753 resultados para behavioural phenotypes


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This study aims to analyze, compare and contrast the behavioral competency of officials in commercial banks headquartered in Kerala. This is done by analyzing the soft skills/behavioral skills possessed by an individual employee in both clerical and managerial levels and the means adopted to enhance their said skills in near future. The study was conducted with the objective of analyzing the behavioral competency of the managers and clerical staff in the commercial banks headquartered in Kerala. The researcher has gone through the available literature with respect to employee competency, job satisfaction and employee performance evaluation to formulate the problem and conceptualize the framework of the study. The study concluded that the competency of the employees differs from one bank to the other but strengthening the employees’ competency is the only possible solution by which the banks can determine their future growth prospects. Only through competency, banks can achieve high level of performance especially under the globalised situation.

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For BIOL 2040. Originally uploaded in Blackboard and uploaded here for linking to Efolio site.

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Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a negative regulator of T-cell activation associated with several autoimmune diseases, including systemic lupus erythematosus (SLE). Missense rs2476601 is associated with SLE in individuals with European ancestry. Since the rs2476601 risk allele frequency differs dramatically across ethnicities, we assessed robustness of PTPN22 association with SLE and its clinical subphenotypes across four ethnically diverse populations. Ten SNPs were genotyped in 8220 SLE cases and 7369 controls from in European-Americans (EA), African-Americans (AA), Asians (AS), and Hispanics (HS). We performed imputation-based association followed by conditional analysis to identify independent associations. Significantly associated SNPs were tested for association with SLE clinical sub-phenotypes, including autoantibody profiles. Multiple testing was accounted for by using false discovery rate. We successfully imputed and tested allelic association for 107 SNPs within the PTPN22 region and detected evidence of ethnic-specific associations from EA and HS. In EA, the strongest association was at rs2476601 (P = 4.761029, OR = 1.40 (95% CI = 1.25–1.56)). Independent association with rs1217414 was also observed in EA, and both SNPs are correlated with increased European ancestry. For HS imputed intronic SNP, rs3765598, predicted to be a cis-eQTL, was associated (P = 0.007, OR = 0.79 and 95% CI = 0.67–0.94). No significant associations were observed in AA or AS. Case-only analysis using lupus-related clinical criteria revealed differences between EA SLE patients positive for moderate to high titers of IgG anti-cardiolipin (aCL IgG .20) versus negative aCL IgG at rs2476601 (P = 0.012, OR = 1.65). Association was reinforced when these cases were compared to controls (P = 2.761025, OR = 2.11). Our results validate that rs2476601 is the most significantly associated SNP in individuals with European ancestry. Additionally, rs1217414 and rs3765598 may be associated with SLE. Further studies are required to confirm the involvement of rs2476601 with aCL IgG.

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Guía que proporciona a los que trabajan con niños con dificultades sociales, emocionales y de conducta cien ideas prácticas de cómo apoyar y desarrollar su aprendizaje. Las ideas están organizadas en quince secciones que incluyen información que va, entre otras, desde la creación de un entorno de aprendizaje, el apoyo al alumno, el desarrollo de técnicas de gestión eficaz del aula, o cómo hacer frente a los comportamientos profundamente difíciles.

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Guía que proporciona a los profesionales una amplia gama de estrategias para ayudar a los niños pequeños con problemas de conducta, emocionales y sociales que afectan a su desarrollo y a su aprendizaje, pero no necesariamente reflejan las experiencias de los niños en la vida real, ya que muchas de la categorías son una división artificial, pero útil, para la discusión y el análisis.

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Guía práctica que proporciona a los profesionales comprensión de los problemas emocionales y de comportamientos; capacidad para la creación de una buena comunicación; gestión del comportamiento en el aula y el desarrollo de un entorno de aprendizaje eficaz. Al final de cada capítulo hay pruebas de opción múltiple para consolidar lo aprendido.

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Recurso que ofrece actividades para involucrar a los estudiantes desmotivados y asegurar que tengan éxito en su experiencia de aprendizaje, independientemente de sus necesidades particulares. A través de una variedad de enfoques y técnicas, incluida la alfabetización emocional, ofrece estrategias de apoyo y da ejemplos prácticos de cómo estimular e involucrar a estos estudiantes en la gestión de su comportamiento y su aprendizaje. Describe las causas del absentismo escolar y expone una serie de síndromes y trastornos que pueden dar lugar a la aversión a la escuela.

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Resumen tomado de la publicación

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Genetic association analyses of family-based studies with ordered categorical phenotypes are often conducted using methods either for quantitative or for binary traits, which can lead to suboptimal analyses. Here we present an alternative likelihood-based method of analysis for single nucleotide polymorphism (SNP) genotypes and ordered categorical phenotypes in nuclear families of any size. Our approach, which extends our previous work for binary phenotypes, permits straightforward inclusion of covariate, gene-gene and gene-covariate interaction terms in the likelihood, incorporates a simple model for ascertainment and allows for family-specific effects in the hypothesis test. Additionally, our method produces interpretable parameter estimates and valid confidence intervals. We assess the proposed method using simulated data, and apply it to a polymorphism in the c-reactive protein (CRP) gene typed in families collected to investigate human systemic lupus erythematosus. By including sex interactions in the analysis, we show that the polymorphism is associated with anti-nuclear autoantibody (ANA) production in females, while there appears to be no effect in males.