Selective expression of the V beta 14 T cell receptor on Leishmania guyanensis--specific CD8+ T cells during human infection.

Peripheral blood mononuclear cells from subjects never exposed to Leishmania were stimulated with Leishmania guyanensis. We demonstrated that L. guyanensis-stimulated CD8(+) T cells produced interferon (IFN)- gamma and preferentially expressed the V beta 14 T cell receptor (TCR) gene family. In addition, these cells expressed cutaneous lymphocyte antigen and CCR4 surface molecules, suggesting that they could migrate to the skin. Results obtained from the lesions of patients with localized cutaneous leishmaniaisis (LCL) showed that V beta 14 TCR expression was increased in most lesions (63.5%) and that expression of only a small number of V beta gene families (V beta 1, V beta 6, V beta 9, V beta 14, and V beta 24) was increased. The presence of V beta 14 T cells in tissue confirmed the migration of these cells to the lesion site. Thus, we propose the following sequence of events during infection with L. guyanensis. After initial exposure to L. guyanensis, CD8(+) T cells preferentially expressing the V beta 14 TCR and secreting IFN- gamma develop and circulate in the periphery. During the infection, these cells migrate to the skin at the site of the parasitic infection. The role of these V beta 14 CD8(+) T cells in resistance to infection remains to be determined conclusively.

Harold Petty [n°116], [V. E.] Horsman [n°117], Stanley Parker [n°122] sur Norton [750 cmc, concurrents de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57962

Liver, Gastrointestinal, and Cardiac Toxicity in Intermediate Hepatocellular Carcinoma Treated With PRECISION TACE With Drug-Eluting Beads: Results From the PRECISION V Randomized Trial.

OBJECTIVE. The purpose of our study was to evaluate hepatic, gastrointestinal, and cardiac toxicity after PRECISION transarterial chemoembolization (TACE) with drug-eluting beads (DEB) versus conventional TACE with doxorubicin in the treatment of intermediate-stage hepatocellular carcinoma (HCC).SUBJECTS AND METHODS. Two hundred twelve patients (185 men and 27 women; mean age, 67 years) were randomized to TACE with DEB or conventional TACE. The majority of patients (67% in both groups) presented in a more advanced stage. Safety was measured by rate of adverse events (Southwest Oncology Group criteria) and changes in laboratory parameters. Cardiotoxicity was assessed with left ventricular ejection fraction (LVEF) mainly on MRI or echocardiography.RESULTS. The mean maximum postchemoembolization alanine transaminase increase in the DEB group was 50% less than in the conventional TACE group (p < 0.001) and 41% less in respect to aspartate transaminase (p < 0.001). End-of-study values returned to approximately baseline levels but with greater variability in conventional TACE patients. Treatment-emergent adverse events in the hepatobiliary system organ class occurred in 16.1% of DEB group patients compared with 25% of conventional TACE patients. There were fewer liver toxicity events in the DEB group. There was a small but statistically significant difference in mean change from baseline in LVEF between the two groups of 4 percentage points for the conventional TACE group (95% CI, 0.71-7.3; p = 0.018).CONCLUSION. PRECISION TACE with DEB loaded with doxorubicin offers a safe therapy option for intermediate-stage HCC, even in patients with more advanced liver disease.

Gènere i identitats en la construcció d'una comunitat colonial a Empúries (segles VI-V a.C.)

El projecte de recerca ha analitzat la complexitat ètnica, social i de gènere de l’assentament colonial d’Empúries a partir d’un exhaustiu estudi contextual dels materials ceràmics d’ús quotidià provinents de diferents sectors excavats als anys vuitanta a la Neàpolis empuritana (N-7000, N-5000 i N-1000). Aquests sectors datats els segles V i IV a.C., corresponen a un moment en el qual s’està construint una identitat colonial diferenciada en l’espai emporità. La comparació dels aixovars domèstics usats quotidianament pels habitants d’aquest tres sectors situats en punts distants de la Neàpolis mostra que estem davant d’un assentament colonial molt heterogeni, on conflueixen materialitats, tradicions tecnològiques i pràctiques quotidianes iberes, gregues i híbrides. Els estudis de materials confirmen que no va existir una segregació espacial entre poblacions d’origen grec i iber en aquest assentament i suggereixen la cohabitació de gent –tant d’homes com de dones- d’origen grec i iber a les diferents àrees estudiades d’aquest assentament portuari. En el registre material ceràmic de totes les zones estudiades s’observa un predomini dels productes ceràmics de tradició grega (colonials o àtics) en els serveis de taula, però no així en els estris utilitzats a la cuina, que són majoritàriament de tradició ibera. També els materials ceràmics relacionats amb l’emmagatzematge domèstic i amb el transport i el comerç (àmfores) són predominantment ibers. Aquest patró suggereix que els ibers que van cohabitar amb els grecs al port emporità no van assumir en tots els casos posicions subalternes, sinó que tingueren un rol rellevant en la gestió econòmica i comercial d’aquest espai portuari.

Testing for potential contextual bias effects during the verification stage of the ACE-V methodology when conducting fingerprint comparisons

This study was conducted to assess if fingerprint specialists could be influenced by extraneous contextual information during a verification process. Participants were separated into three groups: a control group (no contextual information was given), a low bias group (minimal contextual information was given in the form of a report prompting conclusions), and a high bias group (an internationally recognized fingerprint expert provided conclusions and case information to deceive this group into believing that it was his case and conclusions). A similar experiment was later conducted with laypersons. The results showed that fingerprint experts were influenced by contextual information during fingerprint comparisons, but not towards making errors. Instead, fingerprint experts under the biasing conditions provided significantly fewer definitive and erroneous conclusions than the control group. In contrast, the novice participants were more influenced by the bias conditions and did tend to make incorrect judgments, especially when prompted towards an incorrect response by the bias prompt.

Historia antiqua, hoc est : Myrsili Lesbii liber de Origine Italiae et Tyrrhenorum. M. Porcii Catonis Fragmenta ex libris Originum. Archilochi liber de Temporibus. Berosi Babylonii Antiquitatum lib. V. Manethonis Aegyptii liber de Regibus Aegyptiorum. Metasthenes Persa, de Judicio temporum. Xenophon, de Aequivocis. Q. Fabius Pictor, de Aureo saeculo et de origine urbis Romae, ejusque descriptione. C. Sempronius, de Divisione Italiae. Philonis Judaei Antiquitatum biblicarum liber. Accessit censura Gasperis Varrerii in Berosum...

Comprend : Censura in quendam auctorem, qui sub falsa inscripsione Berosi Chaldaei circumfertur, Gaspare Varrerio auctore

Dit is die prologhe và den spieghel onser [...]. [Ceci est le prologue du miroir de notre salut] (Fol. 5, verso :) Hier beghint die spieghel... [Ici commence le miroir de notre salut]. A la fin : Dit boek is volmaect... [Ce livre a été achevé dans la bonne ville de Culenborg par moi Jean Veldener dans l'année 1483]

[Speculum humanae salvationis (néerlandais). 1483]

[Archives de la Parole]. , [The story of the herdsman] : shindi [i.e. sindhi], Indo-aryen, groupe occidental / [Sir George Grierson], éd. ; Linguistic survey of India ; [V.T. Shimpi], voix

[Traditions. Asie. Inde. Province de Bombay. État du Maharashtra. Dhule]