377 resultados para incision


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Extra Ovarian Primary Peritoneal Carcinoma (EOPPC) is a rare type of adenocarcinoma of the pelvic and abdominal peritoneum. The objective examination and the histological aspect of the neoplasia virtually overlaps with that of ovarian carcinoma. The reported case is that of a 72 year-old patient who had undergone a total hysterectomy with bilateral annessiectomy surgery 20 years earlier subsequently to a diagnosis for uterine leiomyomatosis. The patient came to our attention presenting recurring abdominal pain, constipation, weight loss, severe asthenia and fever. Her blood test results showed hypochromic microcytic anemia and a remarkable increase CA125 marker levels. Instrumental diagnostics with Ultrasound (US) and CT scans indicated the presence of a single peritoneal mass (10-12 cm diameter) close to the great epiploon. The patient was operated through a midline abdominal incision and the mass was removed with the great omentum. No primary tumor was found anywhere else in the abdomen and in the pelvis. The operation lasted approximately 50 minutes. The post-operative course was normal and the patient was discharged four days later. The histological exam of the neoplasia, supported by immunohistochemical analysis, showed a significant positivity for CA 125, vimentin and cytocheratin, presence of psammoma bodies, and cytoarchitectural pattern resembling that of a serous ovarian carcinoma even in absence of primitiveness, leading to a final diagnosis of EOPPC. The patient later underwent six cycles of chemotherapy with paclitaxel (135 mg/m2/24 hr) in association with cisplatin (75mg/m2). At the fourth year follow-up no sign of relapse was observed. .

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Aim. The presence of the appendix within a femoral hernia sac is a rare condition known as De Garengeot hernia. We report a case of De Garengeot hernia with concomitant appendicitis and a brief review of the literature on the pathogenesis, diagnosis and treatment of this uncommon condition. Case report. A 33 year-old woman was admitted to our Surgical Unit with acute-onset pain and swelling in the right groin region. Clinical signs and ultrasound imaging suggested the presence of a strangulated femoral hernia and the patient was operated on in emergency setting. An inflamed appendix was discovered within the hernia sac. Appendectomy via McBurney incision and prosthetic repair of the femoral ring were performed. The postoperative course was uneventful and at the 2 week and 1 year follow-up no signs of wound infection and no hernia recurrence were found. Conclusion. Since clinical signs are non-specific and radiological findings may often be misinterpreted, appendicitis within a femoral hernia sac is often an incidental finding during an emergency operation for strangulated femoral hernia. Appendectomy-associated hernia repair may be performed with or without prosthesis depending on the extent of surgical field contamination.

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New high-resolution seismic data complemented with bedrock samples allowed us to propose a revised geological map of the Bay of Seine and to better define the control by the geological substrate on the morphogenesis and evolution of the Seine River during Pleistocene times. The new data confirm previous works. The Bay of Seine can be divided into two geological parts: a Mesozoic monocline domain occupying most of the bay and a syncline domain, mostly Tertiary, in the north, at the transition with the Central English Channel area. The highlighting of Eocene synsedimentary deformations, marked by sliding blocks in the syncline domain, is one of the most original inputs of this new study in the Bay of Seine that underlines the significant role of the substrate on the formation of the Seine paleo-valley. In the monocline domain, three terraces, pre-Saalian, Saalian and Weischelian in age respectively, constitute the infill of the paleovalley, preferentially incised into the middle to upper Jurassic marl-dominated formations, and bounded to the north by the seaward extension of the Oxfordian cuesta. The three terraces are preserved only along the northern bank of the paleovalley, evidencing a NE-to-SW migration of the successive valleys during the Pleistocene. We assume this displacement results from the tectonic tilt of the Paris Basin western margin. In the North, the paleo-Seine is incised into the axis of the tertiary syncline, and comprises three fill terraces that are assumed to have similar ages than those of the terraces. The fill terrace pattern is associated to the subsiding character of this northern domain of the Bay of Seine.

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We examined prevention of surgical site infection (SSI) in a tertiary teaching hospital in northeast Brazil, from January 1994 to December 2003. The survey included 5,742 patients subjected to thoracic, urologic, vascular and general surgery. The criteria for diagnosing SSI were those of the Centers for Disease Control, USA, and the variables of the National Nosocomial Infection Surveillance risk index were used. Data analysis revealed that anesthetic risk scores, wound class and duration of surgery were significantly associated with SSI. A total of 296 SSIs were detected among the 5,742 patients (5.1%). The overall incidence of SSI was 8.8% in 1994; it decreased to 3.3% in 2003. In conclusion, the use of educational strategies, based on guidelines for SSI prevention reduced SSI incidence. Appropriate management of preoperative, intraoperative, and postoperative incision care, and a surveillance system based on international criteria, were useful in reducing SSI rates in our hospital

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A dense grid of high- and very high resolution seismic data, together with piston cores and borehole data providing time constraints, enables us to reconstruct the history of the Bourcart canyon head in the western Mediterranean Sea during the last glacial/interglacial cycle. The canyon fill is composed of confined channel–levee systems fed by a series of successively active shelf fluvial systems, originating from the west and north. Most of the preserved infill corresponds to the interval between Marine Isotope Stage (MIS) 3 and the early deglacial (19 cal ka BP). Its deposition was strongly controlled by a relative sea level that impacted the direct fluvial/canyon connection. During a period of around 100 kyr between MIS 6 and MIS 2, the canyon “prograded” by about 3 km. More precisely, several parasequences can be identified within the canyon fill. They correspond to forced-regressed parasequences (linked to punctuated sea-level falls) topped by a progradational-aggradational parasequence (linked to a hypothetical 19-ka meltwater pulse (MWP)). The bounding surfaces between forced-regressed parasequences are condensed intervals formed during intervals of relative sediment starvation due to flooding episodes. The meandering pattern of the axial incision visible within the canyon head, which can be traced landward up to the Agly paleo-river, is interpreted as the result of hyperpycnal flows initiated in the river mouth in a context of increased rainfall and mountain glacier flushing during the early deglacial.

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Tem sido relatado que as estacas de Camellia sinensis possuem baixa capacidade de emitir raízes, motivando assim a realização de estudos básicos para otimização do processo de propagação por estacas. Assim sendo, o presente trabalho objetivou quantificar o potencial rizogênico de diferentes genótipos e o efeito da posição da estaca no ramo e incisão na base, do substrato, tamanho do recipiente e ácido indolbutírico no enraizamento de estacas semi-lenhosas dessa espécie. Para tal, foram coletados ramos dos genótipos IAC 259, F15 e Comum, em Pariquera-Açu-SP, no inverno de 2010. em seguida, preparadas as estacas, contendo uma gema e uma folha, foram mantidas em viveiro com 70% de sombreamento. Estacas da posição basal e mediana dos ramos são as mais adequadas para estaquia devido a menor mortalidade e maior enraizamento. A injúria na base da estaca não afeta a mortalidade e o enraizamento das estacas, porém induz à formação de calo. Também não houve diferenças na mortalidade e no enraizamento das estacas quando as mesmas foram mantidas em recipiente de 50, 90 e 120 cm³. Comparado com vermiculita, areia e casca de arroz carbonizada, o solo foi o melhor substrato para estaquia, que na presença do ferimento, juntamente com o tratamento das estacas com 10 g L-1 de AIB promoveu a maior porcentagem de enraizamento. Todavia, ainda nessa condição a mortalidade média das estacas foi de 42%. O potencial de enraizamento do genótipo Comum foi superior ao do IAC 259 e F15.

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As unidades estratigráficas que resultaram da evolução do rio Tejo em Portugal, aqui analisadas em pormenor entre Vila Velha de Ródão e Chamusca, possuem distintas características sedimentares e indústrias líticas: uma unidade culminante do enchimento sedimentar (o ancestral Tejo, antes do início da etapa de incisão fluvial) - SLD13 (+142 a 262 m acima do leito actual; com provável idade 3,6 a 1,8 Ma), sem indústrias identificadas; terraço T1 (+76 a 180 m; ca. 1000? a 900 ka), sem indústrias; terraço T2 (+57 a 150 m; idade estimada em ca. 600 ka), sem indústrias; terraço T3 (+36 a 113 m; ca. 460 a 360? ka), sem indústrias; terraço T4 (+26 a 55 m; ca. 335 a 155 ka), Paleolítico Inferior (Acheulense) em níveis da base e intermédios mas Paleolítico Médio inicial em níveis do topo; terraço T5 (+5 a 34 m; 135 a 73 ka), Paleolítico Médio (com talhe Mustierense, Levallois); terraço T6 (+3 a 14 m; 62 a 32 ka), Paleolítico Médio final (Mustierense final); Areias da Carregueira (areias eólicas) e coluviões (+3 a ca. 100 m; 32 a 12 ka), Paleolítico Superior a Epipaleolítico; enchimento da planície aluvial (+0 a 8 m; ca. 12 ka a actual), Mesolítico e indústrias mais recentes. As diferenças na elevação (a.r.b.) das escadarias de terraços resultam de soerguimento diferencial, devido a falhas ativas. Numa dada escadaria datada, a projeção da elevação da superfície de cada terraço (a.r.b.) versus a sua idade permitiu estimar a idade do topo do terraço T2 (ca. 600 ka) e a provável idade do início da etapa de incisão (ca. 1,8 Ma). Obteve-se a duração da fase de agradação dos terraços baixos e médios: T6 – 30 ka; T5 – 62 ka; T4 – ca. 180 ka; T3 – ca. 100? ka. Conclui-se que durante o Plistocénico médio e final, as fases de incisão e alargamento do vale foram curtas (ca. 11-25 ka) e ocorreram durante períodos de nível do mar muito baixo, alternando com mais longas fases de inundação e agradação do vale durante níveis do mar mais altos. Estas oscilações eustáticas de causa climática estão sobrepostas a um contexto de soerguimento de longo termo, controlando o desenvolvimento das escadarias. Calculou-se que para os últimos ca. 155 ka as taxas de incisão de curto-termo apresentam valores (0,09 a 0,41 m/ka), aproximadamente, duplos dos calculados para o intervalo ca. 155 a 900 ka (0,04 a 0,28 m/ka). Este aumento na taxa de incisão deve estar relacionado com um aumento na taxa de soerguimento por intensificação da compressão devido à convergência entre as placas Africana e Eurasiática. Abstract: The terrace staircases of the Lower Tagus River (Ródão to Chamusca) – characterization and interpretation of the sedimentary, tectonic, climatic and Palaeolithic data The stratigraphic units that record the evolution of the Tagus River in Portugal (study area between Vila Velha de Ródão and Chamusca villages) have different sedimentary characteristics and lithic industries: a culminant sedimentary unit (the ancestral Tagus, before the drainage network entrenchment) – SLD13 (+142 to 262 m above river bed – a.r.b.; with probable age 3.6 to 1.8 Ma), without artefacts; T1 terrace (+76 to 180 m; ca. 1000? to 900 ka), without artefacts; T2 terrace (+57 to 150 m; top deposits with a probable age ca. 600 ka), without artefacts; T3 terrace (+36 to 113 m; ca. 460 to 360? ka), without artefacts; T4 terrace (+26 to 55 m; ca. 335 a 155 ka), Lower Paleolithic (Acheulian) at basal and middle levels but early Middle Paleolithic at top levels; T5 terrace (+5 to 34 m; 135 to 73 ka), Middle Paleolithic (Mousterian; Levallois technique); T6 terrace (+3 to 14 m; 62 to 32 ka), late Middle Paleolithic (late Mousterian); Carregueira Sands (aeolian sands) and colluvium (+3 a ca. 100 m; 32 to 12 ka), Upper Paleolithic to Epipaleolithic; alluvial plain (+0 to 8 m; ca. 12 ka to present), Mesolithic and more recent industries. The differences in elevation (a.r.b.) of the several terrace staircases results from differential uplift due to active faults. The age interval for each aggradation phase of T3 to T6 terraces was obtained: T3 – ca. 100? ka; T4 – ca. 180 ka; T5 – 62 ka; T6 – 30 ka. The intervals of river down-cutting and widening of the valley floor were short (ca. 11-25 ka) and coincided with periods of very low sea-level. The plotting of the elevation (a.r.b.) versus the age of each terrace surface allows to estimate the age of the T2 terrace (ca. 600 ka) and the probable age of the beginning of the incision stage (ca. 1.8 Ma). So, the high amplitude sea-level changes that characterized the Middle and Late Pleistocene strongly determined the episodic down-cutting phases of the river during the low stands sea levels that alternated with the flooding and aggradation phases of the incised valley during highstand sea levels. These climate related eustatic oscillations are superimposed onto a long term uplift pattern, controlling the river terrace staircase development. During the last ca. 155 ka, the short-term incision rates (0.09 a 0.41 m/ka) were twice the values determined for the interval 155 to 900 ka (0.04 to 0.28 m/ka). This increase in incision rate should be related with an increase in uplift rate resulting from an intensification of compression due to the convergence between African - Eurasian plates.

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In the Lluta Valley, northern Chile, climate is hyperarid and vegetation is restricted to the valley floors and lowermost footslopes. Fossil tree trunks and leaves of predominantly Escallonia angustifolia, however, are abundant up to ∼15 m above the present valley floor, where they are intercalated with slope deposits, reflecting higher water levels in the past. A total of 17 samples have been radiocarbon dated, yielding ages between 38 and 15k cal a BP. The youngest ages of 15.4k cal a BP are interpreted as reflecting the beginning of river incision and lowering of the valley floor, impeding the further growth of trees at higher parts of the slopes. The most plausible scenario for this observation is intensified river incision after 15.4k cal a BP due to increased stream power and runoff from the Río Lluta headwaters in the Western Cordillera and Altiplano corresponding to the highstand of the Tauca and Central Andean Pluvial Event (CAPE) wet phase.

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The Late Cretaceous to Modern tectonic evolution of central and eastern California has been studied for many decades, with published work generally focusing on specific geographic areas and time periods. The resulting literature leaves the reader, whether graduate student, faculty member, or layperson, wondering what a coherently integrated tectonic evolution might look like, or if it would be at all possible to undertake such a task. This question is the common thread weaving together the four studies presented in this work. Each of the individual chapters is targeted at a specific location and time period which I have identified as a critical yet missing link in piecing together a coherent regional tectonic story. In the first chapter, we re-discover a set of major west down normal faults running along the western slope of the southern Sierra, the western Sierra fault system (WSFS). We show that one of these faults was offset by roughly a kilometer in Eocene time, and that this activity directly resulted in the incision of much of the relief present in modern Kings Canyon. The second chapter is a basement landscape and thermochronometric study of the hanging wall of the WSFS. New data from this study area provide a significant westward expansion of basement thermochronometric data from the southern Sierra Nevada batholith. Thermal modeling results of these data provide critical new constraints on the early exhumation of the Sierra Nevada batholith, and in the context of the results from Chapter I, allow us to piece together a coherent chronology of tectonic forcings and landscape evolution for the southern Sierra Nevada. In the third chapter, I present a study of the surface rupture of the 1999 Hector Mine earthquake, a dextral strike slip event on a fault in the Eastern California Shear Zone (ECSZ). New constraints on the active tectonics in ECSZ will help future studies better resolve the enigmatic mismatch between geologic slip rates and geodetically determined regional rates. Chapter IV is a magnetostratigraphic pilot study of the Paleocene Goler Formation. This study provides strong evidence that continued investigation will yield new constraints on the depositional age of the only fossil-bearing Paleocene terrestrial deposit on the west coast of North America. Each of these studies aims to provide important new data at critical missing links in the tectonic evolution of central and eastern California.

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Background: Sulphites are widely used as a preservative and antioxidant additives in the food and pharmaceutical industries. Many types of biological and toxicological effects of sulphites in multiple organs of mammals have been shown in previous studies. Objective: The aim of this study was to investigate the effects of sodium metabisulfite (SMB) on testicular function and morphometric values of epididymis in adult male Wistar rats. Materials and Methods: A total of 32 rats were randomly divided into four groups. The experimental groups received SMB at doses of 10 mg/kg (S10), 100mg/kg (S100), and 260 mg/kg (S260) while an equal volume of normal saline was administered to the control group via gavage. The rats were anaesthetized after 28 days and the left testis with the head of epididimis was excised following abdominal incision for histological observation using hematoxylin and eosin staining. Serum samples were collected for assay of testosterone level. The initial epididymis was analyzed for motility, morphology, and the number of sperms. Result: The results of this study showed that normal morphology, count, and motility of sperms and testosterone level were decreased in the SMB treated groups. In comparison with the control group, SMB resulted in a lower total number of spermatogonia, primary spermatocyte, spermatids, and Leydig cells. Conclusion: It is suggested that SMB decreases the sperm production and has the potential to affect the fertility adversely in male rats.

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An understanding of rates and mechanisms of incision and knickpoint retreat in bedrock rivers is fundamental to perceptions of landscape response to external drivers, yet only sparse field data are available. Here we present eye witness accounts and quantitative surveys of rapid, amphitheatre-headed gorge formation in unweathered granite from the overtopping of a rock-cut dam spillway by small-moderate floods (B100–1,500m3 s�1). The amount of erosion demonstrates no relationship with flood magnitude or bedload availability. Instead, structural pattern of the bedrock through faults and joints appears to be the primary control on landscape change. These discontinuities facilitate rapid erosion (4270m headward retreat; B100m incision; and B160m widening over 6 years) principally through fluvial plucking and block topple. The example demonstrates the potential for extremely rapid transient bedrock erosion even when rocks are mechanically strong and flood discharges are moderate. These observations are relevant to perceived models of gorge formation and knickpoint retreat.

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Introducción: la colecistectomía laparoscópica es la técnica de elección en pacientes con indicación de extracción quirúrgica de la vesícula; sin embargo, en promedio 20% de éstos requieren conversión a técnica abierta. En este estudio se evaluaron los factores de riesgo preoperatorios para conversión en colecistectomía laparoscópica de urgencia. Metodología: se realizó un estudio de casos y controles no pareado. Se obtuvo información sociodemográfica y de variables de interés de los registros de historias clínicas de pacientes operados entre el 2013 y 2016. Se identificaron los motivos de conversión de técnica quirúrgica. Se caracterizó la población de estudio y se estimaron asociaciones según la naturaleza de las variables. Mediante un análisis de regresión logística se ajustaron posibles variables de confusión. Resultados: se analizaron los datos de 444 pacientes (111 casos y 333 controles). La causa de conversión más frecuente fue la dificultad técnica (50,5%). Se encontró que la mayor edad, el sexo masculino, el antecedente de cirugía abierta en hemiabdomen superior, el signo de Murphy clínico positivo, la dilatación de la vía biliar, la leucocitosis y la mayor experiencia del cirujano, fueron factores de riesgo para conversión. Se encontró un área bajo la curva ROC= 0,743 (IC95% 0,692–0,794, p= <0,001). Discusión: existen unos factores que se asocian a mayor riesgo de conversión en colecistectomía laparoscópica. La mayoría se relacionan con un proceso inflamatorio más severo, por lo que se debe evitar la prolongación del tiempo de espera entre el inicio de los síntomas y la extirpación quirúrgica de la vesícula.

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This study examines the long profiles of tributaries of the Tejo (Tagus) and Zêzere rivers in central eastern Portugal (West Iberia) in order to provide new insights into the patterns, timing and controls on drainage development during the Pleistocene to Holocene incision stage. The long profiles were extracted from lower order tributary streams associated with the trunk drainage of the Tejo River and one main tributary, the Zêzere River (Fig. 1). These streams flow through a landscape strongly influenced by variations in bedrock lithology (mainly granites and metasediments), fault structures delimiting crustal blocks with distinct uplift rates, and a base-level lowering history (tectonic uplift / eustatic). The long profiles of the tributaries of the Tejo and Zêzere rivers record a series of transient and permanent knickpoints. The permanent knickpoints have direct correlation with the bedrock strength, corresponding to the outcropping of very hard quartzites or to the transition from softer (slates/metagreywaques) to harder (granite) basement. The analyzed streams/rivers record also an older transient knickpoint/knickzone separating: a) an upstream relict graded profile, with lower steepness and higher concavity, that reflects a long period of quasi-equilibrium conditions reached after the beginning of the incision stage; and b) a downstream reach displaying a rejuvenated long profile, with steeper gradient and lower concavity, particularly for the final segment, which is often convex (Fig. 2). The rejuvenated reaches testify the upstream propagation of several incision waves that are the response of each stream to continuous or increasing crustal uplift and dominant periods of base-level lowering by the trunk drainages, coeval of low sea level conditions. The long profiles and their morphological configurations enabled spatial and relative temporal patterns of incision to be quantified for each individual tributary stream. The incision values of streams flowing in uplifted blocks of the Portuguese Central Range (PCR) (ca.380-280 m) indicate differential uplift and are higher than the incision values of streams flowing on the adjacent South Portugal planation surface – the Meseta (ca. 200 m). The normalized steepness index, calculated using the method of Wobus et al. (2006), proved to be sensitive to active tectonics, as lower ksn values were found in relict graded profiles of streams located in less uplifted blocks, (e.g. Sertã stream in the PCR), or in those flowing through tectonic depressions. Fig. 1 – Geological map of the study area. 1 – fluvial terraces (Pleistocene); 2 – sedimentary cover (Paleogene and Neogene); 3 – slates and metasandstones (Devonian); 4 – slates and quartzites (Silurian); 5 – quartzites (Ordovician); 6 – slates and metagreywackes (Precambrian to Cambrian); 7 – slates, metagreywackes and limestones (Precambrian); 8 – granites and ortogneisses; 9 – diorites and gabros; 10 - fault. SFf – Sobreira Formosa fault; Sf – Sertã fault; Pf – Ponsul fault; Gf – Grade fault. The differential uplift indicated by the distribution of the ksn values and by the fluvial incision was likely accumulated on a few major faults, as the Sobreira Formosa fault (SFf), thus corroborating the tectonic activity of these faults. Due to the fact that the relict graded profiles can be correlated with other geomorphic references documented in the study area, namely the T1 terrace of the Tagus River (with an age of ca. 1 Myr), the following incision rates can be estimated: a) for the studied streams located in uplifted blocks of the PCR, 0.38 m/kyr to 0.28 m/kyr; b) for the streams flowing on the South Portugal planation surface, 0.20 m/kyr. The differential uplift inferred between crustal blocks in the study area corroborates the neotectonic activity of the bordering faults, which has been proposed in previous studies based upon less robust data. Fig. 2 – Longitudinal profile of the Nisa stream a tributary of the Tejo River. Note the equilibrium relict profile upstream the older transient knickpoint (hatched line) and the downstream rejuvenated profile (continuous line). Legend: tKP – transient knickpoint; rKp – resistant knickpoint; Mt – schist and phyllite; Gr – granite; Hf – hornfels; Og – orthogneisse. In the inset Distance – Slope plots, fill circles correspond to the relict graded profile, crosses correspond to the rejuvenated profile located downstream the older transient knickpoint (tKP).

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NEW DATA ON THE CHRONOLOGY OF THE VALE DO FORNO SEDIMENTARY SEQUENCE (LOWER TAGUS RIVER TERRACE STAIRCASE) AND ITS RELEVANCE AS FLUVIAL ARCHIVE OF THE MIDDLE PLEISTOCENE IN WESTERN IBERIA Pedro P. Cunha 1, António A. Martins 2, Jan-Pieter Buylaert 3,4, Andrew S. Murray 4, Luis Raposo 5, Paolo Mozzi 6, Martin Stokes 7 1 MARE - Marine and Environmental Sciences Centre, Department of Earth Sciences, University of Coimbra, Portugal: pcunha@dct.uc.pt 2 MARE - Marine and Environmental Sciences Centre, Dep. Geociências, University of Évora, Portugal; aam@uevora.pt 3 Centre for Nuclear Technologies, Technical University of Denmark, Risø Campus, Denmark; jabu@dtu.dk 4 Nordic Laboratory for Luminescence Dating, Aarhus University, Risø DTU, Denmark; anmu@dtu.dk 5 Museu Nacional de Arqueologia, Lisboa, Portugal; 3raposos@sapo.pt 6 Department of Geosciences, University of Padova, Italy; paolo.mozzi@unipd.it 7 School of Geography, Earth and Environmental Sciences, University of Plymouth, UK; m.stokes@plymouth.ac.uk The stratigraphic units that record the evolution of the Tagus River in Portugal (study area between Vila Velha de Ródão and Porto Alto villages; Fig. 1) have different sedimentary characteristics and lithic industries (Cunha et al., 2012): - a culminant sedimentary unit (the ancestral Tagus, before the drainage network entrenchment) – SLD13 (+142 to 262 m above river bed – a.r.b.; with probable age ca. 3,6 to 1,8 Ma), without artefacts; - T1 terrace (+84 to 180 m; ca. 1000? to 900 ka), without artefacts; - T2 terrace (+57 to 150 m; top deposits with a probable age ca. 600 ka), without artefacts; - T3 terrace (+43 to 113 m; ca. 460 to 360? ka), without artefacts; - T4 terrace (+26 to 55 m; ca. 335 a 155 ka), Lower Paleolithic (Acheulian) at basal and middle levels but early Middle Paleolithic at top levels; - T5 terrace (+5 to 34 m; 135 to 73 ka), Middle Paleolithic (Mousterian; Levallois technique); - T6 terrace (+3 to 14 m; 62 to 32 ka), late Middle Paleolithic (late Mousterian); - Carregueira Sands (aeolian sands) and colluvium (+3 a ca. 100 m; 32 to 12 ka), Upper Paleolithic to Epipaleolithic; - alluvial plain (+0 to 8 m; ca. 12 ka to present), Mesolithic and more recent industries. The differences in elevation (a.r.b.) of the several terrace staircases results from differential uplift due to active faults. Longitudinal correlation with the terrace levels indicates that a graded profile ca. 200 km long was achieved during terrace formation periods and a strong control by sea base level was determinant for terrace formation. The Neogene sedimentary units constituted the main source of sediments for the fluvial terraces (Fig. 2). Geomorphological mapping, coupled with lithostratigraphy, sedimentology and luminescence dating (quartz-OSL and K-feldspar post-IRIR290) were used in this study focused on the T4 terrace, which comprises a Lower Gravels (LG) unit and an Upper Sand (US) unit. The thick, coarse and dominantly massive gravels of the LG unit indicate deposition by a coarse bed-load braided river, with strong sediment supply, high gradient and fluvial competence, during conditions of rapidly rising sea level. Luminescence dating only provided minimum ages but it is probable that the LG unit corresponds to the earlier part of the MIS9 (ca. 335 to 325 ka), immediately postdating the incision promoted by the very low sea level (reaching ca. -140 m) during MIS10 (362 to 337 ka), a period of relatively cold climate conditions with weak vegetation cover on slopes and low sea level. Fig. 1. Main Portuguese reaches in which the Tagus River can be divided (Lower Tagus Basin): I – from the Spanish border to Arneiro (a general E–W trend, mainly consisting of polygonal segments); II – from Arneiro to Gavião (NE–SW); III – from Gavião to Arripiado (E–W); IV – from Arripiado to Vila Franca de Xira (NNE-SSW); V – from Vila Franca de Xira to the Atlantic shoreline. The faults considered to be the limit of the referred fluvial sectors are: F1 – Ponsul-Arneiro fault (WSW-ENE); F2 – Gavião fault (NW-SE); F3 – Ortiga fault (NW-SE); F4 – Vila Nova da Barquinha fault (W-E); F5 – Arripiado-Chamusca fault (NNE-SSW). 1 – estuary; 2 – terraces; 3 – faults; 4 – Tagus main channel. The main Iberian drainage basins are also represented (inset). The lower and middle parts of the US unit, comprising an alternation of clayish silts with paleosols and minor sands to the east (flood-plain deposits) and sand deposits to the west (channel belt), have a probable age of ca. 325 to 200 ka. This points to formation during MIS9 to MIS7, under conditions of high to medium sea levels and warm to mild conditions. The upper part of the US unit, dominated by sand facies and with OSL ages of ca. 200 to 154 ka, correlates with the early part of the MIS6. During this period, progradation resulted from climate deterioration and relative depletion of vegetation that promoted enhanced sediment production in the catchment, coupled with initiation of sea-level lowering that increased the longitudinal slope. The Vale do Forno and Vale da Atela archaeological sites (Alpiarça, central Portugal) document the earliest human occupation in the Lower Tagus River, well established in geomorphological and environmental terms, within the Middle Pleistocene. The Lower Palaeolithic sites were found on the T4 terrace (+26 m, a.r.b.). The oldest artefacts previously found in the LG unit, display crude bifacial forms that can be attributed to the Acheulian, with a probable age of ca. 335 to 325 ka. The T4 US unit has archaeological sites stratigraphically documenting successive phases of an evolved Acheulian, that probably date ca. 325 to 300 ka. Notably, these Lower Palaeolithic artisans were able to produce tools with different sophistication levels, simply by applying different strategies: more elaborated reduction sequences in case of bifaces and simple reduction sequences to obtain cleavers. Fig. 2. . Simplified geologic map of the Lower Tagus Cenozoic basin, adapted from the Carta Geológica de Portugal, 1/500000, 1992). The study area (comprising the Vale do Forno and Vale de Atela sites) is located on the more upstream sector of the Lower Tagus River reach IV, between Arripiado and Chamusca villages. 1 – alluvium (Holocene); 2 – terraces (Pleistocene); 3 – sands, silts and gravels (Paleogene to Pliocene); 4 – Sintra Massif (Cretaceous); 5 – limestones, marls, silts and sandstones (Mesozoic); 6 – quartzites (Ordovician); 7 – basement (Proterozoic to Palaeozoic); 8 – main fault. The main Portuguese reaches of the Tagus River are identified (I to V). The VF3 site (Milharós), containing a Final Acheulian industry, with fine and elaborated bifaces) found in a stratigraphic level located between the T4 terrace deposits and a colluvium associated with Late Pleistocene aeolian sands (32 to 12 ka), has an age younger than ca. 154 ka but much older than 32 ka. In the study area, the sedimentary units of the T4 terrace seem to record the river response to sea-level changes and climatically-driven fluctuations in sediment supply. REFERENCES Cunha P. P., Almeida N. A. C., Aubry T., Martins A. A., Murray A. S., Buylaert J.-P., Sohbati R., Raposo L., Rocha L., 2012, Records of human occupation from Pleistocene river terrace and aeolian sediments in the Arneiro depression (Lower Tejo River, central eastern Portugal). Geomorphology, vol. 165-166, pp. 78-90.