NEONATAL HANDLING AND THE MATERNAL ODOR PREFERENCE IN RAT PUPS: INVOLVEMENT OF MONOAMINES AND CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN PATHWAY IN THE OLFACTORY BULB

Early-life environmental events, such as the handling procedure, can induce long-lasting alterations upon several behavioral and neuroendocrine systems. However, the changes within the pups that could be causally related to the effects in adulthood are still poorly understood. In the present study, we analyzed the effects of neonatal handling on behavioral (maternal odor preference) and biochemical (cyclic AMP response element-binding protein (CREB) phosphorylation, noradrenaline (NA), and serotonin (5-HT) levels in the olfactory bulb (OB)) parameters in 7-day-old male and female rat pups. Repeated handling (RH) abolished preference for the maternal odor in female pups compared with nonhandled (NH) and the single-handled (SH) ones, while in RH males the preference was not different than NH and SH groups. In both male and female pups, RH decreased NA activity in the OB, but 5-HT activity increased only in males. Since preference for the maternal odor involves the synergic action of NA and 5-HT in the OB, the maintenance of the behavior in RH males could be related to the increased 5-HT activity, in spite of reduction in the NA activity in the OB. RH did not alter CREB phosphorylation in the OB of both male and females compared with NH pups. The repeated handling procedure can affect the behavior of rat pups in response to the maternal odor and biochemical parameters related to the olfactory learning mechanism. Sex differences were already detected in 7-day-old pups. Although the responsiveness of the hypothalamic-pituitary-adrenal axis to stressors is reduced in the neonatal period, environmental interventions may impact behavioral and biochemical mechanisms relevant to the animal at that early age. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.

Two-level network design with intermediate facilities: An application to electrical distribution systems

We consider the two-level network design problem with intermediate facilities. This problem consists of designing a minimum cost network respecting some requirements, usually described in terms of the network topology or in terms of a desired flow of commodities between source and destination vertices. Each selected link must receive one of two types of edge facilities and the connection of different edge facilities requires a costly and capacitated vertex facility. We propose a hybrid decomposition approach which heuristically obtains tentative solutions for the vertex facilities number and location and use these solutions to limit the computational burden of a branch-and-cut algorithm. We test our method on instances of the power system secondary distribution network design problem. The results show that the method is efficient both in terms of solution quality and computational times. (C) 2010 Elsevier Ltd. All rights reserved.

Infeasibility handling in genetic algorithm using nested domains for production planning

In this paper we present a genetic algorithm with new components to tackle capacitated lot sizing and scheduling problems with sequence dependent setups that appear in a wide range of industries, from soft drink bottling to food manufacturing. Finding a feasible solution to highly constrained problems is often a very difficult task. Various strategies have been applied to deal with infeasible solutions throughout the search. We propose a new scheme of classifying individuals based on nested domains to determine the solutions according to the level of infeasibility, which in our case represents bands of additional production hours (overtime). Within each band, individuals are just differentiated by their fitness function. As iterations are conducted, the widths of the bands are dynamically adjusted to improve the convergence of the individuals into the feasible domain. The numerical experiments on highly capacitated instances show the effectiveness of this computational tractable approach to guide the search toward the feasible domain. Our approach outperforms other state-of-the-art approaches and commercial solvers. (C) 2009 Elsevier Ltd. All rights reserved.

Evolutionary model trees for handling continuous classes in machine learning

Model trees are a particular case of decision trees employed to solve regression problems. They have the advantage of presenting an interpretable output, helping the end-user to get more confidence in the prediction and providing the basis for the end-user to have new insight about the data, confirming or rejecting hypotheses previously formed. Moreover, model trees present an acceptable level of predictive performance in comparison to most techniques used for solving regression problems. Since generating the optimal model tree is an NP-Complete problem, traditional model tree induction algorithms make use of a greedy top-down divide-and-conquer strategy, which may not converge to the global optimal solution. In this paper, we propose a novel algorithm based on the use of the evolutionary algorithms paradigm as an alternate heuristic to generate model trees in order to improve the convergence to globally near-optimal solutions. We call our new approach evolutionary model tree induction (E-Motion). We test its predictive performance using public UCI data sets, and we compare the results to traditional greedy regression/model trees induction algorithms, as well as to other evolutionary approaches. Results show that our method presents a good trade-off between predictive performance and model comprehensibility, which may be crucial in many machine learning applications. (C) 2010 Elsevier Inc. All rights reserved.

Advanced functionality for radio analysis in the Offline software framework of the Pierre Auger Observatory

The advent of the Auger Engineering Radio Array (AERA) necessitates the development of a powerful framework for the analysis of radio measurements of cosmic ray air showers. As AERA performs ""radio-hybrid"" measurements of air shower radio emission in coincidence with the surface particle detectors and fluorescence telescopes of the Pierre Auger Observatory, the radio analysis functionality had to be incorporated in the existing hybrid analysis solutions for fluorescence and surface detector data. This goal has been achieved in a natural way by extending the existing Auger Offline software framework with radio functionality. In this article, we lay out the design, highlights and features of the radio extension implemented in the Auger Offline framework. Its functionality has achieved a high degree of sophistication and offers advanced features such as vectorial reconstruction of the electric field, advanced signal processing algorithms, a transparent and efficient handling of FFTs, a very detailed simulation of detector effects, and the read-in of multiple data formats including data from various radio simulation codes. The source code of this radio functionality can be made available to interested parties on request. (C) 2011 Elsevier B.V. All rights reserved.

Formalization of an architectural model for exception handling coordination based on CA action concepts

Architectures based on Coordinated Atomic action (CA action) concepts have been used to build concurrent fault-tolerant systems. This conceptual model combines concurrent exception handling with action nesting to provide a general mechanism for both enclosing interactions among system components and coordinating forward error recovery measures. This article presents an architectural model to guide the formal specification of concurrent fault-tolerant systems. This architecture provides built-in Communicating Sequential Processes (CSPs) and predefined channels to coordinate exception handling of the user-defined components. Hence some safety properties concerning action scoping and concurrent exception handling can be proved by using the FDR (Failure Divergence Refinement) verification tool. As a result, a formal and general architecture supporting software fault tolerance is ready to be used and proved as users define components with normal and exceptional behaviors. (C) 2010 Elsevier B.V. All rights reserved.

Bättre utnyttjande av nya och befintliga förrådslokaler på SSAB Tunnplåt

The purpose of this assignment at SSAB Tunnplåt in Borlänge was mainly to investigate and describe the circumstances for the spare parts stored in storage facilities within the area of operation. Even new facilities which could serve as storage rooms and their opportunities for storing spare parts were an important part of the investigation. This because of the need for improved storing of spare parts. Furthermore, market offers where reviewed for storage of spare parts in more tailored designs. The work will culminate in proposals for improvement which is of importance for the development surrounding the storage and handling of spare parts. This is since the design and management of existing storage facilities is not perceived as satisfactory with regards to spare parts characteristics. Moreover, the amount of stock locations is too few in relation to the actual need. The approach used to achieve objectives of the work was an advanced mapping for collection of vital data. The mapping consisted of interviews with involved parties, both internal and external, for the most comprehensive picture of the problems as possible. In addition, a literature survey was conducted to identify possible options for the objectives of the work as well as a personal study of existing and new storage facilities. Furthermore, the market offers for improved conditions in storage rooms were examined. A clear picture of internal logistics and warehouse activities for spare parts at SSAB Tunnplåt has been obtained during this work. From this picture, it is concluded that work in and around storage facilities can be made more efficient. SSAB Tunnplåt should additionally make efforts in the storage facilities for better use of the available storage space. A number of proposals for improvement for each studied storage facility and spare parts management in general have been conducted. These proposals for improvement include presentations to improve the design of the studied storage facilities towards enabling more stock locations. The proposals also include additional equipment for handling spare parts, scrap handling, as well as expansions of the maintenance system which supports activities in the spare parts management.

Från ord till (e-)handling : - Integration av e-handelssystemi SiteVision

The client, Senselogic, had noticed an increased demand for an e-commerce system integrated into its product, SiteVision, something that did not previously exist. Senselogic wanted to integrate a third-party system to manage e-commerce. The problem was that there were very many e-commerce solutions to choose from. In order to select the best system it was necessary to evaluate the e-commerce systems and compare them to each other. To identify the elements that has to be included in an e-commerce system a study of literature was conducted. From the parts identified in the study of literature, a number of criteria were presented. Those criteria were then supplemented with additional criteria that Senselogic required of an e-commerce system before integrating it with SiteVision. Before the evaluation a number of test cases were created to test whether the ecommerce systems fulfilled to the criteria developed. These test cases were then used in the evaluation of the e-commerce systems while a test score was filled in. Then the evaluations of the different systems were compiled and compared in order to see which system best fulfilled the criteria. There was one system that scored higher than the others in the evaluation created. That was the system chosen to integrate with SiteVision.

Att omsätta vetenskap till handling : Försök som gjorts för att minska förekomst av trycksår samt vårdpersonalens följsamhet till trycksårsförebyggande riktlinjer.

Syftet med studien var att undersöka vilka försök som gjorts för att minska förekomst av trycksår samt att undersöka vårdpersonalens följsamhet till trycksårsförebyggande riktlinjer. Studien utfördes som en litteraturstudie och bygger på resultatet från 13 vetenskapliga artiklar. Artiklarna söktes via databaserna Cinahl och PubMed. För att inkluderas i studien skulle de vara publicerade mellan 2005 och 2010, skrivna på engelska eller svenska, vara relevanta för ämnet samt tillgängliga i fulltext. En sammanfattning av huvudresultatet visade att de flesta försök som gjorts för att minska förekomst av trycksår innebar en implementering av nya riktlinjer. För att höja kompetensnivån hos vårdpersonal har utbildning och information varit ett genomgående tillvägagångssätt i studierna. Ett starkt ledarskap sågs som en avgörande faktor för hur effektivt riktlinjerna efterföljdes av vårdpersonalen. I flera studier framgick att användandet av tryckavlastande madrass var det mest framgångsrika sättet att minska prevalens av trycksår. Studier som gjorts med syfte att beskriva vårdpersonals följsamhet till trycksårsförebyggande riktlinjer visade att det förelåg en diskrepans mellan evidensbaserad vetenskap och vårdpersonalens agerande i den kliniska verksamheten samt att följsamheten till riktlinjerna var låg.

Att utveckla och utvecklas i förskolan : Kunskapande i praktisk handling med reflektionen som grund

Studien belyser ett aktionsforskningsinriktat utvecklingsarbete som iscensattes och genomfördes på tre avdelningar i en svensk förskola under september, oktober och november 2010. Matematik, lek samt samtalsklimatet var de områden som de tio medverkande pedagogerna valde att utveckla. Fallstudien har koppling till specialpedagogik med emfas på att skapa ett förebyggande arbete genom att kontinuerligt dokumentera, följa upp och utveckla förskolans verksamhet för att ge bästa möjliga förutsättningar för utveckling och lärande utifrån barns olika förutsättningar och behov. Det övergripande syftet har varit att i samverkan mellan forskare och pedagoger beskriva ett aktionsforskningsinriktat utvecklingsarbete i en förskolas verksamhet samt att analysera och tolka det beskrivna utvecklingsarbetet. Syftet har också varit att belysa de deltagande pedagogernas uppfattningar av vilka förändringar som ägde rum i verksamheten samt hur och varför förändringarna ägde rum. I utvecklingsarbetet har sociokulturell teoribildning och praktik växelverkat genom att systematiska observationer och dokumentationer har reflekterats i en serie om fyra handledningssamtal med respektive arbetslag. Triangulering har använts som metod där forskarens deltagande observationer, transkriptioner av samtalen samt intervjuer med pedagogerna har fått komplettera varandra. Studien har haft en fenomenografisk ansats vilket här innebar att söka efter variationen av pedagogernas uppfattningar. Studien vilar på socialkonstruktionistisk kunskapssyn och sociokulturell lärandeteoris idé om att lärande kan ske genom interaktion med betydelsefulla andra och att vi utifrån behov och den kontext vi ingår i utvecklar våra verktyg genom aktivitet och handlingar. En fenomenografisk analysmetod har använts där pedagogernas utsagor i respektive arbetslag inordnats i beskrivningskategorier som sedan analyserats i ett horisontalt system. Relationen mellan samtliga arbetslags beskrivningskategorier analyserades i ett hierarkiskt system. Resultatet tolkades och formulerades i en slutsats där utvecklingsarbetet beskrivs som en hierarkisk process i tre steg: Organisering – reflektion – praktisk handling. Att organisera för tid och upplägg av handledningssamtal och dokumentationsverktyg uppfattades av pedagogerna som en grundläggande förutsättning för utvecklingsarbetet. De reflektioner som blev möjliga genom de kontinuerliga handledningssamtalen och utifrån dokumentationerna uppfattades av pedagogerna leda till ett kunskapande om den egna praktiken och om sig själva som pedagoger. De nya kunskaperna ledde i sin tur till de nya aktioner som prövades. Aktionerna beskrevs av pedagogerna dels som gripbara förändringar i miljön och dels som icke gripbara förändringar vilket innebar att pedagogerna ökade sin närvaro, delaktighet och medvetenhet i samspelet med barnen. Studien kan bidra till att andra förskolor inspireras i arbetet med att utveckla sin verksamhet och söka stöd för att se på den egna praktiken samt att låta mötet mellan teori och praktik stimulera till utveckling och förändring.

Mångfald - Från ord till handling : En kvalitativ studie om HRs strategiska arbete med mångfald

Denna studie grundar sig i ett uppdrag från Trafikverket med avsikten att undersöka hur enmångfaldsstrategi kan få ökad effekt i organisationen. Utgångspunkten för denna studie är attdet tycks krävas mer forskning kring hur HR strategiskt kan arbeta med mångfaldsfrågor ochintegrera dem i organisationens alla delar. Syftet med denna studie är således att identifiera hurHR strategiskt kan arbeta med mångfaldsfrågor. Vidare är syftet att visa hur ett strategiskamångfaldsarbete kan bli mer effektivt.Teorier som belyser begreppet mångfald, effekterna av mångfald, strategi, Human ResourceManagement och Strategic Human Resource management kan ses ligga till grund för ettframgångsrikt HRM-arbete med mångfald. Ledarskap, kommunikation, kunskap och att se tillorganisationskulturen belyser teorin som viktiga komponenter för att ett strategiskt arbete skabli mer effektivt och ge effekt i organisationen.Studien bygger på en deduktiv ansats och en kvalitativ metod har genomförts utifrån treindividuella intervjuer och två fokusgrupper. De individuella intervjuernas syfte var att belysaorganisationens nutida arbete med mångfald, framtida perspektiv för hur ett strategisktmångfaldsarbete kan utformas och en målbild för vad arbetet ska resultera i. Den enafokusgruppen bestod av medarbetare från HR från olika regionkontor i landet och hade somsyfte att klargöra hur HR strategiskt kan arbeta med mångfald. Den andra fokusgruppen bestodav chefer från olika regionkontor i landet och hade som syfte att belysa chefers roll och vad deeftersöker i ett strategiskt mångfaldsarbete.Resultatet från intervjuerna har analyserats utifrån den teoretiska referensramen och i dennastudie har vi kommit fram till och identifierat flera betydelsefulla faktorer som för HR är viktigai utformandet av en mångfaldsstrategi. Det är viktigt att definiera begreppet mångfald, klargöraansvarsfrågan, visa på varför organisationen bör arbeta med månglad och kommuniceraeffekterna. Vidare är det viktigt att koppla mångfaldsstrategin till övriga HRM-aktiviteter ochorganisationens övriga strategier och mål för att det strategiska arbetet ska ge effekt. Kunskapom mångfald och att se arbetet som ett förändringsarbete där ledningen utgör en viktig roll harvisat sig vara väsentliga faktorer för att arbetet ska få värde i organisationen.

Does road network density matter in optimally locating facilities?

Optimal location on the transport infrastructure is the preferable requirement for many decision making processes. Most studies have focused on evaluating performances of optimally locate p facilities by minimizing their distances to a geographically distributed demand (n) when p and n vary. The optimal locations are also sensitive to geographical context such as road network, especially when they are asymmetrically distributed in the plane. The influence of alternating road network density is however not a very well-studied problem especially when it is applied in a real world context. This paper aims to investigate how the density level of the road network affects finding optimal location by solving the specific case of p-median location problem. A denser network is found needed when a higher number of facilities are to locate. The best solution will not always be obtained in the most detailed network but in a middle density level. The solutions do not further improve or improve insignificantly as the density exceeds 12,000 nodes, some solutions even deteriorate. The hierarchy of the different densities of network can be used according to location and transportation purposes and increase the efficiency of heuristic methods. The method in this study can be applied to other location-allocation problem in transportation analysis where the road network density can be differentiated. 

How does the use of different road networks effect the optimal location of facilities in rural areas?

The p-median problem is often used to locate P service facilities in a geographically distributed population. Important for the performance of such a model is the distance measure. Distance measure can vary if the accuracy of the road network varies. The rst aim in this study is to analyze how the optimal location solutions vary, using the p-median model, when the road network is alternated. It is hard to nd an exact optimal solution for p-median problems. Therefore, in this study two heuristic solutions are applied, simulating annealing and a classic heuristic. The secondary aim is to compare the optimal location solutions using dierent algorithms for large p-median problem. The investigation is conducted by the means of a case study in a rural region with an asymmetrically distributed population, Dalecarlia. The study shows that the use of more accurate road networks gives better solutions for optimal location, regardless what algorithm that is used and regardless how many service facilities that is optimized for. It is also shown that the simulated annealing algorithm not just is much faster than the classic heuristic used here, but also in most cases gives better location solutions.