Influence of light exposure during early life on the age of onset of bipolar disorder

Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.

Correlates of depression in bipolar disorder

We analyse time series from 100 patients with bipolar disorder for correlates of depression symptoms. As the sampling interval is non-uniform, we quantify the extent of missing and irregular data using new measures of compliance and continuity. We find that uniformity of response is negatively correlated with the standard deviation of sleep ratings (ρ = -0.26, p = 0.01). To investigate the correlation structure of the time series themselves, we apply the Edelson-Krolik method for correlation estimation. We examine the correlation between depression symptoms for a subset of patients and find that self-reported measures of sleep and appetite/weight show a lower average correlation than other symptoms. Using surrogate time series as a reference dataset, we find no evidence that depression is correlated between patients, though we note a possible loss of information from sparse sampling. © 2013 The Author(s).

Clinical guidelines on long-term pharmacotherapy for bipolar disorder in children and adolescents

Bipolar disorder is a severe affective disorder which can present in adolescence, or sometimes earlier, and often requires a pharmacotherapeutic approach. The phenomenology of bipolar disorder in children and adolescents appears to differ from that of adult patients, prompting the need for specific pharmacotherapy guidelines for long-term management in this patient population. Current treatment guidelines were mainly developed based on evidence from studies in adult patients, highlighting the requirement for further research into the pharmacotherapy of children and adolescents with bipolar disorder. This review compares and critically analyzes the available guidelines, discussing the recommended medication classes, their mechanisms of action, side effect profiles and evidence base

Assessing personal financial management in patients with bipolar disorder and its relation to impulsivity and response inhibition

Introduction: Impulsivity and risk-taking behaviours are reported in bipolar disorder (BD). We examined whether financial management skills are related to impulsivity in patients with BD. Methods: We assessed financial management skills using the Executive Personal Finance Scale (EPFS), impulsivity using the Barratt Impulsiveness Scale (BIS) and response inhibition using an emotional go/no-go task in bipolar individuals (N = 21) and healthy controls (HC; N = 23). Results: Patients had fewer financial management skills and higher levels of impulsivity than HC. In patients and controls, increased impulsivity was associated with poorer personal financial management. Patients and HC performed equally on the emotional go/no-go task. Higher BIS scores were associated with faster reaction times in HC. In patients, however, higher BIS scores were associated with slower reaction times, possibly indicating compensatory cognitive strategies to counter increased impulsivity. Conclusions: Patients with BD may have reduced abilities to manage personal finances, when compared against healthy participants. Difficulty with personal finance management may arise in part as a result of increased levels of impulsivity. Patients may learn to compensate for increased impulsivity by modulating response times in our experimental situations although whether such compensatory strategies generalize to real-world situations is unknown.

Managing bipolar depression:a therapeutic challenge?

Most people with bipolar disorder first seek treatment for depressive rather than manic symptoms. However, effective management of bipolar depression remains a challenge. In this review, Celia Feetam highlights how bipolar depression differs from unipolar depression both in its characteristics and in the approach to its treatment. © 2011 John Wiley & Sons, Ltd.

Assessment of social cognition in bipolar disorder

Background: Impairment in social cognition may contribute to deficits in social functioning in patients with bipolar disorder (BD). In this study, a complex social cognition task was administered during a neuroimaging session. The behavioral and neural correlates of social cogniton in patients with BD were compared to healthy comparison (HC) subjects. Methods: The task was administered to 25 HC and 25 patients with depression scores ranging from euthymic to depressed at the time of assessment. The task required participants to evaluate situations that were “enhancing” or “threatening” to self-esteem, directed at both oneself, and at other people. For instance, self-esteem enhancing scenarios involved vignettes of activities such as receiving praise during a sports game, while a threatening scenario involved, for example, receiving criticism at a party. Participants were then required to evaluate characters in the scenarios on the basis of positive (“kind”) or negative (“mean”) descriptors. Evaluations were classified from extremely negative to extremely positive. The frequencies of behavioral responses were analyzed using chi-square tests and fMRI data were analyzed using Statistical Parametric Mapping software. Results: Patients differed significantly from HCs in their evaluation of threatening scenarios, directed at both oneself and at other people (p<0.001). Patients had a lower proportion of responses in the neutral category, and more responses in the positive and negative categories, relative to HCs. Neuroimaging results reveal differential patterns of prefrontal-cortical and limbic-subcortical activation in BDs throughout the task [p<0.05 (unc.)]. Conclusions: Findings will contribute to understanding difficulty in interpersonal functioning in patients with BD.

Internet use by patients with bipolar disorder:results from an international multisite survey

There is considerable international interest in online education of patients with bipolar disorder, yet little understanding of how patients use the Internet and other sources to seek information. 1171 patients with bipolar disorder diagnosis in 17 countries completed a paper-based, anonymous survey. 81% of the patients used the Internet, a percentage similar to the general public. Older age, less education, and challenges in country telecommunications infrastructure and demographics decreased the odds of using the Internet. About 78% of the Internet users looked online for information on bipolar disorder or 63% of the total sample. More years of education in relation to the country mean, and feeling very confident about managing life decreased the odds of seeking information on bipolar disorder online, while having attended support groups increased the odds. Patients who looked online for information on bipolar disorder consulted medical professionals plus a mean of 2.3 other information sources such as books, physician handouts, and others with bipolar disorder. Patients not using the Internet consulted medical professionals plus a mean of 1.6 other information sources. The percentage of patients with bipolar disorder who use the Internet is about the same as the general public. Other information sources remain important.

System to predict bipolar disorder crises analysing massive data

Durante el desarrollo del proyecto he aprendido sobre Big Data, Android y MongoDB mientras que ayudaba a desarrollar un sistema para la predicción de las crisis del trastorno bipolar mediante el análisis masivo de información de diversas fuentes. En concreto hice una parte teórica sobre bases de datos NoSQL, Streaming Spark y Redes Neuronales y después diseñé y configuré una base de datos MongoDB para el proyecto del trastorno bipolar. También aprendí sobre Android y diseñé y desarrollé una aplicación de móvil en Android para recoger datos para usarlos como entrada en el sistema de predicción de crisis. Una vez terminado el desarrollo de la aplicación también llevé a cabo una evaluación con usuarios.

Online information seeking by patients with bipolar disorder:results from an international multisite survey

Background: Information seeking is an important coping mechanism for dealing with chronic illness. Despite a growing number of mental health websites, there is little understanding of how patients with bipolar disorder use the Internet to seek information. Methods: A 39 question, paper-based, anonymous survey, translated into 12 languages, was completed by 1222 patients in 17 countries as a convenience sample between March 2014 and January 2016. All patients had a diagnosis of bipolar disorder from a psychiatrist. Data were analyzed using descriptive statistics and generalized estimating equations to account for correlated data. Results: 976 (81 % of 1212 valid responses) of the patients used the Internet, and of these 750 (77 %) looked for information on bipolar disorder. When looking online for information, 89 % used a computer rather than a smartphone, and 79 % started with a general search engine. The primary reasons for searching were drug side effects (51 %), to learn anonymously (43 %), and for help coping (39 %). About 1/3 rated their search skills as expert, and 2/3 as basic or intermediate. 59 % preferred a website on mental illness and 33 % preferred Wikipedia. Only 20 % read or participated in online support groups. Most patients (62 %) searched a couple times a year. Online information seeking helped about 2/3 to cope (41 % of the entire sample). About 2/3 did not discuss Internet findings with their doctor. Conclusion: Online information seeking helps many patients to cope although alternative information sources remain important. Most patients do not discuss Internet findings with their doctor, and concern remains about the quality of online information especially related to prescription drugs. Patients may not rate search skills accurately, and may not understand limitations of online privacy. More patient education about online information searching is needed and physicians should recommend a few high quality websites.

Differential activation in temporal, cingulate and prefrontal cortices during response inhibition in bipolar disorder

Background: Increased impulsivity and aberrant response inhibition have been observed in bipolar disorder (BD). This study examined the functional abnormalities and underlying neural processes during response inhibition in BD, and its relationship to impulsivity. Methods: We assessed impulsivity using the Barratt Impulsiveness Scale (BIS) and, using functional magnetic resonance imaging (fMRI), measured neural activity in response to an Affective Go-NoGo Task, consisting of emotional facial stimuli (fear, happy, anger faces) and non-emotional control stimuli (neutral female and male faces) in euthymic BD (n=23) and healthy individuals (HI; n=25). Results: BD patients were significantly more impulsive, yet did not differ from HI on accuracy or reaction time on the emotional go/no-go task. Comparing neural patterns of activation when processing emotional Go versus emotional NoGo trials yielded increased activation in BD within temporal and cingulate cortices and within prefrontal-cortical regions in HI. Furthermore, higher BIS scores for BD were associated with slower reaction times, and indicative of compensatory cognitive strategies to counter increased impulsivity. Conclusions: These findings illustrate cognition-emotion interference in BD and the observed differences in neural activation indicate potentially altered emotion modulation. Increased activation in brain regions previously shown in emotion regulation and response inhibition tasks could represent a disease-specific marker for BD

Polymer Light-Emitting Electrochemical Cells with Embedded Bipolar Electrodes: Visualizing Bipolar Electrochemistry in Solid State

The work presented in this thesis examines the properties of BPEs of various configurations and under different operating conditions in a large planar LEC system. Detailed analysis of time-lapsed fluorescence images allows us to calculate the doping propagation speed from the BPEs. By introducing a linear array of BPEs or dispersed ITO particles, multiple light-emitting junctions or a bulk homojunction have been demonstrated. In conclusion, it has been observed that both applied bias voltages and sizes of BPEs affected the electrochemical doping from the BPE. If the applied bias voltage was initially not sufficiently high enough, a delay in appearance of doping from the BPE would take place. Experiments of parallel BPEs with different sizes (large, medium, small) demonstrate that the potential difference across the BPEs has played a vital role in doping initiation. Also, the p-doping propagation distance from medium-sized BPE has displayed an exponential growth over the time-span of 70 seconds. Experiments with a linear array of BPEs with the same size demonstrate that the doping propagation speed of each floating BPE was the same regardless of its position between the driving electrodes. Probing experiments under high driving voltages further demonstrated the potential of having a much more efficient light emission from an LEC with multiple BPEs.

Resolving conflict in bipolar societies: The fate of political settlements in Fiji and Northern Ireland

Ethnically divided societies that might be described as ‘balanced bicommunal’ (where there are two communities, each of which comes close to representing half of the population) pose a particular challenge to conventional principles of collective decision-making, and commonly threaten political stability. This article analyses the experience of two such societies – Northern Ireland and Fiji – with a view to exploring whether there are common processes in the route by which political stability has been pursued. We assess the manner in which a distinctive relationship with Great Britain and its political culture has interacted with local conditions to produce a highly competitive, bipolar party system. This leads to consideration of the devices that have been adopted in an effort to bridge the gap between the communities: the Fiji constitution as amended in 1997, and Northern Ireland’s Good Friday Agreement of 1998. We focus, in particular, on the use of unusual (preferential voting) formulas for the election of parliamentarians and of an inclusive principle in the selection of ministers, and consider the contribution of these institutional devices to the attainment of political stability. We find that, in both cases, the intervention of forces from outside the political system had a decisive impact, though in very different ways. In addition to being underpinned by solid institutional design, for political settlements to work effectively, some minimal level of trust between rival elites is required.

Conhecimento Emocional e Perturbação do Espetro do Autismo: um estudo exploratório com crianças em idade escolar

Introdução: Vários estudos associam a Pertubação do Espetro do Autismo a um défice no processamento social e informação emocional, na reações às emoções dos outros e reconhecimento emocional. O presente estudo, de cariz exploratório, pretende analisar a relação entre o conhecimento emocional e esta perturbação em crianças em idade escolar, não se limitanto à identificação das emoções do outro através da visualização de fotografias, mas também através de apresentação de vinhetas com contextos situacionais e comportamentais. Metodologia: A amostra inclui 40 crianças entre os 6 e os 14 anos: 20 com PEA (média de idade, M = 9,8; desvio padrão, DP = 2,48), 20 sem PEA (média de idade, M = 10,3; desvio padrão, DP = 2,43). Foi aplicada a Escala de Avaliação do Conhecimento Emocional (EACE), traduzida e adaptada à população portuguesa por Alves (2006) do original Assessment of Children’s Emotion Skills (ACES; Schultz, Izard & Bear, 2002), através da qual obtemos a Perceção Emocional Correta (PEC). Resultados: As crianças com PEA pontuam mais baixo (PEC = 27,9; desvio padrão; DP = 3,9), do que as crianças sem PEA (PEC = 33,6; desvio padrão; DP = 2,2). A análise por sub-escalas verifica que as crianças com PEA pontuam mais baixo quando são dadas as vinhetas com contextos situacionais ou comportamentais do que na identificação da emoção utilizando fotografias. Não há evolução no valor de PEC consoante a idade das crianças com PEA. Existem diferenças significativas na média de acertos em todos os sentimentos identificáveis entre as crianças com PEA e sem PEA. Conclusão: O conhecimento emocional contribui para o ajuste psicossocial da criança, sendo necessário a aplicação de programas de ensino de competências sociais e emocionais às crianças com Pertubação do Espetro do Autismo.

Experiências de Combate e a sua Relação com a Sintomatologia Associada à Perturbação Pós-Stress Traumático em Veteranos da Guerra Colonial Portuguesa

Objectivos: O presente estudo avaliou a relação entre diversos aspectos objectivos e subjectivos inerentes às experiências de combate/guerra e sintomatologia associada à Perturbação Pós-Stress Traumático. Os instrumentos de auto-resposta utilizados na colheita dos dados foram analisados quanto às suas principais propriedades psicométricas. Métodos: A amostra foi composta por 105 combatentes da Guerra Colonial Portuguesa. Foram utilizados os seguintes instrumentos de avaliação: um questionário sóciodemográfico de auto-resposta para a caracterização da amostra, o Posttraumatic Stress Disorder Checklist (para militares), o Peritraumatic Dissociative Experiences Questionnaire, o Questionário de Experiências de Combate e duas escalas do Deployment Risk and Resilience Inventory, nomeadamente a Difficult Livings and Working Environment Scale e a Perceived Threat Scale. Resultados: O estudo das qualidades psicométricas dos instrumentos apresenta uma consistência interna superior a .86 e uma estabilidade temporal superior a .79. A análise factorial do Peritraumatic Dissociative Experiences Questionnaire apresenta bons valores na medida de Kaiser-Meyer-Olkin e no teste de esfericidade de Bartlett. Na rotação de Varimax é extraído um factor, predizendo a sua unidimensionalidade, que explica cerca de 70% da variância total do questionário. Os resultados relativos à validade divergentediscriminante indicam, por si só, que esta se apresenta de forma clara entre os instrumentos estudados (PCL-M, PDEQ, DLWES e PTS) no subgrupo com PTSD, com excepção da verificada entre o PCL-M e o PDEQ.. Quanto à validade de critério, constatam-se diferenças entre os subgrupos com e sem PTSD. Através do método da regressão linear múltipla, duas das seis variáveis têm, isoladamente, um peso preditivo significativo para a PTSD, nomeadamente a frequência de exposição a situações típicas e objectivas de combate/ guerra e os desconfortos diários durante a(s) comissão(ões). Ao considerarmos as variáveis no seu conjunto, aquelas que mais contribuem são a dissociação peritraumática e os desconfortos diários durante a(s) comissão(ões). Conclusão: Constata-se que os factores peritraumáticos em estudo desempenham um importante papel no desenvolvimento da sintomatologia inerente à PTSD. /

Estilos Educativos Parentais, Hábitos/Comportamentos Alimentares e Sintomas de Perturbação do Comportamento Alimentar, numa Amostra de Adolescentes

Introdução: Quer na literatura internacional, quer nacional são poucos os estudos que exploram a associação entre os estilos educativos parentais, os hábitos/comportamentos alimentares e a sintomatologia de perturbação do comportamento alimentar (PCA). Pretende-se, então, com este estudo, fundamentalmente, explorar associações entre as dimensões de um instrumento que avalia estilos educativos parentais (o Parental Rearing Style Questionnaire for use With Adolescents/EMBU-A), dimensões de um teste que avalia sintomatologia de PCA (Teste de Atitudes Alimentares/TAA-25), índice de massa corporal (IMC), itens que avaliam hábitos/comportamentos alimentares e diferentes variáveis sociodemográficas, familiares e de saúde. Em função das associações encontradas pretendemos, igualmente, explorar quais as variáveis preditivas da sintomatologia de PCA e dos hábitos/comportamentos alimentares. Metodologia: 402 adolescentes (raparigas: n = 241, 60%) entre os 12 e 18 anos (M = 14,2; DP = 1,62) das cidades de Coimbra, Cantanhede e Matosinhos preencheram um protocolo composto por um questionário sobre variáveis sociodemográficas, familiares e de saúde, o EMBU-A e o TAA-25. Resultados: Verificou-se, de uma forma geral, uma associação negativa entre a dimensão Suporte Emocional do EMBU-A, as dimensões do TAA-25 e a pontuação total deste instrumento. No sentido oposto, verificou-se, genericamente, uma associação positiva geral entre as dimensões Sobreproteção e Rejeição e os mesmos resultados relativos ao TAA-25. A prática de desporto mostrou-se associada a uma pontuação média superior de Motivação para a Magreza e da pontuação total do TAA-25. Nas análises preditivas foi possível constatar que o Suporte Emocional tende a diminuir a probabilidade dos jovens manifestarem sintomatologia de PCA. Por oposição, a Rejeição tende a aumentar a probabilidade dos jovens apresentarem esta sintomatologia. Conclusão/Discussão: A dimensão Suporte Emocional do EMBU-A parece ser protetora do surgimento de sintomatologia de PCA e de hábitos/comportamentos disfuncionais nos adolescentes, enquanto a dimensão Rejeição parece aumentar o risco do desenvolvimento dessa sintomatologia e desses hábitos/comportamentos alimentares. Neste sentido, devem ser trabalhadas estas dimensões junto dos pais, eventualmente através de programas psicoeducativos. Também nas escolas e centros de saúde podem ser implementados programas com vista a melhorar os hábitos/comportamentos alimentares e ajudar a prevenir o surgimento de PCA. / Introduction: There are few studies both in the international and national literature exploring the association between parental educational styles, eating habits/behaviours and symptoms of Eating Disorders (ED). With this study we intend to examine the associations between the dimensions of an instrument assessing parenting styles (Parental Rearing Style Questionnaire for Adolescents/ EMBU-A), dimensions of a test assessing symptoms of eating disorders(Eating Attitudes Test-25/EAT-25), Body Mass Index (BMI), items assessing eating habits/behaviors and different sociodemographic family and health variables. Based on the associations found, we also intend to explore which are the variables that show to be predictors of symptoms of eating disorders and eating habits/behaviours. Methodology: 402 adolescents (girls: n = 241, 60%) between 12 and 18 years old (M = 14,2, SD = 1,62) from Coimbra, Cantanhede and Matosinhos completed a protocol consisting of a sociodemographic questionnaire, the EMBU-A and the EAT-25. Results: In general, we found a negative association between the Emotional Support dimension of EMBU-A, the EAT-25 dimensions and the total score of this instrument. In opposition, there was, generally, a positive association between the Overprotection and Rejection dimensions (EMBU-A) and the same results of the EAT-25. Sports’ practice was associated with a higher mean score of Motivation for Thinness and the total score of the EAT-25. In the predictive analyses, we verified that Emotional Support tends to decrease the likelihood of adolescents manifesting symptoms of ED. In contrast, Rejection tends to increase the likelihood of young people presenting these symptoms. Conclusion/Discussion: The dimension of seems to be protective of the appearance of symptoms of ED and of dysfunctional eating habits/behaviors in adolescents, while Rejection appears to increase the risk of developing such symptoms and these eating habits/behaviors. For these reasons, these dimensions should be worked together with parents, eventually by means of psicoeducational programs. Also, in schools and health centers programs can be implemented in order to improve eating habits/behaviors and to help prevent the development of ED.