Cass. sez. un. 20596-07 Caso oggetto di discussione il 3 aprile 2008

Quesito (entro il 3 aprile 2008): "Il provvedimento del giudice che concede/sospende (ex artt. 648-649 c.p.c.) la provvisoria esecutività del decreto ingiuntivo opposto è sottoponibile a forme di riesame o revocabile?"

Exploring the use of local binary patterns as focus measure

[EN]In this work local binary patterns based focus measures are presented. Local binary patterns (LBP) have been introduced in computer vision tasks like texture classification or face recognition. In applications where recognition is based on LBP, a computational saving can be achieved with the use of LBP in the focus measures. The behavior of the proposed measures is studied to test if they fulfill the properties of the focus measures and then a comparison with some well know focus measures is carried out in different scenarios.

La terminologia informatica e di internet in spagnolo: Problemi e soluzioni nel foro tic del centro virtual cervantes

La terminologia informatica e di Internet in spagnolo è caratterizzata da una forte instabilità lessicale e semantica. La grande presenza di anglicismi che si creano con enorme rapidità, impedisce il corretto processo di incorporazione di tali termini nello spagnolo, favorendo così la convivenza di lessico inglese e termini solo parzialmente adattati alla lingua spagnola, dei quali spesso non si conosce l'esatto significato. I traduttori che operano in queste aree linguistiche, così come gli informatici e tutti gli interessati al corretto utilizzo di questa terminologia, per risolvere le problematiche che incontrano, fanno uso oggi soprattutto di risorse online più facilmente aggiornabili ed accessibili rispetto ai classici dizionari cartacei. Tra queste, sono molto importanti gli spazi che permettono la collaborazione diretta tra professionisti del settore, che favoriscono un approccio dinamico e contestuale nella risoluzione di tali dubbi. Il Foro Tic del Centro Virtual Cervantes, dedicato alla discussione su tale linguaggio, raccoglie interessanti dibattiti sull'argomento.

Tradurre la letteratura: "El Camino" di Miguel Delibes

L’oggetto di questo elaborato è la proposta di traduzione di due capitoli del romanzo El camino dello scrittore spagnolo Miguel Delibes. Questo autore, sebbene sia pressoché sconosciuto in Italia, in Spagna ha ottenuto numerosi riconoscimenti letterari, tra cui il Premio de Literatura en Lengua Castellana “Miguel de Cervantes”. La scelta di traduzione è ricaduta su El camino in quanto esso è uno dei libri di Delibes più acclamati dalla critica. Infatti, in questo romanzo si mescolano insieme essenzialità stilistica, precisione e ricchezza lessicale per creare un vero e proprio esempio di realismo poetico. Come conseguenza, le peculiarità dello stile di Miguel Delibes impongono al traduttore interessanti scelte di resa e gli consentono di mettere in gioco la propria creatività nella traduzione dei tanti nomi parlanti dell’originale. Nel primo capitolo viene offerta una panoramica sulla figura e sull’ opera di Miguel Delibes, nel secondo si prendono in esame le caratteristiche de El camino, nel terzo si propone la traduzione dei capitoli III e XXI e, infine, nel quarto vengono discusse e commentate le principali difficoltà di traduzione.

First-line temozolomide combined with bevacizumab in metastatic melanoma: a multicentre phase II trial (SAKK 50/07)

Oral temozolomide has shown similar efficacy to dacarbazine in phase III trials with median progression-free survival (PFS) of 2.1 months. Bevacizumab has an inhibitory effect on the proliferation of melanoma and sprouting endothelial cells. We evaluated the addition of bevacizumab to temozolomide to improve efficacy in stage IV melanoma.

Predictive value of the MGMT promoter methylation status in metastatic melanoma patients receiving first-line temozolomide plus bevacizumab in the trial SAKK 50/07

The O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive parameter for the response of malignant gliomas to alkylating agents such as temozolomide. First clinical trials with temozolomide plus bevacizumab therapy in metastatic melanoma patients are ongoing, although the predictive value of the MGMT promoter methylation status in this setting remains unclear. We assessed MGMT promoter methylation in formalin-fixed, primary tumor tissue of metastatic melanoma patients treated with first-line temozolomide and bevacizumab from the trial SAKK 50/07 by methylation-specific polymerase chain reaction. In addition, the MGMT expression levels were also analyzed by MGMT immunohistochemistry. Eleven of 42 primary melanomas (26%) revealed a methylated MGMT promoter. Promoter methylation was significantly associated with response rates CR + PR versus SD + PD according to RECIST (response evaluation criteria in solid tumors) (p<0.05) with a trend to prolonged median progression-free survival (8.1 versus 3.4 months, p>0.05). Immunohistochemically different protein expression patterns with heterogeneous and homogeneous nuclear MGMT expression were identified. Negative MGMT expression levels were associated with overall disease stabilization CR+PR+SD versus PD (p=0.05). There was only a poor correlation between MGMT methylation and lack of MGMT expression. A significant proportion of melanomas have a methylated MGMT promoter. The MGMT promoter methylation status may be a promising predictive marker for temozolomide therapy in metastatic melanoma patients. Larger sample sizes may help to validate significant differences in survival type endpoints.

Azacytidine for acute myeloid leukemia in elderly or frail patients: A phase II trial (SAKK 30/07)

Abstract This phase II trial treated elderly or frail AML patients with single agent subcutaneous azacytidine at 100 mg/m(2), on 5 of 28 days for up to 6 cycles. Treatment was stopped for lack of response, or continued to progression in responders. Primary endpoint was response within 6 months. A response rate >34% was considered a positive trial outcome. From 9/2008-4/2010, 45 patients from 10 centres (median age 74 (55-86) years) were accrued. Patients received 4 (1-21) cycles. Best response was CR/CRi in 8 (18%; 95% CI: 8%-32%.), 0 (0%) PR, 7 (16%) hematologic improvement, 17 (38%) stable disease. Three nonresponding patients stopped treatment after 6 cycles, 31 patients had stopped early and 11 patients continued treatment for 8-21 cycles. Adverse events (grade >III) were infections (13), febrile neutropenia (14), thrombocytopenia (7), dyspnea (6), bleeding (5) and anemia (4 patients). Median overall survival was 6 months. Peripheral blood blast counts, grouped at 30% had a borderline significant association with response (p = 0.07). This modified azacytidine schedule is feasible for elderly or frail AML patients in an outpatient setting with moderate, mainly hematologic, toxicity and response in a proportion of patients, although the primary objective was not reached.

Efficacy of cetuximab in metastatic castration-resistant prostate cancer might depend on EGFR and PTEN expression: results from a phase II trial (SAKK 08/07)

The EGF receptor (EGFR) is overexpressed in the majority of metastatic castration-resistant prostate cancers (mCRPC) and might represent a valid therapeutic target. The combination of docetaxel and cetuximab, the monoclonal antibody against EGFR, has not been tested in patients with prostate cancer.

Dynamic Languages and Applications. Report on the Workshop Dyla 07 at ECOOP 2007

Following last two years’ workshop on dynamic languages at the ECOOP conference, the Dyla 2007 workshop was a successful and popular event. As its name implies, the workshop’s focus was on dynamic languages and their applications. Topics and discussions at the workshop included macro expansion mechanisms, extension of the method lookup algorithm, language interpretation, reflexivity and languages for mobile ad hoc networks. The main goal of this workshop was to bring together different dynamic language communities and favouring cross communities interaction. Dyla 2007 was organised as a full day meeting, partly devoted to presentation of submitted position papers and partly devoted to tool demonstration. All accepted papers can be downloaded from the workshop’s web site. In this report, we provide an overview of the presentations and a summary of discussions.