MMTV-trBrca 1 mice display strain-dependent abnormalities in vaginal development
Data(s) |
01/09/2004
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Resumo |
The breast cancer susceptibility gene Brca1 encodes a large multi-functional protein which is implicated as a caretaker of the genome, through its role in regulation of DNA damage response pathways, including apoptosis. Here we show that in mice expressing a dominant-negative Brca1 transgene on a BALB/c background, vaginal entrance remodeling is inhibited, and that the incidence of this phenotype is increased on a p53 +/- genotype. Given that this developmental process is mediated primarily by apoptosis, we hypothesized that disruption of BRCA1 may confer a resistance to apoptosis in normal epithelial cells. Consistent with this, we show that expression of this transgene in vitro leads to resistance to ionizing radiation induced cell killing in mammary epithelial cells. This is the first time that BRCA1 has been implicated in an apoptosis-mediated normal developmental process. |
Identificador | |
Idioma(s) |
eng |
Publicador |
University of the Basque Country Press |
Palavras-Chave | #Brca1 #Mouse #Imperforate Vagina #Apoptosis #Breast-cancer Risk #Transgenic Mice #Brca1 #Apoptosis #Expression #Mutation #Gene #Induction #Tissues #Cells #C1 #321026 Reproduction #321015 Oncology and Carcinogenesis #270603 Animal Physiology - Systems #270106 Cell Development (incl. Cell Division and Apoptosis) #270803 Transgenesis #730108 Cancer and related disorders #730201 Women's health #730116 Reproductive system and disorders |
Tipo |
Journal Article |