Scherz und Ernst : für meine Kinder

[Carl Eduard Buek]

Recension av Andkjær, Søren, Bentsen, Peter & Ejbye-Ernst, Niels (2009) ”Friluftsliv: Natur, samfund og pædagogik” : Ambitiöst om friluftsliv i Danmark – kanske alltför ambitiöst...

Friluftsliv uppvisar ett uppsving som för många säkert är oväntat men som nog till stor del är i samklang med den skandinaviska tidsandan. Visserligen är det ett i huvudsak urbant fenomen, de senaste årens fokus på fysisk aktivitet, konditionsträning och fitness, aktiviteter som dessutom ofta äger rum inomhus i speciella kommersiellt drivna träningshallar – där är luften inte fri! – men trenden tar sig också uttryck i löpning eller joggning i urbana parkområden eller i lagom tuktad natur i anslutning till städer. Man kan tänka att steget inte skulle vara långt till verkliga naturupplevelser, och, som sagt, det finns ett uppsving. Det nymornade intresset för autentiska naturupplevelser kan säkert också bottna i en civilisationskritisk trend i det tidiga tredje millenniet, vars beståndsdelar spretar på ett sätt som gör det omöjligt att närmare skärskåda företeelsen i detta sammanhang. Istället konstaterar vi att forskningen varit kvick att fånga upp friluftsintresset, vilket inte minst märks i recensionsfloran på den här webbplatsen, som denna gång utvidgas med en recension av Friluftsliv: Natur, samfund og pædagogik av Peter Bentsen, Søren Andkjær och Niels Ejbye-Ernst (Munksgaard Danmark). Erik Backman, som disputerat i ämnet, har läst och recenserar, och han bjuder redaktörerna på många tips till förbättringar inför nästa upplaga av boken.

Karl-Ernst Jeismann/Peter Lundgreen(Hrsg.): Handbuch der deutschen Bildungsgeschichte. Band III. 1800-1870: Von der Neuordnung Deutschlands bis zur Gründung des Deutschen Reiches. München: Beck 1987 […] [Sammelrezension]

Sammelrezension von: 1. Karl-Ernst Jeismann/Peter Lundgreen(Hrsg.): Handbuch der deutschen Bildungsgeschichte. Band III. 1800-1870: Von der Neuordnung Deutschlands bis zur Gründung des Deutschen Reiches. München: Beck 1987, 443 S. 2. Dieter Langewiesche/Hehiz-Elmar Tenorth (Hrsg.): Handbuch der deutschen Bildungsgeschichte. Band V. 1918-1945: Die Weimarer Republik und die nationalsozialistische Diktatur. München: Beck 1989. 470 S.

Karl-Ernst Ackermann / Oliver Musenberg / Judith Riegert (Hrsg.): Geistigbehindertenpädagogik!? Disziplin – Profession – Inklusion. Oberhausen: Athena 2013 (443 S.) [Rezension]

Rezension von: Karl-Ernst Ackermann / Oliver Musenberg / Judith Riegert (Hrsg.): Geistigbehindertenpädagogik!? Disziplin – Profession – Inklusion. Oberhausen: Athena 2013 (443 S.; ISBN 978-3-89896-477-7)

“The most artistic lesson I ever heard” - a contribution to the reflection on the comment made by William James regarding a lesson by Ernst Mach

On November the 2nd 1882, William James visited Ernst Mach in Prague, and attended one of his lectures. The conversation with Mach and the lecture were marking events for James. Based, namely, on James’s lectures for teachers and on Mach’s lectures for the general public, we propose a reflection on the defining traits that made that event "the most artistic lesson [James] ever heard". We shall remark on the imaginative joy contained in these texts, which appear to embody some of James' key ideas on Education. The experience of knowledge about the world contained in the texts, reveals that "to experiment" means "not coldly to observe a thing happening outside us, but to undergo, to feel within oneself, to live oneself this or that manner of being".

LOS MATERIALES DE LA TIERRA: ERNST W.G.

Nota bibliográfica de libro

Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides

Tissue damage resulting from the extracellular production of HOCl (hypochlorous acid) by the MPO (myeloperoxidase)-hydrogen peroxide-chloride system of activated phagocytes is implicated as a key event in the progression of a number of human inflammatory diseases. Consequently, there is considerable interest in the development of therapeutically useful MPO inhibitors. Nitroxides are well established antioxidant compounds of low toxicity that can attenuate oxidative damage in animal models of inflammatory disease. They are believed to exert protective effects principally by acting as superoxide dismutase mimetics or radical scavengers. However, we show here that nitroxides can also potently inhibit MPO-mediated HOCl production, with the nitroxide 4-aminoTEMPO inhibiting HOCl production by MPO and by neutrophils with IC50 values of approx. 1 and 6 μM respectively. Structure–activity relationships were determined for a range of aliphatic and aromatic nitroxides, and inhibition of oxidative damage to two biologically-important protein targets (albumin and perlecan) are demonstrated. Inhibition was shown to involve one-electron oxidation of the nitroxides by the compound I form of MPO and accumulation of compound II. Haem destruction was also observed with some nitroxides. Inhibition of neutrophil HOCl production by nitroxides was antagonized by neutrophil-derived superoxide, with this attributed to superoxide-mediated reduction of compound II. This effect was marginal with 4-aminoTEMPO, probably due to the efficient superoxide dismutase-mimetic activity of this nitroxide. Overall, these data indicate that nitroxides have considerable promise as therapeutic agents for the inhibition of MPO-mediated damage in inflammatory diseases.

A method for evaluating lean assembly process at design stage

Lean product design has the potential to reduce the overall product development time and cost and can improve the quality of a product. However, it has been found that no or little work has been carried out to provide an integrated framework of "lean design" and to quantitatively evaluate the effectiveness of lean practices/principles in product development process. This research proposed an integrated framework for lean design process and developed a dynamic decision making tool based on Methods Time Measurement (MTM) approach for assessing the impact of lean design on the assembly process. The proposed integrated lean framework demonstrates the lean processes to be followed in the product design and assembly process in order to achieve overall leanness. The decision tool consists of a central database, the lean design guidelines, and MTM analysis. Microsoft Access and C# are utilized to develop the user interface to use the MTM analysis as decision making tool. MTM based dynamic tool is capable of estimating the assembly time, costs of parts and labour of various alternatives of a design and hence is able to achieve optimum design. A case study is conducted to test and validate the functionality of the MTM Analysis as well as to verify the lean guidelines proposed for product development.

Bear With Me

This project investigates musicalisation and intermediality in the writing and devising of composed theatre. Its research question asks “How does the narrative of a musical play differ when it emerges from a setlist of original songs?”, the aim being to create performance event that is neither music nor theatre. This involves composition of lyrics, music, action and spoken text, projected image: gathered in a script and presented in performance. Scholars such as Kulezic-Wilson(in Kendrick, L and Roesner, D 2011:34) outline the acoustic dimension to the ‘performative turn’ (Mungen, Ernst and Bentzweizer, 2012) as heralding “…a shift of emphasis on how meaning is created (and veiled) and how the spectrum of theatrical creation and reception is widened.” Rebstock and Roesner (2012) capture approaches similar to this, building on Lehmann’s work in the post-dramatic under the new term ‘composed theatre’. This practice led research draws influence from these new theoretical frames, pushing beyond ‘the musical’. Springing from a set of original songs in dialogue with performed narrative, Bear with Me is a 45 minute music driven work for children, involving projected image and participatory action. Bear with Me’s intermedial hybrid of theatrical, screen and concert presentations shows that a simple setlist of original songs can be the starting point for the structure of a complex intermedial performance. Bear with Me was programmed into the Queensland Performing Arts Centre’s Out of the Box Festival. It was first performed in the Tony Gould Gallery at the Queensland in June 2012. The season sold out. A masterclass on my playwriting methodology was presented at the Connecting The Dots Symposium which ran alongside the festival.

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10(-6)) with migraine. These SNPs were significant in a meta-analysis among three replication cohorts and met genome-wide significance in a meta-analysis combining the discovery and replication cohorts (rs2651899, odds ratio (OR) = 1.11, P = 3.8 × 10(-9); rs10166942, OR = 0.85, P = 5.5 × 10(-12); and rs11172113, OR = 0.90, P = 4.3 × 10(-9)). The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache. None of the three SNP associations was preferential for migraine with aura or without aura, nor were any associations specific for migraine features. TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology.