400 resultados para Pursiainen, Pirjo
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Kirjallisuusarvostelu
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Kirjallisuusarvostelu
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Número extraordinario 2006, con el título: PISA. Programa para la Evaluación Internacional de Alumnos. Resumen basado en el de la publicación
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When newly immigrated children and young people begin school in Sweden, certain challengesarise. These may result from weak Swedish-language skills and different schooling backgrounds,as well as organizational and pedagogical limitations in the schools. This generates demands onschool leaders to lead and develop the organization and teachers competences to meet these pupils’needs. This situation was behind the initiation of the project “New Immigrants and Learning—Competence Development for Teachers and School Principals.” The project ran in schools infour Swedish municipalities, its aim was to develop leadership, organizational and pedagogicalskills that would facilitate the schooling and integration of newly arrived pupils. This article aimsto describe and discuss a Participant Action Research (PAR) based on a think tank and researchcircles, drawing special attention to the role of the school leaders. It will also examine whether theresearch circles and the project overall served to develop educational and intercultural leadership,organizational conditions, collegial learning, pedagogical methods and competence in terms ofschooling for this pupil group.
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PURPOSE Glucagon-like peptide-1 receptor (GLP-1R) is a molecular target for imaging of pancreatic beta cells. We compared the ability of [Nle(14),Lys(40)(Ahx-NODAGA-(64)Cu)NH2]-exendin-4 ([(64)Cu]NODAGA-exendin-4) and [Nle(14),Lys(40)(Ahx-NODAGA-(68)Ga)NH2]-exendin-4 ([(68)Ga]NODAGA-exendin-4) to detect native pancreatic islets in rodents. PROCEDURES The stability, lipophilicity and affinity of the radiotracers to the GLP-1R were determined in vitro. The biodistribution of the tracers was assessed using autoradiography, ex vivo biodistribution and PET imaging. Estimates for human radiation dosimetry were calculated. RESULTS We found GLP-1R-specific labelling of pancreatic islets. However, the pancreas could not be visualised in PET images. The highest uptake of the tracers was observed in the kidneys. Effective dose estimates for [(64)Cu]NODAGA-exendin-4 and [(68)Ga]NODAGA-exendin-4 were 0.144 and 0.012 mSv/MBq, respectively. CONCLUSION [(64)Cu]NODAGA-exendin-4 might be more effective for labelling islets than [(68)Ga]NODAGA-exendin-4. This is probably due to the lower specific radioactivity of [(68)Ga]NODAGA-exendin-4 compared to [(64)Cu]NODAGA-exendin-4. The radiation dose in the kidneys may limit the use of [(64)Cu]NODAGA-exendin-4 as a clinical tracer.
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Acknowledgements This paper belongs to the studies carried out by Kuopio Birth Cohort consortium (www.KuBiCo.fi). We thank Ms Pirjo Hänninen for expert laboratory assistance at University of Eastern Finland, Ms Margaret Fraser, Dr Panagiotis Filis and the Proteomics Core Facility at the University of Aberdeen for their expert assistance. We also thank the staff of the Department of Obstetrics and Gynaecology in Kuopio University Hospital for skilful collection of these specimens. This work was supported by the Academy of Finland [122859/2007], the Helena Vuorenmies Foundation, the Emil Aaltonen Foundation, the University of Eastern Finland Doctoral Programme in Drug Research and the Medical Research Council, UK [MR/L010011/1]. The funders played no roles in study design, data collection, data analysis, manuscript preparation and/or publication decisions.
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Este trabajo analiza los resultados de una investigación sobre hábitos lectores del alumnado asturiano de 6º de Educación Primaria en su tiempo libre. El estudio utiliza una muestra de 324 escolares de centros públicos urbanos, con edades comprendidas entre los 11 y 12 años, para analizar datos relativos a la actitud hacia la lectura, la importancia de ésta entre las actividades de ocio y la frecuencia lectora.Más de la mitad de los escolares manifiesta una actitud bastante favorable hacia la lectura, y ésta es una de sus actividades de ocio habituales, aunque dedican más tiempo a ver televisión, practicar deportes, usar el ordenador y escuchar música. La mayoría son lectores frecuentes, aunque los no lectores y lectores ocasionales ascienden hasta un 12,96%. Los escolares encuestados leen principalmente libros, seguidos de revistas y cómics, mientras que poco más de un tercio dice leer periódicos frecuentemente.Esta investigación revela también algunas variaciones en actitud hacia la lectura y frecuencia lectora según el centro educativo de procedencia que se pueden relacionar con variables de tipo socio-económico. Además, se observan diferencias entre niños y niñas, pues éstas superan a sus compañeros varones en interés y frecuencia lectora, además de manifestar también divergencias en las preferencias de materiales de lectura.