New insights into the role of the immune microenvironment in breast carcinoma.

Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future.

Solving Large Location-Allocation problems by Clustering and Simulated Annealing

Globalization involves several facility location problems that need to be handled at large scale. Location Allocation (LA) is a combinatorial problem in which the distance among points in the data space matter. Precisely, taking advantage of the distance property of the domain we exploit the capability of clustering techniques to partition the data space in order to convert an initial large LA problem into several simpler LA problems. Particularly, our motivation problem involves a huge geographical area that can be partitioned under overall conditions. We present different types of clustering techniques and then we perform a cluster analysis over our dataset in order to partition it. After that, we solve the LA problem applying simulated annealing algorithm to the clustered and non-clustered data in order to work out how profitable is the clustering and which of the presented methods is the most suitable

Implantació de les TIC en un institut d'educació secundària

El projecte consisteix en tot el procés d'anàlisi, disseny, implementació i implantació de les tic en un institut , des de la part de sistemes de xarxa i de servidors, fins a la web corporativa de centre, el portal de docència virtual i una eina que permet l'intercanvi de recursos didàctis entre tots els membres de la comunitat educativa d'un o diversos centres.

Estudi de les pressions antròpiques de s’Estany des Peix i cartografia de l’escull-barrera de posidònia de Sa Boca

Realització per primera vegada de la cartografia de l’escull de Posidònia oceànica per tal d’observar la seva evolució, i estudi de s’Estany des Peix, concretament de les fortes pressions antròpiques que rep i posterior elaboració d’una proposta el més sostenible possible. S’estudia també la relació entre aquests dos espais

Comparison of Work Scheduling Using Constraint Programming or Auctions

Business processes designers take into account the resources that the processes would need, but, due to the variable cost of certain parameters (like energy) or other circumstances, this scheduling must be done when business process enactment. In this report we formalize the energy aware resource cost, including time and usage dependent rates. We also present a constraint programming approach and an auction-based approach to solve the mentioned problem including a comparison of them and a comparison of the proposed algorithms for solving them

The Geographical Scope of Industrial Location Determinants: An Alternative Approach

This paper considers the estimation of the geographical scope of industrial location determinants. While previous studies impose strong assumptions on the weighting scheme of the spatial neighbour matrix, we propose a exible parametrisation that allows for di fferent (distance-based) de finitions of neighbourhood and di fferent weights to the neighbours. In particular, we estimate how far can reach indirect marginal e ffects and discuss how to report them. We also show that the use of smooth transition functions provides tools for policy analysis that are not available in the traditional threshold modelling. Keywords: count data models, industrial location, smooth transition functions, threshold models. JEL-Codes: C25, C52, R11, R30.

El cuerpo-especie y la nuda vida. Un estudio comparativo entre Michel Foucault y Giorgio Agamben

Michel Foucault hace pública por primera vez su tesis sobre el biopoder en 1975 y muere en 1984 con tan sólo cincuenta y ocho años, razón por la cual podemos considerar que sus ideas quizá hubieran podido desarrollarse más de haber vivido más tiempo.

La crítica de la verdad en Nietzsche

El objeto del presente trabajo es el analizar la crítica de Nietzsche al concepto de verdad, tratando de identificar aquellos elementos filosóficos fundamentales que le hacen adoptar una de las actitudes más radicales e influyentes del pensamiento contemporáneo.De este modo he elegido los núcleos de su filosofía que ponen en cuestión prácticamente toda la tradición de pensamiento de ccidente.

La Lectura crítica en los libros de educación secundaria : concepción y tratamiento metodológico

La presente investigación propone comparar y analizar la concepción y la forma cómo abordan la lectura crítica los libros de texto del Ministerio de Educación y las editoriales privadas de educación secundaria en el Perú. El estudio se desarrolla desde la perspectiva de los Nuevos Estudios de Literacidad y la Literacidad crítica, que conciben la lectura como una práctica social situada. La metodología es descriptiva y explorativa; se sustenta en el análisis cuantitativo y cualitativo. El corpus de análisis lo constituyen los textos de lectura y las actividades de comprensión crítica de 4 manuales del Ministerio de Educación y 3 de las editoriales Norma y Santillana. Los resultados demuestran que tanto los objetivos como el tratamiento de los textos de lectura se desarrollan desde la perspectiva psicolingüística y lingüística de la lectura. Leer críticamente significa opinar sobre el texto y la práctica de la literacidad crítica es aún incipiente, porque las actividades siguen concentradas en la comprensión literal del texto y, generalmente, se callan las ideologías y las relaciones de poder. En conclusión, no existen diferencias significativas entre los dos tipos de manuales.

Survival and Sensemaking: Organizational Resilience in a Wall Street Trading Room After 9/11

How do organizations cope with extreme uncertainty? The existing literature is divided on this issue: some argue that organizations deal best with uncertainty in the environment by reproducing it in the organization, whereas others contend that the orga nization should be protected from the environment. In this paper we study the case of a Wall Street investment bank that lost its entire office and trading technology in the terrorist attack of September 11 th. The traders survived, but were forced to relocate to a makeshift trading room in New Jersey. During the six months the traders spent outside New York City, they had to deal with fears and insecurities inside the company as well as outside it: anxiety about additional attacks, questions of professional identity, doubts about the future of the firm, and ambiguities about the future re-location of the trading room. The firm overcame these uncertainties by protecting the traders' identities and their ability to engage in sensemaking. The organization held together through a leadership style that managed ambiguities and created the conditions for new solutions to emerge.

Ecologies of Value in a Wall Street Trading Room

Our task in this paper is to analyze the organization of trading in the era of quantitative finance. To do so, we conduct an ethnography of arbitrage, the trading strategy that best exemplifies finance in the wake of the quantitative revolution. In contrast to value and momentum investing, we argue, arbitrage involves an art of association-the construction of equivalence (comparability) of properties across different assets. In place of essential or relational characteristics, the peculiar valuation that takes place in arbitrage is based on an operation that makes something the measure of something else-associating securities to each other. The process of recognizing opportunities and the practices of making novel associations are shaped by the specific socio-spatial and socio-technical configurations of the trading room. Calculation is distributed across persons and instruments as the trading room organizes interaction among diverse principles of valuation.

Gender and attachment representations in the preschool years: comparisons between five countries

Bowlby proposed that the individual's social experiences, as early as in infancy, contribute to the construction of Internal Working Models (IWMs) of attachment, which will later guide the individual's expectations and behaviors in close relationships all along his or her life. The qualitative, individual characteristics of these models reflect the specificity of the individual's early experiences with attachment figures. The attachment literature globally shows that the qualities of IWMs are neither gender specific nor cultural specific. Procedures to evaluate IWMs in adulthood have been well established, based on narrative accounts of childhood experiences. Narrative procedures at earlier ages (e.g., in the preschool years) have been proposed, such as Bretherton's Attachment Story Completion Task (ASCT), to evaluate attachment representations. More than 500 ASCT narratives of preschoolers, coming from five different countries, have been collected, in the perspective of examining possible interactions between gender and culture regarding attachment representations. A specific Q-Sort coding procedure (CCH) has been used to evaluate several dimensions of the narratives. Girls' narratives appeared as systematically more secure than those of same-age boys, whatever their culture. The magnitude of gender differences, however, varied between countries. Taylor's model of gender-specific responses to stress and Harwood's and Posada's hypothesis on inter-cultural differences regarding caregiving are evoked to understand the differences across gender and countries.

Correlació entre resposta radiològica i resposta patològica en pacients amb càncer de mama tractades amb quimioteràpia neoadjuvant.

En pacients amb càncer de mama la ressonància magnètica és superior a altres exploracions per a monitoritzar la resposta a la quimioteràpia neoadjuvant. Analitzem la correlació entre resposta completa radiològica(RCr) valorada amb RM i resposta completa patològica (RCp), globalment i en funció dels diferents immunofenotips. Es tracta d´un estudi clínic, retrospectiu, on s´han inclòs 103 pacients tractades amb quimioteràpia neoadjuvant. Totes les pacients incloses disposaven de RM inicial i de RM post-quimioteràpia. La sensibilitat de la RM per a detectar RCp és d´un 82% i l´especificitat d´un 71%. El valor de sensibilitat més alt, del 100%, s´ha objectivat en els tumors triple negatius. La concordança global entre RCr i RCp és d´un 74%.

Empresa de mudances amb Windows Phone 8 i WPF

Aquest projecte té com a finalitat el desenvolupament d'una solució informàtica per a la gestió dels pressupostos i la facturació d'una empresa de mudances. Tota la solució es crearà amb la plataforma de desenvolupament de programari .NET.