860 resultados para Leeds Phantom


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From 2001, the construction of flats and high-density developments increased in England and the building of houses declined. Does this indicate a change in taste or is it a result of government planning policies? In this paper, an analysis is made of the long-term effects of the policy of constraint which has existed for the past 50 years but the increase in density is identified as occurring primarily after new, revised, planning guidance was issued in England in 2000 which discouraged low-density development. To substantiate this, it is pointed out that the change which occurred in England did not occur in Scotland where guidance was not changed to encourage high-density residential development. The conclusion that the change is the result of planning policies and not of a change in taste is confirmed by surveys of the occupants of new high-rise developments in Leeds. The new flat-dwellers were predominantly young and childless and expressed the intention, in the near future, when they could, of moving out of the city centre and into houses. From recent changes in guidance by the new coalition government, it is expected that the construction of flats in England will fall back to earlier levels over the next few years.

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This paper proposes a new reconstruction method for diffuse optical tomography using reduced-order models of light transport in tissue. The models, which directly map optical tissue parameters to optical flux measurements at the detector locations, are derived based on data generated by numerical simulation of a reference model. The reconstruction algorithm based on the reduced-order models is a few orders of magnitude faster than the one based on a finite element approximation on a fine mesh incorporating a priori anatomical information acquired by magnetic resonance imaging. We demonstrate the accuracy and speed of the approach using a phantom experiment and through numerical simulation of brain activation in a rat's head. The applicability of the approach for real-time monitoring of brain hemodynamics is demonstrated through a hypercapnic experiment. We show that our results agree with the expected physiological changes and with results of a similar experimental study. However, by using our approach, a three-dimensional tomographic reconstruction can be performed in ∼3  s per time point instead of the 1 to 2 h it takes when using the conventional finite element modeling approach

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For compelling reasons of equity and the advance of public health, brief psychotherapy has become the dominant format in both practice and research. One consequence of this is the apparent decline of a distinct stream of brief therapy research. However, much of the agenda formerly identified with that research stream is of increasing importance to the field. Time is indeed of the essence in current psychotherapy research. For example, factors conducive to the time efficiency of brief psychodynamic therapy have been described recently. The important question ‘How much therapy is enough?’ has been addressed by studies inspired by the dose-response analysis of Howard and colleagues. The value of ultra-brief interventions has been examined. These issues are considered in a selective review, drawing in particular on the work of the Sheffield/Leeds psychotherapy of depression research group. This research treats the number of treatment sessions as an independent variable, thereby providing a causal analysis of the dose-response relationship over a range from two to 16 sessions, illuminated by a comparative analysis of change processes in treatments of different durations. Its results enable some specification of the extent and nature of incremental benefit derived from additional sessions in the psychotherapy of depression.

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Challenging behaviours may elicit negative emotional reactions and increase stress within care staff. The Leeds Attributional Coding System (LACS) was used to elicit spontaneous causal attributions of staff toward hypothetical clients with challenging behaviours. It was hypothesized that there would be relationships (1) between staff exposure to challenging behaviours and burnout, and (2) between staff cognitions and burnout. Using a cross-sectional correlational design, 41 care staff took part in a 10 minute interview about two vignettes depicting self-injurious behaviour. Staff also completed measures of demographic information and burnout. Participants made attributions toward self-injurious behaviour that were typically internal to the client, uncontrollable, unstable and specific.There was a significant association between number of clients cared for and emotional exhaustion and personal accomplishment. Staff who made fewer stable attributions had higher levels of burnout. There were no other relationships found between staff cognition and burnout. The LACS can be successfully employed in this context, and may have some benefits over other methods. Future research is required to explore the relationship between cognition and burnout.

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Background: Daily consumption of Concord grape juice (CGJ) over three to four months has been shown to improve memory function in adults with mild cognitive impairment, and reduce blood pressure in hypertensive adults. These benefits are likely due to the high concentration of polyphenols in CGJ. Increased stress can impair cognitive function and elevate blood pressure. Thus we examined the potential beneficial effect of CGJ in individuals experiencing somewhat stressful demanding lifestyles. Objective: To examine the effects of twelve weeks’ daily consumption of CGJ on cognitive function, driving performance, and blood pressure in healthy, middle-aged working mothers. Design: Twenty five healthy mothers of pre-teen children, aged 40-50 years, who were employed for > 30 hours/week consumed 12oz (355ml) CGJ (containing 777mg total polyphenols) or an energy, taste and appearance matched placebo daily for twelve weeks according to a randomised, crossover design with a four week washout. Verbal and spatial memory, executive function, attention, blood pressure and mood were assessed at baseline, six weeks and twelve weeks. Immediately following the cognitive battery, a subsample of seventeen females completed a driving performance assessment in the University of Leeds Driving Simulator. The twenty five minute driving task required participants to match the speed and direction of a lead vehicle. Results: Significant improvements in immediate spatial memory and driving performance were observed following CGJ relative to placebo. There was evidence of an enduring effect of CGJ such that participants who received CGJ in arm 1 maintained better performance in the placebo arm. Conclusions: Cognitive benefits associated with chronic consumption of flavonoid-rich grape juice are not exclusive to adults with mild cognitive impairment. Moreover, these cognitive benefits are apparent in complex everyday tasks such as driving. Effects may persist beyond cessation of flavonoid consumption and future studies should carefully consider the length of washout within crossover designs.

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In medical processes where ionizing radiation is used, dose planning and dose delivery are the key elements to patient safety and treatment success, particularly, when the delivered dose in a single session of treatment can be an order of magnitude higher than the regular doses of radiotherapy. Therefore, the radiation dose should be well defined and precisely delivered to the target while minimizing radiation exposure to surrounding normal tissues [1]. Several methods have been proposed to obtain three-dimensional (3-D) dose distribution [2, 3]. In this paper, we propose an alternative method, which can be easily implemented in any stereotactic radiosurgery center with a magnetic resonance imaging (MRI) facility. A phantom with or without scattering centers filled with Fricke gel solution is irradiated with Gamma Knife(A (R)) system at a chosen spot. The phantom can be a replica of a human organ such as head, breast or any other organ. It can even be constructed from a real 3-D MR image of an organ of a patient using a computer-aided construction and irradiated at a specific region corresponding to the tumor position determined by MRI. The spin-lattice relaxation time T (1) of different parts of the irradiated phantom is determined by localized spectroscopy. The T (1)-weighted phantom images are used to correlate the image pixels intensity to the absorbed dose and consequently a 3-D dose distribution with a high resolution is obtained.

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In this paper, we propose a new method of measuring the very slow paramagnetic ion diffusion coefficient using a commercial high-resolution spectrometer. If there are distinct paramagnetic ions influencing the hydrogen nuclear magnetic relaxation time differently, their diffusion coefficients can be measured separately. A cylindrical phantom filled with Fricke xylenol gel solution and irradiated with gamma rays was used to validate the method. The Fricke xylenol gel solution was prepared with 270 Bloom porcine gelatin, the phantom was irradiated with gamma rays originated from a (60)Co source and a high-resolution 200 MHz nuclear magnetic resonance (NMR) spectrometer was used to obtain the phantom (1)H profile in the presence of a linear magnetic field gradient. By observing the temporal evolution of the phantom NMR profile, an apparent ferric ion diffusion coefficient of 0.50 mu m(2)/ms due to ferric ions diffusion was obtained. In any medical process where the ionizing radiation is used, the dose planning and the dose delivery are the key elements for the patient safety and success of treatment. These points become even more important in modern conformal radio therapy techniques, such as stereotactic radiosurgery, where the delivered dose in a single session of treatment can be an order of magnitude higher than the regular doses of radiotherapy. Several methods have been proposed to obtain the three-dimensional (3-D) dose distribution. Recently, we proposed an alternative method for the 3-D radiation dose mapping, where the ionizing radiation modifies the local relative concentration of Fe(2+)/Fe(3+) in a phantom containing Fricke gel and this variation is associated to the MR image intensity. The smearing of the intensity gradient is proportional to the diffusion coefficient of the Fe(3+) and Fe(2+) in the phantom. There are several methods for measurement of the ionic diffusion using NMR, however, they are applicable when the diffusion is not very slow.

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We consider perturbations in a cosmological model with a small coupling between dark energy and dark matter. We prove that the stability of the curvature perturbation depends on the type of coupling between dark sectors. When the dark energy is of quintessence type, if the coupling is proportional to the dark matter energy density, it will drive the instability in the curvature perturbations: however if the coupling is proportional to the energy density of dark energy, there is room for the stability in the curvature perturbations. When the dark energy is of phantom type, the perturbations are always stable, no matter whether the coupling is proportional to the one or the other energy density. (C) 2008 Elsevier B.V. All rights reserved.

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Purpose: We present an iterative framework for CT reconstruction from transmission ultrasound data which accurately and efficiently models the strong refraction effects that occur in our target application: Imaging the female breast. Methods: Our refractive ray tracing framework has its foundation in the fast marching method (FNMM) and it allows an accurate as well as efficient modeling of curved rays. We also describe a novel regularization scheme that yields further significant reconstruction quality improvements. A final contribution is the development of a realistic anthropomorphic digital breast phantom based on the NIH Visible Female data set. Results: Our system is able to resolve very fine details even in the presence of significant noise, and it reconstructs both sound speed and attenuation data. Excellent correspondence with a traditional, but significantly more computationally expensive wave equation solver is achieved. Conclusions: Apart from the accurate modeling of curved rays, decisive factors have also been our regularization scheme and the high-quality interpolation filter we have used. An added benefit of our framework is that it accelerates well on GPUs where we have shown that clinical 3D reconstruction speeds on the order of minutes are possible.

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L’objet de la présente étude est le personnage principal dans l’oeuvre Le Fantôme de l’Opéra de Gaston Leroux. Le but de cette analyse littéraire est de mettre en évidence l'ambiguïté et la complexité psychologique et morale de ce personnage.L’analyse est basée sur les théories de Vincent Jouve à propos de la perception du personnage romanesque. Le résultat de l'analyse montre que l'ambiguïté du personnage principal peut être déduite de ce que Jouve appelle le « système de la sympathie » constitué de trois codes : le code narratif, le code affectif et le code culturel.

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Os modelos computacionais SATURN e DRACULA avaliam o tráfego através de diferentes fundamentações teóricas. O SATURN é um modelo macroscópico de alocação de tráfego que incorpora uma estrutura mesoscópica de simulação de interseções. O DRACULA é um modelo microscópico de simulação de tráfego: reproduz a progressão dos veículos através da rede, representando cada entidade individualmente. Ambos os modelos foram desenvolvidos no ITS – Institute for Transport Studies – da Universidade de Leeds, e permitem a troca de informações, podendo ser aplicados em conjunto. O presente trabalho de pesquisa compara as estruturas de simulação do SATURN e do DRACULA. O estudo confronta as fundamentações teóricas dos modelos, relacionando-as com a aplicação prática. São avaliados os dados de entrada, os parâmetros de saída, e os processos particulares de estimação de parâmetros de cada modelo. Através de análises de sensibilidade, avalia-se o impacto da variação de dados de entrada nos parâmetros de saída. Em um estudo de caso, avalia-se a aplicação conjunta dos modelos, ao replicarem o mesmo cenário. O estudo identifica divergências e afinidades na conceituação e no tratamento de parâmetros de entrada e saída tais como dados de descrição de rede e demanda, atrasos, velocidades, tempos de viagem, e capacidade viária. Por fim, o estudo propõe recomendações sobre a implementação prática dos modelos, especialmente quando utilizados em conjunto.

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O texto que se segue foi produzido no contexto da pesquisa Empresários e Educação no Brasil, como parte das atividades do Programa de Promoção da Reforma Educativa na América Latina e Caribe (PREAL), sediado no CPDOC da Fundação Getulio Vargas, Rio de Janeiro. A pesquisa foi possível graças ao apoio substantivo da Fundação Ford e à confiança depositada por Nigel Brooke e Elizabeth Leeds à linha de trabalho desenvolvida pelo PREAL no Brasil. O survey foi aplicado pelo IBOPE e os dados foram processados pela equipe do Doxa, IUPERJ, coordenada por Marcus Figueiredo e por José Augusto Rodrigues e Dario Sousa e Silva Filho, do Quantidados, UERJ. A rotina do PREAL envolve extenso e continuado trabalho de secretaria e gerência fina nceiro-administrativa. O CPDOC tem disponibilizado, de forma competente e tranqüilizadora, funcionários qualificados para o desempenho dessas funções. Fica aqui registrado nosso agradecimento à diretora da instituição, Marieta de Moraes Ferreira, e ao gerente administrativo, Felipe Piqueira Rente que coordenam, cada um em sua esfera de atribuição, toda a equipe responsável pelo bom funcionamento do programa no Brasil. Os resultados preliminares desta pesquisa foram apresentados em um seminário realizado na Fundação Getulio Vargas, Rio de Janeiro, em abril de 2002. Estiveram aqui representadas mais de 40 Fundações empresariais envolvidas com projetos educacionais. A dinâmica das discussões e o interesse despertado no público presente fortaleceram nossa convicção de que este é um tema relevante no Brasil hoje. Queremos acreditar que a pesquisa possa contribuir para consolidar uma área de discussão, favorecer o amadurecimento de um campo de ação e a abertura de um espaço de reflexão ainda incipientes no país. Esta publicação nos pareceu ser um dos caminhos possíveis de fortalecimento dessa pretensão.

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Introdução: O zumbido é definido como uma sensação auditiva ilusória sem a presença de um som externo. Acomete homens e mulheres, mais comumente entre 40 e 70 anos de idade, às vezes podendo ocorrer em crianças. Análises de dados epidemiológicos indicam que a exposição ao ruído é uma das causas mais comuns de zumbido. Objetivos: Os objetivos gerais deste estudo foram verificar a prevalência do zumbido em trabalhadores expostos ao ruído ocupacional e avaliar a freqüência e a intensidade do zumbido. Os objetivos específicos foram avaliar a gravidade do zumbido; analisar a presença do zumbido por sexo, cor, idade e tempo de trabalho com exposição ao ruído e analisar a relação do zumbido com as freqüências mais acometidas na audiometria e com a presença e grau da perda auditiva, independente do nexo da perda. Materiais e Métodos: Trata-se de um estudo transversal para o qual foram selecionados 362 prontuários de trabalhadores expostos a ruído ocupacional ≥80dB(NA)/8h diárias. Estes trabalhadores haviam sido submetidos a meatoscopia, anamnese clínica e ocupacional, audiometria de via aérea, avaliação de freqüência e intensidade do zumbido e à escala de avaliação da gravidade do zumbido. Conclusão: A prevalência do zumbido foi de 9,9%. Nas análises de regressão conclui-se que trabalhadores com presença de perda auditiva em pelo menos um dos ouvidos têm 2,396 vezes mais chances de ter zumbido quando comparados com os que não tem perda auditiva. Os trabalhadores com faixa etária acima ou igual a 30 anos tem 5,353 vezes mais chances de ter perda auditiva em pelo menos um dos ouvidos quando comparados com os de faixa etária menor que 30 anos. Com relação ao tempo de trabalho em contato com o ruído, a analise estatística revela que trabalhadores com diferença de 1 ano no tempo de trabalho em contato com ruído tem um risco 5,3 % (OR=1,053) maior de apresentar perda auditiva.