Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean).

BACKGROUND: We estimated the heritability of three measures of glomerular filtration rate (GFR) in hypertensive families of African descent in the Seychelles (Indian Ocean). METHODS: Families with at least two hypertensive siblings and an average of two normotensive siblings were identified through a national hypertension register. Using the ASSOC program in SAGE (Statistical Analysis in Genetic Epidemiology), the age- and gender-adjusted narrow sense heritability of GFR was estimated by maximum likelihood assuming multivariate normality after power transformation. ASSOC can calculate the additive polygenic component of the variance of a trait from pedigree data in the presence of other familial correlations. The effects of body mass index (BMI), blood pressure, natriuresis, along with sodium to potassium ratio in urine and diabetes, were also tested as covariates. RESULTS: Inulin clearance, 24-hour creatinine clearance, and GFR based on the Cockcroft-Gault formula were available for 348 persons from 66 pedigrees. The age- and gender-adjusted correlations (+/- SE) were 0.51 (+/- 0.04) between inulin clearance and creatinine clearance, 0.53 (+/- 0.04) between inulin clearance and Cockcroft-Gault formula and 0.66 (+/- 0.03) between creatinine clearance and Cockcroft-Gault formula. The age- and gender-adjusted heritabilities (+/- SE) of GFR were 0.41 (+/- 0.10) for inulin clearance, 0.52 (+/- 0.13) for creatinine clearance, and 0.82 (+/- 0.09) for Cockcroft-Gault formula. Adjustment for BMI slightly lowered the correlations and heritabilities for all measurements whereas adjustment for blood pressure had virtually no effect. CONCLUSION: The significant heritability estimates of GFR in our sample of families of African descent confirm the familial aggregation of this trait and justify further analyses aimed at discovering genetic determinants of GFR.

Patient Education/Self Management Programmes for People with Long Term Conditions

Regional Summary Report 2012/13

Service Framework for Older People (PDF 1MB)

Easy Access Version

Service Framework for Older People

Easy Access Version

Addressing Young People's Drinking in Northern Ireland: Action to Support the New Strategic Direction for Alcohol and Drugs

This action plan focuses on three main areas: • reducing young people’s demand for alcohol by providing information, education and training to young people and their parents; •restricting the supply of alcohol via measures to reduce accessibility to alcohol (including how alcohol is priced, marketed, and promoted); and • providing treatment and support for those who require additional help. While the emphasis of this action plan is on young people, it recognises that their drinking patterns are very much influenced by modelling the drinking patterns of adults in our society, and it therefore contains actions that will impact on the entire population. Alcohol misuse - however you measure the cost, whether to the individual, the family, the community, the health service, or society as a whole - is one of the biggest public health issues facing Northern Ireland.

Appendices for Complex Needs - The Nursing Response to Children and Young People with Complex Physical Healthcare Needs (PDF 708 KB)

Appendices to Complex Needs Report

Complex Needs - The Nursing Response to Children and Young People with Complex Physical Healthcare Needs (PDF 832 KB)

Departmental review of nursing services in order to ensure that they are facilitated to fully support and respond to children with complex needs and their families, and for them to work in partnership with other professions and agencies.

VFM Aduit of Statutory Residential Homes for Older People - Executive Summary - March 2007 (PDF 430 KB)

VFM Audit of Statutory Residential Homes for Older People - Executive Summary (March 2007)

VFM Audit of Statutory Residential Homes for Older People - March 2007 (PDF 1314 KB)

VFM Audit of Statutory Residential Homes for Older People - Final Report (March 2007)

La nación de "los otros". Afrodescendientes porteños y la construcción de la nación argentina a fines del siglo XIX

Investigación producida a partir de una estancia en Buenos Aires en septiembre del 2007. Los procesos de consolidación de las naciones-estado llevan consigo una serie de políticas y prácticas que se focalizan en la construcción del "pueblo". Particularmente, la construcción del estado nacional argentino en el siglo XIX implicó la definición -por parte de los grupos de poder- de un pueblo que cumpliera con las expectativas que se esperaban de una joven nación que se encaminaba hacia la civilización y el progreso, es decir, lo que en esa época se correspondía con un imaginario de pueblo blanco y europeo. Así, se propiciaron políticas de erosión de quienes habitaban en el territorio nacional pero que no cumplían con aquellos mandatos, promoviendo su “invisibilización”. Nosotros trabajamos una de estas comunidades erosionadas de la memoria y de la historia nacional argentina, la comunidad de afrodescendientes de Buenos Aires. El objeto de la investigación que se está llevando a cabo es justamente el análisis de la población afroargentina de Buenos Aires en las últimas décadas del siglo XIX, un momento en que su presencia e historia estaban siendo negadas de los discursos y de las prácticas. Esta investigación de corte histórico-antropológico necesita para su consecución de un trabajo exhaustivo de archivos, objetivo principal de la beca de investigación fuera de Cataluña. Lo que se intentó en el viaje fue encontrar y rescatar fuentes que permitieran entrever las dinámicas de esta comunidad, sus formas de resistir y/o de negociar un estado nacional cada vez más fuerte y que sentaba las bases de lo que debía ser el “pueblo argentino”.