902 resultados para Biased Innovations
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Most existing color-based tracking algorithms utilize the statistical color information of the object as the tracking clues, without maintaining the spatial structure within a single chromatic image. Recently, the researches on the multilinear algebra provide the possibility to hold the spatial structural relationship in a representation of the image ensembles. In this paper, a third-order color tensor is constructed to represent the object to be tracked. Considering the influence of the environment changing on the tracking, the biased discriminant analysis (BDA) is extended to the tensor biased discriminant analysis (TBDA) for distinguishing the object from the background. At the same time, an incremental scheme for the TBDA is developed for the tensor biased discriminant subspace online learning, which can be used to adapt to the appearance variant of both the object and background. The experimental results show that the proposed method can track objects precisely undergoing large pose, scale and lighting changes, as well as partial occlusion. © 2009 Elsevier B.V.
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The UK is home to a dense network of Citizen Weather Stations (CWS) primarily set up by members of the public. The majority of these stations record air temperature, relative humidity and precipitation, amongst other variables, at sub-hourly intervals. This high resolution network could have benefits in many applications, but only if the data quality is well characterised. Here we present results from an intercomparison field study, in which popular CWS models were tested against Met Office standard equipment. The study identifies some common instrumental biases and their dependencies, which will help us to quantify and correct such biases from the CWS network.
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This paper investigates the main perceptual biases developed by consumers regarding the environmental impact of products. It shows that these biases make consumers unable to distinguish between advertisements for highly versus less sustainable products, but that the inclusion of relevant information can increase the efficiency of arguments for true sustainability.
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The glucagon-like peptide 1 (GLP-1) receptor is a class B G protein-coupled receptor (GPCR) that is a key target for treatments for type II diabetes and obesity. This receptor, like other class B GPCRs, displays biased agonism, though the physiologic significance of this is yet to be elucidated. Previous work has implicated R2.60190 , N3.43240 , Q7.49394 , and H6.52363 as key residues involved in peptide-mediated biased agonism, with R2.60190 , N3.43240 , and Q7.49394 predicted to form a polar interaction network. In this study, we used novel insight gained from recent crystal structures of the transmembrane domains of the glucagon and corticotropin releasing factor 1 (CRF1) receptors to develop improved models of the GLP-1 receptor that predict additional key molecular interactions with these amino acids. We have introduced E6.53364 A, N3.43240 Q, Q7.49493N, and N3.43240 Q/Q7.49 Q/Q7.49493N mutations to probe the role of predicted H-bonding and charge-charge interactions in driving cAMP, calcium, or extracellular signal-regulated kinase (ERK) signaling. A polar interaction between E6.53364 and R2.60190 was predicted to be important for GLP-1- and exendin-4-, but not oxyntomodulin-mediated cAMP formation and also ERK1/2 phosphorylation. In contrast, Q7.49394 , but not R2.60190 /E6.53364 was critical for calcium mobilization for all three peptides. Mutation of N3.43240 and Q7.49394 had differential effects on individual peptides, providing evidence for molecular differences in activation transition. Collectively, this work expands our understanding of peptide-mediated signaling from the GLP-1 receptor and the key role that the central polar network plays in these events.
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Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding of the molecular events coupling ligand binding to intracellular signaling. Activation of class B G protein-coupled receptors is driven by interaction of the peptide N terminus with the receptor core. To understand how this drives signaling, we have used advanced analytical methods that enable separation of effects on pathway-specific signaling from those that modify agonist affinity and mapped the functional consequence of receptor modification onto three-dimensional models of a receptor-ligand complex. This yields molecular insights into the initiation of receptor activation and the mechanistic basis for biased agonism. Our data reveal that peptide agonists can engage different elements of the receptor extracellular face to achieve effector coupling and biased signaling providing a foundation for rational design of biased agonists.
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Megközelítésemben az "innovációs lánc" olyan társadalmi kapcsolathálót jelent, ahol a kapcsolat tartalma egy gazdasági újítás átadása. Dolgozatom fõ kérdése az, hogy egy településen kialakult társadalmi hálózat szerkezete hogyan befolyásolja az innovációk átvételének útját és terjedési sebességét. __________ A chain of innovation is a social network, defined by offering or adopting an economic innovation. The main hypothesis is that the diffusion of rural innovations and the changes of life-style of the peasants (generally: the growth of market economy) do not necessarily restructure or destroy local networks, but in some cases they will be reinforceed.
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A cikk a hazai feldolgozóipari vállalatok környezeti innovációs tevékenységét, annak mozgatórugóit vizsgálja. Felvázolja a témakörrel foglalkozó jelentősebb elméleteket, kutatásokat, illetve az ezek által azonosított, a környezeti innovációs tevékenységet befolyásoló tényezőket (pl. hatósági szabályozás, vállalatméret, környezeti stratégia stb.). A bemutatott kutatás egy kérdőíves felmérésen alapul, melyben közel 300 vállalat vett részt az elektronika, az élelmiszeripar, a gépipar, a járműipar és a vegyipar területéről. A vizsgálat célja a környezeti innováció különböző típusainak (csővégi, megelőző, termék; új, adaptált) differenciált elemzése, figyelembe véve mind a vállalat, mind a környezet jellemzőit. A vállalatok innovációs tevékenysége jelentősen különbözhet az egyes ágazatokban, illetve a különböző méretű cégek között – a cikk ezen eltérések vizsgálatára is kitér. ______ The article examines the environmental innovation activity of Hungarian manufacturing companies and its determinants. It provides a brief overview of the most important theories and recent empirical studies addressing the topic. The research presented is based on a questionnaire survey with the participation of nearly 300 firms from the chemicals, electronics, food, machines and vehicles sectors. The goal of the study is to identify differences in the determinants of the various types of environmental innovation (end-of-pipe, cleaner production, product; novel, adopted), with regard to both the characteristics of the environment and the companies themselves. Differences between firms of various sizes and industries are also a part of the analysis.
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Research on the adoption of innovations by individuals has been criticized for focusing on various factors that lead to the adoption or rejection of an innovation while ignoring important aspects of the dynamic process that takes place. Theoretical process-based models hypothesize that individuals go through consecutive stages of information gathering and decision making but do not clearly explain the mechanisms that cause an individual to leave one stage and enter the next one. Research on the dynamics of the adoption process have lacked a structurally formal and quantitative description of the process. ^ This dissertation addresses the adoption process of technological innovations from a Systems Theory perspective and assumes that individuals roam through different, not necessarily consecutive, states, determined by the levels of quantifiable state variables. It is proposed that different levels of these state variables determine the state in which potential adopters are. Various events that alter the levels of these variables can cause individuals to migrate into different states. ^ It was believed that Systems Theory could provide the required infrastructure to model the innovation adoption process, particularly applied to information technologies, in a formal, structured fashion. This dissertation assumed that an individual progressing through an adoption process could be considered a system, where the occurrence of different events affect the system's overall behavior and ultimately the adoption outcome. The research effort aimed at identifying the various states of such system and the significant events that could lead the system from one state to another. By mapping these attributes onto an “innovation adoption state space” the adoption process could be fully modeled and used to assess the status, history, and possible outcomes of a specific adoption process. ^ A group of Executive MBA students were observed as they adopted Internet-based technological innovations. The data collected were used to identify clusters in the values of the state variables and consequently define significant system states. Additionally, events were identified across the student sample that systematically moved the system from one state to another. The compilation of identified states and change-related events enabled the definition of an innovation adoption state-space model. ^
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The authors report on a survey of 185 hospitality managers to investigate which process activities are related to the success of new hospitality innovations. The results suggest that successful new hospitality projects result from a more holistic, systematic, and professional approach to the innovation process.
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Financial innovations have emerged globally to close the gap between the rising global demand for infrastructures and the availability of financing sources offered by traditional financing mechanisms such as fuel taxation, tax-exempt bonds, and federal and state funds. The key to sustainable innovative financing mechanisms is effective policymaking. This paper discusses the theoretical framework of a research study whose objective is to structurally and systemically assess financial innovations in global infrastructures. The research aims to create analysis frameworks, taxonomies and constructs, and simulation models pertaining to the dynamics of the innovation process to be used in policy analysis. Structural assessment of innovative financing focuses on the typologies and loci of innovations and evaluates the performance of different types of innovative financing mechanisms. Systemic analysis of innovative financing explores the determinants of the innovation process using the System of Innovation approach. The final deliverables of the research include propositions pertaining to the constituents of System of Innovation for infrastructure finance which include the players, institutions, activities, and networks. These static constructs are used to develop a hybrid Agent-Based/System Dynamics simulation model to derive propositions regarding the emergent dynamics of the system. The initial outcomes of the research study are presented in this paper and include: (a) an archetype for mapping innovative financing mechanisms, (b) a System of Systems-based analysis framework to identify the dimensions of Systems of Innovation analyses, and (c) initial observations regarding the players, institutions, activities, and networks of the System of Innovation in the context of the U.S. transportation infrastructure financing.
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The motion-to-suppress safeguard is designed to prevent false eyewitness identifications from leading to wrongful convictions. This safeguard is effective only if judges are sensitive to factors that influence lineup suggestiveness. The present study assessed judicial sensitivity to foil, instruction, and presentation biases. Judges $(N=99)$ read a description of a hypothetical crime, perpetrator, and identification procedure, followed by a motion to suppress the identification. Judges completed a questionnaire in which they ruled on the motion and rated the lineup's suggestiveness and fairness. Foil bias and instruction bias influenced judges' rulings and lineup evaluations as predicted. Hypotheses concerning presentation bias were not supported. Results suggest a need to standardize and record identification procedures and to further educate judges about psychological research on eyewitness memory. ^
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Aims. Long gamma-ray bursts (LGRBs) are associated with the deaths of massive stars and might therefore be a potentially powerful tool for tracing cosmic star formation. However, especially at low redshifts (z< 1.5) LGRBs seem to prefer particular types of environment. Our aim is to study the host galaxies of a complete sample of bright LGRBs to investigate the effect of the environment on GRB formation. Methods. We studied host galaxy spectra of the Swift/BAT6 complete sample of 14 z< 1 bright LGRBs. We used the detected nebular emission lines to measure the dust extinction, star formation rate (SFR), and nebular metallicity (Z) of the hosts and supplemented the data set with previously measured stellar masses M_*. The distributions of the obtained properties and their interrelations (e.g. mass-metallicity and SFR-M_* relations) are compared to samples of field star-forming galaxies. Results. We find that LGRB hosts at z< 1 have on average lower SFRs than if they were direct star formation tracers. By directly comparing metallicity distributions of LGRB hosts and star-forming galaxies, we find a good match between the two populations up to 12 +log (O/H)~8.4−8.5, after which the paucity of metal-rich LGRB hosts becomes apparent. The LGRB host galaxies of our complete sample are consistent with the mass-metallicity relation at similar mean redshift and stellar masses. The cutoff against high metallicities (and high masses) can explain the low SFR values of LGRB hosts. We find a hint of an increased incidence of starburst galaxies in the Swift/BAT6 z< 1 sample with respect to that of a field star-forming population. Given that the SFRs are low on average, the latter is ascribed to low stellar masses. Nevertheless, the limits on the completeness and metallicity availability of current surveys, coupled with the limited number of LGRB host galaxies, prevents us from investigating more quantitatively whether the starburst incidence is such as expected after taking into account the high-metallicity aversion of LGRB host galaxies.
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Peer reviewed