Coreferentiality: A New Method for the Hypothesis-Based Analysis of Phenotypes Characterized by Multivariate Data

Many multifactorial biologic effects, particularly in the context of complex human diseases, are still poorly understood. At the same time, the systematic acquisition of multivariate data has become increasingly easy. The use of such data to analyze and model complex phenotypes, however, remains a challenge. Here, a new analytic approach is described, termed coreferentiality, together with an appropriate statistical test. Coreferentiality is the indirect relation of two variables of functional interest in respect to whether they parallel each other in their respective relatedness to multivariate reference data, which can be informative for a complex effect or phenotype. It is shown that the power of coreferentiality testing is comparable to multiple regression analysis, sufficient even when reference data are informative only to a relatively small extent of 2.5%, and clearly exceeding the power of simple bivariate correlation testing. Thus, coreferentiality testing uses the increased power of multivariate analysis, however, in order to address a more straightforward interpretable bivariate relatedness. Systematic application of this approach could substantially improve the analysis and modeling of complex phenotypes, particularly in the context of human study where addressing functional hypotheses by direct experimentation is often difficult.

Changes in oral microflora in prosthetic patients on hygiene protocol

Poster presented at the 1st International Congress of CiiEM - From Basic Sciences to Clinical Research, 27-28 November 2015, Egas Moniz, Caparica, Portugal.

Failure or Voluntary Exit? Reassessing the Female Underperformance Hypothesis

We reevaluate the female underperformance hypothesis by challenging the assumption that female-owned ventures are more likely to fail. Instead of equating exit with failure, we draw on exit literature and feminist theories to argue that female entrepreneurs are actually more likely than males to exit voluntarily. We argue for further gender differences by using an even more fine-grained conceptualization of entrepreneurial exit (failure, exit for personal reasons, and exit for other professional/financial opportunities). Post-hoc analyses also point to withingender heterogeneity depending on family status. A sample probe of 219 Spanish entrepreneurs who had exited their business supports our overall reasoning.

Catálogo del material escolar enviado á la exposición anexa al IIIer Congreso Internacional de Higiene Escolar, Paris, 2-7 de agosto de 1910 con una noticia sobre la instrucción pública primaria. Catalogue de matériel scolaire présenté á l'exposition annexe au IIIe Congres International d'Hygiene Scolaire, Paris, 2-7 aoút 1910, avec une notice sur l'instruction publique primaire.

Mode of access: Internet.

Industrial hygiene.

Mode of access: Internet.

The hygiene of the schoolroom,

Mode of access: Internet.

School hygiene : a handbook for teachers of all grades, school managers, etc. /

Mode of access: Internet.

Pädagogik und Hygiene : Schul- und Volksgesundheitspflege in der praktischen Berufstätigkeit des Lehrers /

"Nach einem Vortrag, gehalten auf der am 24. Mai 1904 zu Straßburg i. Els. stattgefundenen XI. Hauptversammlung des Katholischen Lehrer-Verbandes des Deutschen Reiches."

Tri-level study: modification. Task 6: a final report on supplemental causation assessments through hypothesis testing.

National Highway Traffic Safety Administration, Washington, D.C.

Irritation and counterirritation, a hypothesis about the autoamputative property of the nervous system; a scientific excursion into theoretical medicine.

Mode of access: Internet.

Community hygiene,

"First printing."