The influence of gender-stereotyped perfumes on leadership attribution

The classification of perfumes as ‘women's’ and ‘men's’ fragrances is based on certain gender stereotypes. In two experiments, female and male participants were asked to assume the role of a manager. In Experiment 1, they read an application for the position of a junior manager written by a male or female job applicant. Application papers were prepared with a typically masculine perfume, a typically feminine perfume or no perfume at all (control group). In Experiment 2, participants conducted a job interview with a female or male applicant (a confederate) who had applied the respective perfume or no perfume. Persons with a typically masculine perfume were ‘employed’ with a higher degree of certainty compared to persons with a typically feminine perfume.

Evaluation of cell responses toward adhesives with different photoinitiating systems

OBJECTIVES The photoinitiator diphenyl-(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) is more reactive than a camphorquinone/amine (CQ) system, and TPO-based adhesives obtained a higher degree of conversion (DC) with fewer leached monomers. The hypothesis tested here is that a TPO-based adhesive is less toxic than a CQ-based adhesive. METHODS A CQ-based adhesive (SBU-CQ) (Scotchbond Universal, 3M ESPE) and its experimental counterpart with TPO (SBU-TPO) were tested for cytotoxicity in human pulp-derived cells (tHPC). Oxidative stress was analyzed by the generation of reactive oxygen species (ROS) and by the expression of antioxidant enzymes. A dentin barrier test (DBT) was used to evaluate cell viability in simulated clinical circumstances. RESULTS Unpolymerized SBU-TPO was significantly more toxic than SBU-CQ after a 24h exposure, and TPO alone (EC50=0.06mM) was more cytotoxic than CQ (EC50=0.88mM), EDMAB (EC50=0.68mM) or CQ/EDMAB (EC50=0.50mM). Cultures preincubated with BSO (l-buthionine sulfoximine), an inhibitor of glutathione synthesis, indicated a minor role of glutathione in cytotoxic responses toward the adhesives. Although the generation of ROS was not detected, a differential expression of enzymatic antioxidants revealed that cells exposed to unpolymerized SBU-TPO or SBU-CQ are subject to oxidative stress. Polymerized SBU-TPO was more cytotoxic than SBU-CQ under specific experimental conditions only, but no cytotoxicity was detected in a DBT with a 200μm dentin barrier. SIGNIFICANCE Not only DC and monomer-release determine the biocompatibility of adhesives, but also the cytotoxicity of the (photo-)initiator should be taken into account. Addition of TPO rendered a universal adhesive more toxic compared to CQ; however, this effect could be annulled by a thin dentin barrier.

A model of factors determining levels of public support for health care policy in the United States

Public preferences for policy are formed in a little-understood process that is not adequately described by traditional economic theory of choice. In this paper I suggest that U.S. aggregate support for health reform can be modeled as tradeoffs among a small number of behavioral values and the stage of policy development. The theory underlying the model is based on Samuelson, et al.'s (1986) work and Wilke's (1991) elaboration of it as the Greed/Efficiency/Fairness (GEF) hypothesis of motivation in the management of resource dilemmas, and behavioral economics informed by Kahneman and Thaler's prospect theory. ^ The model developed in this paper employs ordered probit econometric techniques applied to data derived from U.S. polls taken from 1990 to mid-2003 that measured support for health reform proposals. Outcome data are four-tiered Likert counts; independent variables are dummies representing the presence or absence of operationalizations of each behavioral variable, along with an integer representing policy process stage. Marginal effects of each independent variable predict how support levels change on triggering that variable. Model estimation results indicate a vanishingly small likelihood that all coefficients are zero and all variables have signs expected from model theory. ^ Three hypotheses were tested: support will drain from health reform policy as it becomes increasingly well-articulated and approaches enactment; reforms appealing to fairness through universal health coverage will enjoy a higher degree of support than those targeted more narrowly; health reforms calling for government operation of the health finance system will achieve lower support than those that do not. Model results support the first and last hypotheses. Contrary to expectations, universal health care proposals did not provide incremental support beyond those targeted to “deserving” populations—children, elderly, working families. In addition, loss of autonomy (e.g. restrictions on choice of care giver) is found to be the “third rail” of health reform with significantly-reduced support. When applied to a hypothetical health reform in which an employer-mandated Medical Savings Account policy is the centerpiece, the model predicts support that may be insufficient to enactment. These results indicate that the method developed in the paper may prove valuable to health policy designers. ^

Economies of Scale and Cost Efficiencies: A Panel-Data Stochastic-Frontier Analysis of Real Estate Investment Trusts

This paper extends the existing research on real estate investment trust (REIT) operating efficiencies. We estimate a stochastic-frontier panel-data model specifying a translog cost function, covering 1995 to 2003. The results disagree with previous research in that we find little evidence of scale economies and some evidence of scale diseconomies. Moreover, we also generally find smaller inefficiencies than those shown by other REIT studies. Contrary to previous research, the results also show that self-management of a REIT associates with more inefficiency when we measure output with assets. When we use revenue to measure output, selfmanagement associates with less inefficiency. Also contrary with previous research, higher leverage associates with more efficiency. The results further suggest that inefficiency increases over time in three of our four specifications.

Cost Improvements, Returns to Scale, and Cost Inefficiencies for Real Estate Investment Trusts

This paper extends the existing research on real estate investment trust (REIT) operating efficiencies. We estimate stochastic-frontier, panel-data models specifying a translog cost function. The specified model updates the cost frontier with new information as it becomes available over time. The model can identify frontier cost improvements, returns to scale, and cost inefficiencies over time. The results disagree with most previous research in that we find no evidence of scale economies and some evidence of scale diseconomies. Moreover, we also generally find smaller inefficiencies than those shown by other REIT studies. Contrary to previous research, higher leverage associates with more efficiency.

ROLE OF MIR-19A RELEASED BY INFLAMMATORY BREAST CANCER CELLS IN THE REGULATION OF DENDRITIC CELL FUNCTIONS: IN VITRO MODEL OF CROSSTALK IN THE TUMOR MICROENVIRONMENT OF INFLAMMATORY BREAST CANCER

Inflammatory breast cancer (IBC) is a rare but very aggressive form of locally advanced breast cancer (1-6% of total breast cancer patients in United States), with a 5-year overall survival rate of only 40.5%, compared with 85% of the non-IBC patients. So far, a unique molecular signature for IBC able to explain the dramatic differences in the tumor biology between IBC and non-IBC has not been identified. As immune cells in the tumor microenvironment plays an important role in regulating tumor progression, we hypothesized that tumor-associated dendritic cells (TADC) may be responsible for regulating the development of the aggressive characteristics of IBC. MiRNAs can be released into the extracellular space and mediate the intercellular communication by regulating target gene expression beyond their cells of origin. We hypothesized that miRNAs released by IBC cells can induce an increased activation status, secretion of pro-inflammatory cytokines and migration ability of TADC. In an in vitro model of IBC tumor microenvironment, we found that the co-cultured of the IBC cell line SUM-149 with immature dendritic cells (iDCSUM-149) induced a higher degree of activation and maturation of iDCSUM-149 upon stimulation with lipopolysaccharide (LPS) compared with iDCs co-cultured with the non-IBC cell line SUM-159 (iDCSUM-159), resulting in: increased expression of the costimulatory and activation markers; higher production of pro-inflammatory cytokines (TNF-a, IL-6); and 3) higher migratory ability. These differences were due to the exosome-mediated transfer of miR-19a and miR-146a from SUM-149 and SUM-159, respectively, to iDCs, causing the downregulation of the miR-19a target genes PTEN, SOCS-1 and the miR-146a target genes IRAK1, TRAF6. PTEN, SOCS-1 and IRAK1, TRAF6 are important negative and positive regulator of cytokine- and TLR-mediated activation/maturation signaling pathway in DCs. Increased levels of IL-6 induced the upregulation of miR-19a synthesis in SUM-149 cells that was associated with the induction of CD44+CD24-ALDH1+ cancer stem cells (CSCs) with epithelial-to-mesenchymal transition (EMT) characteristics. In conclusion, in IBC tumor microenvironment IL-6/miR-19a axis can represent a self-sustaining loop able to maintain a pro-inflammatory status of DCs, leading to the development of tumor cells with high metastatic potential (EMT CSCs) responsible of the poor prognosis in IBC patients.

Relationships among epilepsy self-management, health outcomes, and socioeconomic status

The purpose of this study was to investigate the association between epilepsy self-management and disease control and socio-economic status. Study participants were adult patients at two epilepsy specialty clinics in Houston, Texas that serve demographically and socioeconomically diverse populations. Self-management behaviors- medication, information, safety, seizure, and lifestyle management were tested against emergency room visits, hospitalizations, and seizure occurrence. Overall self-management score was associated with a greater likelihood of hospitalizations over a prior twelve month time frame, but not for three months, and was not associated with seizure occurrence or emergency room visits, at all. Scores on specific self-management behaviors varied in their relationships to the different disease control indicators, over time. Contrary to expectations based on the findings of previous research, higher information management scores were associated with greater likelihood of emergency room visits and hospitalizations, over the study's twelve months. Higher lifestyle management scores were associated with lower likelihood of any emergency room visits, over the preceding twelve months and emergency room visits for the last three months. The positive associations between overall self-management scores and information management behaviors and disease control are contrary to published research. These findings may indicate that those with worse disease control in a prior period employ stronger self-management efforts to better control their epilepsy. Further research is needed to investigate this hypothesis.^

Consideraciones en torno de la articulación entre investigación y docencia en educación superior : propuestas de estrategias de intervención e innovación

El presente artículo busca elaborar una reflexión a partir de un conjunto de experiencias en las que profesores del área de humanidades y ciencias sociales diseñaron y ejecutaron proyectos de intervención pedagógica, de carácter innovador, en el desarrollo de sus cursos, y luego los discutieron en el marco de los foros organizados por la red Innova/Cesal. Se abordan marcos de referencia que contribuyan al diseño de intervenciones pedagógicas y brinden insumos que orienten el trabajo de la docencia universitaria interesada en modificar su práctica educativa e innovar sus estrategias de enseñanza y aprendizaje.

Evidencias de las dificultades habituales detectadas al iniciar la formulación de un proyecto de investigación

Una profunda preocupación por las prácticas actuales en investigación geográfica constituye la base de estas reflexiones. No cabe duda de que la tarea de iniciar a los estudiantes en la investigación es ardua porque se trata, en principio, de despertar la vocación por una actividad que deberá ser central en la profesión elegida – la de licenciado -, junto con descubrir las aptitudes necesarias para desarrollarla. El proceso de investigación tiene un comienzo por demás dificultoso como es la selección del tema/problema. Las dificultades arrancan en el mismo comienzo y se vinculan con el grado de motivación para iniciar la tarea, el manejo adecuado de los marcos conceptuales - explicativos y el conocimiento de lo que es estrictamente geográfico.

Hacia un nuevo concepto de liderazgo

En el presente trabajo se han propuesto algunos señalamientos necesarios para reformular un pilar esencial del liderazgo: la relación colectivo - líder. La serie de enunciados expuestos procuran establecer las directrices básicas del planteo teórico acerca de este fenómeno clave de la vida social. Es habitual que la lectura del liderazgo acostumbre a centrarse en el líder. Sin embargo, el proceso cuenta con otro eslabón de la mayor importancia encarnado por el grupo social que se conforma en torno a aquél. Así, los actores sociales necesitan alcanzar un estadio más de sociabilidad y expresar,entre otras cosas, necesidades y objetivos; y lo buscan de manera manifiesta en un elegido - representante. Y éste, a su vez, debe satisfacer las expectativas del colectivo. Es decir, se invierte la asimetría de la citada relación. Además, en el polo del líder se debe discernir entre la persona y el 'personaje'. He ahí cómo se despliega el particular juego del liderazgo. El constructo resultante da cuenta de la construcción de un hecho social significativo

Towards a new concept of leadership

In the present work we have posited some necessary guidelines to reformulate an essential pillar of leadership: the relationship group-leader. The set of enunciations that are developed are meant to establish the basic principles of the theoretical interpretation of this essential phenomenon of social life. In most works dealing with leadership we usually find that texts are centred on the leader. However, the process possesses another member of even greater importance embodied in the social group that forms around him or her. Thus, social actors need to reach a higher degree of sociability and to express, amongst other things, needs and goals, and they look for them openly in a chosen representative. And he or she, in turn, must fulfil the expectations of the group. In other words, the asymmetry of said relationship is inverted. Moreover, at the leader's end, we must discern between the person and the 'character'. This is how the particular game of leadership unfolds. The resulting construct accounts for the construction of a significant social feat.

Hacia un nuevo concepto de liderazgo

En el presente trabajo se han propuesto algunos señalamientos necesarios para reformular un pilar esencial del liderazgo: la relación colectivo - líder. La serie de enunciados expuestos procuran establecer las directrices básicas del planteo teórico acerca de este fenómeno clave de la vida social. Es habitual que la lectura del liderazgo acostumbre a centrarse en el líder. Sin embargo, el proceso cuenta con otro eslabón de la mayor importancia encarnado por el grupo social que se conforma en torno a aquél. Así, los actores sociales necesitan alcanzar un estadio más de sociabilidad y expresar,entre otras cosas, necesidades y objetivos; y lo buscan de manera manifiesta en un elegido - representante. Y éste, a su vez, debe satisfacer las expectativas del colectivo. Es decir, se invierte la asimetría de la citada relación. Además, en el polo del líder se debe discernir entre la persona y el 'personaje'. He ahí cómo se despliega el particular juego del liderazgo. El constructo resultante da cuenta de la construcción de un hecho social significativo

Towards a new concept of leadership

In the present work we have posited some necessary guidelines to reformulate an essential pillar of leadership: the relationship group-leader. The set of enunciations that are developed are meant to establish the basic principles of the theoretical interpretation of this essential phenomenon of social life. In most works dealing with leadership we usually find that texts are centred on the leader. However, the process possesses another member of even greater importance embodied in the social group that forms around him or her. Thus, social actors need to reach a higher degree of sociability and to express, amongst other things, needs and goals, and they look for them openly in a chosen representative. And he or she, in turn, must fulfil the expectations of the group. In other words, the asymmetry of said relationship is inverted. Moreover, at the leader's end, we must discern between the person and the 'character'. This is how the particular game of leadership unfolds. The resulting construct accounts for the construction of a significant social feat.

Hacia un nuevo concepto de liderazgo

En el presente trabajo se han propuesto algunos señalamientos necesarios para reformular un pilar esencial del liderazgo: la relación colectivo - líder. La serie de enunciados expuestos procuran establecer las directrices básicas del planteo teórico acerca de este fenómeno clave de la vida social. Es habitual que la lectura del liderazgo acostumbre a centrarse en el líder. Sin embargo, el proceso cuenta con otro eslabón de la mayor importancia encarnado por el grupo social que se conforma en torno a aquél. Así, los actores sociales necesitan alcanzar un estadio más de sociabilidad y expresar,entre otras cosas, necesidades y objetivos; y lo buscan de manera manifiesta en un elegido - representante. Y éste, a su vez, debe satisfacer las expectativas del colectivo. Es decir, se invierte la asimetría de la citada relación. Además, en el polo del líder se debe discernir entre la persona y el 'personaje'. He ahí cómo se despliega el particular juego del liderazgo. El constructo resultante da cuenta de la construcción de un hecho social significativo

Towards a new concept of leadership

In the present work we have posited some necessary guidelines to reformulate an essential pillar of leadership: the relationship group-leader. The set of enunciations that are developed are meant to establish the basic principles of the theoretical interpretation of this essential phenomenon of social life. In most works dealing with leadership we usually find that texts are centred on the leader. However, the process possesses another member of even greater importance embodied in the social group that forms around him or her. Thus, social actors need to reach a higher degree of sociability and to express, amongst other things, needs and goals, and they look for them openly in a chosen representative. And he or she, in turn, must fulfil the expectations of the group. In other words, the asymmetry of said relationship is inverted. Moreover, at the leader's end, we must discern between the person and the 'character'. This is how the particular game of leadership unfolds. The resulting construct accounts for the construction of a significant social feat.