Stress, inflammation, and cellular vulnerability during early stages of affective disorders: biomarker strategies and opportunities for prevention and intervention

The mood disorder prodrome is conceptualized as a symptomatic, but not yet clinically diagnosable stage of an affective disorder. Although a growing area, more focused research is needed in the pediatric population to better characterize psychopathological symptoms and biological markers that can reliably identify this very early stage in the evolution of mood disorder pathology. Such information will facilitate early prevention and intervention, which has the potential to affect a person’s disease course.This review focuses on the prodromal characteristics, risk factors, and neurobiological mechanisms of mood disorders. In particular, we consider the influence of early-life stress, inflammation, and allostatic load in mediating neural mechanisms of neuroprogression. These inherently modifiable factors have known neuroadaptive and neurodegenerative implications, and consequently may provide useful biomarker targets. Identification of these factors early in the course of the disease will accordingly allow for the introduction of early interventions which augment an individual’s capacity for psychological resilience through maintenance of synaptic integrity and cellular resilience. A targeted and complementary approach to boosting both psychological and physiological resilience simultaneously during the prodromal stage of mood disorder pathology has the greatest promise for optimizing the neurodevelopmental potential of those individuals at risk of disabling mood disorders.

Affective energies : Sensory bodies on the beach in Darwin, Australia

Emerging debates on anti-racism within white majority cultures centre emotion and affect to explore the visceral nature of racialised encounters that unfold in public spaces of the city. This paper builds on such understandings by conceptualising whiteness as a force that exerts affective pressures on bodies of colour who are hypervisible in public spaces. I show that these pressures have the potential to wound, numb and immobilise bodies affecting what they can do or what they can become. This paper argues, however, that affective energies from human and non-human sources are productive forces that are also sensed in public spaces such as the suburban beach. These energies entangle sensuous bodies with the richness of a more-than-human world and have the potential to offer new insights into exploring how racially differentiated bodies live with difference. The paper draws on ethnographic research conducted in Darwin, a tropical north Australian city at the centre of politicised public debates on asylum seeker policy, migrant integration and Indigenous wellbeing. My attention to affective pressures and affective energies contributes to understanding how bodies with complex histories and geographies of racialisation can inhabit a world of becoming. © 2014 Elsevier Ltd. All rights reserved.

Collapse: Clouds of affective dust

All objects emerge from a cloud of activities, virtual pressures and situated encumbrances that precede their status as finished things. Once emerged, traces of their history linger in the object, signposting a range of past and future potentials that are largely inaccessible – or just unnoticed. Objects, in short, always shimmer with connections beyond themselves, through which they are part of ecologies that render them both meaningful and active. We would call this shimmering their ‘abstract life’. However, this life is rarely identified overtly, and tends to linger in the background, rendering their shimmering vitality more mute than manifest. This paper is interested in how that abstract life can become palpably evident though various forms of collapse, where a fallout throws a kind of dust into the lingering cloud – offering visibility, or material presence, to the otherwise largely invisible, abstract life of things. We will touch upon a series of examples, from the World Trade Centre collapse in the attacks of 2001, to the collapse of computational operations and perceptual models. These examples will lead toward experiments in image making – specifically through using panorama software applications on the iPhone – in which a collapse of the programmed panoramic logic creates ‘glitches’, throwing into question the status of the image and their relationship to perception, amongst other things. These experiments will be discussed in order to demonstrate how collapse might operate as a specific technique inside diverse creative practices (from image making to making architecture). By generating clouds of affective dust, related techniques can bring the abstract ‘life’ of objects flickering into the foreground, allowing the agency of the inanimate to shine.

Examining the affective tone of alcohol craving in young drinkers

An abundance of research has examined craving and affective responses to alcohol; however, minimal emphasis has been placed on the relationship between craving and affective states at specific time points of alcohol consumption. Fifty-nine university students (28 light drinkers, 31 heavy drinkers) completed assessments of craving, and positive and negative affect at baseline (Time 1), immediately following consumption of a standard drink of alcohol (Time 2), and 20 min post consumption (Time 3). In light drinkers, craving was positively correlated with positive affect at all 3 time points. In heavy drinkers, craving was only correlated with positive affect at Time 2. There were no associations between craving and negative affect at any time point in either group. A subsequent profile analysis revealed parallel profiles of craving and positive affect over time in light drinkers, but not heavy drinkers. At 20 min post alcohol consumption, a moderated regression showed that the relationship between craving and positive affect weakened as level of alcohol use increased. These findings suggest that craving is positively associated with positive affect in light drinkers, but as levels of drinking escalate, this association dissipates.

Lithium blocks 45Ca2+ uptake into platelets in bipolar affective disorder and controls.

The basal uptake of radiolabelled 45Ca2+ into platelets and the effect of 1 mM lithium on uptake was measured in manic (n = 13) and depressed (n = 15) patients with bipolar disorder and in controls (n = 13). Lithium was significantly associated with inhibition of uptake of 45Ca2+ into platelets in all three groups. There were no significant intergroup differences in either basal levels of calcium uptake or the effects of lithium on calcium uptake (analysis of variance).

Tunable dual-stimuli response of a microgel composite consisting of reduced graphene oxide nanoparticles and poly(N-isopropylacrylamide) hydrogel microspheres

A type of photo- and thermo-responsive composite microsphere composed of reduced graphene oxide nanoparticles and poly(N-isopropylacrylamide) (rGO@pNIPAM) is successfully fabricated by a facile solution mixing method. Due to the high optical absorbance and thermal conduction of rGO, the composite microspheres are endowed with the new property of photo-response, in addition to the intrinsic thermally sensitive property of pNIPAM. This new ability undoubtedly enlarges the scope of applications of the microgel spheres. Furthermore, through controlling the rGO content in the composite, the photo- and thermo-sensitivity of the composite can be effectively modulated. That is, with a lower rGO content (≤32% by weight), the composite microspheres perform only thermally induced changes, such as volume contraction (by ∼45% in diameter) and drug release, when crossing the lower critical solution temperature of pNIPAM. With a higher rGO content (∼47.5%), both temperature and light irradiation can trigger changes in the composite. However, when the rGO content is increased to around 64.5%, the thermo-responsivity of the composite disappears, and the spheres exhibit only photo-induced drug release. With a further increase in rGO content, the environmentally responsive ability of the microspheres vanishes. This journal is © the Partner Organisations 2014.

Affective, linguistic and topic patterns in online autism communities

Online communities offer a platform to support and discuss health issues. They provide a more accessible way to bring people of the same concerns or interests. This paper aims to study the characteristics of online autism communities (called Clinical) in comparison with other online communities (called Control) using data from 110 Live Journal weblog communities. Using machine learning techniques, we comprehensively analyze these online autism communities. We study three key aspects expressed in the blog posts made by members of the communities: sentiment, topics and language style. Sentiment analysis shows that the sentiment of the clinical group has lower valence, indicative of poorer moods than people in control. Topics and language styles are shown to be good predictors of autism posts. The result shows the potential of social media in medical studies for a broad range of purposes such as screening, monitoring and subsequently providing supports for online communities of individuals with special needs.

Analysis of circadian rhythms from online communities of individuals with affective disorders

The circadian system regulates 24 hour rhythms in biological creatures. It impacts mood regulation. The disruptions of circadian rhythms cause destabilization in individuals with affective disorders, such as depression and bipolar disorders. Previous work has examined the role of the circadian system on effects of light interactions on mood-related systems, the effects of light manipulation on brain, the impact of chronic stress on rhythms. However, such studies have been conducted in small, preselected populations. The deluge of data is now changing the landscape of research practice. The unprecedented growth of social media data allows one to study individual behavior across large and diverse populations. In particular, individuals with affective disorders from online communities have not been examined rigorously. In this paper, we aim to use social media as a sensor to identify circadian patterns for individuals with affective disorders in online communities.We use a large scale study cohort of data collecting from online affective disorder communities. We analyze changes in hourly, daily, weekly and seasonal affect of these clinical groups in contrast with control groups of general communities. By comparing the behaviors between the clinical groups and the control groups, our findings show that individuals with affective disorders show a significant distinction in their circadian rhythms across the online activity. The results shed light on the potential of using social media for identifying diurnal individual variation in affective state, providing key indicators and risk factors for noninvasive wellbeing monitoring and prediction.

Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces

Bio-molecular non-covalent interactions provide a powerful platform for material-specific self-organization in aqueous media. Here, we introduce a strategy that integrates a synthetic optically-responsive motif with a materials-binding peptide to enable remote actuation. Specifically, we linked a photoswitchable azobenzene moiety to either terminus of a Au-binding peptide. We employed these hybrid molecules as capping agents for synthesis of Au nanoparticles. Integrated experiments and molecular simulations showed that the hybrid molecules maintained both of their functions, i.e. binding to Au and optically-triggered reconfiguration. The azobenzene unit was optically switched reversibly between trans and cis states while adsorbed on the particle surface. Upon switching, the conformation of the peptide component of the molecule also changed. This highlights the interplay between the surface adsorption and conformational switching that will be pivotal to the creation of actuatable nanoparticle bio-interfaces, and paves the way toward multifunctional peptide hybrids that can produce stimuli responsive nanoassemblies.