The Homology and Relationship of Human (Homo sapiens) Chromosomes 1, 19 and Dusky Langur (Trachypithacus obscurus) Chromosomes 6, 8 Demonstrated with Chromosome Painting

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Functional characterization of the human-specific (type II) form of kallikrein 8, a gene involved in learning and memory

Kallikrein 8 (KLK8) is a serine protease functioning in the central nervous system, and essential in many aspects of neuronal activities. Sequence comparison and gene expression analysis among diverse primate species identified a human-specific splice for

Anti Human Immunodeficiency Virus Type 1 (HIV-1) Agents 4. Discovery of 5,5 '-(p-Phenylenebisazo)-8-hydroxyquinoline Sulfonates as New HIV-1 Inhibitors in Vitro

To search for compounds with superior anti-human immunodeficiency virus type 1 (HIV-1) activity, ten 5,5'-(p-phenylenebisazo)-8-hydroxyquinoline sulfonates (4a-j) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Some compounds demonstrated anti-HIV-1 activity, especially 5,5'-(p-phenylenebisazo)-8-hydroxyquinoline p-ethylbenzenesulfonate (4g) and 5,5'-(p-phenylenebisazo)-8-hydroxyquinoline p-chlorobenzenesulfonate (41) showed the more potent anti-HIV-1 activity with 50% effective concentration (EC50) values of 2.59 and 4.01 mu g/ml, and therapeutic index (TI) values of 31.77 and 24.51, respectively.

Report of the training workshop on the application of Ecopath with Ecosim to BOBLME, Phuket, Thailand, 8-12 September, 2014

The workshop's objective was to provide information to improve a regional Ecopath with Ecoism (EwE) model.The workshop described the basis and principles underlying the software, encompassing the basics of Ecopath to Ecospace, economics and management strategy evaluation.

云南8种树蛙的染色体组型比较研究

报道了云南8种树蛙的染色体组型, 并对目前所已知的树蛙种类的染色体组型进行了比较。

Sequence context analysis of 8.2 million single nucleotide polymorphisms in the human genome

We analyzed n-mers (n=3-8) in the local environment of 8,249,446 human SNPs and compared their distribution with that in the genome reference sequences. The results revealed that the short sequences, which contained at least one CpG dinucleotide, occurred

污水中8种雌激素化合物的定量测定

采用固相萃取-气相色谱-质谱法(GC-MS)测定污水中辛酚(OP)、壬酚(NP)、双酚A(BPA)、己烯雌酚(DES)、雌酮(E1)、17β-雌二醇(E2)、17α-乙炔雌二醇(EE2)和雌三醇(E3)8种具有雌激素活性的化合物。被测组分的加标回收率为(65.4±4.0)%～(110.0±4.5)%,检出限为1.0～7.5ng/L(相对标准偏差为5.2%～15.6%)。经检测,武汉某城市污水处理厂进水中的目标化合物(除EE2外)浓度为6.5～8954.9ng/L;除EE2和E3外,出水中的浓度为3.2～2