Avaliação preliminar dos efeitos de Coffea arabica sobre a obesidade induzida por dieta hipercalórica

Obesity along with overweight, has been considered one of the most serious public health problems in the world, especially because they are the main risk factors for many chronic diseases, such as coronary heart disease, type II diabetes mellitus, hypertension and some types of tumors, which are associated with high mortality rates. The use of functional foods and appropriate diets to call health promotion has grown as a mechanism for prevention, control and treatment of chronic diseases such as obesity. Several ethnopharmacological studies indicate plant species for the treatment of disorders associated with obesity with a major attraction of this regimen is perceived as safer and more effective health than the traditional treatment with appetite suppressants. This work aims to develop and standardize models of biological assays in stress and obesity, also aims to evaluate the effect of oil green beans of Coffea arabica in the regulation of body weight and energy balance in mice. To this end, trials were made in vivo studies of this product and their effects on energy metabolism in non-obese mice with obesity induced by hypercaloric diet. After induction of obesity by 8 weeks, animals were treated for 21 days with the extracts orally. After 21 days the animals were killed to evaluate the effects of these products on daily feed intake and on body weight. The group treated with the oil of Coffea arabica L. showed significant weight loss and feed intake high. According to the results, we conclude that the standardized extract of Coffea arabica L. decreased body weight without restriction or decrease the amount of food ingested

Avaliação preliminar do efeito da Physalis angulata L. sobre a obesidade induzida por dieta hipercalórica

The obesity has been considered one of the most serious public health problem in the worldwide scale, especially for being one of the main risk factors for many chronic diseases that characterize the metabolic syndrome. In addition to these diseases, obesity also causes dermatoses that affect not only the individual emotions but also cause various cutaneous infections. Thus, overweighting can be an agent that causes many types of stress: psychological, physical and social. In order to improve people’s life quality, several ethnopharmacological studies indicate plant species for the treatment of disorders associated with obesity due to the attraction of this regimen is perceived as safer and more health effective when compared to the treatment performed by traditional anorectic substances. If considered both food intake and also oral treatment with different compounds can promote change in the gene expression, besides an appropriate diet has been maintenance mechanism of body's vital functions. The aim of this work was to develop new standard methods for induced obesity and stress, which stress is induced through physical and psychogenic stressors in Swiss male mice. Also to evaluate the effect of supercritical extract of Physalis angulata L. on the food intake and corporeal weight loss

As atividades experimentais no ensino de física

This work was developed from a literature search in order to provide teachers of physics theoretical and methodological requirements for the use of experimentation in physics teaching, with the aim of contributing to the teaching practice of these teachers and, consequently, for improving teaching this discipline. Therefore, to deal in the course of this research, the goals and types of practical activities, new information and communication technologies that fit the experimental approaches and the role of the teacher in this context, specifying the variables that influence and relate with experimental activities. Studies are presented on the methodology and planning of experimental activities to draw attention to the teacher and the important issues relevant to the preparation of these activities as, for example, the proposed objectives and types of discourse and existing approaches for the conduct of practical activities. In this sense, the trend is highlighted for walks where the approach of practical activities, within the context of practices interactionist and are pointed out strengths and weaknesses of different types of activities presented. We also highlight aspects of the learning process associated with some theoretical reference that are on that subject, as Piaget, Vigotski and Ausubel, so that the teacher can apply the concepts in their theories worked in the practical lessons of physics

Efeito da ingestão aguda do suco de laranja sobre o estresse oxidativo em indivíduos eutróficos e com excesso de peso

Estudos clínicos e experimentais têm mostrado que o suco de laranja apresenta propriedades antioxidantes que estão associadas com a redução do risco para doenças cardiovasculares e alguns tipos de câncer. O objetivo deste estudo foi analisar o efeito antioxidante e anti-peroxidação lipídica após a ingestão aguda dos sucos de laranja fresco, pasteurizado e da bebida controle no soro sanguíneo de voluntários eutróficos e com excesso de peso. A avaliação da capacidade antioxidante no soro sanguíneo foi feita pelo método ABTS e a peroxidação lipídica, pela presença de substâncias reativas ao ácido tiobarbitúrico (TBARS). Os voluntários ingeriram a quantidade de 5mL/kg de peso corporal de suco fresco, pasteurizado e da bebida controle. Após o período experimental foi observado um aumento do teor de substâncias antioxidantes (ABTS) e uma redução da peroxidação lipídica (TBARS) no soro, mostrando que os sucos de laranja, fresco e pasteurizado, tiveram efeito protetor contra o estresse oxidativo, sugerindo que o processamento dos sucos não comprometeu os compostos com atividade anti-oxidativa e anti-peroxidação lipídica responsáveis pela redução do estresse oxidativo. Além disso, não houve diferença nas variáveis analisadas (TBARS e ABTS) entre os indivíduos eutróficos e com excesso de peso. Concluiu-se que a ingestão aguda do suco de laranja fresco e pasteurizado promoveu um efeito protetor contra o estresse oxidativo em indivíduos eutróficos e naqueles com excesso de peso.

Avaliação preliminar dos efeitos de Bidens pilosa L. sobre a obesidade induzida por dieta hipercalórica

The obesity along with overweight has been considered one of the most serious public health problems in the world, especially because they are the main risk factors for many chronic diseases such as coronary heart disease, diabetes mellitus, hypertension and some types of tumors, which are associated with high mortality rates. The use of functional foods and appropriate diets to promote health has grown as a prevention mechanism. Previous studies suggested Bidens pilosa L. for the treatment of disorders associated with obesity, with one important attraction of this regiment is perceived as safer and more effective health than the traditional anorexigen .The aim of this project is to standardize a new model of obesity induced by hipercaloric diet in Swiss mice, and also to evaluate the effect of Bidens pilosa L. extract in the reduction of food intake, weight and toxicity. After induction of obesity, the animals were treated for 21 days with the extract. Then the animals were killed and samples were collected for further analysis. Preliminary, the effect of this product has being evaluated on the daily food intake and body weight. In dose of 100mg/Kg, there were no significant changes in food intake and body weight. Thus, this concentration of Bidens pilosa was not effective in reducing body weight of obese animals, and did not reduce food intake

Influência dos flavonoides cítricos na inflamação e controle da obesidade

Nas últimas décadas, o mundo tem vivenciado um grande aumento da prevalência de obesidade. Entre os fatores que levam a esta condição, estão o sedentarismo e o consumo de alimentos altamente calóricos. A obesidade é considerada uma condição de inflamação crônica de baixo grau, que leva ao desenvolvimento de doenças crônicas não transmissíveis, como diabetes mellitus tipo 2 e hipertensão arterial. O consumo de compostos biologicamente ativos, dentre eles os flavonoides cítricos, tem mostrado ter papel importante no controle da inflamação, e de alterações no metabolismo decorrentes do excesso de peso e gordura corporal. Neste trabalho foram revisados trabalhos sobre flavonoides cítricos e seu papel na inflamação relacionada à obesidade, assim como nas alterações decorrentes desse processo. Os artigos foram divididos em dois grupos: suplementação com extratos de flavonoides e com flavonoides isolados. Nos dois grupos os trabalhos demonstraram o papel benéfico dos flavonoides cítricos no metabolismo lipídico, e diminuindo marcadores biológicos de inflamação, como proteínas e enzimas, tanto nos modelos experimentais quanto em linhagens celulares de adipócitos e hepatócitos. A redução de massa corpórea também foi observada em ratos e camundongos suplementados com os flavonoides cítricos. Entretanto, no que concerne à obesidade e diminuição da massa corpórea em humanos, os trabalhos são inconclusivos até o momento.

Dentifrício fluoretado suplementado com hexametafosfato de sódio sobre o processo de desmineralização do esmalte: estudos in vitro e in situ

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Investigação da ação da proteína anexina A1 sobre o processo de angiogênese induzido pelo fator de crescimento do endotélio vascular: modelos experimentais in vivo e in vitro

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Protocolos de natação em modelos experimentais com ratos

Exercise physiology has attempted to reproduce the experimental exercise in the laboratory using mainly rats. The swimming exercise has emerged as one of the leading research in these type ergometers. Thus, this research consisted of a literature review addressing the key issues which involve the exercise of swimming in the model rats. Training of aerobic and anaerobic swimming, evaluation models and models of periodization were the topics suggested in this research. In several studies, models of aerobic and anaerobic training have been proposed with the aim of studying their effect on normal and abnormal physiological parameters. However, earlier studies lacked methods of analysis aiming to determine the exercise intensity in the animal model. For this reason, in the last decade, assessment models have been adapted for humans to animals, especially rats. The maximal lactate steady state (MLSS) and lactate minimum (LM) are among the various techniques used to measure the amount of effort produced by swimming exercise in rats. Thereafter, based on biochemical parameters such as lactate, swimming exercise in rats has become the highest-rated, ie, using as reference the anaerobic threshold (AT). In another aspect, an entirely new line of research has tried to understand and promising swimming training in a periodized and its effects on some biochemical parameters. But this is an area little researched so far. Thus, the experimental model of swimming has proved an important resource of exercise physiology. From this model, it becomes possible to study the exercise, especially swimming, in more accurate, based on invasive and incisive analysis of the rat

Papel do exercício físico na regulação da proteína rock em camundongos obesos: efeitos sobre sinalização da insulina e homeostase da glicose

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Aspectos radiográficos e densitométricos de fraturas experimentais do radio de cães tratadas com plasma rico em plaquetas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeito do tabagismo, atividade física e obesidade sobre os valores de proteína C reativa em adultos jovens de ambos os sexos: coorte de 12 meses

Pós-graduação em Fisioterapia - FCT

As demonstrações experimentais e suas implicações na motivação dos alunos para o aprendizado de conceitos científicos

As demonstrações experimentais são atividades de grande tradição na História da Ciência, sendo realizadas desde 1660 na Royal Society, por grandes expoentes da Física, com o objetivo de promover a divulgação dos conhecimentos científicos desenvolvidos.Com o objetivo de contribuir com a melhoria e o interesse dos alunos pelos estudos das Ciências Exatas, bem como a conscientização destes sobre conceitos relacionados à Energia e seu impacto sobre a sociedade e sobre o meio ambiente, temos realizado atividades de demonstrações experimentais, denominadas de “Show de Energia”, nas escolas públicas de Ensino Médio de cidades da Região de Guaratinguetá, interior do Estado de São Paulo. Em cada um dos shows realizados entrevistamos os alunos, através de um questionário estruturado, buscando avaliar o impacto dessa atividade na motivação dos estudantes para o aprendizado de conceitos científicos. Os resultados apontam para a grande influência que a realização dos shows tem exercido sobre a motivação dos estudantes.

Economia Criativa e a Mídia Radical: laboratórios experimentais para a inovação de plataformas midiáticas, conteúdos e recursos midiáticos

The Creative Economy is an experimental laboratory for the creation , innovation , invention and reinvention of the universe of media - analog and digital . The scenery in the media and converging technologies favors the process of “ creative destruction and destructive creation “ of this field . The mapping of basins and technological corridors distributed through the territory of concentrated areas creates an infrastructural chassis for the production of content , information and entertainment . As locus and logos of immaterial production , digital ecology that gives speed to the flow of production - planning, fundraising , publishing , distribution and enjoyment - and allows the dispossession of their local clusters , the fragmentation and dilution of their creative chains . The collective cultural production and creation appropriating these capilarizados articles and produce content against political, economic and social status quo . The land is fertile and favorable to the emergence of radical media and rebels that recreate the public sphere , and edit poor public spheres , alternative , radical and efficient , the tactical point of view . This article aims to contribute to studies and research that scour the ecosystem of the media for understanding the management of their creative processes, actors and critics of tangible and intangible resources that support their communication actions .

Desenvolvimento de método por cromatografia líquida bidimensional abrange para documentação química de extratos vegetais e estudos metabolômicos

Pós-graduação em Química - IQ