and regions. This leads us to investigate their characteristics in terms of return and risk, and finally evaluate their historical performance using various risk-adjusted performance measures on a small sample of US funds. Hence we are able to not only compare the performance of each fund with each other and with traditional investments, but also assess their relative resilience to the 2007-08 financial crisis.

The VLT-FLAMES Tarantula Survey: XIX. B-type supergiants: Atmospheric parameters and nitrogen abundances to investigate the role of binarity and the width of the main sequence

Context: Model atmosphere analyses have been previously undertaken for both Galactic and extragalactic B-type supergiants. By contrast, little attention has been given to a comparison of the properties of single supergiants and those that are members of multiple systems. 

Aims: Atmospheric parameters and nitrogen abundances have been estimated for all the B-type supergiants identified in the VLT-FLAMES Tarantula survey. These include both single targets and binary candidates. The results have been analysed to investigate the role of binarity in the evolutionary history of supergiants. 

Methods: tlusty non-local thermodynamic equilibrium (LTE) model atmosphere calculations have been used to determine atmospheric parameters and nitrogen abundances for 34 single and 18 binary supergiants. Effective temperatures were deduced using the silicon balance technique, complemented by the helium ionisation in the hotter spectra. Surface gravities were estimated using Balmer line profiles and microturbulent velocities deduced using the silicon spectrum. Nitrogen abundances or upper limits were estimated from the Nii spectrum. The effects of a flux contribution from an unseen secondary were considered for the binary sample. Results. We present the first systematic study of the incidence of binarity for a sample of B-type supergiants across the theoretical terminal age main sequence (TAMS). To account for the distribution of effective temperatures of the B-type supergiants it may be necessary to extend the TAMS to lower temperatures. This is also consistent with the derived distribution of mass discrepancies, projected rotational velocities and nitrogen abundances, provided that stars cooler than this temperature are post-red supergiant objects. For all the supergiants in the Tarantula and in a previous FLAMES survey, the majority have small projected rotational velocities. The distribution peaks at about 50 km s^-1 with 65% in the range 30 km s^-1 ≤ ν_e sin i ≤ 60 km s^-1. About ten per cent have larger ve sin i (≥100 km s^-1), but surprisingly these show little or no nitrogen enhancement. All the cooler supergiants have low projected rotational velocities of ≤70 km s^-1 and high nitrogen abundance estimates, implying that either bi-stability braking or evolution on a blue loop may be important. Additionally, there is a lack of cooler binaries, possibly reflecting the small sample sizes. Single-star evolutionary models, which include rotation, can account for all of the nitrogen enhancement in both the single and binary samples. The detailed distribution of nitrogen abundances in the single and binary samples may be different, possibly reflecting differences in their evolutionary history. 

Conclusions: The first comparative study of single and binary B-type supergiants has revealed that the main sequence may be significantly wider than previously assumed, extending to T_eff = 20 000 K. Some marginal differences in single and binary atmospheric parameters and abundances have been identified, possibly implying non-standard evolution for some of the sample. This sample as a whole has implications for several aspects of our understanding of the evolutionary status of blue supergiants.

Statin use and breast cancer survival: a nationwide cohort study in Scotland

Background: Preclinical evidence suggests that statins could delay cancer progression. Previous epidemiological findings have been inconsistent and some have been limited by small sample sizes, as well as certain time-related biases. This study aimed to investigate whether breast cancer patients who were exposed to statins had reduced breast cancer-specific mortality. Methods: We conducted a retrospective cohort study of 15,140 newly diagnosed invasive breast cancer patients diagnosed from 2009 to 2012 within the Scottish Cancer Registry. Dispensed medication usage was obtained from linkages to the Scottish Prescribing Information System and breast cancer-specific deaths were identified from National Records of Scotland Death Records. Using time-dependent Cox regression models, hazard ratios (HR) and 95 % confidence intervals (CI) were calculated for the association between post-diagnostic exposure to statins (including simvastatin) and breast cancer-specific mortality. Adjustments were made for a range of potential confounders including age at diagnosis, year of diagnosis, cancer stage, grade, cancer treatments received, comorbidities, socioeconomic status and use of aspirin. Results: A total of 1,190 breast cancer-specific deaths occurred up to January 2015. Overall, after adjustment for potential confounders, there was no evidence of an association between statin use and breast cancer-specific death (adjusted HR 0.93, 95 % CI 0.77, 1.12). No significant associations were observed in dose–response analyses or in analysis of all-cause mortality. For simvastatin use specifically, a weak non-significant reduction in breast cancer-specific mortality was observed compared to non-users (adjusted HR 0.89, 95 % CI 0.73, 1.08). Statin use before diagnosis was weakly associated with a reduction in breast cancer-specific mortality (adjusted HR 0.85, 95 % CI 0.74, 0.98). Conclusion: Overall, we found little evidence of a protective association between post-diagnostic statin use and cancer-specific mortality in a large nation-wide cohort of breast cancer patients. These findings will help inform the decision whether to conduct randomised controlled trials of statins as an adjuvant treatment in breast cancer.

RAS mutations and cetuximab in locally advanced rectal cancer: results of the EXPERT-C trial.

Background: RAS mutations predict resistance to anti-epidermal growthfactor receptor (EGFR) monoclonal antibodies in metastatic colorectal cancer. We analysed RAS mutations in 30 non-metastatic rectal cancer patients treated with or without cetuximab within the 31 EXPERT-C trial.

Methods: Ninety of 149 patients with tumours available for analysis were KRAS/BRAF wild-type, and randomly assigned to capecitabine plus oxaliplatin (CAPOX) followed by chemoradiotherapy, surgery and adjuvant CAPOX or the same regimen plus cetuximab (CAPOX-C). Of these, four had a mutation of NRAS exon 3, and 84 were retrospectively analysed for additional KRAS (exon 4) and NRAS (exons 2/4) mutations by using bi-directional Sanger sequencing. The effect of cetuximab on study end-points in the RAS wild-type population was analysed.

Results: Eleven (13%) of 84 patients initially classified as KRAS/BRAF wild-type were found to have a mutation in KRAS exon 4 (11%) or NRAS exons 2/4 (2%). Overall, 78/149 (52%) assessable patients were RAS wild-type (CAPOX, n = 40; CAPOX-C, n = 38). In this population, after a median follow-up of 63.8 months, in line with the initial analysis, the addition of cetuximab was associated with numerically higher, but not statistically significant, rates of complete response (15.8% versus 7.5%, p = 0.31), 5-year progression-free survival (75.5% versus 67.5%, hazard ratio (HR) 0.61, p = 0.25) and 5-year overall survival (83.8% versus 70%, HR 0.54, p = 0.20).

Conclusions: RAS mutations beyond KRAS exon 2 and 3 were identified in 17% of locally advanced rectal cancer patients. Given the small sample size, no definitive conclusions on the effect of additional RAS mutations on cetuximab treatment in this setting can be drawn and further investigation of RAS in larger studies is warranted.

Informal caregiving and mental ill health – differential relationships by workload, gender, age and area-remoteness in a UK region

Informal caregiving can be a demanding role which has been shown to impact on physical, psychological and social wellbeing. Methodological weaknesses including small sample sizes and subjective measures of mental health have led to inconclusive evidence about the relationship between informal caregiving and mental health. This paper reports on a study carried out in a UK region which investigated the relationship between informal caregiving and mental ill health. The analysis was conducted by linking three datasets, the Northern Ireland Longitudinal Study, the Northern Ireland Enhanced Prescribing Database and the Proximity to Service Index from the Northern Ireland Statistics and Research Agency. Our analysis used both a subjective measure of mental ill health, i.e. a question asked in the 2011 Census, and an objective measure, whether the respondents had been prescribed antidepressants by a General Practitioner between 2010 and 2012. We applied binary logistic multilevel modelling to these two responses to test whether, and for what sub-groups of the population, informal caregiving was related to mental ill health. The results showed that informal caregiving per se was not related to mental ill health although there was a strong relationship between the intensity of the caregiving role and mental ill health. Females under 50, who provided over 19 hours of care, were not employed or worked part-time and who provided care in both 2001 and 2011 were at a statistically significantly elevated risk of mental ill health. Caregivers in remote areas with limited access to shops and services were also at a significantly increased risk as evidenced by prescription rates for antidepressants. With community care policies aimed at supporting people to remain at home, the paper highlights the need for further research in order to target resources appropriately.

Shared Photography: (Photo)journalism and political mobilisation in Rio de Janeiro's favelas

One of the most important civic phenomena emerging from favelas in Rio de Janeiro today is “community (photo)journalism”, which is practised by favela residents who are trained in journalistic and artistic techniques to raise critical awareness and promote political mobilisation in- and outside favelas. This paper looks at some of the work produced at one training place for community photographers, the agency-school Imagens do Povo (“Images of the People”) in Nova Holanda, a favela located in Rio’s North Zone. Using an ethnographic approach, this article first provides an account of the working practices of the School and its photographers. This is followed by a discussion of a small sample of their photographic work, for which we employ a social semiotic paradigm of image analysis. This methodological synergy provides insights into how these journalists document long-term structural as well as “spectacular” violence in favelas, while at the same time striving to capture some of the “beauty” of these communities. The paper concludes that this form of photographic work constitutes an important step towards a more analytical brand of journalism with different news values that encourage a more context-sensitive approach to covering urban violence and favela life.

KEYWORDS: alternative media, Imagens do Povo, multimodality, news values, photojournalism.

Effektiv lagerstyrning med AHP och tvådimensionell artikelklassificering : En fallstudie på Permobil AB, Timrå

Costs related to inventory are usually a significant amount of the company’s total assets. Despite this, companies in general don’t pay a lot of interest in it, even if the benefits from effective inventory are obvious when it comes to less tied up capital, increased customer satisfaction and better working environment. Permobil AB, Timrå is in an intense period when it comes to revenue and growth. The production unit is aiming for an increased output of 30 % in the next two years. To make this possible the company has to improve their way to distribute and handle material,The purpose of the study is to provide useful information and concrete proposals for action, so that the company can build a strategy for an effective and sustainable solution when it comes to inventory management. Alternative methods for making forecasts are suggested, in order to reach a more nuanced perception of different articles, and how they should be managed. Analytic Hierarchy Process (AHP) was used in order to give specially selected persons the chance to decide criteria for how the article should be valued. The criteria they agreed about were annual volume value, lead time, frequency rate and purchase price. The other method that was proposed was a two-dimensional model where annual volume value and frequency was the criteria that specified in which class an article should be placed. Both methods resulted in significant changes in comparison to the current solution. For the spare part inventory different forecast methods were tested and compared with the current solution. It turned out that the current forecast method performed worse than both moving average and exponential smoothing with trend. The small sample of ten random articles is not big enough to reject the current solution, but still the result is a reason enough, for the company to control the quality of the forecasts.

Vinculação, Estilos Educativos Parentais e Esquemas Precoces Mal Adaptativos em Reclusos

Introdução: Sobretudo estudos internacionais focam a importância da vinculação e dos estilos educativos parentais no desenvolvimento de comportamentos delinquentes e antissociais. Em Portugal, alguns estudos focados na população reclusa, analisam, separadamente, estilos educativos parentais, personalidade e esquemas precoces mal adaptativos mas, segundo sabemos, nenhum explora, simultaneamente, a vinculação, os estilos educativos parentais e os esquemas precoces mal adaptativos nesta população. São nossos objetivos caracterizar uma amostra de reclusos quanto à vinculação em diferentes relacionamentos, estilos educativos parentais e esquemas precoces mal adaptativos (EPM) e, sobretudo, explorar associações entre estas três variáveis (e destas com variáveis sociodemográficas, familiares, clínicas e relativas à pena). Metodologia: 44 reclusos do sexo masculino (M = 37,3 anos; DP = 10,98; variação = 23-67) preencheram voluntariamente um questionário sociodemográfico e os seguintes instrumentos: EMBU – Memórias de Infância, Experiências em Relações Próximas - Questionário de Estruturas Relacionais e Questionário de Esquemas de Young (QEY). Resultados: Verificou-se, quanto às associações entre vinculação e estilos educativos parentais que: menor suporte emocional paterno associou-se a maior evitamento pai, evitamento mãe e evitamento companheira; menor suporte emocional materno associou-se a maior evitamento mãe, evitamento pai, ansiedade mãe e ansiedade pai; maior rejeição paterna associou-se a maior evitamento mãe, evitamento pai, ansiedade mãe e ansiedade pai; maior rejeição materna associou-se a maior evitamento pai e evitamento mãe. No que toca às associações entre as dimensões de vinculação e EPM, é de enfatizar a associação positivas entre os EPM do domínio distanciamento e rejeição com o evitamento mãe, ansiedade mãe e ansiedade pai, particularmente, os EPM de abandono, desconfiança/abuso e isolamento social, por consistentemente se associaram às dimensões de vinculação. No domínio autonomia e desempenho deteriorados, o fracasso e a dependência/incompetência associaram-se positivamente ao evitamento mãe, a dependência/incompetência à ansiedade pai e o fracasso ao evitamento companheira. Quanto ao domínio limites deteriorados, a grandiosidade associou-se positivamente à ansiedade pai. No domínio vigilância e inibição o pessimismo/negativismo correlacionou-se positivamente com a ansiedade mãe e pai e a autopunição com a ansiedade mãe. Quanto às associações entre dimensões de estilos educativos parentais e os EPM, o domínio distanciamento e rejeição apresentou, de novo resultados relevantes: menores níveis de suporte emocional materno associaram-se a maiores níveis de privação emocional; maiores níveis de rejeição e sobreproteção materna e paterna a maiores os níveis de abandono; maiores níveis de rejeição materna e paterna a maiores níveis de desconfiança/abuso; maiores níveis de rejeição materna e sobreproteção materna e paterna a maiores níveis de isolamento social; maiores níveis de rejeição e sobreproteção paterna a maiores níveis de defeito. Enfatiza-se, também, a associação entre níveis maiores de rejeição paterna e os EPM de grandiosidade, padrões excessivos e pessimismo. Maiores níveis de rejeição materna associaram-se a maiores níveis de pessimismo e autopunição. Discussão: Embora numa amostra pequena, este estudo explorou, pela primeira vez, numa amostra de reclusos portugueses, em simultâneo, associações entre a vinculação, os estilos educativos parentais e os esquemas precoces mal adaptativos. O domínio esquemático distanciamento e rejeição parece ser o mais influenciado pela vinculação estabelecida em diferentes relacionamentos e pelos estilos educativos parentais. / Introduction: Mainly international studies focus on the importance of attachment and parental rearing styles in the development of delinquent and antisocial behaviors. In Portugal some studies focused in the inmate population analyze, separately, parental rearing styles, personality and early maladaptive schemas but, to our knowledge, none simultaneously explores attachment, parental rearing styles and early maladaptive schemas in this population. It is our objective to characterize a sample of inmates concerning attachment in different relationships, parental rearing styles and early maladaptive schemas (EMS) and, above all, explore associations between this three variables (and also with sociodemographic, family, clinic and sentence related variables). Methodology: 44 male inmates (M = 37,3 years; SD = 10,98; variation = 23-67) voluntarily filled in a sociodemographic questionnaire and the following instruments: EMBU – Childhood Memories, Experiments in Close Relationships – Structural Relationship Form and the Young Schema Questionnaires (YSQ) Results: we verified, regarding associations between attachment and parental rearing styles that: less paternal emotional support associated with higher father avoidance (in attachment), mother avoidance and partner avoidance; less maternal emotional support associated with higher mother avoidance, father avoidance, mother anxiety and father anxiety; higher paternal rejection associated with higher mother avoidance, father avoidance, mother anxiety and father anxiety; higher mother rejection associated with father avoidance and mother avoidance. Regarding associations between attachment dimensions and EMS, we emphasize positive associations between EMS in the disconnection and rejection domain with mother avoidance, mother anxiety and father anxiety, particularly, the abandonment, distrust/abuse and social isolation EMS, as they were consistently associated with the this attachment dimension. In the impaired autonomy and performance domain, the failure and dependency/incompetence EMS are positively associated with mother avoidance, the dependence/incompetence EMS to father anxiety and failure to partner avoidance. About the impaired limits domain, grandiosity EMS positively associated with father anxiety. In the overvigilance and inhibition domain, pessimist/negativism EMS positively correlated with mother and father anxiety and self-punishment EMS with mother anxiety. About the associations between parental rearing styles and the EMS, the disconnection and rejection domain presented again relevant results: lower levels of maternal emotional support associated with higher levels of emotional deprivation; higher levels of maternal and paternal rejection and overprotection associated with higher levels of abandonment; higher levels of maternal and paternal rejection associated with higher levels of distrust/abuse; higher levels of maternal rejection and maternal and paternal overprotection associated with higher levels of social isolation; higher levels of paternal rejection and overprotection associated with higher levels of defectiveness. We also emphasize the association between higher levels of paternal rejection and the grandiosity, excessive patterns and pessimism EMS. Higher levels of maternal rejection associated with higher levels of pessimism and self-punishment EMS. Discussion: Although in a small sample, this study explored, for the first time, in sample of Portuguese inmates, simultaneously, the associations between attachment, parental rearing styles and early maladaptive schemas. The schematic domain of disconnection and rejection seems to be the most influenced by the established attachment in different relationships and by parental rearing styles.

Resiliência, Coping e Autocompaixão em Cuidadores Formais da Rede Nacional de Cuidados Continuados Integrados

Introdução: Na literatura internacional e nacional verifica-se a inexistência de estudos sobre os correlatos psicológicos de cuidadores formais, como a resiliência e o coping. Apesar de se reconhecer a importância de uma prestação de cuidados mais compassivos e humanizados, mais uma vez, não existem estudos nesta área. Este facto estende-se aos cuidadores formais que trabalham com pessoas em situação de dependência, na Rede Nacional de Cuidados Continuados Integrados. Assim, foram nossos objetivos: caraterizar os cuidadores formais de algumas Unidades de Cuidados Continuados (UCC) da RNCCI em variáveis sociodemográficas e profissionais; analisar os seus níveis de resiliência, coping e autocompaixão; verificar se existem associações significativas entre estas variáveis e com as variáveis sociodemográficas e profissionais. Metodologia: 78 cuidadores formais (sexo feminino, n = 76; 97,4%), com uma média de idades de 35,45 anos (DP = 9,0) forneceram o seu consentimento informado para preencherem um questionário sociodemográfico e profissional, a Escala de Avaliação Global da Resiliência, o Brief COPE e a Self Compassion Scale (SELFCS). Resultados: Os cuidadores revelaram um nível médio de resiliência (total). A dimensão de coping com média mais elevada foi o Coping ativo e a com média mais baixa foi o Uso de substâncias. Na SELFCS a dimensão com média mais elevada foi o Calor/compreensão e a com média mais baixa foi o Isolamento. No geral, a pontuação total de resiliência correlacionou-se de forma positiva com as dimensões positivas da autocompaixão (SELFCS) e de forma negativa com as dimensões negativas desta escala. As dimensões mais positivas de coping correlacionaram-se de forma positiva com as dimensões positivas de autocompaixão e as mais negativas de coping com as dimensões negativas de autocompaixão. Quanto maior a idade dos cuidadores menor o nível de Suporte Emocional e maior o nível de Religião e Mindfulness. Mais horas de trabalho associaram-se a menor resiliência e a maior nível de Suporte Emocional Discussão: Este estudo revelou, ainda que numa amostra reduzida, que os cuidadores formais das UCC parecem revelar níveis equilibrados em correlatos psicológicos importantes quando se “cuida” de outra pessoa. Porém, as UCC devem preocupar-se em fomentar, junto dos cuidadores, níveis mais elevados de resiliência, estratégias mais positivas de coping e a compaixão auto e hétero dirigida, para assegurar um “cuidar” mais pleno quer para os profissionais, quer para aqueles que são cuidados. / Introduction: In the international and national literature, we verified the inexistence of studies about psychological correlates of formal caregivers, such as resilience and coping. Although the importance of more humanized and compassive care is recognized, again, there are no studies in this area. This is also verified regarding formal caregivers that work with people in a dependence situation, as in the National Network of Continuous Care. Our aims were to characterize the formal caregivers from some units of the National Network of Continuous Care in sociodemographic and professional variables; analyze these professionals levels of resilience, coping and self-compassion; verify if there are significant associations between these variables and with the sociodemographic and professional variables. Methodology: 78 formal caregivers (female, n = 76; 97,4%), with an mean age of 35,45 years (SD = 9,0) provided their informed consent to fill in a professional and sociodemographic questionnaire, the Global Resiliency Evaluation Scale, the Brief COPE and the Self Compassion Scale (SELFCS). Results: The caregivers showed a medium level of resilience. The coping dimension with the highest mean was Active coping and the dimension with the lowest mean was Substance Use. Regarding SELFCS the dimension with the highest mean was Warmth, contrasting with Isolation, the dimension with the lowest mean. Overall, the total score of resilience was positively correlated with self-compassion positive dimensions (SELFCS) and negatively correlated with the negative dimensions of this scale. The most positive dimensions of coping were positively correlated with the positive dimensions of self-compassion and the most negative dimensions of coping were correlated with the negative dimensions of self-compassion. Older caregivers showed lower use of Emotional support and higher level of Religion and Mindfulness use. More daily hours of work were associated with less resilience and higher Emotional Support. Discussion: This study revealed, although in a small sample, that Continuous Care Units (CCU) formal caregivers seem to have balanced levels of psychological correlates that are important while caring for others. However, the CCU should promote, in the caregivers higher levels of resilience, coping and self-compassion, to ensure a better care, simultaneously the professionals and patients.

Objetivos de Vida e Satisfação na Vida Conjugal em Pais/Progenitores de Crianças com Autismo

Introdução: A presença do diagnóstico de autismo numa criança é algo marcante no seio familiar. Implica inúmeros desafios para os seus pais/progenitores, podendo influenciar os objetivos delineados para as suas vidas e a satisfação na relação conjugal. Os nossos objetivos foram: caraterizar progenitores de crianças com autismo quanto aos objetivos de vida e satisfação na vida conjugal e explorar as associações existentes entre estas duas variáveis (e com variáveis sociodemográficas e relativas ao apoio recebido). Não deixamos de explorar os níveis de depressão, ansiedade, e stress, vivenciados por estes pais. Metodologia: 66 progenitores (sexo feminino, n = 52, 78,8%; idade média, M = 40,2, DP = 6,45) de crianças com autismo preencheram um questionário sociodemográfico, o Teste dos objetivos de vida/PIL-R, a Escala de Avaliação da Satisfação em Áreas da Vida Conjugal/EASAVIC e a Depression, Anxiety and Stress Scale-21/DASS-21. Resultados: Os progenitores revelaram valores médios de objetivos de vida (PIL-R). Foi na dimensão vivencial (PIL-R) e nas dimensões Comunicação e Intimidade Emocional (satisfação em áreas da vida conjugal/EASAVIC) que os progenitores apresentaram valores médios mais elevados. No caso da DASS-21, foi na escala Stress que os progenitores apresentaram valores mais elevados. Porém, em todas as dimensões da DASS-21, os níveis encontrados foram normais. Não se verificaram diferenças estatisticamente significativas por sexo em todas as dimensões do PIL-R, da EASAVIC e DASS-21. Ambas as dimensões do PIL-R, dimensional e existencial, bem como a sua pontuação total mostraram estar associadas com todas as dimensões da EASAVIC (satisfação em áreas da vida conjugal). As três dimensões da DASS-21 (Depressão, Ansiedade e Stress) revelaram estar associada (negativamente) com praticamente todas as dimensões da EASAVIC e do PIL-R. Os progenitores que pertenciam a associações de apoio apenas se diferenciaram dos progenitores que pertenciam a um grupo (de apoio e partilha) numa rede social na dimensão Ansiedade, com estes últimos a apresentarem um nível mais elevado. Discussão: Neste estudo (ainda que numa amostra de tamanho reduzido), inovador pelo tema explorado, os níveis dos objetivos de vida e de satisfação em áreas da vida conjugal (bem como de sintomas de psicopatologia) pareceram “não sofrer” o impacto associado ao facto dos progenitores terem um filho com autismo. Os objetivos de vida mantidos por estes pais influenciam a sua satisfação com a vida conjugal e vice-versa, indicando a importância das equipas que trabalham com estes pais não esquecerem a promoção destas variáveis. / Introduction: The presence of the diagnosis of autism in a child is something remarkable in the family. Involves many challenges for parents/progenitors, which can influence the goals they define in their lives and their satisfaction with the marital relationship. Our objectives were to characterize parents of children with autism on the objectives of life and satisfaction with marital life and explore the associations between these two variables (and with sociodemographic and support variables). We will not forget to explore the levels of depression, anxiety, and stress, experienced by these parents. Methodology: 66 parents (females, n = 52, 78.8%, mean age, M = 40.2, SD = 6.45) of children with autism completed a sociodemographic questionnaire, the Test of Life Goals/PIL-R, the Areas of Marital Satisfaction Rating Scale/EASAVIC and the Depression, Anxiety and Stress Scale-21/DASS-21. Results: Parents showed a mean value of life goals (PIL-R). Was in the experiential dimension (PIL-R) and the Communication and Emotional Intimacy dimensions (satisfaction in areas of marital life/EASAVIC) that the parents presented higher mean values. Regarding DASS-21, Stress was the scale in which the parents had higher values. However, in all the DASS-21, levels were “normal”. There were no statistically significant differences by gender in all the PIL-R, EASAVIC and DASS-21 scales. Both dimensions of the PIL-R, dimensional and existential, as well as the total score were found to be associated with all the dimensions of EASAVIC (satisfaction in areas of marital life). The three dimensions of the DASS-21 (Depression, Anxiety and Stress) revealed to be associated (negatively) with virtually all dimensions of the EASAVIC and the PIL-R. Parents who belonged to associations only differed from the parents from a social network group (of support and sharing) in the anxiety dimension, with the later presenting an higher level. Discussion: In this study (even if in a small sample size), innovative by the theme explored, levels of life goals and satisfaction in areas of marital life (as well as symptoms of psychopathology) seemed not to suffer from the impact of the parents having a child with autism. The life goals held by these parents influence their satisfaction with marital life and vice versa, indicating the importance of teams working with these parents of not forgetting the promotion of these variables.

Methods for Confounding Adjustment and High-Dimensional Environmental Exposures

Thesis (Ph.D.)--University of Washington, 2016-08

Evaluation of Community-led Complementary Feeding and Learning Sessions

Thesis (Master's)--University of Washington, 2016-08

Development and application of sensitive genome-wide platforms to study the genetic and epigenetic (DNA methylation) makeup of gametes and early bovine embryos

Pour ce projet, nous avons développé une plateforme pour l’analyse pangénomique de la méthylation de l’ADN chez le bovin qui est compatible avec des échantillons de petites tailles. Cet outil est utilisé pour étudier les caractéristiques génétiques et épigénétiques (méthylation de l’ADN) des gamètes soumis aux procédures de procréation médicalement assisitée et des embryons précoces. Dans un premier temps, une plateforme d’analyse de biopuces spécifiques pour l’étude de la méthylation de l’ADN chez l’espèce bovine a été développée. Cette plateforme a ensuite été optimisée pour produire des analyses pangénomiques de méthylation de l’ADN fiables et reproductibles à partir d’échantillons de très petites tailles telle que les embryons précoces (≥ 10 ng d’ADN a été utilisé, ce qui correspond à 10 blastocystes en expansion). En outre, cet outil a permis d’évaluer de façon simultanée la méthylation de l’ADN et le transcriptome dans le même échantillon, fournissant ainsi une image complète des profils génétiques et épigénétiques (méthylation de l’ADN). Comme preuve de concept, les profils comparatifs de méthylation de l’ADN spermatique et de blastocystes bovins ont été analysés au niveau de l’ensemble du génome. Dans un deuxième temps, grâce à cette plateforme, les profils globaux de méthylation de l’ADN de taureaux jumeaux monozygotes (MZ) ont été analysés. Malgré qu’ils sont génétiquement identiques, les taureaux jumeaux MZ ont des descendants avec des performances différentes. Par conséquent, l’hypothèse que le profil de méthylation de l’ADN spermatique de taureaux jumeaux MZ est différent a été émise. Dans notre étude, des différences significatives entre les jumeaux MZ au niveau des caractéristiques de la semence ainsi que de la méthylation de l’ADN ont été trouvées, chacune pouvant contribuer à l’obtention de performances divergentes incongrues des filles engendrées par ces jumeaux MZ. Dans la troisième partie de ce projet, la même plateforme a été utilisée pour découvrir les impacts d’une supplémentation à forte concentration en donneur de méthyle universel sur les embryons précoces bovins. La supplémentation avec de grandes quantités d’acide folique (AF) a été largement utilisée et recommandée chez les femmes enceintes pour sa capacité bien établie à prévenir les malformations du tube neural chez les enfants. Cependant, plus récemment, plusieurs études ont rapporté des effets indésirables de l’AF utilisé à des concentrations élevées, non seulement sur le développement de l’embryon, mais aussi chez les adultes. Au niveau cellulaire, l’AF entre dans le métabolisme monocarboné, la seule voie de production de S-adénosyl méthionine (SAM), un donneur universel de groupements méthyles pour une grande variété de biomolécules, y compris l’ADN. Par conséquent, pour résoudre cette controverse, une forte dose de SAM a été utilisée pour traiter des embryons produits in vitro chez le bovin. Ceci a non seulement permis d’influencer le phénotype des embryons précoces, mais aussi d’avoir un impact sur le transcriptome et le méthylome de l’ADN. En somme, le projet en cours a permis le développement d’une plateforme d’analyse de la méthylation de l’ADN à l’échelle du génome entier chez le bovin à coût raisonnable et facile à utiliser qui est compatible avec les embryons précoces. De plus, puisque c’est l’une des premières études de ce genre en biologie de la reproduction bovine, ce projet avait trois objectifs qui a donné plusieurs nouveaux résultats, incluant les profils comparatifs de méthylation de l’ADN au niveau : i) blastocystes versus spermatozoïdes ; ii) semence de taureaux jumeaux MZ et iii) embryons précoces traités à de fortes doses de SAM versus des embryons précoces non traités.

Supervision For School Staff: What is Valuable about Solution Circles?

Group supervision is used for support, education and/or monitoring. Despite the potential value of these elements for school staff, it is rarely practised. This mixed methods research, from a critical realist perspective, explored the use of Solution Circles to structure staff supervision groups in three schools. Five circles were run in each school, involving thirty-one participants, eighteen of whom contributed data. Thirteen staff trained as facilitators. The self-efficacy, resilience and anxiety levels of the staff taking part were not found to be significantly different as a result of the intervention. However, a small effect size was noted for self-efficacy, perhaps worthy of further investigation in the context of the small sample size. Thematic analysis of participant feedback (gathered during the last circle, which ran as a Focus Group) indicated the following mechanisms as affecting the value of Solution Circles for staff supervision groups: the structure of the sessions; aspects linked to the groups meeting a ‘need to talk’; elements which helped participants to ‘feel like a team’; and, school context factors. Semi-structured interview data from six facilitators indicated that the structure of the circles, individual characteristics of facilitators, the provision of support for facilitators, and elements of the wider school context, were all mechanisms which affected the facilitation of the programme. Further research might implement elements of these mechanisms and measure their impact.

O falar paranaense

This book didactically addresses relevant issues for researchers in the linguistic field as well as professors, journalists and whoever else is interested in understating the so called “paranaense dialect”. It is relevant to clarify, however, that there is not one single dialect from Parana as the state has three distinctive dialectal areas. That means the traditional speech from the state corresponds to its historical settlement. The first area dates back to the XVIII century in the center-south-coast direction; the second area dates from the 1920´s and 1930´s matching the arrival of immigrants from Rio Grande do Sul and Santa Catarina in the search for new territories, clearing forestry regions from the Southwest and Western regions in Parana, turning them into harvesting areas. The third linguistic area corresponds to the North and Northwest of Parana, which were colonized in the 1940´s and 1950´s by immigrants from Minas Gerais and São Paulo who came to grow coffee plants in its rich red land. Such dialectal diversity constitutes only a small fraction of what is understood as the Brazilian Portuguese. So, having it described means to collaborate to map the great linguistic mosaic that characterizes the whole Brazilian territory. We then seek to offer readers a small sample of the analyses carried out by researchers concerning the different performances of the Portuguese spoken in Parana (Banco VARSUL, ALERS, Atlas Linguístico do Paraná, Banco VARLINFE). We expect these findings encourage new approaches and Linguistic studies from other regions of the state.