Dictionnaire historique et critique. T. IV, Bosc-Caussin / de Pierre Bayle... ; éd. augm. de notes extraites de Chaufepié, Joly, La Monnoie, Leduchat, L.-J. Leclerc, Prosper Marchand, etc...

Collection : Archives de la linguistique française ; 30

Thrombocytosis as a prognostic marker in stage III and IV serous ovarian cancer.

OBJECTIVE: Thrombocytosis is an adverse prognostic factor in many types of cancer. We investigated if pre-treatment increased platelet counts provide prognostic information specifically in patients with stage III and IV serous ovarian cancer which is the most common clinical presentation of ovarian cancer. METHODS: Platelet number on diagnosis of stage III and IV serous ovarian adenocarcinoma was evaluated in 91 patients for whom there were complete follow-up data on progression and survival. Survival and progression free survival of patients with normal platelet counts (150-350 ×10(9)/L) was compared with that of patients with thrombocytosis (>350×10(9)/L) by χ(2) and logrank tests. RESULTS: The median age of the patients was 66 years-old. From the 91 patients, 52 (57.1%) had normal platelet counts (median, 273×10(9)/L; range, 153-350) at diagnosis of their disease and 39 patients (42.9%) had thrombocytosis (median, 463×10(9)/L; range, 354-631). In the group of patients with normal platelet counts, 24 of the 52 patients had died with a median survival of 43 months (range, 3-100). In the group of patients with thrombocytosis, 24 of the 39 patients had died with a median survival of 23 months (range, 4-79). In the entire group of 91 patients there was a statistically significant difference of the overall survival and progression-free survival between the two groups (logrank test P=0.02 and P=0.007, respectively). CONCLUSION: In this retrospective analysis of stage III and IV ovarian cancer patients, thrombocytosis at the time of diagnosis had prognostic value regarding overall survival and progression-free survival.

Catalogue des manuscrits chinois de Touen-Houang. Volume IV, Nos 3501-4000 : fonds Pelliot chinois de la Bibliothèque nationale / [réd. sous la dir. de Michel Soymié ; publ. de l'Équipe de recherche sur les manuscrits de Dunhouang, École pratique des hautes études]

Collection : Publications hors série de l'École française d'Extrême-Orient

Notes fitocenologiques IV

En connexion avec un travail monographique sur la vallée de Ribes (Pyrénées orientales), l'auteur décrit huit associations nouvelles: Veronico (urticifoliae)-Betuletum, forêt acidophile et hygrophile propre aux versants très ombragés; Allio-Calamagrostietum arundinaceae, mégaphorbiée de l'alliance Calamagrostion; Bellardiochloo-Festucetum nigrescentis, pelouse' très acidophile peuplant les pentes rocheuses et chaudes de l'étage subalpin; Rhinantho (mediterranei)-Trisetetum flavescentis et Astrantio-Avenuletum pubescentis, prairies de fauche, la première ( al. Arrhenatherion') très étendue dans tout l'étage montagnard, la deuxième (al. Polygono-Trisetion) assez localisée dans le montagnard supérieur ; Gentianô' (luteae)-Trisetetum, type de prairie faisant le passage entre l'Arrhenatherion et le Mesobromion; et Swertio-Caricetum nigrae, bas marais d'haute montagne, silicicole mais pas nettement acidophile. Au sein de l'association Prunello-Sarothamnetum, l'auteur propose deux nouvelles sous-associations: buxetosum, la plus commune dans l'étage montagnard, et genistetosum purgantis, en contact avec le Genistion purgantis.

Proximity of excitatory synapses and astroglial gap junctions in layer IV of the mouse barrel cortex.

Neurons and astrocytes, the two major cell populations in the adult brain, are characterized by their own mode of intercellular communication--the synapses and the gap junctions (GJ), respectively. In addition, there is increasing evidence for dynamic and metabolic neuroglial interactions resulting in the modulation of synaptic transmission at the so-called "tripartite synapse". Based on this, we have investigated at the ultrastructural level how excitatory synapses (ES) and astroglial GJ are spatially distributed in layer IV of the barrel cortex of the adult mouse. We used specific antibodies for connexin (Cx) 30 and 43 to identify astroglial GJ, these two proteins are known to be present in the majority of astroglial GJ in the cerebral cortex. In electron-microscopic images, we measured the distance between two ES, between two GJ and between a GJ and its nearest ES. We found a ratio of two GJ per three ES in the hollow and septal areas. Taking into account the size of an astrocyte domain, the high density of GJ suggests the occurrence of reflexive type, i.e. GJ between processes of the same astrocyte. Interestingly, the distance between an ES and an astroglial GJ was found to be significantly lower than that between either two synapses or between two GJ. These observations indicate that the two modes of cell-to-cell communication are not randomly distributed in layer IV of the barrel cortex. Consequently, this feature may provide the morphological support for the recently reported functional interactions between neuronal circuits and astroglial networks.

National survey of noncommunicable diseases in Seychelles 2013‐2014 (Seychelles Heart Study IV) : main findings

The 2013 survey addressed the following objectives: Primary objectives : a) Distribution of health behaviors related to NCDs, particularly tobacco use, alcohol drinking, and physical activity ; b) Distribution of the main modifiable risk factors of NCDs, particularly blood pressure, adiposity markers, diabetes and blood lipids ; c) Rates of awareness, treatment and control of hypertension, diabetes and dyslipidemia ; d) Comparison of findings in the survey 2013 with results in previous similar NCD surveys in 1989, 1994, 2004 ; e) Dietary patterns ; f) Knowledge, attitudes and practices related to NCDs and NCD risk factors. Secondary objectives : g) Assessment of indicators of quality of health (e.g. SF‐12) ; h) Assessment of psychological stress and relation with NCD ; i) Assessment of several indicators of frailty (e.g. handgrip strength test, chair strand test, functional limitations) ; j) Assessment of knowledge and level of agreement with current policies on tobacco control ; k) Use of public and private health care services, particularly for NCDs ; l) Exposure to advice on health behaviors given by health professionals at health care level ; m) Burden of chronic diseases not related to the main NCDs (e.g. musculoskeletal, mental health, etc) ; n) Screening of selected cancers ; o) Assessment of the kidney function ; p) Frequency of heart arrhythmias (one‐lead ECG) and heart murmurs (auscultation) ; q) Assessment of bone mineral density (ultrasound of calcaneus) ; r) Exposure of the population to mass media, particularly in relation to health programs, and use by the population of new communication technologies ; s) Assessment of a number of social variables and their association with the variables measured in the survey ; t) More generally, the survey provides broad information (medical, social, environment, etc) that can be useful for tailoring NCD prevention and control programs.

National Survey of Noncommunicable Diseases in Seychelles, 2013-2014 (Seychelles Heart Study IV) : methods and main findings

This report provides information on selected summary results of the National Survey of Noncommunicable Diseases in Seychelles in 2013‐2014 (Seychelles Heart Study IV). The survey is also referred shortly as the "2013 Survey" in this report. Overall crude results were reported in a comprehensive report in November 2014. Further detailed analyses and recommendations on particular topics will be performed separately.

Illa gran i fecunds. 'Amphilaphés píeira nesos' (A.R. Arg.IV 982-1222)

Un episodio del retorno de los argonautas, en el Libro IV de Apolonio, inserta bruscamente un escenario homérico. Desde la isla de Eea, donde han sido purificados por Circe, son conducidos bajo la protección de Hera hasta Corcira -Esqueria en Odisea-, en una veloz travesía que ve sucederse sin riesgos los otrora peligrosos escollos de la ruta de Odiseo. La idea de hacer coincidir a los argonautas con los feacios homéricos aparece solo claramente en los poetas helenísticos. Calímaco parece haber dedicado especial atención a la escala feacia, en terminus similares -peso no idénticos- a los de Apolonio',y Filitas menciona unas hadas de Medea y Jason en el palacio de Alcinoa'. Testimonios anteriores asocian asimismo a Medea, Jason y sus hijos con Corcina...