Orquestração de migração massiva de máquinas virtuais baseada em análise cíclica para ambientes de computação na nuvem.

Um das principais características da tecnologia de virtualização é a Live Migration, que permite que máquinas virtuais sejam movimentadas entre máquinas físicas sem a interrupção da execução. Esta característica habilita a implementação de políticas mais sofisticadas dentro de um ambiente de computação na nuvem, como a otimização de uso de energia elétrica e recursos computacionais. Entretanto, a Live Migration pode impor severa degradação de desempenho nas aplicações das máquinas virtuais e causar diversos impactos na infraestrutura dos provedores de serviço, como congestionamento de rede e máquinas virtuais co-existentes nas máquinas físicas. Diferente de diversos estudos, este estudo considera a carga de trabalho da máquina virtual um importante fator e argumenta que escolhendo o momento adequado para a migração da máquina virtual pode-se reduzir as penalidades impostas pela Live Migration. Este trabalho introduz a Application-aware Live Migration (ALMA), que intercepta as submissões de Live Migration e, baseado na carga de trabalho da aplicação, adia a migração para um momento mais favorável. Os experimentos conduzidos neste trabalho mostraram que a arquitetura reduziu em até 74% o tempo das migrações para os experimentos com benchmarks e em até 67% os experimentos com carga de trabalho real. A transferência de dados causada pela Live Migration foi reduzida em até 62%. Além disso, o presente introduz um modelo que faz a predição do custo da Live Migration para a carga de trabalho e também um algoritmo de migração que não é sensível à utilização de memória da máquina virtual.

Priority realloc: um mecanismo para alocação de rotas e recursos em redes EON.

Backbone networks are responsible for long-haul data transport serving many clients with a large volume of data. Since long-haul data transport service must rely on a robust high capacity network the current technology broadly adopted by the industry is Wavelength Division Multiplexing (WDM). WDM networks enable one single ber to operate with multiple high capacity channels, drastically increasing the ber capacity. In WDM networks each channel is associated with an individual wavelength. Therefore a whole wavelength capacity is assigned to a connection, causing waste of bandwidth in case the connection bandwidth requirement is less than the channel total capacity. In the last half decade, Elastic Optical Networks (EON) have been proposed and developed based on the fexible use of the optical spectrum known as the exigrid. EONs are adaptable to clients requirements and may enhance optical networks performance. For these reasons, research community and data transport providers have been demonstrating increasingly high interest in EONs which are likely to replace WDM as the universally adopted technology in backbone networks in the near future. EONs have two characteristics that may limit its ecient resources use. The spectrum fragmentation, inherent to the dynamic EON operation, decrease the network capacity to assign resources to connection requests increasing network blocking probability. The spectrum fragmentation also intensifides the denial of service to higher rate request inducing service unfairness. Due to the fact EONs were just recently developed and proposed, the aforementioned issues were not yet extensively studied and solutions are still being proposed. Furthermore, EONs do not yet provide specific features as differentiated service mechanisms. Differentiated service strategies are important in backbone networks to guarantee client\'s diverse requirements in case of a network failure or the natural congestion and resources contention that may occur at some periods of time in a network. Impelled by the foregoing facts, this thesis objective is three-fold. By means of developing and proposing a mechanism for routing and resources assignment in EONs, we intend to provide differentiated service while decreasing fragmentation level and increasing service fairness. The mechanism proposed and explained in this thesis was tested in a EON simulation environment and performance results indicated that it promotes beneficial performance enhancements when compared to benchmark algorithms.

Abstracts of legislation relating to Harvard College governance (manuscript notebook), ca. 1723

Octavo-sized notebook containing handwritten abstracts of Massachusetts General Court legislation between 1650 and August 24, 1723 related to Harvard governance. The volume contains informal notes with extracts and summaries of legislation that established or amended the makeup and power of the Harvard Corporation. The authors of the volume are unidentified, but the notes appear to be in two different hands. The volume was presumably created during the fellowship controversy that erupted in the early 1720s after tutors Henry Flynt, Nicholas Sever, and Thomas Robie presented a memorial to the Board of Overseers calling for the tutors' right of fellowship in the Corporation.

Justice of the peace day book, 1797-1816

Contains records of summons and judgements in various court cases, and fines paid.

Letters to George Simpson, 1796, 1806

Two letters to the cashier of the Bank of the United States requesting that funds be transferred to Andrew Bayard in Philadelphia, so that Paterson could receive his salary as associate justice of the U.S. Supreme Court.

Papers of George Godfrey, 1739-1792

The bulk of this collection consists of brief records of civil actions heard by George Godfrey as a justice of the peace for Bristol County, Massachusetts. With only a few interruptions, these records run from February 1754 through the early 1780s. The other documents include several small volumes and loose pages of household accounts, as well as a handful of pages of court records and marriages heard by George Godfrey and his father, John Godfrey.

Documents: concerning North American Atlantic coastal areas : manuscript, [17--]

Acts, reports, petitions, court opinions, and other documents, spanning 1680-1725, concerning Antigua, Barbados, the Carolinas, St. Christopher [Saint Kitts], Jamaica, New York, Virginia, and other areas on the Atlantic coast.

Letter from Isaac Hull to William Tudor,

Three letters regarding the court martial and trial of Tudor’s brother-in-law, Charles Stewart, and French naval activities in the area. One letter was written by Hull’s wife.

Chicago, Illinois, 1853 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: City of Chicago : Cook Co., Illinois, surveyed and published by Henry Hart ; drawn by C. Potter. It was published in 1853. Scale [ca. 1:5,000]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Illinois East State Plane Coordinate System NAD83 (in Feet) (Fipszone 1201). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, selected public buildings and private buildings, names of selected landowners, block numbers, property lot number, dimensions, and areas, city ward boundaries, and more. Includes engraving of Cook County Court House and a list of references. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

A Minor Change?: A Case Study of Carleton Place's Integration of Minor Variance Procedures into Ontario's Development Permit System

The Development Permit System has been introduce with minimal directives for establishing a decision making process. This is in opposition to the long established process for minor variances and suggests that the Development Permit System does not necessarily incorporate all of Ontario’s fundamental planning principles. From this concept, the study aimed to identify how minor variances are incorporated into the Development Permit System. In order to examine this topic, the research was based around the following research questions: • How are ‘minor variance’ applications processed within the DPS? • To what extent do the four tests of a minor variance influence the outcomes of lower level applications in the DPS approval process? A case study approach was used for this research. The single-case design employed both qualitative and quantitative research methods including a review of academic literature, court cases, and official documents, as well as a content analysis of Class 1, 1A, and 2 Development Permit application files from the Town of Carleton Place that were decided between 2011 and 2015. Upon the completion of the content analysis, it was found that minor variance issues were most commonly assigned to Class 1 applications. Planning staff generally met approval timelines and embraced their delegated approval authority, readily attaching conditions to applications in order to mitigate off-site impacts. While staff met the regulatory requirements of the DPS, ‘minor variance’ applications were largely decided on impact alone, demonstrating that the principles established by the four tests, the defining quality of the minor variance approval process, had not transferred to the Development Permit System. Alternatively, there was some evidence that the development community has not fully adjusted to the requirements of the new approvals process, as some applications were supported using a rationale containing the four tests. Subsequently, a set of four recommendations were offered which reflect the main themes established by the findings. The first two recommendations are directed towards the Province, the third to municipalities and the fourth to developers and planning consultants: 1) Amend Ontario Regulation 608/06 so that provisions under Section 4(3)(e) fall under Section 4(2). 2) Change the rhetoric from “combining elements of minor variances” to “replacing minor variances”. 3) Establish clear evaluation criteria. 4) Understand the evaluative criteria of the municipality in which you are working.

Doença de Addison no adulto

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Étude du polymorphisme rs3846662 de l’HMGCR dans le cerveau et le système périphérique

Dans cette thèse, l’impact du polymorphisme rs3846662 sur l’épissage alternatif de la 3-hydroxy-3-méthylglutaryl coenzyme A réductase (HMGCR) a été investigué in vivo, chez des patients atteints d’hypercholestérolémie familiale (HF) ou de maladie d’Alzheimer (MA). Le premier manuscrit adresse la problématique de la normalisation de la quantification relative des ARNm par PCR quantitative. Les découvertes présentées dans ce manuscrit nous ont permis de déterminer avec un haut niveau de confiance les gènes de référence à utiliser pour la quantification relative des niveaux d’ARNm de l’HMGCR dans des échantillons de sang (troisième manuscrit) et de tissus cérébraux post-mortem (quatrième manuscrit). Dans le deuxième manuscrit, nous démontrons grâce à l’emploi de trois cohortes de patients distinctes, soit la population canadienne française du Québec et les deux populations nord américaines « Alzheimer’s Disease Cooperative Study (ADCS) » et « Alzheimer’s Disease Neuroimaging Initiative (ADNI) », que le génotype AA au locus rs3846662 confère à ces porteurs une protection considérable contre la MA. Les femmes porteuses de ce génotype voient leur risque de MA diminuer de près de 50% et l’âge d’apparition de leurs premiers symptômes retarder de 3.6 ans. Les porteurs de l’allèle à risque APOE4 voient pour leur part leurs niveaux de plaques séniles et dégénérescences neurofibrillaires diminuer significativement en présence du génotype AA. Enfin, les individus atteints de déficit cognitif léger et porteurs à la fois de l’allèle APOE4 et du génotype protecteur AA voient leur risque de convertir vers la MA chuter de 76 à 27%. Dans le troisième manuscrit, nous constatons que les individus atteints d’HF et porteurs du génotype AA ont, contrairement au modèle établi chez les gens normaux, des niveaux plus élevés de cholestérol total et de LDL-C avant traitement comparativement aux porteurs de l’allèle G. Le fait que cette association n’est observée que chez les non porteurs de l’APOE4 et que les femmes porteuses du génotype AA présentent à la fois une augmentation des niveaux d’ARNm totaux et une résistance aux traitements par statines, nous indique que ce génotype influencerait non seulement l’épissage alternatif, mais également la transcription de l’HMGCR. Comme une revue exhaustive de la littérature ne révèle aucune étude abondant dans ce sens, nos résultats suggèrent l’existence de joueurs encore inconnus qui viennent influencer la relation entre le génotype AA, l’épissage alternatif et les niveaux d’ARNm de l’HMGCR. Dans le quatrième manuscrit, l’absence d’associations entre le génotype AA et les niveaux d’ARNm Δ13 ou de protéines HMGCR nous suggère fortement que ce polymorphisme est non fonctionnel dans le SNC affecté par la MA. Une étude approfondie de la littérature nous a permis d’étayer cette hypothèse puisque les niveaux de HNRNPA1, la ribonucléoprotéine influencée par l’allèle au locus rs3846662, sont considérablement réduits dans la MA et le vieillissement. Il est donc proposé que les effets protecteurs contre la MA associés au génotype AA soient le résultat d’une action indirecte sur le processus physiopathologique.

The Eurasian Economic Union – more political, less economic. OSW Commentary Number 157/20.01.2015

The Eurasian Economic Union is undoubtedly the most comprehensive form of economic integration of the post-Soviet countries since the break-up of the Soviet Union. However, the way in which the integration process has been unfolding, as well as Russia’s aggressive policy over the last year, are indications that the EEU has become primarily a political project, and the importance of its economic aspects has eroded. This has triggered a change in the way Kazakhstan and Belarus treat the EEU. Initially, the two countries viewed integration as an opportunity for the development of genuine economic co-operation. However, Russia’s annexation of Crimea and the conflict in Ukraine have revealed the real significance of the EEU project – as a tool to reinforce Russian influence in the post-Soviet area and isolate the post-Soviet countries from the West and China. While the Kremlin presents the EEU as the Eurasian equivalent of the European Union, the project is in reality an imitation of integration. The reasons for this include the nature of the political systems in the participating countries, which are authoritarian, prone to instrumentalise law, and affected by systemic corruption; the aggressive policy that Russia has been pursuing over the last year; and Russia’s dominant role in defining the shape of the EEU. The EEU appears to be based on forceful integration, and is becoming less and less economically attractive for its member countries other than Russia. Moreover, it is clearly assuming a political dimension that those other member countries perceive as dangerous. For these reasons, its functioning will depend on the power and position of Russia. In the longer term it is likely that the other member states will try to ‘sham’ and delay closer integration within the EEU. This means that if Russia becomes politically and economically weaker, the EEU may evolve into an increasingly dysfunctional organisation – a development that will be reinforced by the low standards of legal culture in its member states and their reluctance to integrate. Should Russia’s power increase, the EEU will become an effective instrument of Russian dominance in the area of the former USSR.

Texas juvenile probation report.

"Statistical and other data on the state juvenile justice system."

Survey of London /

Later vols. published by the Athlone Press for the Greater London Council.