Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.

Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) as a putative genetic risk factor for MS. Genotyping of PLG p.G420D (rs139071351) in 2160 MS patients, and 886 controls from Canada, identified 10 additional probands, two sporadic patients and one control with the variant. Segregation in families harboring the rs139071351 variant, identified p.G420D in 26 out of 30 family members diagnosed with MS, 14 unaffected parents, and 12 out of 30 family members not diagnosed with disease. Despite considerably reduced penetrance, linkage analysis supports cosegregation of PLG p.G420D and disease. Genotyping of PLG p.G420D in 14446 patients, and 8797 controls from Canada, France, Spain, Germany, Belgium, and Austria failed to identify significant association with disease (P = 0.117), despite an overall higher prevalence in patients (OR = 1.32; 95% CI = 0.93-1.87). To assess whether additional rare variants have an effect on MS risk, we sequenced PLG in 293 probands, and genotyped all rare variants in cases and controls. This analysis identified nine rare missense variants, and although three of them were exclusively observed in MS patients, segregation does not support pathogenicity. PLG is a plausible biological candidate for MS owing to its involvement in immune system response, blood-brain barrier permeability, and myelin degradation. Moreover, components of its activation cascade have been shown to present increased activity or expression in MS patients compared to controls; further studies are needed to clarify whether PLG is involved in MS susceptibility.

The letters of Dorothy Wadham, 1609-1618;

Mode of access: Internet.

Il salvatore co'dodici apostoli dappresso Raffaelle D'Vrbino : dipinti nella chiesa de' SS. Vincenzo ed Anastasio alle tre fontane fvori di porta S. Paolo e svlle stampe di Marcantonio /

Cover title.

Complexion : Natür vnd Eigenschafft eines yeden Menschen zü erfaren, auch seiner Gebürtstund vnnd Zeychen, ... auss zü rechnen.

Signatures: A-D⁴ (16 leaves).

Ḥabīb-i siyar jild al-thānī, [1026, i.e. 1617].

This is the second of three volumes which comprise Khvandemīr's well known and important general history, completed in 929/1523, which spans the creation of the world up to the death of Shah Ismāʻīl Safavī I. The work includes particularly detailed information about Herat under Sultan Husayn Bayqara, the last Timurid ruler in Herat, as well as Shah Ismāʻīl and Bābur's life. This work has been published in both Persian and English editions.

Peder Månssons Skrifter på svenska; efter handskrifter i Sockholm, Uppsala och Linköping, med en inledning utgifna

The originals (if any) of the 5th and 7th-12th treatises are unknown. cf. Inledning.

Melanchthons Briefwechsel : Kritische und kommentierte Gesamtausgabe /

Bd. T 1. Texte 1-254 (1514-1522) -- Bd. T 2. Texte 255-520 (1523-1526) -- Bd. T 3. Texte 521-858 (1527-1529) -- Bd. T 5 Texte 1110-1394 (1531-1533) -- Bd. T 6. Texte 1395-1683 (1534-1535) -- Bd. T.7. Texte 1684-1979 (1536-1537) -- T.13. Texte 3421-3779 (1544) -- T.16. Texte 4530-4790 (Januar-Juni 1547).

Sefer Shaʻar ha-yiḥudim ; ṿe-Sefer Tsadiḳ yesod ʻolam : mayim ḳedoshim mi-peleg Eloḳim /

Reprint, with new introduction. Originally published: Lemberg : Leib Rappaport, 1855.

Biographie de Thierry Martens d'Alost, premier imprimeur de la Belgique, suivie de la bibliographie de ses éditions,

"Cantate compos"ee pour l'inauguration de la statue de Thierry Martens," 3 l. at end.

Fernando de Herrera : poesías /

Mode of access: Internet.

The visitation of Cheshire in the year 1580,

Mode of access: Internet.

Archiv für schweizerische reformations-geschichte.

"Durch die direction: graf Theodor Scherer-Boccard ... Friedrich Fiala ... [und] Peter Bannwart."

Hoc in volumine haec continentur Artificialis medicatio, constans paraphrasi in Galeni Librum de Artis Medicae Constitutione /

Mode of access: Internet.

Histoire générale des voyages, ou, Nouvelle collection de toutes les relations de voyages par mer et par terre, qui ont été publiées jusqu'à présent dans les différentes langues de toutes les nations connues : ce qui'il y a de plus remarquable, de plus utile et de mieux averé dans les pays ou les voyageurs ont penetré, avec les moeurs des habitans, la religion, les usages, arts, sciences, commerce, manufactures, &c, pour former un systême complet d'histoire & de géographie moderne, qui représente l'état actuel de toutes les nations : enrichi de cartes géographiques et de figures; Tome quarante-neuviéme.

Contiene: Avertissement. - Approbation. - Troisieme partie, Livre sixieme, Suite des voyages, des découvertes, & des etablissemens en Amérique. [Se incluyen los relatos de Verazzani 1523, Cartier 1534-40, Pizarre 1526, 1531-34, Almagro 1535, Pizarre 1538-41, Vacca de Castro 1541-42, Nuñez de Vela 1543-46].

Antonii Posseuini Societatis Iesu Christiana methodus ad Iurisprudentiam ex selecta autoris bibliotheca ratio verae politiae expenditur.

Mode of access: Internet.