Stem cell mobilization chemotherapy with gemcitabine is effective and safe in myeloma patients with bortezomib-induced neurotoxicity.

Vinorelbine chemotherapy with granulocyte-colony stimulating factor (G-CSF) stimulation is a widely applied non-myelosuppressive mobilization regimen in Switzerland for myeloma patients, but its neurotoxic potential limits its use in patients with bortezomib-induced polyneuropathy. In this single-center study, we alternatively evaluated safety and effectiveness of gemcitabine chemotherapy with G-CSF for mobilization of autologous stem cells. Between March 2012 and February 2013, all bortezomib-pretreated myeloma patients planned to undergo first-line high-dose melphalan chemotherapy received a single dose of 1250 mg/m(2) gemcitabine, with G-CSF started on day 4. The 24 patients in this study had received a median of four cycles of bortezomib-dexamethason-based induction. Bortezomib-related polyneuropathy was identified in 21 patients (88%) by clinical evaluation and a standardized questionnaire. Administration of gemcitabine mobilization did not induce new or aggravate pre-existing neuropathy. Stem cell mobilization was successful in all 24 patients, with a single day of apheresis being sufficient in 19 patients (78%). The median yield was 9.51 × 10(6) CD34+ cells/kg. Stem collection could be accomplished at day 8 in 67%. Our data suggest that single-dose gemcitabine together with G-CSF is an effective mobilization regimen in myeloma patients and a safe alternative non-myelosuppressive mobilization chemotherapy for myeloma patients with bortezomib-induced polyneuropathy.

The Nelaton Catheter Guard for Safe and Effective Placement of Subdural Drain for Two-Burr-Hole Trephination in Chronic Subdural Hematoma: A Technical Note

BACKGROUND For chronic subdural hematoma, placement of a Blake drain with a two-burr-hole craniotomy is often preferred. However, the placement of such drains carries the risk of penetrating the brain surface or damaging superficial venous structures. OBJECTIVE To describe the use of a Nelaton catheter for the placement of a subdural drain in two-burr-hole trephination for chronic subdural hematoma. METHOD A Nelaton catheter was used to guide placement of a Blake drain into the subdural hematoma cavity and provide irrigation of the hematoma cavity. With the two-burr-hole method, the Nelaton catheter could be removed easily via the frontal burr hole after the Blake drain was in place. RESULTS We used the Nelaton catheters in many surgical procedures and found it a safe and easy technique. This method allows the surgeon to safely direct the catheter into the correct position in the subdural space. CONCLUSIONS This tool has two advantages. First, the use of a small and flexible Nelaton catheter is a safe method for irrigation of a chronic subdural hematoma cavity. Second, in comparison with insertion of subdural drainage alone through a burr hole, the placement of the Nelaton catheter in subdural space is easier and the risk of damaging relevant structures such as cortical tissue or bridging veins is lower. Thus this technique may help to avoid complications when placing a subdural drain.

Dust measurements in the coma of comet 67P/Churyumov-Gerasimenko inbound to the Sun

Critical measurements for understanding accretion and the dust/gas ratio in the solar nebula, where planets were forming 4.5 billion years ago, are being obtained by the GIADA (Grain Impact Analyser and Dust Accumulator) experiment on the European Space Agency's Rosetta spacecraft orbiting comet 67P/Churyumov-Gerasimenko. Between 3.6 and 3.4 astronomical units inbound, GIADA and OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) detected 35 outflowing grains of mass 10(-10) to 10(-7) kilograms, and 48 grains of mass 10(-5) to 10(-2) kilograms, respectively. Combined with gas data from the MIRO (Microwave Instrument for the Rosetta Orbiter) and ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) instruments, we find a dust/gas mass ratio of 4 +/- 2 averaged over the sunlit nucleus surface. A cloud of larger grains also encircles the nucleus in bound orbits from the previous perihelion. The largest orbiting clumps are meter-sized, confirming the dust/gas ratio of 3 inferred at perihelion from models of dust comae and trails.

HACCP Drives Safe Seafood

Seafood is part of a healthy diet, but how can you be sure that the seafood on your plate has not become contaminated somewhere between the boat and your home? HACCP training helps seafood processors and handlers meet FDA regulations to control potential hazards along the way.

2006: A Safe Year for Falls at John Dempsey Hospital!

Our Goal: To Prevent Harm The most important goal for the Collaborative Center for Clinical Care Improvement (C4I) Patient Falls Group is to prevent any serious injury should a fall occur. While our goal is also to reduce the number of patient falls, it is especially important to prevent any serious harm to the patient. During calendar year 2006 (January-December), we accomplished our most important goal - there were no serious injuries related to any patient falls that occurred in the hospital during the past twelve months.

Changing Tides and Changing Focus: Mapping the Challenges and Successes of One State's Implementation Of the Adoption and Safe Families Act of 1997

In 1997, the Adoption and Safe Families Act shifted from the preservation of families to an emphasis on safety, permanency, and well-being through expediting the termination of parental rights, establishing exceptions to the reasonable efforts clause of preserving the family, and fiscal incentives for finalizing adoptions. The current project assessed the role of a full service array in achieving the outcomes set forth in ASF A. Concept mapping was utilized to elicit information from participants (both urban and rural) regarding the identified research question. Participants recognized family preservation versus safety, community connections, mandates versus reality, and worker recruitment and retention as critical components for meeting ASFA goals. Perceived importance and level of success in implementing these services was also highlighted. Recommendations supported through the data are also provided.

Packages of interventions for family planning, safe abortion care, maternal, newborn and child health

The evidence shows that high maternal, perinatal, neonatal and child mortality rates are associated with inadequate and poor quality health services. Evidence also suggests that explicit, evidence-based, cost effective packages of interventions can improve the processes and outcomes of health care when appropriately implemented. This document describes the key effective interventions organized in packages across the continuum of care through pre-pregnancy, pregnancy, childbirth, postpartum, newborn care and care of the child. The packages are defined for community and/or facility levels in developing countries and provide guidance on the essential components needed to assure adequacy and quality of care

Safe abortion: technical and policy guidance for health systems

Esta 2da edición de la Guía recoge la última evidencia disponible no sólo respecto de la atención del aborto seguro sino también de cómo deben organizarse los recursos humanos, los insumos y las instituciones de salud para garantizar los derechos humanos, incluyendo los derechos sexuales y reproductivos de las mujeres.

Working to improve access to safe abortion

Presentación en la 4ta. Conferencia Regional del CLACAI. Reafirmando el legado de Cairo: Aborto legal y seguro. Lima, 21 y 22 de Agosto de 2014

Política y militarismo : Sun Tzu y Engels

Los acontecimientos revolucionarios de 1848 fueron decisivos en los desarrollos conceptuales posteriores. La guerra, y la violencia, ocuparon un lugar central en el estudio detallado de sus reglas. Este trabajo intenta presentar algunos puntos nodales que intentan avanzar en la respuesta a esta pregunta: ¿Cabe la analogía de la guerra con la lucha de clases? En este sentido el trabajo se limita a señalar los ejes de este debate sobre la base de una relectura de dos clásicos. Sun Tzu y su Arte de la guerra, y varios textos de Engels. La hipótesis sostenida en el trabajo es que la lucha de clases, como momento político, encierra la posibilidad de la guerra sólo como un momento del antagonismo. El conocimiento de esas reglas potencia la capacidad de resolver de manera victoriosa el enfrentamiento, pero no es su contenido. Fijar el antagonismo como guerra es hacer de la lucha un militarismo que soslaya la construcción de una fuerza capaz de dar ese enfrentamiento directo. Intentaré mostrar cómo este debate señala puntos relevantes para entender las líneas políticas a finales de los sesenta en la Argentina

Política y militarismo : Sun Tzu y Engels

Los acontecimientos revolucionarios de 1848 fueron decisivos en los desarrollos conceptuales posteriores. La guerra, y la violencia, ocuparon un lugar central en el estudio detallado de sus reglas. Este trabajo intenta presentar algunos puntos nodales que intentan avanzar en la respuesta a esta pregunta: ¿Cabe la analogía de la guerra con la lucha de clases? En este sentido el trabajo se limita a señalar los ejes de este debate sobre la base de una relectura de dos clásicos. Sun Tzu y su Arte de la guerra, y varios textos de Engels. La hipótesis sostenida en el trabajo es que la lucha de clases, como momento político, encierra la posibilidad de la guerra sólo como un momento del antagonismo. El conocimiento de esas reglas potencia la capacidad de resolver de manera victoriosa el enfrentamiento, pero no es su contenido. Fijar el antagonismo como guerra es hacer de la lucha un militarismo que soslaya la construcción de una fuerza capaz de dar ese enfrentamiento directo. Intentaré mostrar cómo este debate señala puntos relevantes para entender las líneas políticas a finales de los sesenta en la Argentina