Contact dermatitis from shoes: an update

Contact dermatitis is a common inflammatory skin condition characterized by erythematous and pruritic skin lesions that occur after contact with a foreign substance. There are two forms of contact dermatitis: irritant and allergic. Irritant contact dermatitis is caused by the non–immune-modulated irritation of the skin by a substance, leading to skin changes. Allergic contact dermatitis is a delayed hypersensitivity reaction in which a foreign substance comes into contact with the skin; skin changes occur after reexposure to the substance. A medical condition referred to as “shoe dermatitis” is a form of contact dermatitis caused by the contact of the foot with parts of the shoe due to these materials. Shoe dermatitis is a diagnostic and therapeutic challenge and is a common type of contact dermatitis. It is imperative the foot and ankle physician become familiar with recognizing signs and symptoms of shoe dermatitis so that their patients can be accurately diagnosis and appropriately treated to avoid secondary infections and disability. This review will first present causative factors for the etiology of shoe contact dermatitis supported by clinical-based evidence as found in the medical literature. Secondly, a description of the signs and symptoms of shoe contact dermatitis will be presented in a narrative fashion. Finally, both treatment options and preventative measures to avoid shoe.

Upplevelser av "Employer Branding" : En kvalitativ fallstudie av anställda hos BA

Syftet med denna studie var att undersöka hur medarbetarna på BA (fiktivt namn) upplever organisationens interna Employer Branding-arbete samt att belysa de aspekter som eventuellt skiljer strategi mot upplevelse. Det gjordes ett målinriktat urval av organisation medan valet av deltagare var ett slumpmässigt urval vilket resulterade i åtta respondenter (n= 8). Studien var en kvalitativ fallstudie med ett psykologiskt angreppssätt och innehöll en ostrukturerad intervju som tillsammans med dokumentation utgjorde intervjuguiden för den primära datainsamlingen genom åtta semistrukturerade intervjuer med medarbetarna. Fördelningen av urvalet var fyra kvinnor och fyra män med varierade yrkesroller inom en bemanningsdivision. Både den ostrukturerade intervjun och de semistrukturerade intervjuerna analyserades med hjälp av analysmetoden tematisk analys. Studiens resultat visade att BA:s interna Employer Branding och medarbetarnas upplevelser i stora drag överensstämde. Värderingar och interna karriärmöjligheter var centrala aspekter som både organisationen och respondenterna belyste. 

Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method

Immunohistochemistry (IHC) is the group of techniques that use antibodies as specific reagents to identify and demonstrate several cell and tissue components that are antigens. This linking allows locating and identifying the in situ presence of various substances by means of color that is associated with the formed antigen-antibody complexes. The practical value of this biotechnology area, widely used in Pathology and Oncology, in diagnostic, prognostic, theranostic and research context, results from the possibility of combining a colour marker with an antibody without causing any damage to specific binding established between antibody and antigen. This provides the microscopic observation of the target locations where the antibody and hence the antigen are present. IHC is presented as a powerful means for identification of several cellular and tissue structures that can be associated with pathologies, and of the consequences, at functional and morphological level, of these same elements action.

Aplicação para pesquisa de clip arts em dispositivos móveis baseada em esboços

Trabalho Final de Mestrado para obtenção do Grau de Mestre em Engenharia de Redes de Comunicação e Multimédia

Programa de aquisição de alimentos (2003-2010): avaliação da implementação pela CONAB no Rio Grande do Norte

This thesis aimed to evaluate the implementation of the Food Acquisition Program(PAA) through CONAB RN in the period of 2003-2010 with the perception of all agents involved in the implementation of the government program.For the methodological trajectory it was adopted a descriptive bibliographical and documentary approach with triangular qualitative and quantitative, also called evaluative research.The theoretical model was supported by the authors Draibe (2001), Aguilar and Ander-Egg (1994) and Silva(2001), among others, that focused on family farming and evaluation of implementation of public policy having as a category of analysis the size implementation of policy and the latter divided into 10 theoretical dimensions.The universe consisted of three groups: the first were the managers and technicians from CONAB(RN and Brasilia), totaling 15 subjects. The second group was of associations/cooperatives that participated in the programin 2010, totaling a sample in each access of 15 representatives. The third group of subjects totaled with 309 representatives of governmental and non-governmental organizations that received donations of food for the same period. Semi-structured interviews and forms were adopted as instruments of data collection.The data were processed qualitatively by the analysis of content (interviews and documents) and quantitatively by means of statistical tests that allowed inferences and adoption of frequencies. Among the key find ingests that the program is not standing as a structure supported by planning. The interests of the performers do not necessarily converge with the objectives of the Food Acquisition Program (PAA). A shockof goals was identified (within the same program) when comparingthe financial agent (Ministry of Rural Development and of Social Development and Fight Against Hunger Ministry r) and the executor, CONAB/RN. Within the assessed dimensions, the most fragileis the sub-managerial decision-making and Organizational Environment and internal assessment, still deserves attention the sizeof logistical and operational Subsystem, as this also proved weak.The focusin the quest toexpand thequantificationof the resultsof theFood Acquisition Program (PAA)by CONAB/RN does forget a quality management focused on what really should be:the compliance with the institutional objectives of the government program.Finally, the perspective for the traded implementation should be re-examined because excessive discretion by managers along with technical staff has characterized there al role of the Food Acquisition Program (PAA) as public policy. We conclude that the implementation model, which apparently aggregates values to the benefitted citizens, has weakened the context of work on family farms having the management model of the implementation process be reviewed by the Federal Government and point too ther paths, which have as a guide line the emancipation and developmentof the field or in the field andat the same time enables the reduction of nutritional deficiency of beneficiaries in a balanced and coherent way

Haruki

Il y une opinion selon laquelle la pensée de Lacan pourrait être taxée de phallocentrisme. Certes, on peut reconnaître dans la théorie lacanienne des premières années une partie qu’on peut interpréter de cette façon, bien qu’un tel jugement soit peu fondé. Mais lorsque, dans ses dernières années, Lacan a insisté sur le caractère incomplet du Symbolique en donnant plus d’importance au Réel, on ne peut plus d’aucune manière considérer sa psychanalyse comme phallocentrique. A travers les recherches précédentes, l’auteur du présent article tend à croire de plus en plus que la féminité est une notion clé pour comprendre cet aspect théorique de la pensée de Lacan. C’est ce que le présent article veut affirmer plus formellement en se fondant sur les écrits lacaniens des dernières années et en particulier le Séminaire XX. L’exemple qui nous servira de support, c’est la figure de Médée qu’on pourrait qualifier de trop féminine.

Modelación geofísica con métodos potenciales en un ambiente geológico multicapa de densidades inversas, aplicado a la cuenca de la Popa, NE de México

En este trabajo de investigación se presenta el análisis integral de datos gravimétricos y aeromagnéticos en el área de la Cuenca de La Popa y las estructuras geológicas que la rodean. El análisis fue complementado con un Modelo Digital de Elevaciones (MDE) que, combinado con la revisión de estudios geológicos previos, sirvió para comparar las estructuras en superficie y bloques del basamento en el área de estudio. Se hizo la separación de los bloques tectónicos más importantes, llegando por último al desarrollo de tres modelos geológicos-geofísicos 2D que representan de manera general las características estructurales más importantes del noreste de México.

Modelo de conducta sexual en hombres que tienen sexo con hombres

Evaluar un modelo explicativo de la conducta sexual de los HSH a partir de algunos conceptos del MPS, como las características personales (biológicas, psicológicas y socioculturales), las cogniciones (autoeficacia percibida, beneficios percibidos, barreras percibidas, influencias interpersonales y situacionales) y la conducta de salud, además de los conceptos de identidad sexual, búsqueda de sensaciones sexuales y homofobia internalizada. Se utilizó un diseño de comprobación de modelo. La muestra estuvo conformada por 241 HSH, la cual se calculó con un nivel de significancia de .05, un Coeficiente de Determinación de R2 = .1, una potencia de prueba de 90% para un modelo de Regresión Lineal Multivariado con 14 variables. Se utilizó el muestreo dirigido por entrevistados (MDE). Los instrumentos utilizados fueron: escala de búsqueda de sensaciones sexuales, escala de homofobia internalizada, sub-escala de beneficios percibido de la escala de creencias de salud sida, sub-escala de efectos sobre la experiencia sexual en hombres, escala de autoeficacia para el uso del condón, escala provisión social para sexo seguro para medir el apoyo familiar y de la pareja, escala de influencias situacionales para la conducta sexual en HSH y escala de conducta sexual en HSH estos últimos (2), fueron elaboradas para el presente estudio. Los instrumentos fueron aplicados en lápiz y papel y en línea, éste último aplicado a través del portal SurveyMonkey. Todos los instrumentos mostraron confiabilidad aceptable. Se utilizó estadística descriptiva e inferencial, la prueba de Kolmogorov-Smirnov con corrección de Lilliefors, coeficientes correlación de Sperman, pruebas de Regresión Lineal Múltiple y el Modelo de Ecuaciones Estructurales. Contribución y Conclusiones: La variable número de parejas sexuales en el último año, presentó una media de 10.52 (Mdn= 3.0, DE= 30.54, min= 1, max= 300) y el 12.9% de los participantes señalaron haber tenido al menos una ITS (Media= .13, DE= .33). En relación a los modelos de regresión, en el primer modelo de factores biológicos, socioculturales y psicológicos en la percepción para el uso del condón, se encontró que una identidad bisexual, hombre o gay perciben mayores beneficios (F[6,231]= 3.27, p < .001). También, a mayor escolaridad y búsqueda de sensaciones sexuales perciben mayores barreras para usar el condón (F[6,231]= 6.66, p < .001). Los HSH que se identifican como gay y tienen mayor escolaridad perciben mayor autoeficacia en la comunicación y en el uso correcto del condón (F[6,231]= 4.32, p < .001; F[6,231]= 2.44, p < .05, respectivamente). En el segundo modelo de factores biológicos, socioculturales y psicológicos en las influencias interpersonales para la conducta sexual en HSH, demostró que los HSH con mayor escolaridad y menor búsqueda de sensaciones sexuales tienen mayor apoyo de la pareja para practicar sexo seguro (F [9,210]= 2.61, p < .001).

Hypersensitivity of BRCA1 Heterozygote Lymphoblastoid cells to Gamma radiation and PARP inhibitors

PARP inhibitors can be used to induce synthetic lethality in cells with bi-allelic BRCA1 and BRCA2 mutations. However the effect of PARP inhibitors in combination with radiation on cells with mono-allelic mutations of BRCA1 and BRCA2 is unknown. We have examined the cell survival response of lymphoblastoid cells derived from normal individuals and those derived from carriers of BRCA1 and BRCA2 mutations, following exposure to ionising radiation and the PARP inhibitor Olaparib. Two lymphoblastoid cell lines from normal individuals and three with mono-allelic mutations in BRCA1 and BRCA2 were exposed to increasing doses of gamma radiation either alone or in combination with 5 μM Olaparib. Cell survival was measured using the MTT assay. Exposure to increasing doses of gamma radiation caused a reduction in cell survival of all cell types. The combined exposure to gamma radiation and 5 μM Olaparib did not enhance cell kill in normal or BRCA2 heterozygote lymphoblastoid cells but significantly enhanced cell kill in cells derived from BRCA1 carriers (P = 0.02). The treatment of cancer patients carrying mutations in the BRCA1 gene with radiotherapy and the PARP inhibitor Olaparib may significantly enhance radiation induced normal tissue toxicity in these patients.

Marketing channel behaviour and performance

Thesis submitted to University of Manchester for the degree of Doctor of Philosophy in the Faculty of Business Administration.

Oral Anticoagulation in the Elderly: New Oral Anticoagulants-Innovative Solution for an Old Problem?

Direct oral anticoagulants emerge as the most innovative and promising drug toward preventing and treating cardiovascular disease, raising great interest among the scientific community. Numerous studies and meta-analysis generated much data clarifying clinicians' doubts; however, uncertainties remain regarding their use in particular groups such as patients with prosthetic valves, in valvular atrial fibrillation (defined as atrial fibrillation related to mitral rheumatic heart disease or prosthetic heart valves), among the elderly, in paraneoplastic thromboembolism, in pulmonary embolism with hemodynamic compromise, and scarcity of specific antidotes. This review article intends to condense the vast scientific production addressing new oral anticoagulants by focusing on their advantages and disadvantages when used on the elderly.

Analisis histórico de algunas instituciones del Código Civil respecto a las personas

Teniendo en cuenta que nuestro Código Civil es eminentemente romanista, se ha optado por un estudio de sus raíces, esto es el mismo derecho Romano y su más completa recopilación que subyace en las Institutas de Justiniano. En este análisis del libro de las personas veremos los cambios que han tenido las normasasí como la creación de leyes a partir de las necesidades sociales; la posterior evolución de estas instituciones a través de los siglos y como ha influenciado a otras legislaciones hasta llegar al Código Civil Napoleónico donde se codifican los logros de la revolución, el que a su vez sentaría las bases para que Don Andrés Bello elaborase el Código Civil Chileno. Ya en nuestro Código Civil veremos cómo este se han ido nutriendo de los distintos códigos y legislaciones e incluso de los cambios sociales para culminar con las leyes que nos rigen, comparando las semejanzas y más que nada las grandes diferencias que con el pasar de los años se han dado frente a las institutas de Justiniano; y como pese a esta continua adaptación y evolución aún tenemos ejemplos de normas que desde ciertos puntos de vista vulneran principios establecidos en la Constitución.

Zonas úmidas nas bacias dos rios Murucutu e Aurá para identificar áreas suscetíveis a contaminantes.

O objetivo neste trabalho foi identificar zonar úmidas nas bacias hidrográficas dos rios Murucutu e Aurá (BHMA) para identificar áreas suscetíveis a contaminantes. Técnicas de manipulação e análises de dados matriciais de Modelo Digital de Elevação (MDE) permitiram a delimitação de áreas úmidas em decorrência de enchente e/ou alagamento. Características físicas da bacia (declividade, uso e cobertura do solo e altimetria) foram usadas em álgebra de mapas em Sistema de Informação Geográfica (SIG). A partir de critérios de ponderação foram gerados novos planos de informação (PIs). Fez-se a reclassificação nos planos de informação gerados e atribui-se pesos para aplicação do método de Análise Hierárquica Ponderada (AHP). Os pressupostos metodológicos de geomática possibilitaram a delimitação de zonas com muito alta e alta umidade. Os resultados apontaram que cerca de 56% dessas bacias estão suscetíveis a contaminantes, principalmente pelo chorume que apresenta pode ser transportado pelo lixão do Aurá. Conclui-se que como mais da metade da BHMA possui zonas com muito alta e alta umidade, os efeitos decorrentes de contaminantes pode ser intensificado em eventos de chuvas extremas e marés altas. O ponto de conexão entre as duas bacias evidencia que o transporte de contaminantes pode ameaçar os mananciais de Bolonha e Água Preta que abastecem Belém e Ananindeua.

Modelar o programar en prácticas de robótica

En este trabajo se muestra la experiencia de usar una herramienta de desarrollo de ingeniería basada en modelos (MDE) frente a otra herramienta tradicional de programacion de sistemas embebidos en lenguaje C, para la realizacion de clases practicas de robotica. Se ha plantea do una practica basada en el control cinemático de un robot móvil en ambos entornos con similares bloques y funciones de partida. Los resultados muestran tanto la comparación de las evaluaciones objetivas realiza das a los dos grupos como los datos relativos a los tiempos requeridos para la realización de las diferentes partes de la practica. Si bien, los resultados del aprendizaje son mayores en el caso del método basado en programacion, la diferencia en tiempos invertidos y otras valoraciones hacen m´as adecuado el MDE .

Contribuição da Geodésia ao monitoramento costeiro do Litoral Setentrional do Rio Grande do Norte, área de influência da indústria petrolífera

The general objective of this thesis has been seasonal monitoring (quarterly time scale) of coastal and estuarine areas of a section of the Northern Coast of Rio Grande do Norte, Brazil, environmentally sensitive and with intense sediment erosion in the oil activities to underpin the implementation of projects for containment of erosion and mitigate the impacts of coastal dynamics. In order to achieve the general objective, the work was done systematically in three stages which consisted the specific objectives. The first stage was the implementation of geodetic reference infrastructure for carrying out the geodetic survey of the study area. This process included the implementation of RGLS (Northern Coast of the RN GPS Network), consisting of stations with geodetic coordinates and orthometric heights of precision; positioning of Benchmarks and evaluation of the gravimetric geoid available, for use in GPS altimetry of precision; and development of software for GPS altimetry of precision. The second stage was the development and improvement of methodologies for collection, processing, representation, integration and analysis of CoastLine (CL) and Digital Elevation Models (DEM) obtained by geodetic positioning techniques. As part of this stage have been made since, the choice of equipment and positioning methods to be used, depending on the required precision and structure implanted, and the definition of the LC indicator and of the geodesic references best suited, to coastal monitoring of precision. The third step was the seasonal geodesic monitoring of the study area. It was defined the execution times of the geodetic surveys by analyzing the pattern of sediment dynamics of the study area; the performing of surveys in order to calculate and locate areas and volumes of erosion and accretion (sandy and volumetric sedimentary balance) occurred on CL and on the beaches and islands surfaces throughout the year, and study of correlations between the measured variations (in area and volume) between each survey and the action of the coastal dynamic agents. The results allowed an integrated study of spatial and temporal interrelationships of the causes and consequences of intensive coastal processes operating in the area, especially to the measurement of variability of erosion, transport, balance and supply sedimentary over the annual cycle of construction and destruction of beaches. In the analysis of the results, it was possible to identify the causes and consequences of severe coastal erosion occurred on beaches exposed, to analyze the recovery of beaches and the accretion occurring in tidal inlets and estuaries. From the optics of seasonal variations in the CL, human interventions to erosion contention have been proposed with the aim of restoring the previous situation of the beaches in the process of erosion.