996 resultados para 04081423 CTD-56


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通过 4 1 0MeV82 Se轰击天然Ba靶引起的深部非弹反应布居产生了类弹和类靶余核的激发态 ,利用在束γ谱学方法测量了它们的退激γ .通过γ -γ符合测量估计了类弹、类靶余核激发态的产生截面 ,在多个类靶余核中观测到了新γ跃迁 ,并建立了136 Ba的新能级纲图 ,说明利用深部非弹反应研究Z≈ 56,N≈ 80区高自旋态是有效、可行的

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根据1951—2006年的气温和降水资料,研究了干旱少雨、生态环境脆弱、土地荒漠化严重的科尔沁沙地近56年的气候变化特征。结果表明:1951—2006年,科尔沁沙地的气温以0.28℃.10a-1的速度上升,远大于全球近50年来0.13℃.10a-1的平均增温速率;各季节气温都呈上升趋势,冬、春季增温速率极显著(P<0.001),增温速率分别为0.46和0.39℃.10a-1;年最高气温(0.17℃.10a-1)与年最低气温(0.42℃.10a-1)均呈极显著地增加趋势(P<0.01);降水量年际间波动较大,无明显的变化趋势,各季节降水量也没有明显的变化规律;年降水日数呈显著减少趋势(1.3d.10a-1),各季的降水日数虽都有逐年减少趋势,但没有达到显著水平;年降水强度和各季降水强度都没有明显的变化规律;年总小雨日数呈显著的减少趋势(P<0.05),减少速率为1.0d.10a-1。

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利用聚乙烯醇-海藻酸钠(PVA-Na.A lg)联合包埋固定化一株黄杆菌O il-56,进行污染地表水修复实验研究,结果表明固定化细菌的修复效果明显好于游离细菌。同时利用扫描电子显微镜观察了固定化颗粒内部细菌形态的变化,解释了由于Na.A lg溶解导致水体CODC r升高的原因,并分析了固定化颗粒传质扩散性能的缺陷,指出PVA-Na.A lg固定化工艺尚需改进。

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In the presence of 1,10-phenanthroline (phen), lanthanide chlorides LnCl3 reacted with cyclopentadienylsodium to give the novel complexes [Na.3phen]+[Ln(C5H5)3Cl]-.phen (Ln = La, Pr or Nd). In the praseodymium case, crystal structure analysis showed that

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Practice Links is a free e-publication for practitioners working in Irish social services, voluntary and nongovernmental sectors. Practice Links was created to enable practitioners to keep up-to-date with new publications, electronic resources and conference opportunities. Issue 56 includes listings for upcoming conferences, resources, recent policy reports as well as reviews of publications.

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BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.

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We present the results of BVRIZ photometry of 56 near-Earth objects (NEOs) obtained with the 1-m Jacobus Kapteyn telescope on La Palma during 2000 and 2001. Our sample includes many NEOs with particularly deep 1 - mum pyroxene/olivine absorption bands, similar to Q-type asteroids. We also classify three NEOs with particularly blue colors. No D-type asteroids were found, placing an upper limit of similar to2% on the fraction of the NEO population originating in the outer main belt or the Trojan clouds. The ratio of dark to bright objects in our sample was found to be 0.40, significantly higher than current theoretical predictions. As well as classifying the NEOs, we have investigated color trends with size and orbit. We see a general trend for larger silicate objects to have shallower absorption bands but find no significant difference in the distribution of taxonomic classes at small and large sizes. Our data clearly show that different taxonomic classes tend to occupy different regions of (a, e) space. By comparing our data with current model predictions for NEO dynamical evolution we see that Q- R-, and V-type NEOs tend to have orbits associated with "fast track" delivery from the main belt, whereas S-type NEOs tend to have orbits associated with "slow track" delivery. This outcome would be expected if space weathering occurs on time scales of >10(6) years. (C) 2003 Elsevier Science (USA). All rights reserved.