Polymorphisms in DNA-repair genes in a cohort of prostate cancer patients from different areas in Spain: heterogeneity between populations as a confounding factor in association studies

Background: Differences in the distribution of genotypes between individuals of the same ethnicity are an important confounder factor commonly undervalued in typical association studies conducted in radiogenomics. Objective: To evaluate the genotypic distribution of SNPs in a wide set of Spanish prostate cancer patients for determine the homogeneity of the population and to disclose potential bias. Design, Setting, and Participants: A total of 601 prostate cancer patients from Andalusia, Basque Country, Canary and Catalonia were genotyped for 10 SNPs located in 6 different genes associated to DNA repair: XRCC1 (rs25487, rs25489, rs1799782), ERCC2 (rs13181), ERCC1 (rs11615), LIG4 (rs1805388, rs1805386), ATM (rs17503908, rs1800057) and P53 (rs1042522). The SNP genotyping was made in a Biotrove OpenArrayH NT Cycler. Outcome Measurements and Statistical Analysis: Comparisons of genotypic and allelic frequencies among populations, as well as haplotype analyses were determined using the web-based environment SNPator. Principal component analysis was made using the SnpMatrix and XSnpMatrix classes and methods implemented as an R package. Non-supervised hierarchical cluster of SNP was made using MultiExperiment Viewer. Results and Limitations: We observed that genotype distribution of 4 out 10 SNPs was statistically different among the studied populations, showing the greatest differences between Andalusia and Catalonia. These observations were confirmed in cluster analysis, principal component analysis and in the differential distribution of haplotypes among the populations. Because tumor characteristics have not been taken into account, it is possible that some polymorphisms may influence tumor characteristics in the same way that it may pose a risk factor for other disease characteristics. Conclusion: Differences in distribution of genotypes within different populations of the same ethnicity could be an important confounding factor responsible for the lack of validation of SNPs associated with radiation-induced toxicity, especially when extensive meta-analysis with subjects from different countries are carried out.

Row Crop Response to Topsoil Restored on Borrow Areas, HR-186, Supplemental Report, 1982

Borrow areas are created where soil is needed to provide fill for construction projects. This research evaluated (1) the changes in row crop productivity resulting from removal of soil for highway construction in Iowa and (2) restoration methods which included: depth of topsoil, subsoil tillage, manure application, and two years of legume growth prior to row cropping. The research was carried out from 1977-1981 at four locations. Corn and soybean y1elds from borrow areas have been below, equal to; and greater than yields from undisturbed, neighboring farmland. Little or no yield increase was noted from restored topsoil at coarse textured sites. At finer textured sites, a marked yield increase of both crops occurred after the addition of 6 inches of topsoil but little added yield increase resulted from restoring 12 inches of topsoil. Subsoil tillage has shown little or no beneficial effect on crop yields. The manure treatment has resulted in a corn yield increase but only in the first year after application.

Row Crop Response to Topsoil Restored on Borrow Areas, HR-186, 1982

Borrow areas are created where soil is needed to provide fill for construction projects. The changes in row-crop productivity resulting from removal of soil for highway construction in Iowa and restoration methods, which included addition to topsoil, subsoil tillage, manure application, and 2 yr of legume growth before row cropping, were evaluated. The research was carried out from 1977 to 1981 at four locations. Corn and soybean yields from borrow areas have been below, equal to, and greater than yields from undisturbed neighboring farmland. Little or no yield increase was noted from restored topsoil at coarse-textured sites. At finer-textured sites, a marked yield increase of both crops occurred after the addition of 6 in. of topsoil but little added yield increase resulted from restoring 12 in. of topsoil. Subsoil tillage has shown little or no beneficial effect on crop yields. The manure treatment has resulted in a corn yield increase but only in the first year after application.

Lossless Image Data Embedding in Plain Areas

This letter presents a lossless data hiding scheme for digital images which uses an edge detector to locate plain areas for embedding. The proposed method takes advantage of the well-known gradient adjacent prediction utilized in image coding. In the suggested scheme, prediction errors and edge values are first computed and then, excluding the edge pixels, prediction error values are slightly modified through shifting the prediction errors to embed data. The aim of proposed scheme is to decrease the amount of modified pixels to improve transparency by keeping edge pixel values of the image. The experimental results have demonstrated that the proposed method is capable of hiding more secret data than the known techniques at the same PSNR, thus proving that using edge detector to locate plain areas for lossless data embedding can enhance the performance in terms of data embedding rate versus the PSNR of marked images with respect to original image.

Choice of Optimal MembraneProcesses for Economical Treatment of Paper Machine Clear Filtrate

In this thesis membrane filtration of paper machnie clear filtrate was studied. The aim of the study was to find membrane processes which are able to produce economically water of sufficient purity from paper machine white water or its saveall clarified fractions for reuse in the paper machnie short circulation. Factors affecting membrane fouling in this application were also studied. The thesis gives an overview af experiments done on a laboratory and a pilot scale with several different membranes and membrane modules. The results were judged by the obtained flux, the fouling tendency and the permeate quality assessed with various chemical analyses. It was shown that membrane modules which used a turbulence promotor of some kind gave the highest fluexes. However, the results showed that the greater the reduction in the concentration polarisation layer caused by increased turbulence in the module, the smaller the reductions in measured substances. Out of the micro-, ultra- and nanofiltration membranes tested, only nanofiltration memebranes produced permeate whose quality was very close to that of the chemically treated raw water used as fresh water in most paper mills today and which should thus be well suited for reuse as shower water both in the wire and press section. It was also shown that a one stage nanofiltration process was more effective than processes in which micro- or ultrafiltration was used as pretreatment for nanofiltration. It was generally observed that acidic pH, high organic matter content, the presence of multivalent ions, hydrophobic membrane material and high membrane cutoff increased the fouling tendency of the membranes.

Patents in the Information and Communications Technology Sector - Development Trends, Problem Areas and Pressures for Change

The patent system was created for the purpose of promoting innovation by granting the inventors a legally defined right to exclude others in return for public disclosure. Today, patents are being applied and granted in greater numbers than ever, particularly in new areas such as biotechnology and information andcommunications technology (ICT), in which research and development (R&D) investments are also high. At the same time, the patent system has been heavily criticized. It has been claimed that it discourages rather than encourages the introduction of new products and processes, particularly in areas that develop quickly, lack one-product-one-patent correlation, and in which theemergence of patent thickets is characteristic. A further concern, which is particularly acute in the U.S., is the granting of so-called 'bad patents', i.e. patents that do not factually fulfil the patentability criteria. From the perspective of technology-intensive companies, patents could,irrespective of the above, be described as the most significant intellectual property right (IPR), having the potential of being used to protect products and processes from imitation, to limit competitors' freedom-to-operate, to provide such freedom to the company in question, and to exchange ideas with others. In fact, patents define the boundaries of ownership in relation to certain technologies. They may be sold or licensed on their ownor they may be components of all sorts of technology acquisition and licensing arrangements. Moreover, with the possibility of patenting business-method inventions in the U.S., patents are becoming increasingly important for companies basing their businesses on services. The value of patents is dependent on the value of the invention it claims, and how it is commercialized. Thus, most of them are worth very little, and most inventions are not worth patenting: it may be possible to protect them in other ways, and the costs of protection may exceed the benefits. Moreover, instead of making all inventions proprietary and seeking to appropriate as highreturns on investments as possible through patent enforcement, it is sometimes better to allow some of them to be disseminated freely in order to maximize market penetration. In fact, the ideology of openness is well established in the software sector, which has been the breeding ground for the open-source movement, for instance. Furthermore, industries, such as ICT, that benefit from network effects do not shun the idea of setting open standards or opening up their proprietary interfaces to allow everyone todesign products and services that are interoperable with theirs. The problem is that even though patents do not, strictly speaking, prevent access to protected technologies, they have the potential of doing so, and conflicts of interest are not rare. The primary aim of this dissertation is to increase understanding of the dynamics and controversies of the U.S. and European patent systems, with the focus on the ICT sector. The study consists of three parts. The first part introduces the research topic and the overall results of the dissertation. The second part comprises a publication in which academic, political, legal and business developments that concern software and business-method patents are investigated, and contentiousareas are identified. The third part examines the problems with patents and open standards both of which carry significant economic weight inthe ICT sector. Here, the focus is on so-called submarine patents, i.e. patentsthat remain unnoticed during the standardization process and then emerge after the standard has been set. The factors that contribute to the problems are documented and the practical and juridical options for alleviating them are assessed. In total, the dissertation provides a good overview of the challenges and pressures for change the patent system is facing,and of how these challenges are reflected in standard setting.

Areas de evaluación en el peritaje judicial psicológico en derecho penal: aportaciones de interés

Se hace referencia a la labor de evaluación del psicólogo forense en base a instrumentos psicométricos de uso clínico y a técnicas específicas para la medida de las habilidades cognitivas y personalidad. Al contrario de la gran cantidad de instrumentos de evaluación encontrados en la bibliografía anglosajona, en nuestro ámbito no existen apenas técnicas de evaluación psicológica válidas y fiables para ser aplicadas por el psicólogo forense, al margen de las habituales utilizadas en psicología clínica. Se ofrecen datos de varios cuestionarios para la evaluación de la personalidad desinhibida y antisocial obtenidos en muestras españolas de delincuentes y no delincuentes; los cuales pueden servir de referencia, en base a las teorías que los suscentan, para la valoración de delincuentes con fines de peritaje forense.

Tasasähkönjakelun käyttöpotentiaalin määrittäminen

Sähkönjakeluverkkojen kehittäminen nykyistä käyttövarmemmiksi ja taloudellisemmiksi vaatii jatkuvasti uusia ratkaisumalleja. Lupaavaksi tekniikaksi sähkönjakeluverkkojen kehittämisessä on osoittautumassa tasasähkönjakelu tehoelektronisten komponenttien kehittyessä ja hintojen laskiessa samanaikaisesti. Pienjännitedirektiivi mahdollistaa tasajännitteen myötä aiempaa suurempien jännitteiden käytön pienjänniteverkoissa. Tasajännitteen käytöllä voidaan saavuttaa etuja mm. tehonsiirtokyvyssä, sähkönlaadussa, käyttövarmuudessa sekä kustannuksissa. Työssä tehdään yksityiskohtaisia teknistaloudellisia tarkasteluja perinteistä 20/0,4 kV tekniikkaa, 1000 V sähkönjakelua sekä tasasähköjärjestelmiä hyödyntäen ja verrataan näiden järjestelmien kustannuksia ja ominaisuuksia toisiinsa. Tutkimusalueet on valittu Fortum Sähkönsiirto Oy:n maaseutu- ja taajamaverkoista. Työssä pyritään hahmotta-maan teknistaloudellista käyttöaluetta eri tasasähkönjakelujärjestelmille sekä määrittä-mään tasasähkönjakelun käyttöpotentiaali tutkimuskohteena olleissa verkoissa. Lisäksi tutkitaan eri tekijöiden vaikutuksia tasasähköjakelun kannattavuuteen ja käyttövarmuu-teen sekä pyritään tuomaan esiin muitakin tasasähkönjakelujärjestelmien ominaisuuksia.

Representation of Sound Objects within Early-Stage Auditory Areas: A Repetition Effect Study Using 7T fMRI.

Environmental sounds are highly complex stimuli whose recognition depends on the interaction of top-down and bottom-up processes in the brain. Their semantic representations were shown to yield repetition suppression effects, i. e. a decrease in activity during exposure to a sound that is perceived as belonging to the same source as a preceding sound. Making use of the high spatial resolution of 7T fMRI we have investigated the representations of sound objects within early-stage auditory areas on the supratemporal plane. The primary auditory cortex was identified by means of tonotopic mapping and the non-primary areas by comparison with previous histological studies. Repeated presentations of different exemplars of the same sound source, as compared to the presentation of different sound sources, yielded significant repetition suppression effects within a subset of early-stage areas. This effect was found within the right hemisphere in primary areas A1 and R as well as two non-primary areas on the antero-medial part of the planum temporale, and within the left hemisphere in A1 and a non-primary area on the medial part of Heschl's gyrus. Thus, several, but not all early-stage auditory areas encode the meaning of environmental sounds.

Merituulivoiman kannattavuus Kokkolan seudun rannikolla

Tässä diplomityössä selvitetään teollisen mittakaavan merituulipuistojen taloudellisia ja osin myös teknisiä rakentamisedellytyksiä Kokkolan seudun rannikolla. Lisäksi työssä tarkastellaan erilaisten tukitoimien vaikutusta tuulivoiman kannattavuuteen sekä selvitetään lyhyesti merituulivoiman hallinnollisia ja oikeudellisia edellytyksiä. Esimerkkikohteina tarkastellaan viittä Kokkolan edustalle suunniteltua merituulipuistoa, joiden tehot ovat 20 – 100 MW ja yksikkökoot 1,8 – 5 MW. Tuulipuistojen tuuliolot on arvioitu läheisten mittauspisteiden tietojen perusteella ja niiden pohjalta on laskettu puistojen energiantuotto. Tuulivoimaloiden huipunkäyttöajoiksi on saatu noin 2400 – 2500 h/a. Puistojen investointikustannukset ovat noin 6 500 –10 200 mk/kW: itse turbiinin lisäksi suurimpia kustannuseriä ovat perustukset ja sähköverkkoliitäntä. Vuosittaisten käyttö- ja kunnossapitokustannusten suuruudeksi on arvioitu noin 3 % investointikustannuksista. Kannattavuustarkastelut on suoritettu 5 % laskentakorolla ja 25 vuoden pitoajalle. Tuotantokustannukset ovat ilman tukia noin 27 – 38 p/kWh. Kun sähkön hintana on 150 mk/MWh, ei taloudellista kannattavuutta voida saavuttaa edes nykyisin käytössä olevan investointi- ja tuotantotuen avulla. Tuulisähköstä saatava mahdollinen ”vihreän sähkön lisä” tai päästökaupan aloittaminen voisivat mahdollistaa tuulivoiman taloudellisen kannattavuuden myös silloin, kun sähkön hintataso on matala. Kannattavuutta voitaisiin parantaa myös tukijärjestelmällä, joka painottaa nykyistä enemmän tuotantoa.

Innovative implementation by non-state actors in environment-related areas : towards a positive implementation gap ?

This contribution (presented in the first International Conference on Public Policy (ICPP) in Grenoble in June 2013) explores the phenomena of innovation in action ("innovative implementation"). To do so, we operationalize "innovative implementation" as a strategy by which (coalitions of) non-state actors seek to develop ad hoc solutions to address a given environmental issue, going beyond what is provided for in formal policy designs. Following an inductive research strategy, we elaborate a conceptual framework whose main advantage is to bring the actors and their coalition (in all their diversity) back in the analysis. More concretely, we state that perceiving implementation as broader 'social interaction processes' (De Boer & Bressers 2011) within which actors play strategic 'games' (Bardach 1977, Scharpf 1997) opens interesting lines of research to better account for their innovative and strategic behaviours. In a second step, we apply this framework to three strategies of innovative implementation in different contexts, and identify on this basis empirical regularities in the individual pathways related to the emergence and success (or failure) of these strategies.

A Large-Sized Multiwire Proportional Counter for Radiological Survey of Large Areas and Surfaces

Työn tavoitteena oli selvittää, miten eri parametrit vaikuttavat monilankaisen verrannollisuuslaskurin laskennallisiin ominaisuuksiin sekä voidaanko suurikokoista monilankaverrannollisuuslaskuria käyttää tehokkaasti suurien pintojen ? - ja ?- kontaminaation mittaamiseen. Ensin selvitettiin EU:n nykyistä clearing-käytäntöä sekä hahmoteltiin tulevia materiaalivirtoja, esiteltiin verrannollisuuslaskurin ja sen monilankamallin toimintaperiaate sekä käytettävien materiaalien ominaisuudet. Kootun teorian pohjalta selvitettiin tärkeimpien parametrien vaikutus ilmaisimen laskennallisiin ominaisuuksiin. Lopuksi suoritettiin rakenteilla olevan monilankaverrannollisuuslaskurin alustava testaus. Tulevien vuosien aikana eri puolilla maailmaa suljettavat erityyppiset ydinlaitokset luovat suuren tarpeen tehokkaiden kontaminaatiomittauslaitteistojen kehittämiselle. Tällä hetkellä mittaukset suoritetaan lähinnä noin 1 dm2 käsi-instrumentein, joten suurikokoinen, automatisoitu mittauslaitteisto sekä tehostaisi mittausprosessia suuresti sekä säästäisi runsaasti miestyötunteja. Jatkotoimenpiteiksi ehdotetaan laitteiston jatkotestausta, liikkeen ja nopeuden testausta sekä lopulta paikkaherkkyystoiminnon toteuttamisperiaatteen valintaa ja testausta.