Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders.

Aberrations of the long arm of chromosome 11 are among the most common chromosome abnormalities in lymphoproliferative disorders (LPD). Translocations involving BCL1 at 11q13 are strongly associated with mantle cell lymphoma. other nonrandom aberrations, especially deletions and, less frequently, translocations, involving bands 11q21-923 have been identified by chromosome banding analysis. To date, the critical genomic segment and candidate genes involved in these deletions have not been identified. In the present study, we have analyzed tumors from 43 patients with LPD (B-cell chronic lymphocytic leukemia, n = 40; mantle cell lymphoma, n = 3) showing aberrations of bands 11q21-923 by fluorescence in situ hybridization. As probes we used Alu-PCR products from 17 yeast artificial chromosome clones spanning chromosome bands 11q14.3-923.3, including a panel of yeast artificial chromosome clones recognizing a contiguous genomic DNA fragment of approximately 9-10 Mb in bands 11q22.3-923.3. In the 41 tumors exhibiting deletions, we identified a commonly deleted segment in band 11q22.3-923.1; this region is approximately 2-3 Mb in size and contains the genes coding for ATM (ataxia telangiectasia mutated), RDX (radixin), and FDX1 (ferredoxin 1). Furthermore, two translocation break-points were localized to a 1.8-Mb genomic fragment contained within the commonly deleted segment. Thus, we have identified a single critical region of 2-3 Mb in size in which 11q14-923 aberrations in LPD cluster. This provides the basis for the identification of the gene(s) at 11q22.3-923.1 that are involved in the pathogenesis of LPD.

Programm zu dem ausgeschriebenen Concurse um den Preis, welchen das k.k. österreichische Ministerium für Handel, Gewerbe und öffentliche Bauten für die entsprechendste Construction einer zu den transporten auf der Eisenbahn über das Semmering-Gebirge geeigneten Locomotive bestimmt hat. Program of a prize offered for public competition...for the most suitable construction of a locomotive adapted to convey goods and passengers on the railway over the Semmering Mountain.

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A new and general biographical dictionary : containing an historical and critical account of the lives and writings of the most eminent persons ... /

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A critical appreciation of Kālidāsa's Meghasandeśa.

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The groans of the talents; or, Private sentiments on public occurences. In six epistles from certain ex-ministers to their colleagues, most wonderfully intercepted. To which are added notes, critical, explanatory, and edifying.

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The Eloquence of the British Senate; being a selection of the best speeches of the most distinguished English, Irish, and Scotch Parliamentary speakers, from the beginning of the reign of Charles I, to the present time. With notes, biographical, critical, and explanatory by William Hazlitt.

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A sequel to the Common school grammar; containing, in addition to other materials and illustrations, notes and critical remarks on the philosophy of the English language; and explaining some of its most difficult idiomatic phrases. Designed for the use of the first class in common schools.

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The New Testament of our Lord and Saviour Jesus Christ : the text carefully printed from the most correct copies of the present authorized version including the marginal readings and parallel texts, with a commentary and critical notes, designed as a help to a better understanding of the sacred writings /

Spine title: Clarke's commentary, New Testament.

Select British eloquence : embracing the best speeches entire, of the most eminent orators of Great Britain for the last two centuries, with sketches of their lives, an estimate of their genius, and notes, critical and explanatory /

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G.K. Chesterton, a critical study,

Bibliography (to July, 1915): p. 185-[191]

Notes on the Gospels, critical and explanatory; so prepared as to accompany the questions of the American Sunday school union: and incorporating with the notes; on a new plan, the most approved harmony of the four Gospels.

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Practical philosophy of the Muhammadan people, exhibited in its professed connexion with the European, so as to render either an introduction to the other; being a translation of the Akhlāk-i Jalāly the most esteemed ethical work of Middle Asia, from the Persian of Fakīr Jāny Muhammad Asäad:

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British theatre : comprising tragedies, comedies, operas, and farces from the most classic writers, with biography, critical account and explanatory notes /

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The New Testament of our Lord and Saviour Jesus Christ : with text carefully printed from the most correct copies of the present Authorized version ... with a commentary and critical notes designed as a help to a better understanding of the sacred writings /

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