Curso de regimento interno

Organizado em formato de curso, com linguagem clara e objetiva, o livro traz comentários atualizados sobre todos os dispositivos do Regimento Interno da Câmara dos Deputados – com remissões à Constituição Federal, ao Regimento Comum do Congresso Nacional e ao Regimento Interno do Senado Federal –, sempre balizados pelos ensinamentos da doutrina e pelas decisões de tribunais.

La poesía bucólica en época de Nerón : lectura virgiliana, ideología senequiana y propaganda imperial

[ES] Durante los pocos años del gobierno de Nerón la poesía bucólica latina experimenta un auge anormal y desarrolla una función propagandística particularmente clara. En este artículo se trata de reconstruir, a partir de textos que hasta ahora no se habían implicado debidamente en la cuestión (cuarta égloga de Virgilio, Apocolocyntosis de Séneca, etc.), las motivaciones inmediatas de este resurgir del género: la poesía bucólica de la época responde en parte a una invitación expresa que Séneca formula en un pasaje de su Apocolocyntosis donde, además, se impone como modelo la égloga cuarta de Virgilio, que proporciona símbolos congruentes con la ideología filohelena de la corte de Nerón y conlleva la identificación entre Augusto y Nerón.

Tratado Luso-Espanhol Sobre Limites Coloniais

A primeira guerra mundial aconteceu entre 1757 e 1763 e é a única guerra que tem diversos nomes nos países que atingiu. Envolveu a Prússia, de Frederico II, o Império Austro-Húngaro, a Rússia, a França, a Espanha, a Inglaterra e o seu tradicional aliado, Portugal.

Parametric Study of the Device Angle Dependency of a Single Vortex Generator on a Flat Plate

Ponencia presentada en el 10th World Congress on Computational Mechanics (WCCM 2012), Sao Paulo (Brazil).Publicados los abstracts en documento con ISBN: 978-85-86686-69-6.

A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12

Background: Colorectal cancer (CRC) is a disease of complex aetiology, with much of the expected inherited risk being due to several common low risk variants. Genome-Wide Association Studies (GWAS) have identified 20 CRC risk variants. Nevertheless, these have only been able to explain part of the missing heritability. Moreover, these signals have only been inspected in populations of Northern European origin. Results: Thus, we followed the same approach in a Spanish cohort of 881 cases and 667 controls. Sixty-four variants at 24 loci were found to be associated with CRC at p-values <10-5. We therefore evaluated the 24 loci in another Spanish replication cohort (1481 cases and 1850 controls). Two of these SNPs, rs12080929 at 1p33 (P-replication=0.042; P-pooled=5.523x10(-03); OR (CI95%)=0.866(0.782-0.959)) and rs11987193 at 8p12 (P-replication=0.039; P-pooled=6.985x10(-5); OR (CI95%)=0.786(0.705-0.878)) were replicated in the second Phase, although they did not reach genome-wide statistical significance. Conclusions: We have performed the first CRC GWAS in a Southern European population and by these means we were able to identify two new susceptibility variants at 1p33 and 8p12 loci. These two SNPs are located near the SLC5A9 and DUSP4 loci, respectively, which could be good functional candidates for the association signals. We therefore believe that these two markers constitute good candidates for CRC susceptibility loci and should be further evaluated in other larger datasets. Moreover, we highlight that were these two SNPs true susceptibility variants, they would constitute a decrease in the CRC missing heritability fraction.

Arquitectura subcelular del sistema endocannabinoide en el núcleo ventromedial del hipotálamo de ratón

356 p. : il., graf. Nota: Contiene versión resumida en inglés p.237-256 con el título “Subcellular architecture of the endocannabinoid system in the mouse ventromedial nucleus of the hypothalamus”

Feminización del hábito lector

[ES] En este artículo se exponen los resultados obtenidos en una investigación descriptiva sobre la feminización del ámbito lector en la Literatura Infantil y Juvenil (LIJ) vasca. La tesis que desde el principio sostuvo esta investigación se fundamentó en que el progresivo aumento de la presencia de la mujer en el sistema literario vasco tendría que reflejarse también de alguna manera en el ámbito lector. Se utilizó el cuestionario como instrumento metodológico y se eligió una población escolar de 300 niños y niñas de edades comprendidas entre los 11 y 12 años en Vitoria. Se verificó la hipótesis preliminar; no obstante, se detectó una tendencia clara a una mayor presencia femenina en las lecturas de las niñas que en la de los niños. Las lectoras leen un mundo imaginario en un 21.6% más femenino que los lectores.

Evidence for classification of c.1852_1853AA > GC in MLH1 as a neutral variant for Lynch syndrome

Background: Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS patients are unclassified. Reports on the pathogenicity of the c.1852_1853AA>GC (p.Lys618Ala) variant of the MLH1 gene are conflicting. In this study, we provide new evidence indicating that this variant has no significant implications for LS. Methods: The following approach was used to assess the clinical significance of the p.Lys618Ala variant: frequency in a control population, case-control comparison, co-occurrence of the p.Lys618Ala variant with a pathogenic mutation, co-segregation with the disease and microsatellite instability in tumours from carriers of the variant. We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls). Three well-characterized LS families that fulfilled the Amsterdam II Criteria and consisted of members with the p.Lys618Ala variant were included to assess co-occurrence and co-segregation. A subset of colorectal tumour DNA samples from 17 patients carrying the p.Lys618Ala variant was screened for microsatellite instability using five mononucleotide markers. Results: Twenty-seven individuals were heterozygous for the p.Lys618Ala variant; nine had sporadic CRC (2.41%), seven were suspected of having hereditary CRC (2.8%) and 11 were controls (2.68%). There were no significant associations in the case-control and case-case studies. The p.Lys618Ala variant was co-existent with pathogenic mutations in two unrelated LS families. In one family, the allele distribution of the pathogenic and unclassified variant was in trans, in the other family the pathogenic variant was detected in the MSH6 gene and only the deleterious variant co-segregated with the disease in both families. Only two positive cases of microsatellite instability (2/17, 11.8%) were detected in tumours from p.Lys618Ala carriers, indicating that this variant does not play a role in functional inactivation of MLH1 in CRC patients. Conclusions: The p.Lys618Ala variant should be considered a neutral variant for LS. These findings have implications for the clinical management of CRC probands and their relatives.

Temperature-and pH-Sensitive Nanohydrogels of Poly(N-Isopropylacrylamide) for Food Packaging Applications: Modelling the Swelling-Collapse Behaviour

Temperature-sensitive poly(N-isopropylacrylamide) (PNIPA) nanohydrogels were synthesized by nanoemulsion polymerization in water-in-oil systems. Several cross-linking degrees and the incorporation of acrylic acid as comonomer at different concentrations were tested to produce nanohydrogels with a wide range of properties. The physicochemical properties of PNIPA nanohydrogels, and their relationship with the swelling-collapse behaviour, were studied to evaluate the suitability of PNIPA nanoparticles as smart delivery systems (for active packaging). The swelling-collapse transition was analyzed by the change in the optical properties of PNIPA nanohydrogels using ultraviolet-visible spectroscopy. The thermodynamic parameters associated with the nanohydrogels collapse were calculated using a mathematical approach based on the van't Hoff analysis, assuming a two-state equilibrium (swollen to collapsed). A mathematical model is proposed to predict both the thermally induced collapse, and the collapse induced by the simultaneous action of two factors (temperature and pH, or temperature and organic solvent concentration). Finally, van't Hoff analysis was compared with differential scanning calorimetry. The results obtained allow us to solve the problem of determining the molecular weight of the structural repeating unit in cross-linked NIPA polymers, which, as we show, can be estimated from the ratio of the molar heat capacity (obtained from the van't Hoff analysis) to the specific heat capacity (obtained from calorimetric measurements).

Association between CASP8-652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study

The common 2652 6N del variant in the CASP8 promoter (rs3834129) has been described as a putative low-penetrance risk factor for different cancer types. In particular, some studies suggested that the deleted allele (del) was inversely associated with CRC risk while other analyses failed to confirm this. Hence, to better understand the role of this variant in the risk of developing CRC, we performed a multi-centric case-control study. In the study, the variant 2652 6N del was genotyped in a total of 6,733 CRC cases and 7,576 controls recruited by six different centers located in Spain, Italy, USA, England, Czech Republic and the Netherlands collaborating to the international consortium COGENT (COlorectal cancer GENeTics). Our analysis indicated that rs3834129 was not associated with CRC risk in the full data set. However, the del allele was under-represented in one set of cases with a family history of CRC (per allele model OR = 0.79, 95% CI = 0.69-0.90) suggesting this allele might be a protective factor versus familial CRC. Since this multi-centric case-control study was performed on a very large sample size, it provided robust clarification of the effect of rs3834129 on the risk of developing CRC in Caucasians.

Design and synthesis of biofunctional magnetic/fluorescent glyco-nanoparticles and quantum dots and their application as specific molecular imaging probes

206 p.

Disminución de la Ansiedad Estado previa al Cateterismo Cardiaco programado tras una intervención de enfermería

Los pacientes sometidos a cateterismo cardíaco (CC) experimentan niveles significativos de ansiedad relacionados con el procedimiento y puede ser percibido como una amenaza. Es fundamental por ello desarrollar estrategias de educación que se centren en las necesidades psicológicas y fisiológicas, manteniendo una información ordenada y clara, con el propósito de manejar y prevenir las complicaciones que se pueden presentar. El objetivo de este estudio es conocer si disminuye la ansiedad del paciente por medio de una intervención educativa enfermera, previa a la realización por primera vez del CC programado e Identificar el nivel de conocimientos sobre la prueba, el grado de satisfacción y confianza tras los cuidados enfermeros. Basado tanto en la información verbal, escrita y visualizada por medio de CD, como por la realización de técnicas cognitivas-conductuales. Apoyado por musicoterapia durante el periodo de espera previo al inicio del CC. Metodología: Sera un estudio experimental de ensayo clínico aleatorio, desarrollado en el Hospital Universitario Cruces (País Vasco-España), donde se crearan dos grupos: grupo control (pacientes antes de aplicar la intervención educativa, es decir, con la atención habitual) y grupo experimental (pacientes a los que se les aplica la intervención educativa).Formaran parte los primeros 225 pacientes mayores de 18 años que cumplan los requisitos de inclusión. Considero que es justificable la realización de este estudio, puesto que permitirá comprobar la eficacia de una intervención educativa de enfermería contribuyendo así a la disminución de la ansiedad y por consiguiente se podría protocolizar la intervención previa al procedimiento.

Guia Trabajo Fin de Grado. Escuela Universitaria de Enfermería de Leioa. Curso 14/15

Guia docente de la asignatura Trabajo Fin de Grado (TFG) en la Escuela Universitaria de Enfermería de Leioa para el curso 14/15. realizado por la comisión de TFG.

A dynamical systems analysis of vortex pinch-off

Vortex rings constitute the main structure in the wakes of a wide class of swimming and flying animals, as well as in cardiac flows and in the jets generated by some moss and fungi. However, there is a physical limit, determined by an energy maximization principle called the Kelvin-Benjamin principle, to the size that axisymmetric vortex rings can achieve. The existence of this limit is known to lead to the separation of a growing vortex ring from the shear layer feeding it, a process known as `vortex pinch-off', and characterized by the dimensionless vortex formation number. The goal of this thesis is to improve our understanding of vortex pinch-off as it relates to biological propulsion, and to provide future researchers with tools to assist in identifying and predicting pinch-off in biological flows.

To this end, we introduce a method for identifying pinch-off in starting jets using the Lagrangian coherent structures in the flow, and apply this criterion to an experimentally generated starting jet. Since most naturally occurring vortex rings are not circular, we extend the definition of the vortex formation number to include non-axisymmetric vortex rings, and find that the formation number for moderately non-axisymmetric vortices is similar to that of circular vortex rings. This suggests that naturally occurring vortex rings may be modeled as axisymmetric vortex rings. Therefore, we consider the perturbation response of the Norbury family of axisymmetric vortex rings. This family is chosen to model vortex rings of increasing thickness and circulation, and their response to prolate shape perturbations is simulated using contour dynamics. Finally, the response of more realistic models for vortex rings, constructed from experimental data using nested contours, to perturbations which resemble those encountered by forming vortices more closely, is simulated using contour dynamics. In both families of models, a change in response analogous to pinch-off is found as members of the family with progressively thicker cores are considered. We posit that this analogy may be exploited to understand and predict pinch-off in complex biological flows, where current methods are not applicable in practice, and criteria based on the properties of vortex rings alone are necessary.

Mujer y aborto. Vivencias y análisis de la manipulación de conceptos

429 p. -- Tesis doctoral original leida en la Universidad Pública de Navarra (UPNA, Dpto. Ciencias de la Salud