Portaria n?? 181, de 17 de julho de 2013: aprova a Pol??tica Editorial da Escola Nacional de Administra????o P??blica e institui a Comiss??o Editorial da Enap

O objetivo da portaria ?? instituir a Comiss??o Editorial da ENAP.

Portaria n?? 181, de 17 de julho de 2013

A pol??tica editorial da Escola Nacional de Administra????o P??blica (ENAP), ?? regulamentada pela Portaria n?? 181, de 17 de julho de 2013.

Detection of anti-Giardia lamblia serum antibody among children of day care centers

OBJETIVES: To detect anti-Giardia lamblia serum antibodies in healthy children attending public day care centers and to assess serological tests as tools for estimating the prevalence of G. lamblia in endemic areas. METHODS: Three separate stool specimens and filter paper blood samples were collected from 147 children ranging from 0 to 6 years old. Each stool sample was processed using spontaneous sedimentation and zinc sulfate flotation methods. Blood samples were tested by indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assay (ELISA) for Giardia IgG. RESULTS AND CONCLUSIONS: Of 147 individuals tested, 93 (63.3%) showed Giardia cysts in their feces. Using IIF and ELISA, serum antibodies were detected in 93 (63.3%) and 100 (68%) samples , respectively. Sensitivity of IIF and ELISA was 82% and 72%, respectively. However, ELISA revealed to be less specific (39%) than IIF (70%). IIF also showed a higher concordance with microscopic examination than ELISA.

Números curiosos: os intrigantes 11, 17 e 23

(...) Desde logo, salienta-se um aspeto curioso. Estamos na presença de três números primos (significa que são divisíveis apenas por eles próprios e pela unidade) separados uns dos outros por seis unidades: 11+6=17 e 17+6=23. Ou seja, o 6 volta aqui a estar em destaque! (...) Destacam-se algumas ocorrências do número 11 associadas a vários acontecimentos históricos. Em 1998, um avião da Swissair, com 229 pessoas a bordo, despenhou-se no Oceano Atlântico sem sobreviventes. Era um modelo McDonnell Douglas MD-11 com número de voo SWR111. Todos nos recordamos da tragédia decorrente do sismo e tsunami de Sendai, no Japão. Estima-se que este sismo, que assolou a costa japónica a 11 de março de 2011, tenha sido o maior sismo a atingir o Japão e um dos cinco maiores do mundo desde que os registros modernos começaram a ser compilados. (...) O 17 é considerado por muitos povos um número tão azarento como o 13, como acontece, por exemplo, em Itália. Uma das justificações para esta triste fama prende-se com a escrita do 17 em numeração romana, XVII, e com um dos seus anagramas, VIXI, que significa “vivi”. E se “vivi” é porque estou morto! A aversão a este número em Itália é tal que levou a Renault, marca francesa de automóveis, a mudar a designação do seu modelo R17 para R177, para que o pudesse vender em território italiano. Ainda hoje não se encontra facilmente em Itália prédios com andares 17 e hotéis com quartos 17, nem tão pouco assentos de aviões italianos com esse número. Terminamos com algumas curiosidades relativas ao 23, um dos números favoritos em muitas teorias da conspiração: 2/3 é aproximadamente igual a 0,666, sendo 666 o número da Besta; quando foi assassinado, Júlio César terá sido esfaqueado 23 vezes; William Shakespeare nasceu a 23 de abril de 1564 e morreu a 23 de abril de 1616; o famoso Titanic afundou-se na madrugada do dia 15 de abril de 1912 (1+5+4+1+9+1+2=23); a bomba atómica foi lançada sobre Hiroshima pelas 8h15 (8+15=23); (...)

A Herança do Ensino e o 17 de Abril de 1969

O texto fala um pouco sobre o dia da revolução estudantil de Coimbra, que aconteceu no dia 17 de abril de 1969. Contém algumas notas biográficas do autor.

Unesp Informa, 2011, ano 2, número 17

Boletim elaborado pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP

Unesp Ciência, 2011, ano 2, número 17

Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP

Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease

Objectives - The aim of this work was to study the interaction between genetic polymorphisms (single-nucleotide polymorphisms, SNPs) of pro- and anti-inflammatory cytokines and fat intake on the risk of developing Crohn's disease (CD) or modifying disease activity. Methods - Seven SNPs in interleukin 1 (IL1), tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and IL6 genes were analyzed in 116 controls and 99 patients with CD. The type of fat intake was evaluated, and the interaction between SNPs and dietary fat in modulating disease activity was analyzed. Results - Individuals who were homozygous for the IL6-174G/C polymorphism had a six-fold higher risk for CD (odds ratio (OR)=6.1; 95% confidence interval (95% CI)=1.9-19.4), whereas the TT genotype on the TNFalpha-857C/T polymorphism was associated with more active disease (OR=10.4; 95% CI=1.1-94.1). A high intake of total, saturated, and monounsaturated fats, as well as a higher ratio of n-6/n-3 polyunsaturated fatty acid (PUFA), was associated with a more active phenotype (P<0.05). Furthermore, there was an interaction between dietary fat intake and SNPs, with a high intake of saturated and monounsaturated fats being associated with active disease, mainly in patients carrying the variant alleles of the 857 TNFalpha polymorphism (OR=6.0, 95% CI=1.4-26.2; OR=5.17; 95% CI=1.4-19.2, respectively) and the 174 IL6 polymorphism (OR=2.95; 95% CI=1.0-9.1; OR=3.21; 95% CI=1.0-10.4, respectively). Finally, low intake of n-3 PUFA and high n-6/n-3 PUFA ratio in patients with the TNFalpha 857 polymorphism were associated with higher disease activity (OR=3.6; 95% CI=1.0-13.0; OR=5.92; 95% CI=1.3-26.5, respectively). Conclusions - These results show that different types of fat may interact with cytokine genotype, modulating disease activity.

Analysis of a 17.9 kb region from Saccharomyces cerevisiae chromosome VII reveals the presence of eight open reading frames, including BRF1 (TFIIIB70) and GCN5 genes

We report the nucleotide sequence of a 17,893 bp DNA segment from the right arm of Saccharomyces cerevisiae chromosome VII. This fragment begins at 482 kb from the centromere. The sequence includes the BRF1 gene, encoding TFIIIB70, the 5' portion of the GCN5 gene, an open reading frame (ORF) previously identified as ORF MGA1, whose translation product shows similarity to heat-shock transcription factors and five new ORFs. Among these, YGR250 encodes a polypeptide that harbours a domain present in several polyA binding proteins. YGR245 is similar to a putative Schizosaccharomyces pombe gene, YGR248 shows significant similarity with three ORFs of S. cerevisiae situated on different chromosomes, while the remaining two ORFs, YGR247 and YGR251, do not show significant similarity to sequences present in databases.

Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the yeast PMT and EF1G genes, of the human and bacterial electron-transferring flavoproteins (beta-chain) and of the Escherichia coli phosphoserine phosphohydrolase, and five new ORFs.

A 17.6 kb DNA fragment from the right arm of chromosome VII of Saccharomyces cerevisiae has been sequenced and analysed. The sequence contains twelve open reading frames (ORFs) longer than 100 amino acids. Three genes had already been cloned and sequenced: CCT, ADE3 and TR-I. Two ORFs are similar to other yeast genes: G7722 with the YAL023 (PMT2) and PMT1 genes, encoding two integral membrane proteins, and G7727 with the first half of the genes encoding elongation factors 1gamma, TEF3 and TEF4. Two other ORFs, G7742 and G7744, are most probably yeast orthologues of the human and Paracoccus denitrificans electron-transferring flavoproteins (beta chain) and of the Escherichia coli phosphoserine phosphohydrolase. The five remaining identified ORFs do not show detectable homology with other protein sequences deposited in data banks. The sequence has been deposited in the EMBL data library under Accession Number Z49133.

Adoção da NCRF 17 nas maiores empresas do sector agrícola em Portugal

Mestrado em Contabilidade