Uso da função discriminante linear na classificação dos fatores que determinam o êxodo rural.

A presente aplicacao da funcao discriminante linear na classificacao de fatores que determinam o exodo rural foi realizada a partir dos dados coletados em pequenas propriedades na regiao de Ouricuri, no alto sertao de Pernambuco. Dentro do complexo de problemas que condicionam o exodo rural foi escolhido um conjunto de variaveis que explicariam o fenomeno. Estas variaveis foram estudadas em duas populacoes (com exodo rural e sem exodo), para verificar em que grau se explica esse fenomeno. O objetivo do trabalho consistiu em testar instrumentos tecnicos e metodos estatisticos sobre problemas socio-economicos que possam ser usados posteriormente pelos orgaos de desenvolvimento.

Propostas para o desenvolvimento da agroecologia no Estado de Mato Grosso do Sul.

2005

Melhoramento genético: a nova arma no controle de doenças.

2000

Nematoides em cultivos integrados.

2013

Seguimento farmacoterapêutico em idosos polimedicados

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

Evaluación de docentes y estudiantes de bachillerato mediante pruebas objetivas y estandarizadas de matemáticas

En este estudio participaron profesores de matemáticas y estudiantes de tercer grado de bachillerato, a los cuales se les aplicó una prueba de matemáticas, con tres propósitos: primero conocer sus fortalezas y debilidades ante una prueba objetiva y estandarizada de matemáticas; segundo, determinar cursos de actualización para los docentes que conviertan sus debilidades en fortalezas; y tercero, que los profesores conozcan las debilidades de los estudiantes y apliquen las estrategias pertinentes para potenciar su aprendizaje. De los datos obtenidos, se detectaron los reactivos de mayor dificultad, en el caso de los docentes, los reactivos con un porcentaje menor o igual al 90% de respuestas correctas; y en el caso de los estudiantes, los de un porcentaje de respuestas correctas menor o igual al 60%. Los resultados señalan que las debilidades de los docentes, son las debilidades de los estudiantes.

Situaciones didácticas en la comprensión del concepto de número racional en alumnos de nivel medio superior

Esta investigación se realizó con alumnos de Nivel Medio Superior (NMS) que habían cursado la asignatura de Matemáticas I y que tenían dificultades con la comprensión del concepto de número racional. El propósito fue poner en escena situaciones didácticas, para explorar sus efectos en la comprensión de este concepto. Para tener información precisa de cuál es el estado que guardaba este conocimiento en los alumnos, se hizo un diagnóstico, por lo que se diseñaron y validaron las situaciones que se utilizarían tanto en el diagnóstico como en la puesta en escena. En su diseño se consideraron los contenidos de aritmética de NMS, diferentes sistemas de representación y el modelo utilizado por Sierpinska sobre los actos de comprensión de conceptos matemáticos. Al comparar los resultados que se obtuvieron en el diagnóstico con los de la puesta en escena de las situaciones didácticas, se encontró que: el permitir que los alumnos conocieran diferentes formas de representar a los números racionales, el significado de cada una de ellas, así como convertir o traducir unas representaciones en otras a través de las situaciones didácticas, propició la construcción de este concepto y mejoraran su comprensión.

The Afroporteña press and Afro-Argentine’s thought in the late nineteenth century

The journalistic boom that occurred in Argentina from the second half of the nineteenth century saw the emergence of an active afroporteña press that defend the interests of the black community. This paper, in addition to reviewing the history of the Afro-Argentines newspapers, emphasizes the role played by the elite of African descent in the promotion of modernity among his brothers, while exploring the possible bases for an identity in the ideas spread.

A new teaching category at the Spanish University of Franco’s regime: the appearance on the scene of the senior lecturer

The Law of 17 July 1965 on the structure of university faculties and their teaching staff placed the figure of the university senior lecturer on stage. During the sixties, the gestation process, adoption and subsequent integration of the new figure in the academic pyramid did not escape controversy, leading to a complex phenomenon to which, however, non comprehensive studies have been devoted to reveal: how, when, why and under which conditions this teacher appeared in the Spanish University of Franco’s regime. This paper aims to provide an overview of the process of materialization of the senior lecturer, the legislative framework that definitely established this new educational category and the provisions that were in charge of regulating the processes to get tenure. Also, the first approved aggregate endowments and their distribution among universities, colleges and studies will be discussed. Finally, it was a first approach to the possible motivations that led to the creation of this new educational category in a university afflicted by serious problems waiting for a solution that had been delayed sine die. Asimismo, se analizarán las primeras dotaciones de agregados aprobadas y la distribución de las mismas por universidades, facultades y estudios. Para terminar, se realiza un primer acercamiento a las posibles motivaciones que condujeron a la creación de esta nueva figura docente en una universidad aquejada de graves problemas que esperaban a una solución que venía demorándose sine die.

In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine

Background: Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma. Five species of Schistosoma are known to infect humans, out of which S. haematobium is the most prevalent, causing the chronic parasitic disease schistosomiasis that still represents a major problem of public health in many regions of the world and especially in tropical areas, leading to serious manifestations and mortality in developing countries. Since the 1970s, praziquantel (PZQ) is the drug of choice for the treatment of schistosomiasis, but concerns about relying on a single drug to treat millions of people, and the potential appearance of drug resistance, make identification of alternative schistosomiasis chemotherapies a high priority. Alkylphospholipid analogs (APLs), together with their prototypic molecule edelfosine (EDLF), are a family of synthetic antineoplastic compounds that show additional pharmacological actions, including antiparasitic activities against several protozoan parasites.

Methodology/Principal Findings: We found APLs ranked edelfosine> perifosine> erucylphosphocholine> miltefosine for their in vitro schistosomicidal activity against adult S. mansoni worms. Edelfosine accumulated mainly in the worm tegument, and led to tegumental alterations, membrane permeabilization, motility impairment, blockade of male-female pairing as well as induction of apoptosis-like processes in cells in the close vicinity to the tegument. Edelfosine oral treatment also showed in vivo schistosomicidal activity and decreased significantly the egg burden in the liver, a key event in schistosomiasis.

Conclusions/Significance: Our data show that edelfosine is the most potent APL in killing S. mansoni adult worms in vitro. Edelfosine schistosomicidal activity seems to depend on its action on the tegumental structure, leading to tegumental damage, membrane permeabilization and apoptosis-like cell death. Oral administration of edelfosine diminished worm and egg burdens in S. mansoni-infected CD1 mice. Here we report that edelfosine showed promising antischistosomal properties in vitro and in vivo.

Endoplasmic reticulum targeting in Ewing’s sarcoma by the alkylphospholipid analog edelfosine

Ewing's sarcoma (ES) is the second most common bone cancer in children and young people. Edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) is the prototype of a family of synthetic antitumor compounds, collectively known as alkylphospholipid analogs (APLs). We have found that APLs ranked edelfosine>perifosine>erucylphosphocholine>miltefosine for their capacity to promote apoptosis in ES cells. Edelfosine accumulated in the endoplasmic reticulum (ER) and triggered an ER stress response that eventually led to caspase-dependent apoptosis in ES cells. This apoptotic response involved mitochondrial-mediated processes, with cytochrome c release, caspase-9 activation and generation of reactive oxygen species. Edelfosine-induced apoptosis was also dependent on sustained c-Jun NH2-terminal kinase activation. Oral administration of edelfosine showed a potent in vivo antitumor activity in an ES xenograft animal model. Histochemical staining gave evidence for ER stress response and apoptosis in the ES tumors isolated from edelfosine-treated mice. Edelfosine showed a preferential action on ES tumor cells as compared to non-transformed osteoblasts, and appeared to be well suited for combination therapy regimens. These results demonstrate in vitro and in vivo antitumor activity of edelfosine against ES cells that is mediated by caspase activation and ER stress, and provide the proof of concept for a putative edelfosine-and ER stress-mediated approach for ES treatment.