Determination of the cytotoxic capacity of organotin compounds derivatives from salicylidene benzoylhidrazone

The successful application of metal complexes in the treatment of many diseases, including cancer, is a rapidly expanding area in biomedical chemistry and research. Organotin compounds studies show the versatility and the attractive features of these molecules. In the same manner, has been reported the development of new compounds derivative from bezoylhidrazones, which possess the azomethine fragment (-N = CH-), key pillar for designing new drugs with biological activity. Based on the above, we are interested in to synthesize four tin compounds derivatives from benzoylhidrazones, and the evaluation of their cytotoxic capacity. Conclusions and contribution: In this research work, we reported four new tin compounds derivatives from bezoylhidrazones, which were characterized by spectroscopic and spectrometric techniques and X-ray diffraction In the same manner, cytotoxic ability of each compound was studied and reported and compared with metaled base drugs like cisplatin and carboplatin. Also, in some cases it was possible to use their luminescent ability to study their intracellular behavior.

A Framework for Energy-Efficiency in Smart Home Environments

Part 7: Cyber-Physical Systems

Performance and ruminal morphologic characteristics of Saanen kids fed ground, pelleted or extruded total ration

The aim of the present study was to determine feed intake and average weight gain and to evaluate the ruminal morphologic characteristics of Saanen kids slaughtered at 30, 45 and 60 days of age, according to a completely randomized design. Thirty-six non-castrated male Saanen kids were fed ground total ration, pelleted total ration, or extruded total ration. Feed intake and refusals were controlled daily and the animals were weighed at birth and then once a week. Newborn kids received a milk replacer and were weaned at 45 days. Immediately after slaughter, the animals were eviscerated, the entire digestive apparatus was removed from the carcass. The reticulo-rumen was separated, emptied, washed and weighed. Samples were collected from the dorsal sac, pillar area and ventral sac of the rumen, fixed for about 24h in Bouin's solution, dehydrated, embedded in Histosec and cut into 5 mu m sections. Results showed that dry matter intake (DMI) at weaning and post-weaning and weight gain were higher (P < 0.05) in animals that received the pelleted total ration. The weight of the reticulo-rumen accompanied body development and was heavier in these animals. Histologically, after weaning ruminal papillae were more developed in animals that received pelleted total ration. Length of papillae increased with increase of age. The ratio of papillary height to papillary width increased with age in the ventral sac and until weaning (P > 0.05). We conclude that the pelleting process of the total ration favored increased intake, with a 46.7% increase in weight gain and increase in rumen weight and papillae length, suggesting that best results are obtained with this processing. In general, no difference was observed between the results obtained with extruded and ground total ration, although animals fed extruded total ration showed an increase in rumen weight and papillae width. (c) 2004 Elsevier B.V All rights reserved.

Factores sociales que influyen en el ingreso de estudiantes de sexo masculino a la carrera de enfermería de la Universidad de Cuenca, 2015

Antecedentes. La educación es un pilar fundamental en el desarrollo del país, por tanto, el ingresar a la educación superior marca definitivamente su futuro. Wright (2005) considera que las decisiones vienen como resultado de fuerzas exteriores, pertenencia étnica, influencias de otros individuos, instituciones donde se estudió. Este trabajo pretende analizar los factores sociales que influyen en el ingreso a la Escuela de enfermería de estudiantes de sexo masculino, y determinar si el aumento se relaciona con: prestigio social, espíritu de época, coeficiente de tradicionalidad familiar, necesidades vitales, vocación, motivación, actitud y aptitud. Objetivo. Identificar los factores sociales que influyen en el ingreso de estudiantes de sexo masculino a la Escuela de Enfermería de la Universidad de Cuenca, 2015. Material y Métodos. Se trata de un estudio descriptivo con un universo de 92 estudiantes de sexo masculino, se aplicó un formulario elaborado por los autores. La información se procesó en el programa SPSS 21.0, Microsoft Excel, Microsoft Word; permitió identificar porcentajes, resultados y se presentaron en tablas simples y cruzadas, con su respectivo análisis. Resultados. 77.2% tienen 20 y 25 años es una población joven, provienen de la provincia del Azuay, 90.2 % son católicos, 80,96% son solteros, 25 % están en segundo ciclo, 45.65% estudia enfermería porque le gusta la profesión, 31.5% descubrió su vocación al realizar pasantías en hospitales, 23,91% eligen como primera opción enfermería en su postulación

Large scale fabrication of nitrogen vacancy-embedded diamond nanostructures for single-photon source applications

Some color centers in diamond can serve as quantum bits which can be manipulated with microwave pulses and read out with laser, even at room temperature. However, the photon collection efficiency of bulk diamond is greatly reduced by refraction at the diamond/air interface. To address this issue, we fabricated arrays of diamond nanostructures, differing in both diameter and top end shape, with HSQ and Cr as the etching mask materials, aiming toward large scale fabrication of single-photon sources with enhanced collection efficiency made of nitrogen vacancy (NV) embedded diamond. With a mixture of O2 and CHF3 gas plasma, diamond pillars with diameters down to 45 nm were obtained. The top end shape evolution has been represented with a simple model. The tests of size dependent single-photon properties confirmed an improved single-photon collection efficiency enhancement, larger than tenfold, and a mild decrease of decoherence time with decreasing pillar diameter was observed as expected. These results provide useful information for future applications of nanostructured diamond as a single-photon source.

Representações sociais do envelhecimento ativo num olhar genderizado

O objetivo deste estudo é analisar as representações sociais do envelhecimento ativo, procurando detetar os impactos das conceções diferenciadas de homens e mulheres idosos. Foi desenvolvido um estudo de coorte transversal. Foram inquiridas 123 pessoas idosas (M=76,84; DP=8,46). Utilizámos para aceder às evocações sobre o envelhecimento ativo a Técnica de Associação Livre de Palavras. As representações que emergiram com maior frequência foram a “família”, “passeio”, “convívio” e “saúde”. Foi possível destacar diferenças na representação social do envelhecimento ativo a partir de um olhar genderizado. Das evocações exclusivas do sexo masculino a evocação proeminente ancora no “desporto”, enquanto no sexo feminino a “atividade doméstica” predomina. Ambos os sexos elegeram a “família” como evocação proeminente na representação social do envelhecimento ativo. As mulheres, refletindo os papéis que desempenharam ao longo da sua vida parecem assumir que um envelhecimento ativo representa a execução das tarefas que sempre fizeram, centrando-se muitas das suas evocações em conteúdos de cariz familista, onde o papel de cuidadoras se destaca. As atividades de carácter instrumental e associadas à esfera privada, como as tarefas domésticas emergem com maior proeminência. No caso dos homens, a componente familista é também evocada, emergindo concomitantemente atividades de lazer.

The Master Programe on Intercultural Mediation and Social Intervention

Portugal, in particular, and Europe in general are paradigms of diversity in unity and of the need for intercultural mediation and social intervention policies enabling the reception, hospitality, respect for others and their training in a more inclusive society. From a research and sociological and anthropological level of knowledge, the ESECS-IPLeiria invested, in 2013, on a Master program in Intercultural Mediation and Social Intervention that is a unique example in Portugal. In this paper, in addition to present the Master’s curriculum, we invest in the distinction between preventive mediation, transformative and social empowerment, rather than focusing on solving, typical of conflict resolution, based on the questionable pillar of neutrality and impartiality.

Determinants of the Design and Use of PMS in Portuguese Government Agencies: A Complementary Theoretical Approach

Performance measurement is seen as a main pillar of public management reforms. However, prior research did not mitigate the level of ambiguity on PMS development and use and many questions left unanswered. Our findings provide knowledge on the design and use of PMS in the public sector answer- ing to calls for a complementary approach among institutional and contingency factors. The authors find that the design of PMS and the use of performance information for external purposes are increased to legitimate the organizational’ work and to obtain external support. Moreover, structural variables such as type of agency and management autonomy are also determinants on the organizational responses. Finally, the authors find some coupling between the design of PMS and outcomes. So, both contingent and institutional approaches play an important role on the empirical model.

Incidencia del proyecto “ASEAN community” en el desarrollo humano de Tailandia (2004-2014)

Esta investigación se interesa en evaluar los logros y retos que ha presentado el proyecto ASEAN Community en cada una de sus tres áreas de acción (Comunidad económica, comunidad de política y seguridad, y comunidad socio-cultural) ante su aplicación en Tailandia. De esta manera, se busca analizar la incidencia que ha tenido el proyecto en el Desarrollo Humano de Tailandia durante el periodo 2004-2014. A través del análisis del estatus actual a la luz del concepto de libertades instrumentales se realiza la evaluación de los resultados de los proyectos y su conveniencia o no para el desarrollo humano de la sociedad tailandesa.

Tratamiento quirúrgico del síndrome de apnea hipopnea obstructiva del sueño en la Clínica Rivas, Bogotá – Colombia

Introducción: El Síndrome de Apnea Hipopnea Obstructiva del Sueño es un trastorno respiratorio del sueño mayor ampliamente conocido, con importantes implicaciones para los pacientes y cuya incidencia ha venido en aumento durante los últimos años; comprende diversas manifestaciones clínicas que varían desde el ronquido hasta consecuencias cardiovasculares importantes. Objetivo: Describir la experiencia de los procedimientos quirúrgicos más utilizados para el tratamiento de pacientes con Trastornos Respiratorios del Sueño en la Clínica Rivas. Diseño: Estudio observacional descriptivo. Métodos: Revisión de 366 historias clínicas de pacientes con diagnóstico clínico y Polisomnográfico de SAHOS intervenidos quirúrgicamente debido al Trastorno Respiratorio del Sueño por rechazo de terapia de presión positiva en 3 años de observación. Resultados: Se evaluaron diferencias en medianas de los cambios del IAH, índice de Saturación de oxigeno basal y mínima, y el índice de microdespertares nocturnos tanto prequirúrgica como postquirúrgicamente. Como medida de evaluación secundaria se evaluaron las complicaciones quirúrgicas. Conclusión: En nuestra institución, como centro de referencia en apnea del sueño, la cirugía ha demostrado que disminuye de forma significativa gravedad del SAHOS y disminuye el riesgo de los pacientes con trastornos respiratorios del sueño que han rechazado el dispositivo de presión positiva.