Educação e Desenvolvimento Humano Programa de doutoramento em parceria com a Universidade de Santiago de Compostela (Espanha)

A maioria dos estudos sobre desenvolvimento apontam a educação e a formação como principais factores decisivos para o progresso humano e económico de uma sociedade. O Programa de Educação de Desenvolvimento Humano, perspectivas teóricas, históricas e sociais pretende formar investigadores altamente qualificados, destinados principalmente ao ensino superior sem excluir outras instituições relacionadas com a problemática da educação e formação. O objectivo principal do curso consiste em estudar os processos de desenvolvimento humano na perspectiva histórica, teórica e social. Outro objectivo é de analisar os processos de desenvolvimento tanto depende da perspectiva integrada de dimensão (sistema educativo, curriculum, etc) como das situações relacionadas com processos educativos não formais e informais (cidade educativa, educação ambiental. Pretende-se também examinar as situações de desenvolvimento institucional das escolas, a qualidade de educação e a profissionalização de professores.

Pierre-Joseph Proudhon. Papiers. VI Cahiers de notes et extraits.

Fauré-Fremiet, Mme. Manuscrit(s) provenant d'elle

Validation d'une version française de l'inventaire rationnel-experientiel (REI) et application au tabagisme

The Rational-Experiential Inventory REI (Pacini and Epstein, 1999) is a self-administered test comprising two scales measuring the attitude of respondents towards two thinking styles respectively referred to as the rational and the experiential thinking styles. Two validation studies were conducted using a new French-language version of the REI. The first study confirms the validity of the French translation. The second study, which is concerned with the REI's construct validity, assesses the questionnaire's capacity to discriminate between a group of smokers and a group of non-smokers. Both studies give generally satisfactory results. In particular, the advantages of using the two-dimensional REI rather than the better known Need For Cognition scale (Cacioppo & Petty, 1982) are made quite clear.

Ancient kings of Peru : the reliability of the Chronicle of Fernando de Montesinos

Doctoral dissertation, University of Turku

Henri VI ou La guerre des deux roses : drame en six tableaux et en vers / par Martial Audoin,...

Collection : Théâtre anglais. William Shakespeare

Early onset collagen VI myopathies: Genetic and clinical correlations.

OBJECTIVE: Mutations in the genes encoding the extracellular matrix protein collagen VI (ColVI) cause a spectrum of disorders with variable inheritance including Ullrich congenital muscular dystrophy, Bethlem myopathy, and intermediate phenotypes. We extensively characterized, at the clinical, cellular, and molecular levels, 49 patients with onset in the first 2 years of life to investigate genotype-phenotype correlations. METHODS: Patients were classified into 3 groups: early-severe (18%), moderate-progressive (53%), and mild (29%). ColVI secretion was analyzed in patient-derived skin fibroblasts. Chain-specific transcript levels were quantified by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), and mutation identification was performed by sequencing of complementary DNA. RESULTS: ColVI secretion was altered in all fibroblast cultures studied. We identified 56 mutations, mostly novel and private. Dominant de novo mutations were detected in 61% of the cases. Importantly, mutations causing premature termination codons (PTCs) or in-frame insertions strikingly destabilized the corresponding transcripts. Homozygous PTC-causing mutations in the triple helix domains led to the most severe phenotypes (ambulation never achieved), whereas dominant de novo in-frame exon skipping and glycine missense mutations were identified in patients of the moderate-progressive group (loss of ambulation). INTERPRETATION: This work emphasizes that the diagnosis of early onset ColVI myopathies is arduous and time-consuming, and demonstrates that quantitative RT-PCR is a helpful tool for the identification of some mutation-bearing genes. Moreover, the clinical classification proposed allowed genotype-phenotype relationships to be explored, and may be useful in the design of future clinical trials.