925 resultados para tensionless vaginal tape


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"Issued December 1992."

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Publié pour la première fois dans La Revue des deux mondes, au cours des années 1901, 1902 et 1903.

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Pencil on tracing paper; signed. 57x44 cm. Scale: 1/4"=1' [from photographic copy by Lance Burgharrdt]

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Ink on linen; location, type of trees; notes; area bounded by Lake, Elmwood, North Blvd. and Scoville; signed. 58x64 cm. Scale: 1"=20' [from photographic copy by Lance Burgharrdt]

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Ink on linen; signed. 56x33 cm. Scale: 1"=10' [from photographic copy by Lance Burgharrdt]

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"Greg J. Duncan and James N. Morgan are the principal researchers."

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Mode of access: Internet.

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The breast cancer susceptibility gene Brca1 encodes a large multi-functional protein which is implicated as a caretaker of the genome, through its role in regulation of DNA damage response pathways, including apoptosis. Here we show that in mice expressing a dominant-negative Brca1 transgene on a BALB/c background, vaginal entrance remodeling is inhibited, and that the incidence of this phenotype is increased on a p53 +/- genotype. Given that this developmental process is mediated primarily by apoptosis, we hypothesized that disruption of BRCA1 may confer a resistance to apoptosis in normal epithelial cells. Consistent with this, we show that expression of this transgene in vitro leads to resistance to ionizing radiation induced cell killing in mammary epithelial cells. This is the first time that BRCA1 has been implicated in an apoptosis-mediated normal developmental process.