929 resultados para Rectifying Potassium Channels
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Stream degradation due to steep stream gradients and large deposits of loess soil is a serious problem in western Iowa. One solution to this problem is to construct grade stabilization structures at critical points along the length of the stream. Iowa Highway Research Board project HR-236, "Pottawattamie County Evaluation of Control Structures for Stabilizing Degrading Stream Channels", was initiated in order to study the effectiveness of such structures in preventing stream degradation. This report describes the construction and 4-year performance of a gabion drop structure constructed along Keg Creek during the winter of 1982-83.
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With the objective of studying the effect of increasing phosphorus and potassium doses on the agronomical and technological characteristics of the cotton (Gossypium hirsutum L.), cultivar IAC 20, an experiment was carried out during 1994/95 on a Red-Dark Latossol at the Embrapa-Centro de Pesquisa Agropecuária do Oeste (CPAO) in Ponta Porã, MS, Brazil. A randomized bloch design was used in a 3 x 5 factorial arrangement with four replications. The doses were 30, 60 and 90 kg ha-1 of P2O5, applied as triple superphosphate, and 0, 30, 60, 90 and 120 kg ha-1 of K2O as KCl. The K2O doses used had a significant influence on the seed cotton yield, plant height and weight of 100 seeds and of bolls.
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An experiment was conducted to determine the fruit size, mineral composition and quality of trickle-irrigated tomatoes as affected by potassium fertilizer rates. Six potassium (K) rates were applied as KCl, corresponding to 0, 48.4, 118.6, 188.8, 259.0 and 399.4 kg ha-1, with four replicates, following a randomized block design. Quadratic responses to K rates were observed for double extra large (diameter > 60 mm), extra large (56 to 60 mm) and large (52 to 56 mm) fruit yields. Maximum yields of these classes were achieved with K rates of 116, 190 and 233 kg ha-1, respectively. Fruit dry matter, phosphorus, sulfur and magnesium contents were not affected by K rates, but nitrate and K contents showed significant increments as K rates were increased. Vitamin C, total soluble solids, lycopene and beta-carotene contents in the fruits were not affected by K rates. Increments in the K rate lowered the fruit pH and increased total acids content.
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Tomato (Lycopersicon esculentum Mill.) cv. Santa Clara was grown on a silt clay soil with 46 mg dm-3 Mehlich 1 extractable K, to evaluate the effects of trickle-applied K rates on fruit yield and to establish K critical concentrations in soil and in plant petioles. Six potassium rates (0, 48, 119, 189, 259 and 400 kg ha-1 K) were applied in a randomized complete block design with four replications. Soil and plant K critical levels were determined at two plant growth stages (at the beginning of the second and fourth cluster flowering). Total, marketable and weighted yields increased with K rates, reaching their maximum of 86.4, 73.4, and 54.9 ton ha-1 at 198, 194, and 125 kg ha-1 K , respectively. At the first soil sampling date K critical concentrations in the soil associated with K rates for maximum marketable and weighted yields were 92 and 68 mg dm-3, respectively. Potassium critical concentrations in the dry matter of the petioles sampled by the beginning of the second and fourth cluster flowering time, associated with maximum weighted yield, were 10.30 and 7.30 dag kg-1, respectively.
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Tiivistelmä: Kuusen neulasanalyyttinen kaliumravitsemuksen arviointi eri vuodenaikoina
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INTRODUCTION: The evaluation of a new drug in normotensive volunteers provides important pharmacodynamic and pharmacokinetic information as long as the compound has a specific mechanism of action which can be evaluated in healthy subjects as well as in patients. The purpose of the present paper is to discuss the results that have been obtained in normal volunteers with the specific angiotensin II receptor antagonist, losartan potassium. DOSE-FINDING: Over the last few years, studies in normotensive subjects have demonstrated that the minimal dose of losartan that produces maximal efficacy is 40-80 mg. Losartan has a long duration of action and its ability to produce a sustained blockade of the renin-angiotensin system is due almost exclusively to the active metabolite E3174. HORMONAL EFFECTS: Angiotensin II receptor blockade with losartan induces an expected increase in plasma renin activity and plasma angiotensin II levels. A decrease in plasma aldosterone levels has been found only with a high dose of losartan (120 mg). RENAL AND BLOOD PRESSURE EFFECTS: In normotensive subjects, losartan has little or no effect on blood pressure unless the subjects are markedly salt-depleted. Losartan causes no change in the glomerular filtration rate and either no modification or only a slight increase in renal blood flow. Losartan significantly increases urinary sodium excretion, however, and surprisingly produces a transient rise in urinary potassium excretion. Finally, losartan increases uric acid excretion and lowers plasma uric acid levels. CONCLUSIONS: These results suggest that losartan is an effective angiotensin II receptor antagonist in normal subjects. Its safety and clinical efficacy in hypertensive patients will be addressed in large clinical trials.
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Selostus: Natriumpitoisuuden pienentäminen lihavalmisteissa korvaamalla natriumfosfaatti kaliumfosfaatilla
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Since the turn of the century, tributaries to the Missouri River in western Iowa have entrenched their channels to as much as six times their original depth. This channel degradation is accompanied by widening as the channel side slopes become unstable and landslides occur. The deepening and widening of these streams have endangered about 25% of the highway bridges in 13 counties [Lohnes et al. 1980]. Grade stabilization structures have been recommended as the most effective remedial measure for stream degradation [Brice et al., 1978]. In western Iowa, within the last seven years, reinforced concrete grade stabilization structures have cost between $300,000 and $1,200,000. Recognizing that the high cost of these structures may be prohibitive in many situations, the Iowa Department of Transportation (Iowa DOT) sponsored a study at Iowa State University (ISU) to find low-cost alternative structures. This was Phase I of the stream degradation study. Analytical and laboratory work led to the conclusion that alternative construction materials such as gabions and soil-cement might result in more economical structures [Lohnes et al. 1980]. The ISU study also recommended that six experimental structures be built and their performance evaluated. Phase II involved the design of the demonstration structures, and Phase III included monitoring and evaluating their performance.
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Since the beginning of channel straightening at the turn of the century, the streams of western Iowa have degraded 1.5 to 5 times their original depth. This vertical degradation is often accompanied by increases in channel widths of 2 to 4 times the original widths. The deepening and widening of these streams has jeopardized the structural safety of many bridges by undercutting footings or pile caps, exposing considerable length of piling, and removing soil beneath and adjacent to abutments. Various types of flume and drop structures have been introduced in an effort to partially or totally stabilize these channels, protecting or replacing bridge structures. Although there has always been a need for economical grade stabilization structures to stop stream channel degradation and protect highway bridges and culverts, the problem is especially critical at the present time due to rapidly increasing construction costs and decreasing revenues. Benefits derived from stabilization extend beyond the transportation sector to the agricultural sector, and increased public interest and attention is needed.
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The epithelial Na(+) channel (ENaC) and the acid-sensing ion channels (ASICs) form subfamilies within the ENaC/degenerin family of Na(+) channels. ENaC mediates transepithelial Na(+) transport, thereby contributing to Na(+) homeostasis and the maintenance of blood pressure and the airway surface liquid level. ASICs are H(+)-activated channels found in central and peripheral neurons, where their activation induces neuronal depolarization. ASICs are involved in pain sensation, the expression of fear, and neurodegeneration after ischemia, making them potentially interesting drug targets. This review summarizes the biophysical properties, cellular functions, and physiologic and pathologic roles of the ASIC and ENaC subfamilies. The analysis of the homologies between ENaC and ASICs and the relation between functional and structural information shows many parallels between these channels, suggesting that some mechanisms that control channel activity are shared between ASICs and ENaC. The available crystal structures and the discovery of animal toxins acting on ASICs provide a unique opportunity to address the molecular mechanisms of ENaC and ASIC function to identify novel strategies for the modulation of these channels by pharmacologic ligands.
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Abstract
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A lysimeter experiment was carried out with sugarcane aiming to evaluate the leaching of nitrogen derived from either urea (15N) or the soil/sugarcane crop residues. The leaching of K+, Ca2+, and Mg2+ was also evaluated. The experiment was a factorial 2x4. The influencing factors were: firstly, the differential addition of two kinds of sugarcane remains to the soil, simulating conditions of cane- plantation renewal after the cane crop harvest, with and without previous straw removal by burning; secondly, four doses of N: 0, 30, 60, and 90 kg ha-1. During the experimental period the total volume of water received by the sugarcane-soil system was 2,015 mm, with 1,255 mm as precipitation and 760 mm as irrigation. The loss of N by leaching from the fertilizer (15N) was not detected. In the first three weeks the largest losses of N by leaching occurred, originating from the soil/sugarcane remains-N. The mean of leached N during the experimental period of 11 months was of 4.5 kg ha-1. The mean losses of K+, Ca2+, and Mg2+ were of 13, 320 and 80 kg ha-1, respectively.
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Cotton (Gossypium hirsutum) is known to have a high requirement for K and to be very sensitive to low soil pH. Most of K reaches plant roots by diffusion in the soil. As K interacts with Ca and Mg, liming can interfere in K movement in the soil, affecting eventually the plant nutrition. The objective of this work was to study the effect of dolomitic lime and 0, 15, 30, 45 and 60 g kg-1 of K on the supply of K to cotton roots. Cotton plants were grown up to 40 days in 5 L pots containing a Dark Red Latosol (Typic Haplusthox) with 68% and 16% of sand and clay, respectively. There was an increase in dry matter yields and in K accumulation due to K fertilization. Root interception of soil K was also increased by K application, but was not affected by lime. Mass flow and diffusion increased linearly with K levels up to 60 mg kg-1, in pots with lime. In pots without lime the amount of K reaching the roots by diffusion increased up to 45 mg kg-1, but decreased at the highest K level. Accordingly, there was more K reaching the roots through mass flow at the highest K level. This happened because there were more fine roots in pots without lime, at the highest K level. As the roots grew closer, there was a stronger root competition leading to a decrease in the amount of K diffused to cotton roots.
Sweet orange trees grafted on selected rootstocks fertilized with nitrogen, phosphorus and potassium
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The majority of citrus trees in Brazil are grafted on 'Rangpur lime' (Citrus limonia Osb.) rootstock. Despite its good horticultural performance, search for disease tolerant rootstock varieties to improve yield and longevity of citrus groves has increased. The objective of this work was to evaluate yield efficiency of sweet oranges on different rootstocks fertilized with N, P, and potassium. Tree growth was affected by rootstock varieties; trees on 'Swingle' citrumelo [Poncirus trifoliata (L.) Raf. × C. paradisi Macf.] presented the smallest canopy (13.3 m³ in the fifth year after tree planting) compared to those on 'Rangpur lime' and 'Cleopatra' mandarin [C. reshni (Hayata) hort. ex Tanaka] grown on the same grove. Although it was observed an overall positive relationship between canopy volume and fruit yield (R² = 0.95**), yield efficiency (kg m-3) was affected by rootstocks, which demonstrated 'Rangpur lime' superiority in relation to Cleopatra. Growth of citrus trees younger than 5-yr-old might be improved by K fertilization rates greater than currently recommended in Brazil, in soils with low K and subjected to nutrient leaching losses.
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A parametric procedure for the blind inversion of nonlinear channels is proposed, based on a recent method of blind source separation in nonlinear mixtures. Experiments show that the proposed algorithms perform efficiently, even in the presence of hard distortion. The method, based on the minimization of the output mutual information, needs the knowledge of log-derivative of input distribution (the so-called score function). Each algorithm consists of three adaptive blocks: one devoted to adaptive estimation of the score function, and two other blocks estimating the inverses of the linear and nonlinear parts of the channel, (quasi-)optimally adapted using the estimated score functions. This paper is mainly concerned by the nonlinear part, for which we propose two parametric models, the first based on a polynomial model and the second on a neural network, while [14, 15] proposed non-parametric approaches.